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Erbium(III) complexes with fluoroquinolones: Structure and biological properties J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-15 Eleni Arnaouti, Christina Georgiadou, Antonios G. Hatizdimitriou, Stavros Kalogiannis, George Psomas
Four erbium(III) complexes with the fluoroquinolones enrofloxacin, levofloxacin, flumequine and sparfloxacin as ligands were synthesized and were characterized by a wide range of physicochemical and spectroscopic techniques as well as single–crystal X–ray crystallography. The compounds were evaluated for their activity against the bacterial strains , which was higher than that of corresponding free
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Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-12 Zhi-Chang Xu, Xiu-Rong Ma, Li-Juan Zhang, Hui-Ting Chen, Ding-Mei Qing, Rong-Tao Li, Rui-Rong Ye, Rui-Rui Wang
With the abuse of antibiotics and azoles, drug-resistant infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having
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Tyrosine nitration of glucagon impairs its function: Extending the role of heme in T2D pathogenesis J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-12 Xiaoyin Ying, Guoqi Ni, Xuan Zhang, Shitao Fu, Hailing Li, Zhonghong Gao
New studies raise the possibility that the higher Glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass
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Systematic review on antibacterial photodynamic therapeutic effects of transition metals ruthenium and iridium complexes J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-11 Anadil Gul, Munir Ahmad, Raza Ullah, Rizwan Ullah, Yan Kang, Wenchao Liao
The prevalence of antibiotic-resistant pathogenic bacteria poses a significant threat to public health and ranks among the principal causes of morbidity and mortality worldwide. Antimicrobial photodynamic therapy is an emerging therapeutic technique that has excellent potential to embark upon antibiotic resistance problems. The efficacy of this therapy hinges on the careful selection of suitable photosensitizers
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Characterization of ferredoxins involved in electron transfer pathways for nitrogen fixation implicates differences in electronic structure in tuning 2[4Fe[sbnd]4S] Fd activity J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-07 Nathan M. Lewis, Effie C. Kisgeropoulos, Carolyn E. Lubner, Kathryn R. Fixen
Ferredoxins (Fds) are small proteins which shuttle electrons to pathways like biological nitrogen fixation. Physical properties tune the reactivity of Fds with different pathways, but knowledge on how these properties can be manipulated to engineer new electron transfer pathways is lacking. Recently, we showed that an evolved strain of uses a new electron transfer pathway for nitrogen fixation. This
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Novel Titanocene Y derivative with albumin affinity exhibits improved anticancer activity against platinum resistant cells J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-06 Sergio Gomez-Lopez, Rosario Serrano, Boiko Cohen, Isabel Martinez-Argudo, Laura Lopez-Sanz, Marta Carmen Guadamillas, Raul Calero, Maria Jose Ruiz
The antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain
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Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-06 Yi Chen, Chenxi Wang, Meiling Qi, Yinyu Wei, Hongliang Jiang, Zhifeng Du
Cisplatin is widely used as anticancer drugs, and DNA is considered as the main target. Considering its high affinity towards cysteines and the important role of cystine containing proteins, we applied a competitive activity-based protein profiling strategy to identify protein cysteines that bind with cisplatin in HeLa cells. Living cells were treated with cisplatin at cytotoxic concentrations, then
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Polypyridyl ruthenium complexes with benzothiazole moiety as membrane disruptors and anti-resistance agents for Staphylococcus aureus J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-05 Wei Deng, Chun-Yan Zhang, Li-Xin Dou, Li-Ting Huang, Jin-Tiao Wang, Xiang-Wen Liao, Li-Ping Wang, Ru-Jian Yu, Yan-Shi Xiong
Developing new antimicrobials to combat drug-resistant bacterial infections is necessary due to the increasing problem of bacterial resistance. In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, displayed remarkable inhibitory activity against () with a minimum inhibitory concentration (MIC) of 1.56 μg/mL
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Fluorination of porphyrin β-periphery boosts nickel(II)-catalyzed hydrogen evolution reaction J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-02 Haozong Xue, Zhuo-Yan Wu, Jun-Long Zhang
Tunichlorin, the naturally occurring chlorophyll cofactor containing Ni(II) ion, sets up a golden standard for designing the electrocatalysts for hydrogen evolution reaction (HER) -peripheral modification. Besides the fine-tuning of the porphyrin β-periphery such as adjusting the aromatics (the saturated level of tetrapyrrole) or installing hydroxyl group (hydrogen bond network) to enhance the catalytic
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Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-03-01 Tangli Wei, Lihua Chen, Pengmin Shi, Changli Wang, Yusheng Peng, Jing Yang, Xiali Liao, Bo Yang, Chuanzhu Gao
Chemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing
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Spectroscopy and absolute quantum efficiency of near-infrared electrochemiluminescence for a macrocyclic palladium complex J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-24 Congyang Zhang, Ruizhong Zhang, Ruijing Zhang, Qiao Zhang, Jun-Long Zhang zhangjunlong@pku.edu.cn, Zhifeng Ding
Electrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of
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Thermoresponsive carboplatin-releasing prodrugs J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-15 Aemilia D. McAdam, Lucinda K. Batchelor, Jan Romano-deGea, Dmitry Vasilyev, Paul J. Dyson
Platinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated
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Exploring the potential of the vitamin B12 derivative azidocobalamin to undergo Huisgen 1,3-dipolar azide-alkyne cycloaddition reactions J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-10 Ben J. Stackpole, Jessica M. Fredericksen, Nicola E. Brasch
There is considerable interest in using the metalloprotein cofactor vitamin B as a vehicle to deliver drugs and diagnostic agents into mammalian or bacterial cells by exploiting the B-specific active uptake pathways. Conjugation of the cargo via the β-axial site or the 5’-OH of the ribose of the nucleotide are the most desirable, to maximise intracellular uptake. Herein we show the potential of conjugation
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The green cupredoxin CopI is a multicopper protein able to oxidize Cu(I) J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-08 Melanie Rossotti, Diletta Arceri, Pascal Mansuelle, Olivier Bornet, Anne Durand, Soufian Ouchane, Hélène Launay, Pierre Dorlet
Anthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein
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Stabilization of a Cu-binding site by a highly conserved tryptophan residue J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-07 Yuri Rafael de Oliveira Silva, Dia Zheng, Stephen C. Peters, Oriana S. Fisher
Copper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria import copper and maintain homeostasis. To obtain a better understanding of how these processes work, here we focus on the operon responsible for regulating copper levels in the Gram-positive bacterium . This operon encodes three Cu-related proteins:
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A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-02-06 Xiaomin Shen, Yue Peng, Haixia Zhou, Xiaoxia Ye, Zhong Han, Xiangchao Shi
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Monomeric copper(II) complexes with unsymmetrical salen environment: Synthesis, characterization and study of biological activities J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-24 Deepika Mohapatra, Sushree Aradhana Patra, Pratikshya Das Pattanayak, Gurunath Sahu, Takahiro Sasamori, Rupam Dinda
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The structure of the diheme cytochrome c4 from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-24 Fangfang Zhong, Morgan E. Reik, Michael J. Ragusa, Ekaterina V. Pletneva
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Determination of the role of specific amino acids in the binding of Zn(II), Ni(II), and Cu(II) to the active site of the M10 family metallopeptidase J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-27 Paulina Potok, Martyna Zawada, Sławomir Potocki
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Anticancer behaviour of 2,2′-(pyridin-2-ylmethylene)bis(5,5-dimethylcyclohexane-1,3-dione)-based palladium(II) complex and its DNA, BSA binding propensity and DFT study J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-22 Mohamed A. Ragheb, Marwa H. Soliman, Ismail A. Abdelhamid, Mohamed M. Shoukry, Matti Haukka, Mona S. Ragab
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In Memoriam – Ademir Neves *1951-†2022 J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-21 Rosely A. Peralta
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Redox potentials elucidate the electron transfer pathway of NAD+-dependent formate dehydrogenases J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-20 Benjamin R. Duffus, Marcel Gauglitz, Christian Teutloff, Silke Leimkühler
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Evaluation of heteroscorpionate ligands as scaffolds for the generation of Ruthenium(II) metallodrugs in breast cancer therapy J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-18 Elena Domínguez-Jurado, Consuelo Ripoll, Agustín Lara-Sánchez, Alberto Ocaña, Iñigo J. Vitórica-Yrezábal, Iván Bravo, Carlos Alonso-Moreno
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Hole-scavenging in photo-driven N2 reduction catalyzed by a CdS-nitrogenase MoFe protein biohybrid system J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-09 Andrew Clinger, Zhi-Yong Yang, Lauren M. Pellows, Paul King, Florence Mus, John W. Peters, Gordana Dukovic, Lance C. Seefeldt
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JIB Ademir Neves Special Issue Preface/Editorial J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-10 Cláudio Verani, Rosely Peralta
Abstract not available
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Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-08 Ariel Schuelke-Sanchez, Neela H. Yennawar, Emily E. Weinert
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Investigating Cu(I) binding to model peptides of N-terminal Aβ isoforms J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-09 Abigail Strausbaugh Hjelmstad, M. Jake Pushie, Kaylee Ruth, Maria Escobedo, Kristin Kuter, Kathryn L. Haas
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Mercury binding to proteins disclosed by ESI MS experiments: The case of three organomercurials J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-06 Andrea Geri, Stefano Zineddu, Lara Massai, Luisa Ronga, Ryszard Lobinski, Jurgen Gailer, Luigi Messori
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Dinuclear copper(II) complexes with bridging a bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-04 Zdeněk Trávníček, Ján Vančo, Jan Belza, Giorgio Zoppellaro, Zdeněk Dvořák
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Zinc complexes of chloroquine and hydroxychloroquine versus the mixtures of their components: Structures, solution equilibria/speciation and cellular zinc uptake J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-03 Andrea Squarcina, Alicja Franke, Laura Senft, Constantin Onderka, Jens Langer, Thibaut Vignane, Milos R. Filipovic, Peter Grill, Bernhard Michalke, Ivana Ivanović-Burmazović
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Chronic nickel exposure alters extracellular vesicles to mediate cancer progression via sustained NUPR1 expression J. Inorg. Biochem. (IF 3.9) Pub Date : 2024-01-02 Shan Liu, Max Costa, Angelica Ortiz
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Antitumor active trans‑platinum complexes through metabolic stability and enhanced cellular accumulation J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-29 Vijay Menon, Samantha J. Katner, Daniel E. Lee, Erica J. Peterson, Jennifer E. Koblinski, Nicholas P. Farrell
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Effect of proline content and histidine ligation on the dynamics of Ω-loop D and the peroxidase activity of iso-1-cytochrome c J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-28 William J. Martin, Levi J. McClelland, Shiloh M. Nold, Kassandra L. Boshae, Bruce E. Bowler
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Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans? J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-29 Klaudia Szarszoń, Aleksandra Mikołajczyk, Manuela Grelich-Mucha, Robert Wieczorek, Agnieszka Matera-Witkiewicz, Joanna Olesiak-Bańska, Magdalena Rowińska-Żyrek, Joanna Wątły
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Decomposition of 2,4-dihalophenols by dehaloperoxidase activity and spontaneous reaction with hydrogen peroxide J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-24 Mst Sharmin Aktar, Ransom Hill, Wyatt Holbert, Stefan Franzen
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DNA structural changes (photo)induced by tricarbonyl (pterin)rhenium(I) complex J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-24 F. Ragone, J.G. Yañuk, F.M. Cabrerizo, E. Prieto, E. Wolcan, G.T. Ruiz
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N-heterocyclic-carbene vs diphosphine auxiliary ligands in thioamidato Cu(I) and Ag(I) complexes towards the development of potent and dual-activity antibacterial and apoptosis-inducing anticancer agents J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-23 Despoina Varna, George Geromichalos, Dimitra Gioftsidou, Demetrios Tzimopoulos, Antonios G. Hatzidimitriou, Panagiotis Dalezis, Rigini Papi, Dimitrios Trafalis, Panagiotis A. Angaridis
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Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-20 Jose A. Amaya, Olivia M. Manley, Julia C. Bian, Cooper D. Rutland, Nicholas Leschinsky, Steven C. Ratigan, Thomas M. Makris
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Soluble meso and deuteroporphyrin analogs of the malaria pigment hematin anhydride J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-22 Liliana Suárez, Aaron J. Kosar, Erin L. Dodd, Dagobert Tazoo, Ambre Charlotte Lambert, D. Scott Bohle
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Intramolecular CH bond amination catalyzed by myoglobin reconstituted with iron porphycene J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-21 Yoshiyuki Kagawa, Koji Oohora, Takashi Hayashi
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Probing the mechanism of the dedicated NO sensor [4Fe-4S] NsrR: the effect of cluster ligand environment J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-21 Erin L. Dodd, Nick E. Le Brun
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Effects of removal of the axial methionine heme ligand on the binding of S. cerevisiae iso-1 cytochrome c to cardiolipin J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-18 Alessandro Paradisi, Marzia Bellei, Carlo Augusto Bortolotti, Giulia Di Rocco, Antonio Ranieri, Marco Borsari, Marco Sola, Gianantonio Battistuzzi
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–HH and –HAAAH motifs act as fishing nets for biologically relevant metal ions in metallopeptides J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-19 Aleksandra Hecel, Kinga Garstka, Henryk Kozłowski, Magdalena Rowińska-Żyrek
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Differential superoxide production in phosphorylated neuronal nitric oxide synthase mu and alpha variants J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-11 Yadav Prasad Gyawali, Ting Jiang, Jing Yang, Huayu Zheng, Rui Liu, Haikun Zhang, Changjian Feng
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Carbon monoxide poisoning: A problem uniquely suited to a medicinal inorganic chemistry solution J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-07 A. Leila Parker, Timothy C. Johnstone
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Computational and crystallographic study of hydrogen bonds in the second coordination sphere of chelated amino acids with a free water molecule: Influence of complex charge and metal ion J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-03 Sonja S. Zrilić, Jelena M. Živković, Snežana D. Zarić
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Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-03 Ester Giorgi, Michele Mannelli, Tania Gamberi, Maria Durante, Chiara Gabbiani, Damiano Cirri, Alessandro Pratesi
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8-hydroxyquinoline-N-oxide copper(II)- and zinc(II)-phenanthroline and bipyridine coordination compounds: Design, synthesis, structures, and antitumor evaluation J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-02 Ling-Qi Du, Chu-Jie Zeng, Dong-Yin Mo, Qi-Pin Qin, Ming-Xiong Tan, Hong Liang
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Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-12-01 , Vinod Kumar, Ramesh Kataria
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A voltammetric peptide biosensor for Cu2+ metal ion quantification in coffee seeds J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-29 Gabriella Magarelli, Jonatas Gomes da Silva, Caroline Luchtenberg Ribeiro, Thiago Viana de Freitas, Magali Aparecida Rodrigues, Eric de Souza Gil, Pierre Marraccini, Jurandir Rodrigues de Souza, Clarissa Silva Pires de Castro, Marcelo Porto Bemquerer
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Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-24 Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
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Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-23 Inês Maximiano, Catarina Henriques, Ricardo G. Teixeira, Fernanda Marques, Andreia Valente, Alexandra M.M. Antunes
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Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-25 Silas Brown, Sydney Marchi, C. Sumner Thomas, Ashlyn R. Hale, Molly Lockart, Michael K. Bowman, George Christou, Stephen A. Woski, John B. Vincent
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Structural motifs in the early metallation steps of Zn(II) and Cd(II) binding to apo-metallothionein 1a J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-21 Natalie C. Korkola, Martin J. Stillman
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Structure prediction of physiological bis(amino acidato)copper(II) species in aqueous solution: The copper(II) compounds with l-glutamine and l-histidine J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-21 Michael Ramek, Jasmina Sabolović
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A novel benzothiazole-based mononuclear platinum(II) complex displaying potent antiproliferative activity in HepG-2 cells via mitochondrial-mediated apoptosis J. Inorg. Biochem. (IF 3.9) Pub Date : 2023-11-22 Dandan Zhao, Hongyan Zhen, Jian Xue, Zhipeng Tang, Xiaofang Han, Zhanfen Chen