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Increased Expression of VCAM1 on Brain Endothelial Cells Drives Blood–Brain Barrier Impairment Following Chronic Cerebral Hypoperfusion ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-05-06 Huiwen Zhang, Junkui Shang, Wei Li, Dandan Gao, Jiewen Zhang
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Exploring the Interactions between two Ligands, UCB-J and UCB-F, and Synaptic Vesicle Glycoprotein 2 Isoforms ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-05-03 Junhao Li, Rongfeng Zou, Andrea Varrone, Sangram Nag, Christer Halldin, Hans Ågren
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Parvalbumin Regulates GAD Expression through Calcium Ion Concentration to Affect the Balance of Glu-GABA and Improve KA-Induced Status Epilepticus in PV-Cre Transgenic Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-05-02 Chunmei Zeng, Yuling Lu, Xing Wei, Lanfeng Sun, Lei Wei, Sijie Ou, Qi Huang, Yuan Wu
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Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-05-01 Vasyl Bondarenko, Qiang Chen, Tommy S. Tillman, Yan Xu, Pei Tang
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Ligand Profiling as a Diagnostic Tool to Differentiate Patient-Derived α-Synuclein Polymorphs ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-05-01 Timothy S. Chisholm, Ronald Melki, Christopher A. Hunter
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Chronic Behavioral and Neurochemical Effects of Four Novel N-Benzyl-2-phenylethylamine Derivatives Recently Identified as “Psychoactive” in Adult Zebrafish Screens ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-29 Nikita P. Ilyin, Arslan D. Nabiullin, Anna D. Kozlova, Olga V. Kupriyanova, Vadim A. Shevyrin, Tatyana Gloriozova, Dmitry Filimonov, Alexey Lagunin, David S. Galstyan, Tatiana O. Kolesnikova, Mikael S. Mor, Evgeniya V. Efimova, Vladimir Poroikov, Konstantin B. Yenkoyan, Murilo S. de Abreu, Konstantin A. Demin, Allan V. Kalueff
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β-Amyloid Is a Kinocidin Cytokine ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-29 Donald F. Weaver
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Correction to “Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo” ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-28 Shinghung Mak, Zheng Liu, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Ziyan Liu, Shengquan Hu, Jiajun Wang, Guozhen Cui, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Yifan Han, Zaijun Zhang
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Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis–trans Isomerase and Chaperone Activities of Its Cyclophilin Domain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-24 Hemangi Patil, Haiqing Yi, Kyoung-in Cho, Paulo A. Ferreira
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Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-24 Michal Kaleta, Jana Oklestkova, Kateřina Klíčová, Miroslav Kvasnica, Dorota Koníčková, Kateřina Menšíková, Miroslav Strnad, Ondřej Novák
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Synthesis and Neuroprotective Evaluation of Substituted Indanone/Benzofuranone and Piperidine Hybrids ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-24 Qing Zeng, Ziwei Zhang, Zhifang Cai, Pei Hu, Zunhua Yang, Yang Wan, Huilan Li, Jian Xiong, Yulin Feng, Yuanying Fang
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Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-23 Farjana Parvin, Samuel Haglund, Bettina Wegenast-Braun, Mathias Jucker, Takashi Saito, Takaomi C. Saido, K. Peter R. Nilsson, Per Nilsson, Sofie Nyström, Per Hammarström
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Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-22 Hossein Mousavi, Mehdi Rimaz, Behzad Zeynizadeh
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Dopaminergic Modulation and Computational ADMET Insights for the Antidepressant-like Effect of N-(3-(Phenylselanyl)prop-2-yn-1-yl)benzamide ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-19 Evelyn Mianes Besckow, Kauane Nayara Bahr Ledebuhr, Camila Simões Pires, Marcia Juciele da Rocha, Natália Emanuele Biolosor Kuntz, Benhur Godoi, Cristiani Folharini Bortolatto, César Augusto Brüning
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The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-19 Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
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Remote Ischemic Postconditioning-Mediated Neuroprotection against Stroke by Promoting Ketone Body-Induced Ferroptosis Inhibition ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Lin-yan Huang, Yi-de Zhang, Yi-ning Liu, Zhi-yan Liang, Jie Chen, Bin Wang, Qi-long Yin, Pei-pei Wang, Wan Wang, Su-hua Qi
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Cyclic-NDGA Effectively Inhibits Human γ-Synuclein Fibrillation, Forms Nontoxic Off-Pathway Species, and Disintegrates Preformed Mature Fibrils ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Sneh Lata Singh, Rajiv Bhat
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Formation of Calprotectin Inhibits Amyloid Aggregation of S100A8 and S100A9 Proteins ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Ieva Baronaitė, Darius Šulskis, Aurimas Kopu̅stas, Marijonas Tutkus, Vytautas Smirnovas
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14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Gobert Heesink, Maxime C. M. van den Oetelaar, Slav A. Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M. A. E. Claessens
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Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Lin Qiu, Hao Jiang, Kevin Cho, Yanbo Yu, Lynne A. Jones, Tianyu Huang, Joel S. Perlmutter, Robert J. Gropler, Matthew R. Brier, Gary J. Patti, Tammie L. S. Benzinger, Zhude Tu
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Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-18 Po-Chun Chu, Hsiang-Yu Yu, Robert S. Fisher, Hao-Li Liu
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Heparin-Modified Superparamagnetic Iron Oxide Nanoparticles Suppress Lithium Chloride/Pilocarpine-Induced Temporal Lobe Epilepsy in Rats through Attenuation of Inflammation and Oxidative Stress ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-17 Hanbing Xu, Yubo Wang, Congcong Yu, Chunhong Han, Huifei Cui
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4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-15 Alex R. Lovins, Kevin A. Miller, Anne K. Buck, D. Sophia Ensey, Rose K. Homoelle, Megan C. Murtha, Nathan A. Ward, Liam A. Shanahan, Gopichand Gutti, Pratik Shriwas, Craig A. McElroy, Christopher S. Callam, Christopher M. Hadad
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Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-13 Benjamin M. Williams, Nathan D. Steed, Joel T. Woolley, Aubrey A. Moedl, Christina A. Nelson, Gavin C. Jones, Matthew D. Burris, Hugo R. Arias, Oc-Hee Kim, Eun Young Jang, Arik J. Hone, J. Michael McIntosh, Jordan T. Yorgason, Scott C. Steffensen
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Protective Effect of Hop Ethyl Acetate Extract on Corticosterone-Induced PC12 and Improvement of Depression-like Behavior in Mice ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-13 Ziwei Ma, Yuming Yu, Ming Gao, Peng Chen, Huixia Hong, Dingle Yu, Zhenjiang Liang, Yu Bai, Qinlian Ye, Yachao Wang, Guodong Huang, Hui Tan
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BDNF- and VEGF-Responsive Stimulus to an NGF Mimic Cyclic Peptide with Copper Ionophore Capability and Ctr1/CCS-Driven Signaling ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-11 Barbara Tomasello, Francesco Bellia, Irina Naletova, Antonio Magrì, Giovanni Tabbì, Francesco Attanasio, Marianna Flora Tomasello, Warren R. L. Cairns, Mariagrazia Fortino, Adriana Pietropaolo, Valentina Greco, Diego La Mendola, Sebastiano Sciuto, Giuseppe Arena, Enrico Rizzarelli
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Synthesis and Functional Evaluation of Synthetic Cannabinoid Receptor Agonists Related to ADB-HEXINACA ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-10 Eric Sparkes, Axelle Timmerman, Jack W. Markham, Rochelle Boyd, Rebecca Gordon, Katelyn A. Walker, Richard C. Kevin, David E. Hibbs, Samuel D. Banister, Elizabeth A. Cairns, Christophe Stove, Adam Ametovski
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Prophylactic Administration of Gut Microbiome Metabolites Abrogated Microglial Activation and Subsequent Neuroinflammation in an Experimental Model of Japanese Encephalitis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-06 Indira Priya Siva Venkatesh, Atreye Majumdar, Anirban Basu
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Similar Binding Modes of cGMP Analogues Limit Selectivity in Modulating Retinal CNG Channels via the Cyclic Nucleotide-Binding Domain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-05 Palina Pliushcheuskaya, Sandeep Kesh, Emma Kaufmann, Sophie Wucherpfennig, Frank Schwede, Georg Künze, Vasilica Nache
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Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-05 Nina Nitzan Soto, Patricia Gaspar, Alberto Bacci
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Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1 ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-04 Hui Li, Qiong Ye, Da Wang, Bowen Shi, Wenjing Xu, Shuning Zhang, Xiaoyang Han, Xiao-Yong Zhang, Garth J. Thompson
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Serotonin Receptors in Myocardial Infarction: Friend or Foe? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-04 F.S. Bahr, M. Ricke-Hoch, E. Ponimaskin, F.E. Müller
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Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-02 Asmaa R. Hashim, Dina W. Bashir, Eman Rashad, Mona K. Galal, Maha M. Rashad, Heba M. A. Khalil, Nasrallah M. Deraz, El-Gharbawy S. M.
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Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-04-01 Robert A. Ellingford, Mizuki Tojo, M. Albert Basson, Laura C. Andreae
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Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments? ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-29 Selim Boukabara, Mehdi Farokhnia, Lorenzo Leggio
Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Delineating the biobehavioral correlates of amylin in relation to alcohol seeking and consumption has the potential of identifying new treatment targets for AUD, yet additional
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Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-28 Kichitaro Nakajima, Tomoki Ota, Hajime Toda, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi
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Substrate Selection Criteria in Regulated Intramembrane Proteolysis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Celine Moser, Nadja Guschtschin-Schmidt, Mara Silber, Julia Flum, Claudia Muhle-Goll
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Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Gourav Singh, Gauri Shankar, Samir Ranjan Panda, Sunil Kumar, Sanskriti Rai, Himanshu Verma, Prabhat Kumar, Prasanta Kumar Nayak, V.G.M. Naidu, Saripella Srikrishna, Saroj Kumar, Gyan Modi
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Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Ge Li, Lan Lan, Tingting He, Zheng Tang, Shuhua Liu, Yunfeng Li, Zhongqiang Huang, Yalun Guan, Xuejiao Li, Yu Zhang, Hsin-Yi Lai
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Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-25 Sadhana Sharma, Sydney Risen, Vincenzo S. Gilberto, Sean Boland, Anushree Chatterjee, Julie A. Moreno, Prashant Nagpal
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Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-24 Therése Klingstedt, Linda Lantz, Hamid Shirani, Junyue Ge, Jörg Hanrieder, Ruben Vidal, Bernardino Ghetti, K. Peter R. Nilsson
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Selective Potentiation of the (α4)3(β2)2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-21 Rebecca Appiani, Franco Viscarra, Philip C. Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
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Rapid FRET Assay for the Early Detection of Alpha-Synuclein Aggregation in Parkinson’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Hang Yu, Rui Feng, Fenglin Chen, Zuodong Wu, Dehai Li, Xue Qiu
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Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Sydney J. Risen, Sean W. Boland, Sadhana Sharma, Grace M. Weisman, Payton M. Shirley, Amanda S. Latham, Arielle J. D. Hay, Vincenzo S. Gilberto, Amelia D. Hines, Stephen Brindley, Jared M. Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno
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Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Maria Teresa Gallo, Beatrice Dolci, Fabio Fumagalli, Paola Brivio, Francesca Calabrese
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Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-20 Theodosia Vallianatou, Carina de Souza Anselmo, Ioanna Tsiara, Nicholas B. Bèchet, Iben Lundgaard, Daniel Globisch
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Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kayed
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Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 James Everett, Jake Brooks, Vindy Tjendana Tjhin, Frederik Lermyte, Ian Hands-Portman, Germán Plascencia-Villa, George Perry, Peter J. Sadler, Peter B. O’Connor, Joanna F. Collingwood, Neil D. Telling
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Histone Lysine Demethylase KDM5 Inhibitor CPI-455 Induces Astrocytogenesis in Neural Stem Cells ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-19 Thin Thin San, Junhyung Kim, Hyun-Jung Kim
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The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-18 Galina Portnova, Guzal M. Khayrullina, Ivan V. Mikheev, Sofiya M. Byvsheva, Elena V. Proskurnina, Olga Martynova
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Serotonin Signaling through Lipid Membranes ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-18 Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, Christian P. Müller
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Investigating a Novel Neurodegenerative Disease Toxic Mechanism Involving Lipid Binding Specificity of Amyloid Oligomers ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-15 Sarah S. Hirschbeck, Edward T. Lindberg, Joshua H. Jang, MaKenna R. Jacob, Kristi L. Lazar Cantrell, Thanh D. Do
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Structures and Dynamics of β-Rich Oligomers of ATTR (105–115) Assembly ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Liqun Liang, Yuqi Zhang, Yanyan Zhu, Juxia Bai, Yangyang Ni, Junfeng Wan, Haiyan Yue, Qingjie Zhao, Huiyu Li
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Research Report: A Link between Sertraline Treatment and Susceptibility to (Mis)information ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Michal Piksa, Karolina Noworyta, Jan Piasecki, Aleksander Gundersen, Jonas Kunst, Mikolaj Morzy, Rafal Rygula
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Influence of Cigarette Aerosol in Alpha-Synuclein Oligomerization and Cell Viability in SH-SY5Y: Implications for Parkinson’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-14 Yu-Xin Shen, Pe-Shuen Lee, Ming-Chu Teng, Jhih-Hong Huang, Chia C. Wang, Hsiu-Fang Fan
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Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer’s Disease ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Joanna M. Wasielewska, Kathryn Szostak, Lachlan E. McInnes, Hazel Quek, Juliana C. S. Chaves, Jeffrey R. Liddell, Jari Koistinaho, Lotta E. Oikari, Paul S. Donnelly, Anthony R. White
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Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-13 Lieve van Veggel, Tamara A.M. Mocking, Hubert J. Sijben, Rongfang Liu, Marina Gorostiola González, Majlen A. Dilweg, Jeroen Royakkers, Anna Li, Vijay Kumar, Yin Yao Dong, Alex Bullock, David B. Sauer, Hanne Diliën, Gerard J.P. van Westen, Rudy Schreiber, Laura H. Heitman, Tim Vanmierlo
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Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-12 Qinqin Pei, Qiurong Zhao, Chunhui Lang, Shilong Feng, Juanjuan Meng, Guangjiao Tan, Wei Cui, Cheng Zhang, Xiaohe Luo, Lixin Xu, Jian Chen
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Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-11 Muthu Raj Salaikumaran, Pallavi P. Gopal
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Kynurenines Dynamics in the Periphery and Central Nervous System Steers Behavioral Deficits in Rats under Hypobaric Hypoxia ACS Chem. Neurosci. (IF 5.0) Pub Date : 2024-03-10 Kalyani Verma, Amitabh, Dipti N. Prasad, M. Prasanna Kumar Reddy, Ekta Kohli