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Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-12 Liesl K. Janssens, Katleen Van Uytfanghe, Jeffrey B. Williams, Kirk W. Hering, Donna M. Iula, Christophe P. Stove
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Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-09 René Geci, Domenico Gadaleta, Marina García de Lomana, Rita Ortega-Vallbona, Erika Colombo, Eva Serrano-Candelas, Alicia Paini, Lars Kuepfer, Stephan Schaller
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Targeting gut microbiota for immunotherapy of diseases Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-09 Ya-Jie Yu, Xiao-Dong Liu, Cai Liao, Rui Yu, Xin Wang, Ming Li, Yun Wang
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Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-04 Aizhen Xiong, Longhui Lu, Kaiyuan Jiang, Xiaoning Wang, Yan Chen, Xunjiang Wang, Wei Zhang, Yuzheng Zhuge, Wendong Huang, Lujin Li, Qi Liao, Fan Yang, Ping Liu, Lili Ding, Zhengtao Wang, Li Yang
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The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-05 Christopher J. Borgert, Lyle D. Burgoon, John C. Matthews
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Thresholds of adversity for endocrine disrupting substances: a conceptual case study Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-05 Judy Choi, Stefanie Rotter, Vera Ritz, Carsten Kneuer, Philip Marx-Stoelting, Marize de Lourdes Marzo Solano, Angelika Oertel, Susanne Rudzok, Andrea Ziková-Kloas, Tewes Tralau, Andreas Hensel
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Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-07 Julie Nilles, Dirk Theile, Johanna Weiss, Walter E. Haefeli, Stephanie Ruez
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Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-02 Hanna Gruszczynska, Rosemary E. Barnett, Gavin R. Lloyd, Ralf J. M. Weber, Thomas N. Lawson, Jiarui Zhou, Elena Sostare, John K. Colbourne, Mark R. Viant
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Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-30 Miriam N. Jacobs, Sebastian Hoffmann, Heli M. Hollnagel, Petra Kern, Susanne N. Kolle, Andreas Natsch, Robert Landsiedel
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The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-30 Merve Güdül Bacanlı
Antibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic
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Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-26 Elisabeth Eckert, Thomas Jäger, Julia Hiller, Edgar Leibold, Michael Bader, Thomas Göen
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The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-25 Iman Saleh, Randa Zeidan, Mohammed Abu-Dieyeh
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AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-25 Yanping Xiao, Yang Shen, Hui Song, Fang Gao, Zhenguang Mao, Qiang Lv, Chao Qin, Lin Yuan, Dongmei Wu, Haiyan Chu, Meilin Wang, Mulong Du, Rui Zheng, Zhengdong Zhang
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In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-24 Abdulkarim Najjar, Sebastien Grégoire, Beate Nicol, Andreas Natsch, Nazanin Golbamaki, Fanny Boisleve, Amaia Irizar, Brian Wall, Angus Swinscoe, Valérie Masini-Etévé, Dan Selechnik, Anne Marie Api, Peter Griem, Nicola Hewitt, Estefania Cardamone
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Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-18 Chien-Ying Lee, Sheng-Wen Wu, Jiann-Jou Yang, Wen-Ying Chen, Chun-Jung Chen, Hsin-Hung Chen, Yi-Chia Lee, Chun-Hung Su, Yu-Hsiang Kuan
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Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-17 Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota, Hideki Wanibuchi
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-17 Yuxi Li, Qiangen Wu, Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Lei Guo, Si Chen
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The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-16 Xinyi Lu, Xin Wang, Shuo Chen, Tengjiao Fan, Lijiao Zhao, Rugang Zhong, Guohui Sun
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Tl(I) and Tl(III)-induce genotoxicity, reticulum stress and autophagy in PC12 Adh cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-15 Damiana M. Salvatierra-Fréchou, Sandra V. Verstraeten
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Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-15 Hamza Zahid, Hilal Tayara, Kil To Chong
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-15 Jung Dae Lee, Jin-Sook Bae, Hyang Yeon Kim, Si-Whan Song, Jong-Choon Kim, Byung-Mu Lee, Kyu-Bong Kim
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Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-14 Reo Matsuzaka, Hiroki Yamaguchi, Chiharu Ohira, Tomoe Kurita, Naoki Iwashita, Yoshiichi Takagi, Tomomi Nishino, Kyoko Noda, Kazutoshi Sugita, Masayo Kushiro, Shiro Miyake, Tomoki Fukuyama
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Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-14 Lydia Johnson-Ferguson, Lilly Shanahan, Michelle Loher, Laura Bechtiger, Tina M. Binz, Markus Baumgartner, Denis Ribeaud, Manuel Eisner, Boris B. Quednow
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-12 Sang-Jin Park, Heeseon Park, Seng-Min Back, Young Ju Lee, Joung‐Wook Seo, Dabi Kim, Jeong Hwa Lee, Chaewon Kwak, Kang-Hyun Han, Hwa-Young Son, Yong-Bum Kim
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Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-11 Zhaotian Feng, Muhua Luan, Wenshuai Zhu, Yuanxin Xing, Xiaoli Ma, Yunshan Wang, Yanfei Jia
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The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-10 Thiago Guedes Pinto, Thayza Aires Dias, Ana Claudia Muniz Renno, Milena de Barros Viana, Daniel Araki Ribeiro
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Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-09 Elisabeth Varga, Hélène-Christine Prause, Matthias Riepl, Nadine Hochmayr, Deniz Berk, Eva Attakpah, Endre Kiss, Nikola Medić, Giorgia Del Favero, Thomas Ostenfeld Larsen, Per Juel Hansen, Doris Marko
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Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2 Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-08 Sara Ahmed Eltayeb, Julia M. Dressler, Lukas Schlatt, Moritz Pernecker, Ute Neugebauer, Uwe Karst, Giuliano Ciarimboli
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-07 Ji-Eun Seo, Yuan Le, Javier Revollo, Jaime Miranda-Colon, Hannah Xu, Page McKinzie, Nan Mei, Tao Chen, Robert H. Heflich, Tong Zhou, Timothy Robison, Jessica A. Bonzo, Xiaoqing Guo
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Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-06 Omayema Taoussi, Diletta Berardinelli, Simona Zaami, Francesco Tavoletta, Giuseppe Basile, Robert Kronstrand, Volker Auwärter, Francesco P. Busardò, Jeremy Carlier
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-06 Baixiu Zheng, Yanrong Zheng, Weiwei Hu, Zhong Chen
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Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-04 Gerhard Eisenbrand, Andrea Buettner, Patrick Diel, Bernd Epe, Petra Först, Tillman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Hans-Ulrich Humpf, Henry Jäger, Sabine Kulling, Alfonso Lampen, Marcel Leist, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Joachim Spranger, Pablo Steinberg, Stefan Vieths, Wim Wätjen, Jan G. Hengstler
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The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-04 Yanwei Wang, Jingru Qiu, Hua Yan, Nan Zhang, Shixuan Gao, Ning Xu, Cuiyan Wang, Haiyan Lou
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Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller’s fruit fly findings, and Muller fails to cite Snell’s findings Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-04 Edward J. Calabrese, Paul B. Selby
In 1931, Hermann J. Muller’s postdoctoral student, George D. Snell (Nobel Prize recipient––1980) initiated research to replicate with mice Muller’s X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and
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Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-04 C. Kalisch, M. Reiter, M. Krieger, L. Wüst, C. Klotz, R. Dekant, D. W. Lachenmeier, O. Scherf-Clavel, A. Mally
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Intestinal carcinogenicity screening of environmental pollutants using organoid-based cell transformation assay Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-02 Ziwei Wang, Shen Chen, Yuzhi Guo, Rui Zhang, Qi Zhang, Xinhang Jiang, Miao Li, Yue Jiang, Lizhu Ye, Xiaoyu Guo, Chuang Li, Guangtong Zhang, Daochuan Li, Liping Chen, Wen Chen
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Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-02 Liao-Chen Chen, Hwei-Hsien Chen, Ming-Huan Chan
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Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-30 Deyuan Ning, Jinfang Xue, Xiran Lou, Ruifei Shao, Yu Liu, Guobing Chen
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Effects of the nerve agent VX on hiPSC-derived motor neurons Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-30 Catherine Schaefers, Wolfgang Schmeißer, Harald John, Franz Worek, Theo Rein, Simone Rothmiller, Annette Schmidt
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A problem formulation framework for the application of in silico toxicology methods in chemical risk assessment Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-30 Jerry Achar, Mark T. D. Cronin, James W. Firman, Gunilla Öberg
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Female offspring of mice perinatally exposed to benzophenone-3 showed early subfertility linked to a poor oocyte stockpile Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-30 Valentina Galliani, Julián Elías Abud, María Laura Zenclussen, Horacio Adolfo Rodríguez
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The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-29 Olamide B. Adelusi, Jephte Y. Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
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Review: myogenic and muscle toxicity targets of environmental methylmercury exposure Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-28 Lok Ming Tam, Matthew D. Rand
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Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-28 Youlim Son, Hyun Jung Lee, Dojin Ryu, Jae-Ryong Kim, Hwa-Young Kim
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The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-27 Lei Bao, Qingping Liu, Jingyuan Wang, Lili Shi, Yaxian Pang, Yujie Niu, Rong Zhang
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Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-27 Zhenyu Li, Wendi Zhang, Siqi Li, Xiaobo Tao, Huiwen Xu, Yutong Wu, Qiong Chen, Anhui Ning, Tian Tian, Lei Zhang, Jiahua Cui, Wei Wang, Minjie Chu
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Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-05-01
Abstract Excavatolide C (EXCC), a marine coral-derived compound, exhibits an antiproliferation effect on bladder cancer cells. The present study evaluated the improvement in the antiproliferation ability of EXCC by co-treatment with cisplatin in bladder cancer cells. EXCC/cisplatin (12.5 and 1 μg/mL) showed higher antiproliferation effects on bladder cancer cells than single treatments (EXCC or cisplatin
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PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-25 Anja Lehmann, Ina Geburek, Stefanie Hessel-Pras, Anne-Margarethe Enge, Hans Mielke, Christine Müller-Graf, Charlotte Kloft, Christoph Hethey
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Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-24 Xiaoqi Zhao, Hao Xiao, Xiaomin Li, Lu Zhu, Yu Peng, Huijun Chen, Liaobin Chen, Dan Xu, Hui Wang
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Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-23 Slobodan P. Rendic, F. Peter Guengerich
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CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-18 Cai Liao, Zhen-Wei He, Rui Yu, Ya-Jie Yu, Xiao-Ru Liu, De-Lei Kong, Yun Wang
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Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-18 Cinthya Kimori Okamoto, Carmen W. van den Berg, Paula C. Pohl, Denise V. Tambourgi
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The estimation of acute oral toxicity (LD50) of G-series organophosphorus-based chemical warfare agents using quantitative and qualitative toxicology in silico methods Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-17 Maciej Noga, Agata Michalska, Kamil Jurowski
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Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-17 Thiago Guedes Pinto, Barbara dos Anjos Rosario, Andrea Cristina de Moraes Malinverni, Rosana Xavier, Yasmin Alaby Martins Ferreira, Luciana Pellegrini Pisani, Pedro Everson Alexandre de Aquino, Glauce Socorro de Barros Viana, Daniel Vitor de Souza, Milena de Barros Viana, Daniel Araki Ribeiro
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Flavonoids commonly induce hormetic responses Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227–1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT assay within a pre-conditioning experimental protocol, with each agent showing a similar biphasic concentration response relationship. We use
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Identification of key neuronal mechanisms triggered by dimethyl fumarate in SH-SY5Y human neuroblastoma cells through a metabolomic approach Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract Dimethyl fumarate (DMF) is an old drug used for psoriasis treatment that has recently been repurposed to treat relapse–remitting multiple sclerosis, mostly due to its neuro- and immunomodulatory actions. However, mining of a pharmacovigilance database recently ranked DMF as the second pharmaceutical most associated with cognitive adverse events. To our best knowledge, the signaling mechanisms
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ATF4 in cellular stress, ferroptosis, and cancer Arch. Toxicol. (IF 6.1) Pub Date : 2024-04-01
Abstract Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, particularly in the management of endoplasmic reticulum stress, amino acid deprivation, and oxidative challenges. ATF4's primary function lies in regulating gene expression to ensure cell
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Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Yongfang Li, Jiao Liu, Dianqi Yao, Zijun Guo, Xuheng Jiang, Chengwen Zhang, Litong Qu, Yuyan Liu, Yuxin Hu, Lanyue Gao, Yi Wang, Yuanyuan Xu
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Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-14 Katharina E. Ebert, Peter Griem, Tobias Weiss, Thomas Brüning, Heiko Hayen, Holger M. Koch, Daniel Bury
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Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation Arch. Toxicol. (IF 6.1) Pub Date : 2024-03-16 Xin-Man Hu, Yan-Yao Hou, Xin-Ru Teng, Yong Liu, Yu Li, Wei Li, Yan Li, Chun-Zhi Ai