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  • Transcription: Shedding light on alternative promoter selection
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-20
    Katharine H. Wrighton

    Transcription: Shedding light on alternative promoter selection Transcription: Shedding light on alternative promoter selection, Published online: 20 November 2017; doi:10.1038/nrg.2017.100

    更新日期:2017-11-20
  • Prioritizing diversity in human genomics research
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-20
    Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio, Eric D. Green

    Prioritizing diversity in human genomics research Prioritizing diversity in human genomics research, Published online: 20 November 2017; doi:10.1038/nrg.2017.89 Including diverse populations in genomic studies has the potential to improve the use of genomic data in the clinic. Here, members of the National Human Genome Research Institute review the benefits of increasing diversity, the challenges to overcome and key recommendations for how to achieve this goal.

    更新日期:2017-11-20
  • Transcription: Shedding light on alternative promoter selection
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-20
    Katharine H. Wrighton

    Transcription: Shedding light on alternative promoter selection Transcription: Shedding light on alternative promoter selection, Published online: 20 November 2017; doi:10.1038/nrg.2017.100

    更新日期:2017-11-20
  • Prioritizing diversity in human genomics research
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-20
    Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio, Eric D. Green

    Prioritizing diversity in human genomics research Prioritizing diversity in human genomics research, Published online: 20 November 2017; doi:10.1038/nrg.2017.89 Including diverse populations in genomic studies has the potential to improve the use of genomic data in the clinic. Here, members of the National Human Genome Research Institute review the benefits of increasing diversity, the challenges to overcome and key recommendations for how to achieve this goal.

    更新日期:2017-11-20
  • Transcription: Putting R loops firmly on the map
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Katharine H. Wrighton

    Transcription: Putting R loops firmly on the map Transcription: Putting R loops firmly on the map, Published online: 13 November 2017; doi:10.1038/nrg.2017.98

    更新日期:2017-11-13
  • Functional genomics: Shining a light on genetic screen strategies
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Darren J. Burgess

    Functional genomics: Shining a light on genetic screen strategies Functional genomics: Shining a light on genetic screen strategies, Published online: 13 November 2017; doi:10.1038/nrg.2017.99

    更新日期:2017-11-13
  • Statistical and integrative system-level analysis of DNA methylation data
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Andrew E. Teschendorff, Caroline L. Relton

    Statistical and integrative system-level analysis of DNA methylation data Statistical and integrative system-level analysis of DNA methylation data, Published online: 13 November 2017; doi:10.1038/nrg.2017.86 NatureArticleSnippet(type=short-summary, markup= The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data. , isJats=true)

    更新日期:2017-11-13
  • Towards a genomics-informed, real-time, global pathogen surveillance system
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Jennifer L. Gardy, Nicholas J. Loman

    Towards a genomics-informed, real-time, global pathogen surveillance system Towards a genomics-informed, real-time, global pathogen surveillance system, Published online: 13 November 2017; doi:10.1038/nrg.2017.88 NatureArticleSnippet(type=short-summary, markup= Next-generation sequencing has the potential to support public health surveillance systems to improve the early detection of emerging infectious diseases. This Review delineates the role of genomics in rapid outbreak response and the challenges that need to be tackled for genomics-informed pathogen surveillance to become a global reality. , isJats=true)

    更新日期:2017-11-13
  • Transcription: Putting R loops firmly on the map
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Katharine H. Wrighton

    Transcription: Putting R loops firmly on the map Transcription: Putting R loops firmly on the map, Published online: 13 November 2017; doi:10.1038/nrg.2017.98

    更新日期:2017-11-13
  • Functional genomics: Shining a light on genetic screen strategies
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Darren J. Burgess

    Functional genomics: Shining a light on genetic screen strategies Functional genomics: Shining a light on genetic screen strategies, Published online: 13 November 2017; doi:10.1038/nrg.2017.99

    更新日期:2017-11-13
  • Statistical and integrative system-level analysis of DNA methylation data
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Andrew E. Teschendorff, Caroline L. Relton

    Statistical and integrative system-level analysis of DNA methylation data Statistical and integrative system-level analysis of DNA methylation data, Published online: 13 November 2017; doi:10.1038/nrg.2017.86 NatureArticleSnippet(type=short-summary, markup= The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data. , isJats=true)

    更新日期:2017-11-13
  • Towards a genomics-informed, real-time, global pathogen surveillance system
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-13
    Jennifer L. Gardy, Nicholas J. Loman

    Towards a genomics-informed, real-time, global pathogen surveillance system Towards a genomics-informed, real-time, global pathogen surveillance system, Published online: 13 November 2017; doi:10.1038/nrg.2017.88 NatureArticleSnippet(type=short-summary, markup= Next-generation sequencing has the potential to support public health surveillance systems to improve the early detection of emerging infectious diseases. This Review delineates the role of genomics in rapid outbreak response and the challenges that need to be tackled for genomics-informed pathogen surveillance to become a global reality. , isJats=true)

    更新日期:2017-11-13
  • Cancer genomics: The driving force of cancer evolution
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Linda Koch

    Cancer genomics: The driving force of cancer evolutionCancer genomics: The driving force of cancer evolution, Published online: 07 November 2017; doi:10.1038/nrg.2017.95NatureArticleSnippet(type=short-summary, markup=Two novel comprehensive analyses in Cell provide important insights into the dynamics of tumour evolution and the mutational burden of a wide range of cancer types., isJats=true)

    更新日期:2017-11-07
  • Navigating complexity to breed disease-resistant crops
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Rebecca Nelson, Tyr Wiesner-Hanks, Randall Wisser, Peter Balint-Kurti

    Navigating complexity to breed disease-resistant cropsNavigating complexity to breed disease-resistant crops, Published online: 07 November 2017; doi:10.1038/nrg.2017.82NatureArticleSnippet(type=short-summary, markup=Disease-resistant crops have the potential to reduce crop losses. This Review discusses how advances in genetic and genomic technologies are contributing to efforts by plant breeders to generate durable, broad-spectrum disease resistance in crop plants., isJats=true)

    更新日期:2017-11-07
  • Gene expression: Principles of gene regulation across tissues
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Darren J. Burgess

    Gene expression: Principles of gene regulation across tissuesGene expression: Principles of gene regulation across tissues, Published online: 07 November 2017; doi:10.1038/nrg.2017.94

    更新日期:2017-11-07
  • Cancer genomics: The driving force of cancer evolution
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Linda Koch

    Cancer genomics: The driving force of cancer evolutionCancer genomics: The driving force of cancer evolution, Published online: 07 November 2017; doi:10.1038/nrg.2017.95NatureArticleSnippet(type=short-summary, markup=Two novel comprehensive analyses in Cell provide important insights into the dynamics of tumour evolution and the mutational burden of a wide range of cancer types., isJats=true)

    更新日期:2017-11-07
  • Navigating complexity to breed disease-resistant crops
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Rebecca Nelson, Tyr Wiesner-Hanks, Randall Wisser, Peter Balint-Kurti

    Navigating complexity to breed disease-resistant cropsNavigating complexity to breed disease-resistant crops, Published online: 07 November 2017; doi:10.1038/nrg.2017.82NatureArticleSnippet(type=short-summary, markup=Disease-resistant crops have the potential to reduce crop losses. This Review discusses how advances in genetic and genomic technologies are contributing to efforts by plant breeders to generate durable, broad-spectrum disease resistance in crop plants., isJats=true)

    更新日期:2017-11-07
  • Gene expression: Principles of gene regulation across tissues
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-11-07
    Darren J. Burgess

    Gene expression: Principles of gene regulation across tissuesGene expression: Principles of gene regulation across tissues, Published online: 07 November 2017; doi:10.1038/nrg.2017.94

    更新日期:2017-11-07
  • Human gene essentiality
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-30
    István Bartha, Julia di Iulio, J. Craig Venter, Amalio Telenti

    Human gene essentiality Nature Reviews Genetics, Published online: 30 October 2017; doi:10.1038/nrg.2017.75 Characterizing the essentiality of human genes provides insights into gene function and genome evolution and facilitates the clinical interpretation of genetic variants. This article analyses essentiality metrics based on the statistical intolerance to loss-of-function mutations in human population sequencing studies and discusses commonalities and distinctions relative to data sets from knockout mice and functional genomics screens in human cell culture. Implications for disease genetics and extrapolation to non-coding regions are also discussed.

    更新日期:2017-10-30
  • Transcription: Promoters dictate termination mode
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-30
    Grant Otto

    Transcription: Promoters dictate termination mode Nature Reviews Genetics, Published online: 30 October 2017; doi:10.1038/nrg.2017.93

    更新日期:2017-10-30
  • Population genetics of sexual conflict in the genomic era
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Judith E. Mank

    Population genetics of sexual conflict in the genomic era Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.83 Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved.

    更新日期:2017-10-30
  • Genetic engineering: On the road to efficient gene drives
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-24
    Michelle Trenkmann

    Genetic engineering: On the road to efficient gene drives Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.91

    更新日期:2017-10-30
  • Transcription: Intragenic enhancers dampen gene expression
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-24
    Katharine H. Wrighton

    Transcription: Intragenic enhancers dampen gene expression Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.90

    更新日期:2017-10-30
  • Human gene essentiality
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-30
    István Bartha, Julia di Iulio, J. Craig Venter, Amalio Telenti

    Human gene essentiality Nature Reviews Genetics, Published online: 30 October 2017; doi:10.1038/nrg.2017.75 Characterizing the essentiality of human genes provides insights into gene function and genome evolution and facilitates the clinical interpretation of genetic variants. This article analyses essentiality metrics based on the statistical intolerance to loss-of-function mutations in human population sequencing studies and discusses commonalities and distinctions relative to data sets from knockout mice and functional genomics screens in human cell culture. Implications for disease genetics and extrapolation to non-coding regions are also discussed.

    更新日期:2017-10-30
  • Transcription: Promoters dictate termination mode
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-30
    Grant Otto

    Transcription: Promoters dictate termination mode Nature Reviews Genetics, Published online: 30 October 2017; doi:10.1038/nrg.2017.93

    更新日期:2017-10-30
  • Population genetics of sexual conflict in the genomic era
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-24
    Judith E. Mank

    Population genetics of sexual conflict in the genomic era Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.83 Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved.

    更新日期:2017-10-30
  • Genetic engineering: On the road to efficient gene drives
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-24
    Michelle Trenkmann

    Genetic engineering: On the road to efficient gene drives Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.91

    更新日期:2017-10-30
  • Transcription: Intragenic enhancers dampen gene expression
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-10-24
    Katharine H. Wrighton

    Transcription: Intragenic enhancers dampen gene expression Nature Reviews Genetics, Published online: 24 October 2017; doi:10.1038/nrg.2017.90

    更新日期:2017-10-30
  • Gene regulation: Closing the loop on noisy gene expression
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Dorothy Clyde

    Gene regulation: Closing the loop on noisy gene expression Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.85

    更新日期:2017-10-16
  • Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Ross Cloney

    Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.87

    更新日期:2017-10-16
  • Emerging and evolving concepts in gene essentiality
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Giulia Rancati, Jason Moffat, Athanasios Typas, Norman Pavelka

    Emerging and evolving concepts in gene essentiality Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.74 Identifying which genes in a genome are essential for survival has been a long-standing goal of geneticists. This Review discusses our evolving understanding of cellular gene essentiality across diverse organisms. It describes how essentiality is often non-absolute but is instead dependent on the environment or genetic background and how this knowledge can be exploited therapeutically.

    更新日期:2017-10-16
  • The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Frank Lyko

    The DNA methyltransferase family: a versatile toolkit for epigenetic regulation Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.80 The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes. Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in addition to establishing and maintaining DNA methylation patterns, DNMT enzymes function in transcriptional silencing, transcriptional activation and post-transcriptional regulation.

    更新日期:2017-10-16
  • Gene regulation: Closing the loop on noisy gene expression
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Dorothy Clyde

    Gene regulation: Closing the loop on noisy gene expression Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.85

    更新日期:2017-10-16
  • Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Ross Cloney

    Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.87

    更新日期:2017-10-16
  • Emerging and evolving concepts in gene essentiality
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Giulia Rancati, Jason Moffat, Athanasios Typas, Norman Pavelka

    Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases.

    更新日期:2017-10-16
  • The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Frank Lyko

    The DNA methyltransferase family: a versatile toolkit for epigenetic regulation Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.80 The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes. Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in addition to establishing and maintaining DNA methylation patterns, DNMT enzymes function in transcriptional silencing, transcriptional activation and post-transcriptional regulation.

    更新日期:2017-10-16
  • Convergence between biological, behavioural and genetic determinants of obesity
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Sujoy Ghosh, Claude Bouchard

    Convergence between biological, behavioural and genetic determinants of obesity Nature Reviews Genetics, Published online: 9 October 2017; doi:10.1038/nrg.2017.72 Recent large-scale genome-wide association studies have identified numerous variants that are associated with obesity-relevant traits such as body mass index or body fat percentage. Here, the authors explore to what extent this genomic evidence matches the evidence from functional and mechanistic studies.

    更新日期:2017-10-11
  • Genome organization: Compartmentalizing chromatin without cohesin
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Katharine H. Wrighton

    Genome organization: Compartmentalizing chromatin without cohesin Nature Reviews Genetics, Published online: 9 October 2017; doi:10.1038/nrg.2017.84

    更新日期:2017-10-11
  • Functional genomics: Identifying global RNA–chromatin interactions by GRID-seq
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Grant Otto

    Functional genomics: Identifying global RNA–chromatin interactions by GRID-seq Nature Reviews Genetics, Published online: 3 October 2017; doi:10.1038/nrg.2017.81

    更新日期:2017-10-11
  • Technique: CRISPR CAPTURE for multi-omic probing of genomic loci
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Darren J. Burgess

    Technique: CRISPR CAPTURE for multi-omic probing of genomic loci Nature Reviews Genetics, Published online: 3 October 2017; doi:10.1038/nrg.2017.79

    更新日期:2017-10-11
  • Convergence between biological, behavioural and genetic determinants of obesity
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Sujoy Ghosh, Claude Bouchard

    Convergence between biological, behavioural and genetic determinants of obesity Nature Reviews Genetics, Published online: 9 October 2017; doi:10.1038/nrg.2017.72 Recent large-scale genome-wide association studies have identified numerous variants that are associated with obesity-relevant traits such as body mass index or body fat percentage. Here, the authors explore to what extent this genomic evidence matches the evidence from functional and mechanistic studies.

    更新日期:2017-10-11
  • Genome organization: Compartmentalizing chromatin without cohesin
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Katharine H. Wrighton

    Genome organization: Compartmentalizing chromatin without cohesin Nature Reviews Genetics, Published online: 9 October 2017; doi:10.1038/nrg.2017.84

    更新日期:2017-10-11
  • Functional genomics: Identifying global RNA–chromatin interactions by GRID-seq
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Grant Otto

    Functional genomics: Identifying global RNA–chromatin interactions by GRID-seq Nature Reviews Genetics, Published online: 3 October 2017; doi:10.1038/nrg.2017.81

    更新日期:2017-10-11
  • Technique: CRISPR CAPTURE for multi-omic probing of genomic loci
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Darren J. Burgess

    Technique: CRISPR CAPTURE for multi-omic probing of genomic loci Nature Reviews Genetics, Published online: 3 October 2017; doi:10.1038/nrg.2017.79

    更新日期:2017-10-11
  • Demographic history, selection and functional diversity of the canine genome
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Elaine A. Ostrander, Robert K. Wayne, Adam H. Freedman, Brian W. Davis

    The domestic dog represents one of the most dramatic long-term evolutionary experiments undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in phenotype and behaviour has developed in dogs, providing a model for understanding the developmental and genomic mechanisms of diversification. We discuss pattern and process in domestication, beginning with general findings about early domestication and problems in documenting selection at the genomic level. Furthermore, we summarize genotype–phenotype studies based first on single nucleotide polymorphism (SNP) genotyping and then with whole-genome data and show how an understanding of evolution informs topics as different as human history, adaptive and deleterious variation, morphological development, ageing, cancer and behaviour.

    更新日期:2017-09-25
  • Development: Epigenome dynamics from seed to seedling
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Linda Koch

    Development: Epigenome dynamics from seed to seedling Nature Reviews Genetics, Published online: 25 September 2017; doi:10.1038/nrg.2017.78

    更新日期:2017-09-25
  • Demographic history, selection and functional diversity of the canine genome
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Elaine A. Ostrander, Robert K. Wayne, Adam H. Freedman, Brian W. Davis

    The domestic dog represents one of the most dramatic long-term evolutionary experiments undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in phenotype and behaviour has developed in dogs, providing a model for understanding the developmental and genomic mechanisms of diversification. We discuss pattern and process in domestication, beginning with general findings about early domestication and problems in documenting selection at the genomic level. Furthermore, we summarize genotype–phenotype studies based first on single nucleotide polymorphism (SNP) genotyping and then with whole-genome data and show how an understanding of evolution informs topics as different as human history, adaptive and deleterious variation, morphological development, ageing, cancer and behaviour.

    更新日期:2017-09-25
  • Development: Epigenome dynamics from seed to seedling
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Linda Koch

    Development: Epigenome dynamics from seed to seedling Nature Reviews Genetics, Published online: 25 September 2017; doi:10.1038/nrg.2017.78

    更新日期:2017-09-25
  • Development: Transcriptomic blueprints
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Linda Koch

    Development: Transcriptomic blueprints Nature Reviews Genetics, Published online: 18 September 2017; doi:10.1038/nrg.2017.77

    更新日期:2017-09-19
  • Development: Transcriptomic blueprints
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Linda Koch

    Development: Transcriptomic blueprints Nature Reviews Genetics, Published online: 18 September 2017; doi:10.1038/nrg.2017.77

    更新日期:2017-09-19
  • Model organisms: New tools, new insights — probing social behaviour in ants
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Dorothy Clyde

    Eusocial insects display complex social behaviours, but the underlying molecular mechanisms are largely unknown. Now, a trio of papers in Cell decribe two genes (orco and corazonin) that control social behaviour in ants. Furthermore, two of the studies describe the first

    更新日期:2017-09-15
  • Chromosome biology: Different turfs for cohesin and condensin
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Eytan Zlotorynski

    The structural maintenance of chromosomes (SMC) complexes cohesin and condensin are ring-shaped protein machines that encircle the chromatin and control various aspects of chromosome function, including the formation of chromatin loops, sister chromatid cohesion and mitotic chromosome compaction. Schalbetter et al. now show that

    更新日期:2017-09-15
  • Pathogen genetics: Evolutionary dynamics driving drug resistance
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-08-14
    Linda Koch

    The broad application of antibiotics is responsible for the development of antimicrobial resistance in many bacterial pathogens. Two recent studies now reconstruct the evolutionary history of the first methicillin-resistant Staphylococcus aureus (MRSA) and the multidrug-resistant Escherichia coli lineage ST131. Harkins et al.

    更新日期:2017-09-15
  • Gene therapy: Human genome editing in heart disease
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Gregory B. Lim

    Human germline genome editing with CRISPR–Cas9 was used with high efficiency, accuracy and safety to correct a heterozygous, autosomal dominant mutation in MYBPC3 associated with hypertrophic cardiomyopathy, according to a new study in Nature.CRISPR–Cas9 is a versatile tool for recognizing a specific

    更新日期:2017-09-15
  • Genetic engineering: Pigs without PERVs
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Linda Koch

    Pig-to-human organ transplantation holds promise for resolving the existing shortage of transplantable organs, but the potential transmission risk of porcine endogenous retroviruses (PERVs) to humans has remained a concern. Now, Niu et al. report the successful generation of PERV-inactivated pigs by somatic cell nuclear

    更新日期:2017-09-15
  • Evolutionary biology through the lens of budding yeast comparative genomics
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-07-17
    Souhir Marsit, Jean-Baptiste Leducq, Éléonore Durand, Axelle Marchant, Marie Filteau, Christian R. Landry

    The budding yeast Saccharomyces cerevisiae is a highly advanced model system for studying genetics, cell biology and systems biology. Over the past decade, the application of high-throughput sequencing technologies to this species has contributed to this yeast also becoming an important model for evolutionary genomics. Indeed, comparative genomic analyses of laboratory, wild and domesticated yeast populations are providing unprecedented detail about many of the processes that govern evolution, including long-term processes, such as reproductive isolation and speciation, and short-term processes, such as adaptation to natural and domestication-related environments.

    更新日期:2017-09-15
  • Settling the score: variant prioritization and Mendelian disease
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Karen Eilbeck, Aaron Quinlan, Mark Yandell

    When investigating Mendelian disease using exome or genome sequencing, distinguishing disease-causing genetic variants from the multitude of candidate variants is a complex, multidimensional task. Many prioritization tools and online interpretation resources exist, and professional organizations have offered clinical guidelines for review and return of prioritization results. In this Review, we describe the strengths and weaknesses of widely used computational approaches, explain their roles in the diagnostic and discovery process and discuss how they can inform (and misinform) expert reviewers. We place variant prioritization in the wider context of gene prioritization, burden testing and genotype–phenotype association, and we discuss opportunities and challenges introduced by whole-genome sequencing.

    更新日期:2017-09-15
  • Synthetic lethality and cancer
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-06-26
    Nigel J. O'Neil, Melanie L. Bailey, Philip Hieter

    A synthetic lethal interaction occurs between two genes when the perturbation of either gene alone is viable but the perturbation of both genes simultaneously results in the loss of viability. Key to exploiting synthetic lethality in cancer treatment are the identification and the mechanistic characterization of robust synthetic lethal genetic interactions. Advances in next-generation sequencing technologies are enabling the identification of hundreds of tumour-specific mutations and alterations in gene expression that could be targeted by a synthetic lethality approach. The translation of synthetic lethality to therapy will be assisted by the synthesis of genetic interaction data from model organisms, tumour genomes and human cell lines.

    更新日期:2017-09-15
  • Dissecting evolution and disease using comparative vertebrate genomics
    Nat. Rev. Genet. (IF 40.282) Pub Date : 2017-07-24
    Jennifer R. S. Meadows, Kerstin Lindblad-Toh

    With the generation of more than 100 sequenced vertebrate genomes in less than 25 years, the key question arises of how these resources can be used to inform new or ongoing projects. In the past, this diverse collection of sequences from human as well as model and non-model organisms has been used to annotate the human genome and to increase the understanding of human disease. In the future, comparative vertebrate genomics in conjunction with additional genomic resources will yield insights into the processes of genome function, evolution, speciation, selection and adaptation, as well as the quantification of species diversity. In this Review, we discuss how the genomics of non-human organisms can provide insights into vertebrate biology and how this can contribute to the understanding of human physiology and health.

    更新日期:2017-09-15
  • Harnessing ancient genomes to study the history of human adaptation
    Nat. Rev. Genet. (IF 40.282) Pub Date : 
    Stephanie Marciniak, George H. Perry

    The past several years have witnessed an explosion of successful ancient human genome-sequencing projects, with genomic-scale ancient DNA data sets now available for more than 1,100 ancient human and archaic hominin (for example, Neandertal) individuals. Recent 'evolution in action' analyses have started using these data sets to identify and track the spatiotemporal trajectories of genetic variants associated with human adaptations to novel and changing environments, agricultural lifestyles, and introduced or co-evolving pathogens. Together with evidence of adaptive introgression of genetic variants from archaic hominins to humans and emerging ancient genome data sets for domesticated animals and plants, these studies provide novel insights into human evolution and the evolutionary consequences of human behaviour that go well beyond those that can be obtained from modern genomic data or the fossil and archaeological records alone.

    更新日期:2017-09-11
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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