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Central angiotensin-(1–7) attenuates hypoglycemia in sepsis-like conditions via reducing systemic and hepatic inflammation Cytokine (IF 3.8) Pub Date : 2024-05-08 Gabriel Cardoso Santos, Aline Alves de Jesus, Patrícia Passaglia, Henrique J. Novaes Morgan, Luiz Carlos Carvalho Navegantes, Lucila Leico Kagohara Elias, Evelin Capellari Cárnio
Sepsis is understood as the result of initiating systemic inflammation derived from an inadequate host response against pathogens. In its acute phase, sepsis is marked by an exacerbated reaction to infection, tissue damage, organ failure, and metabolic dysfunction. Among these, hypoglycemia, characterized by disorders of the gluconeogenesis pathway, is related to one of the leading causes of mortality
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Effect of IL-2 polymorphism rs2069762 on single-unit cord blood transplant outcomes Cytokine (IF 3.8) Pub Date : 2024-05-07 Takaaki Konuma, Megumi Hamatani-Asakura, Maki Monna-Oiwa, Seiko Kato, Masamichi Isobe, Kazuaki Yokoyama, Satoshi Takahashi, Yasuhito Nannya
Interleukin-2 (IL-2) is one of the most important cytokines that regulate the activation and proliferation of T cells and natural killer cells. The production of IL-2 may be affected by polymorphisms in the promoter region of the gene (rs2069762). In allogeneic hematopoietic cell transplantation (HCT) from adult donors, rs2069762 has been associated with the incidence of acute and chronic graft-versus-host
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Chitinase 3 like-1 activates the Akt pathway, inducing NF-κB-dependent release of pro-inflammatory cytokines and promoting the proliferative ability in nasopharyngeal carcinoma cells Cytokine (IF 3.8) Pub Date : 2024-05-05 Dajun Li, Gai Fan, Yeqi Zhou
Chitinase 3 like-1 (CHI3L1) has been reported to function as an oncogene in many types of cancer. However, the biological function of CHI3L1 in nasopharyngeal carcinoma (NPC) remains unknown. Differentially expressed genes (DEGs) in NPC tissues in GSE64634 and GSE12452 were downloaded from Gene Expression Omnibus (GEO). CHI3L1, interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) mRNA expression
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Is it possible to treat melanoma by intercepting the CXCR4/CXCL12 pathway? Cytokine (IF 3.8) Pub Date : 2024-05-04 Miriam Motlak, Meghna Mathews, Omar S. Al-Odat, Manoj K. Pandey
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Apolipoprotein E is a prognostic factor for pancreatic cancer and associates with immune infiltration Cytokine (IF 3.8) Pub Date : 2024-05-04 Bin Wu, Xiaodan Yang, Fei Chen, Zhengwei Song, Xuhui Ding, Xiaoguang Wang
The expression level of apolipoprotein E (APOE) in pancreatic ductal adenocarcinoma (PDAC) and its effect on the prognosis of PDAC patients are not clear. The effect of APOE on the immune status of patients with PDAC has not been elucidated. We obtained pancreatic cancer data from the TCGA and GETx databases. Patients with PDAC who underwent pancreatic surgery at the Second Affiliated Hospital of Jiaxing
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Leishmania donovani mitogen-activated protein kinases as a host-parasite interaction interface Cytokine (IF 3.8) Pub Date : 2024-05-03 Neelam Bodhale, Saptaparnee Saha, Dhiraj Gurjar, Nicolas Grandchamp, Arup Sarkar, Bhaskar Saha
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Evaluation of some proinflammatory cytokines and biochemical parameters in pre and postmenopausal breast cancer women Cytokine (IF 3.8) Pub Date : 2024-05-02 Maryam Mohammed Bakheet, Hiba Mohssin Ali, Tabarak Jalil Talab
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Baricitinib protects ICIs-related myocarditis by targeting JAK1/STAT3 to regulate Macrophage polarization Cytokine (IF 3.8) Pub Date : 2024-05-02 Xuejun Wang, Jiahui Chen, Yihui Shen, Hui Zhang, Yuchen Xu, Jian Zhang, Leilei Cheng
The emergence of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, but these drugs can also cause severe immune-related adverse effects (irAEs), including myocarditis. Researchers have become interested in exploring ways to mitigate this side effect, and one promising avenue is the use of baricitinib, a Janus kinase inhibitor known to have anti-inflammatory properties. This study
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Genetic variations in immune mediators and prostate cancer risk: A field synopsis with Bayesian calculations Cytokine (IF 3.8) Pub Date : 2024-05-01 Matheus Santos Freire, André Victor de Oliveira Monteiro, Tayane Moura Martins, Márcia Socorro Silva Lima Duarte, Antonio Carlos Lima, Alessandro Luiz Araújo Bentes Leal, Felipe Rodolfo Pereira da Silva, José Fernando Marques Barcellos
Our study aimed to revaluate the significant data from -analyses on genetic variations in immune mediators and the risk of prostate cancer (PCa) by Bayesian approaches. We performed a search on the literature before September 5th, 2023, for -analytic studies on polymorphisms in immune mediator genes and the risk of PCa. Two Bayesian approaches were used to assess the level of noteworthiness in the
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Epstein-Barr virus-encoded BART9 and BART15 miRNAs are elevated in exosomes of cerebrospinal fluid from relapsing-remitting multiple sclerosis patients Cytokine (IF 3.8) Pub Date : 2024-04-30 Mina Mohammadinasr, Soheila Montazersaheb, Vahid Hosseini, Houman Kahroba, Mahnaz Talebi, Ommoleila Molavi, Hormoz Ayromlou, Mohammad Saeid Hejazi
Epstein-Barr virus (EBV) infection is approved as the main environmental trigger of multiple sclerosis (MS). In this path, we quantified ebv-miR-BART9-3p and ebv-miR-BART15 in exosomes of cerebrospinal fluid (CSF) of untreated relapsing-remitting MS (RRMS) patients in comparison with the control group. Interestingly, patients displayed significant upregulation of ebv-miR-BART9-3p (18.4-fold) and ebv-miR-BART15
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The role of innate lymphoid cells in systemic lupus erythematosus Cytokine (IF 3.8) Pub Date : 2024-04-28 Yong Chen, Xiaotian Gu, Kunyu Cao, Miao Tu, Wan Liu, Jiyu Ju
Systemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known
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Resveratrol has neuroprotective effects and plays an anti-inflammatory role through Dectin-1/p38 pathway in Aspergillus fumigatus keratitis Cytokine (IF 3.8) Pub Date : 2024-04-27 Weilin Diao, Min Yin, Yinghe Qi, Yudong Fu, Lingwen Gu, Jing Lin, Lina Zhang, Nan Jiang, Qian Wang, Yuwei Wang, Wendan Yi, Menghui Chi, Cui Li, Guiqiu Zhao
To determine the antifungal, anti-inflammatory and neuroprotective effects of resveratrol (RES) in ) keratitis. Cytotoxicity assay and Draize eye assay were performed to assess the toxicity of RES. The antifungal effect of RES was assessed by minimal inhibitory concentration, scanning or transmission electron microscopy, propidium iodide uptake assay, and Calcofluor white staining. Phosphorylation
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Circulating cytokines levels and osteoarthritis: A Mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-04-26 Jiale Xie, Xianjie Wan, Mingyi Yang, Hui Yu, Jinrong Hao, Ke Xu, Jiachen Wang, Peng Xu
Previous traditional observational studies have suggested the contribution of several cytokines and growth factors to the development of osteoarthritis (OA). This study aimed to determine the association of circulating cytokine and growth factor levels with OA. We used two-sample Mendelian randomization (MR) to explore the causality between circulating cytokine and growth factor levels and OA [including
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IL-23 regulation of myeloid cell biology during inflammation Cytokine (IF 3.8) Pub Date : 2024-04-25 Kevin M.-C. Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey, Martha Zeeman, Anne M. Fourie, John A. Hamilton
Interleukin (IL)–23 is implicated in the pathogenesis of several inflammatory diseases and is usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate immune biology in such diseases. We therefore examined the effects of IL-23p19 genetic deletion and/or neutralization on macrophage activation and in an innate immune-driven peritonitis model.
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Association between CBL gene polymorphism and susceptibility of microscopic polyangiitis in a Chinese population: A case-control analysis Cytokine (IF 3.8) Pub Date : 2024-04-25 Liu Liu, Yan Zhu, Jingjing Lan, Liepeng Chu, Wei Li, Chao Xue
To assess whether () gene polymorphism influences the risk of microscopic polyangiitis (MPA) in Chinese populations. In total, 266 MPA patients and 297 healthy controls were recruited for a case-control study. Five SNPs were genotyped using multiplex polymerase chain reaction and high-throughput sequencing. The relationship between SNPs and the risk of MPA under different genetic models was evaluated
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Diagnostic accuracy and cellular origin of pleural fluid CXCR3 ligands for tuberculous pleural effusion Cytokine (IF 3.8) Pub Date : 2024-04-24 Zhi Yan, Jian-Xun Wen, Yan Niu, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Qi Chen, Ya-Fei Wang, Li Yan, Zhi-De Hu, Wen-Qi Zheng
Pleural biomarkers represent potential diagnostic tools for tuberculous pleural effusion (TPE) due to their advantages of low cost, short turnaround time, and less invasiveness. This study evaluated the diagnostic accuracy of two CXCR3 ligands, C-X-C motif chemokine ligand 9 (CXCL9) and CXCL11, for TPE. In addition, we investigated the cellular origins and biological roles of CXCL9 and CXCL11 in the
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Immune profiles of MCP-1 with M tb antigens and recombinant cytokines stimulation in tuberculosis Cytokine (IF 3.8) Pub Date : 2024-04-21 Ashwini Pullagurla, Bhagyalaxmi Rapolu, Shazia Ahmad, Sumanlatha Gaddam
Tuberculosis is caused by (), which is recognized by macrophages and produces inflammatory cytokines, and chemokines at the site of infection. The present study was proposed to understand the interaction of antigens, cytokines, and chemokines. We have evaluated the chemokine MCP-1 levels and its expression in PBMCs stimulated with antigens Ag85A, ESAT6 and recombinant cytokines rhTNF-α, rhIFN-γ, rhTGF-β
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Microalgae extracts modulates the immune response in Trypanosoma cruzi-infected human cells Cytokine (IF 3.8) Pub Date : 2024-04-21 José Noé da Silva Júnior, Kamila Kassia dos Santos Oliveira, Ana Carla da Silva, Virginia Maria Barros de Lorena, Daniela de Araújo Viana Marques, Raquel Pedrosa Bezerra, Ana Lúcia Figueiredo Porto
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Transcriptome of bone marrow-Derived stem cells reveals new inflammatory mediators related to increased survival in patients with multiple myeloma Cytokine (IF 3.8) Pub Date : 2024-04-20 Stefania Tagliari de Oliveira, Renata Binato, Geise Ellen Broto, Erika Tomie Takakura, Leticia Navarro Gordan Ferreira Martins, Eliana Abdelhay, Carolina Panis
Although multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem cells obtained from MM patients and compared the clinical outcomes of death and survival six months after bone marrow transplantation. The leukapheresis
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Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis Cytokine (IF 3.8) Pub Date : 2024-04-20 Fang Hou, Jing Gao, Li Zhang, Chang Liu
To analyze the relationship between IL and 6 572C/G polymorphism with sepsis. Searching 8 databases the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chongqing VIP, Embase, PubMed, WanFang Data, and Web of Science from inception to October 1, 2023. Meta-analysis was performed by using Review Manager 5.4 and STATA 15.0. 9 studies were included, 1 study
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Immune response to colonization of Candida albicans in mice treated with Cefoperazone Cytokine (IF 3.8) Pub Date : 2024-04-18 Hussein Muttaleb Asfoor, Atyaf Saied Hamied
species are a normal human flora in humans' digestive and reproductive systems, oral cavity, skin, and mucosal surfaces. This study aimed to detect the immunological role of infection by using some immunological markers. The results of levels in serum showed high concentrations of IgA (56.20 ± 12 pg/ml,29.55 ± 4.5 pg/ml respectively) and IgG (12.05 ± 3.218 pg/ml, 3.836 ± 1.23 pg/ml respectively) in
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The roles of SFKs in the regulation of proinflammatory cytokines and NLRP3 in familial mediterranean fever patients Cytokine (IF 3.8) Pub Date : 2024-04-18 Irmak İçen Taşkın, Sevim Gürbüz, Ahmet Koç, Samet Kocabay, Servet Yolbaş, Muhammed Furkan Keser
Familial Mediterranean Fever (FMF) is caused by mutations in pyrin, a protein produced in innate immune cells that regulates the development of interleukin (IL)-1β by interacting with caspase-1 and other components of inflammasomes. Although overexpression of proinflammatory cytokines have been observed in FMF patients, no studies have been conducted on the role of Src family kinases (SFKs). The purpose
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Immune responses induced by Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) upon co-administration with Bacillus Calmette-Guérin in mice Cytokine (IF 3.8) Pub Date : 2024-04-18 Fangzheng Guo, Jing Wei, Yamin Song, Jianhan Song, Ying Wang, Kangsheng Li, Baiqing Li, Zhongqing Qian, Xiaojing Wang, Hongtao Wang, Tao Xu
To preliminarily assess the immunogenicity of Mtb-HAg in mice and the synergistic effect provided by HAg when co-immunised with BCG. Mice were randomly grouped for different immunisations and then spleens were aseptically removed and lymphocytes were extracted for immediate detection of cytokines transcript levels and stimulation index(SI), cytokine secretion and multifunctional antigen-specific T
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Increased IL-22 in cerebrospinal fluid of neuro-behçet’s disease patients Cytokine (IF 3.8) Pub Date : 2024-04-16 Meriam Belghith, Olfa Maghrebi, Rafika Ben Laamari, Mariem Hanachi, Sana Hrir, Zakaria Saied, Samir Belal, Adel Driss, Samia Ben Sassi, Thouraya Boussoffara, Mohamed-Ridha Barbouche
Remitting-Relapsing Multiple Sclerosis (RRMS) and Neuro-Behçet Disease (NBD) are two chronic neuro-inflammatory disorders leading to brain damage and disability in young adults. Herein, we investigated in these patients the cytokine response by beads-based multiplex assays during the early stages of these disorders. Cytokine investigations were carried out on treatment-naive patients suffering from
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Serum levels of sirtuins, leptin and adiponectin in women with pregnancy-induced hypertension Cytokine (IF 3.8) Pub Date : 2024-04-16 Magdalena Golańska-Wróblewska, Jolanta Fryczak, Agnieszka Siejka
Pregnancy-induced hypertension (PIH) and preeclampsia (PE) are associated with disturbed maternal inflammatory response, oxidative stress and vascular endothelial cell dysfunction. Obesity is one of risk factors of PE. Leptin is elevated in obesity and its level correlates positively with the amount of adipose tissue. In contrast, adiponectin levels are decreased in obesity. Sirtuins are expressed
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Multi-species synbiotic supplementation increased fecal short chain fatty acids and anti-inflammatory cytokine interleukin-10 in adult men with dyslipidemia; A randomized, double-blind, clinical trial Cytokine (IF 3.8) Pub Date : 2024-04-16 Shekoufeh Salamat, Alireza Jahan-Mihan, Lida Gharibvand, Mohammad Reza Tabandeh, Anahita Mansoori
Mounting evidence revealed that an imbalance of Gut Microbiota (GM) leads to metabolic disorders. Synbiotics through regulation of GM composition can be an effective intervention in the management of metabolic diseases. This study aimed to investigate the effects of multi-species synbiotic supplementation on serum interleukin10 (IL-10) and fecal Short Chain Fatty Acids (SCFAs) in patients with dyslipidemia
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Targeting TNF-α-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin's mediated therapeutic approach Cytokine (IF 3.8) Pub Date : 2024-04-15 Monu, Prachi Agnihotri, Mohd Saquib, Sagarika Biswas
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The sex-dependent impact of adipose tissue and inflammation on chronic pain – A cross-sectional study from the all of us research program Cytokine (IF 3.8) Pub Date : 2024-04-14 Deepak Berwal, Dumitru D. Branisteanu, Mia Glickman, Amit Sagar, Julie G. Pilitsis
Emerging evidence suggests an association between chronic pain and elevated body fat. We sought to determine if individuals with higher body fat, measured by hip circumference (HC) and waist circumference (WC), are at risk for chronic pain when they demonstrate higher expression of inflammatory markers. We investigated the incidence and severity of pain in patients with varying WC/HC and inflammatory
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Recombinant human IL-37 attenuates acute cardiac allograft rejection in mice Cytokine (IF 3.8) Pub Date : 2024-04-08 Bo Shao, Jing-yi Zhang, Shao-hua Ren, Ya-fei Qin, Hong-da Wang, Yong-chang Gao, De-jun Kong, Yong-hao Hu, Hong Qin, Guang-ming Li, Hao Wang
Allograft rejection remains a major obstacle to long-term graft survival. Although previous studies have demonstrated that IL-37 exhibited significant immunomodulatory effects in various diseases, research on its role in solid organ transplantation has not been fully elucidated. In this study, the therapeutic effect of recombinant human IL-37 (rhIL-37) was evaluated in a mouse cardiac allotransplantation
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Diagnostic, monitoring, and prognostic value of combined detection of cerebrospinal fluid heparin-binding protein, interleukin-6, interleukin-10, and procalcitonin for post-neurosurgical intracranial infection Cytokine (IF 3.8) Pub Date : 2024-04-06 Xinfang Pan, Dina Haishaer, Mei Liu, Shaobo Zhou, Heya Na, Hongmei Zhao
Intracranial infection is a common complication after neurosurgery and can increase the length of hospital stay, affect patient prognosis, and increase mortality. We aimed to investigate the value of the combined detection of cerebrospinal fluid (CSF) heparin-binding protein (HBP), interleukin-6 (IL-6), interleukin-10 (IL-10), and procalcitonin (PCT) for post-neurosurgical intracranial infection. This
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Low expression of interleukin-1 receptor antagonist correlates with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma Cytokine (IF 3.8) Pub Date : 2024-04-05 Yujie Ding, Jie Yi, Yufei Shan, Jiaqi Gu, Zhida Sun, Jie Lin
Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, or cells and can be used to monitor a wide range of biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene and tumor biomarker. The goal of this study was to investigate the expression of IL1RA, its probable carcinogenic
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Establishment of reference intervals for plasma IL-2, IL-4, IL-5, and IL-17A in healthy adults from the Jiangsu region of eastern China using flow cytometry: A single-center study Cytokine (IF 3.8) Pub Date : 2024-04-05 Qian Liu, Zhengping Xia, Tingting Huang, Fang Yang, Xizhen Wang, Fumeng Yang
Cytokines are of utmost importance in both the physiological and pathological immune responses of the human body. This study utilized flow cytometry to measure the levels of plasma interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-17A (IL-17A) and established their reference intervals, aiming to provide data support for the diagnosis and treatment of clinical diseases
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Expression and function of cytokine interleukin-22 gene in the tumor microenvironment of triple negative breast cancer Cytokine (IF 3.8) Pub Date : 2024-04-05 Yibin Xiao, Xia Zhao, Yihui Guo, Yanping Li
The tumor microenvironment (TME) and interleukin-22 (IL-22) in cytokines have recently attracted much attention due to their potential impact on tumor biology. However, the role of IL-22 in triple negative breast cancer (TNBC) TME is still poorly understood. This article investigated the gene expression and function of IL-22 in TNBC TME. Tumor samples from TNBC patients were collected, and adjacent
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LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review Cytokine (IF 3.8) Pub Date : 2024-04-04 Shayan Khalilollah, Sina Kalantari Soltanieh, Raed Obaid Saleh, Abdullah Ali Alzahrani, Hatem Ghaleb Maabreh, Mais Mazin Al-Hamdani, Mahmoud Dehghani-Ghorbi, Metanat Shafiei Khonachaei, Reza Akhavan-Sigari
The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological diseases are associated with the differentiation of the proinflammatory T cell subset TH17 and its balance with the production of Treg. Recently, long non-coding
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Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2 Cytokine (IF 3.8) Pub Date : 2024-04-03 Daisuke Kawata, Hideyuki Iwai, Seiya Oba, Yoji Komiya, Ryuji Koike, Sho Miyamoto, Takayuki Kanno, Akira Ainai, Tadaki Suzuki, Tadashi Hosoya, Shinsuke Yasuda
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Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility Cytokine (IF 3.8) Pub Date : 2024-03-30 Alireza Omidvar-Mehrabadi, Fateme Ebrahimi, Mehdi Shahbazi, Mousa Mohammadnia-Afrouzi
Numerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and
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Correlation of circulating fibroblast growth factor 21 levels with inflammatory factors and the degree of coronary artery stenosis in patients with acute myocardial infarction Cytokine (IF 3.8) Pub Date : 2024-03-29 Xu Liu, Mengying Dong, Tianyi Li, Junnan Wang
Fibroblast growth factor 21 (FGF21) is a secreted protein that plays an important role in atherosclerosis and pathological cardiac remodeling. However, the correlation between FGF21 and the degree of coronary artery stenosis and its potential role in acute myocardial infarction (AMI) remain unclear. We examined whether changes in FGF21 levels in AMI correlate with the degree of coronary artery stenosis
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Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study Cytokine (IF 3.8) Pub Date : 2024-03-29 Mayoko Tsuji, Mitsuko Kondo, Yasuto Sato, Azusa Miyoshi, Fumi Kobayashi, Ken Arimura, Kaoru Yamashita, Satoshi Morimoto, Naoko Yanagisawa, Atsuhiro Ichihara, Etsuko Tagaya
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical significance of serum vascular endothelial growth factor A (VEGF-A) in COVID-19 patients and its association with disease severity and pulmonary injury. We prospectively collected
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FOXP3 (in)stability and cancer immunotherapy Cytokine (IF 3.8) Pub Date : 2024-03-27 Keywan Mortezaee
Dysregulation of regulatory T cells (Tregs) is described in the context of inflammatory and autoimmune diseases, and cancer. Forkhead box P3 (FOXP3) is a transcription factor that its activity is an indicator of Treg identity. FOXP3 induces metabolic versatility in intra-tumoral Tregs, so that its deficiency mediates Treg instability or even gives rise to the acquisition of effector T cell phenotype
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Atypical chemoattractants and their receptors: A potential gateway to novel therapeutic strategies Cytokine (IF 3.8) Pub Date : 2024-03-26 James Edward Pease, Silvano Sozzani
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Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab Cytokine (IF 3.8) Pub Date : 2024-03-25 Kazuki M. Matsuda, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Liver fibrosis is a terminal manifestation of various chronic liver diseases. There are no drugs that can reverse the condition. Recently, the importance of interleukin-17 (IL17) in the pathophysiology has been revealed and has attracted attention as a therapeutic target. We aimed to reveal the roles of IL17A and IL17F in liver fibrosis, and to validate the potential of their dual blockade as therapeutic
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Understanding long COVID myocarditis: A comprehensive review Cytokine (IF 3.8) Pub Date : 2024-03-19 Arti Srivastava, Shankar Nalroad Sundararaj, Jagriti Bhatia, Dharamvir Singh Arya
Infectious diseases are a cause of major concern in this twenty-first century. There have been reports of various outbreaks like severe acute respiratory syndrome (SARS) in 2003, swine flu in 2009, Zika virus disease in 2015, and Middle East Respiratory Syndrome (MERS) in 2012, since the start of this millennium. In addition to these outbreaks, the latest infectious disease to result in an outbreak
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Platelet-derived sTLT-1 is associated with platelet-mediated inflammation in coronary artery disease patients Cytokine (IF 3.8) Pub Date : 2024-03-19 Amir Ali, Nadella Mounika, Bishamber Nath, Ebin Johny, Indra Kuladhipati, Rajesh Das, Monowar Hussain, Arun Bandyopadhyay, Ramu Adela
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Serum cytokine profiles during engraftment syndrome and acute graft-versus-host disease in adult patients after hematopoietic stem cell transplantation Cytokine (IF 3.8) Pub Date : 2024-03-16 Beiying Wu, Cen Jiang, Lilan Jin, Xiayidan Azadan, Jiafei Lin, Lin Lin, Xiaomeng Nie, Gang Cai
The underlying biology of engraftment syndrome (ES) following allogeneic hematopoietic stem cell transplantation (HSCT) is not fully elucidated, and the extent of its overlap with acute graft-versus-host disease (aGvHD) remains unclear. In order to establish potential indicator to distinguish ES more accurately, we conducted a retrospective analysis of cytokine levels during HSCT. A total of 121 consecutive
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Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi Cytokine (IF 3.8) Pub Date : 2024-03-14 Xiaohua Xiang, Di Wang, Jun Leng, Ning Li, Chuandong Wei
To investigate the association of circulating adiponectin (APN) level and single nucleotide polymorphisms (rs1501299 and rs266729) of the APN gene in the coronary heart disease (CHD) population of Northern Guangxi Province. Two hundred and sixty-three CHD patients and 235 healthy controls from our hospital from August 2018 to October 2020 were included in this study. ELISA was used to determine the
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Corrigendum to “The relationship between serum cytokine profile and vitamin D in calves with neonatal diarrhea” [Cytokine 165 (2023) 156173] Cytokine (IF 3.8) Pub Date : 2024-03-13 Mehmet Çalışkan, Murat Dabak, Kenan Çağrı Tümer
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Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF-κB pathway Cytokine (IF 3.8) Pub Date : 2024-03-13 Diljeet Kumar, Aminur Rahman Sarkar, Nusrit Iqbal Andrabi, Syed Assim Haq, Manzoor Ahmed, Sanket Kumar Shukla, Zabeer Ahmed, Rajkishor Rai
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Genetic liability to elevated circulating IP-10, IFNγ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-03-13 Qianxi Ye, Miao Chen, Liang Ma
Inflammation is associated with thoracic aortic aneurysm (TAA) but the effects of each circulating inflammatory factor on TAA remain unclear. In this study, we explored the relationship between circulating inflammatory factors and TAA risk using Mendelian randomization (MR) approach based on summary statistics from the latest genome-wide association study (GWAS) of 41 circulating inflammatory factors
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Comprehensive analysis of multiple cytokines to stratify uropathogenic Escherichia coli pathogenesis in mouse model of urinary tract infection Cytokine (IF 3.8) Pub Date : 2024-03-12 Snehashis Koley, Mandira Mukherjee
Urinary tract infection (UTI) is one of the most common human bacterial infections primarily caused by uropathogenic (UPEC). Empiric treatment in UTI cause emergence of multidrug resistance and limit treatment options. Understanding UTI at the molecular level with respect to the causative pathogen as well as subsequent host response pose an absolute necessity towards appropriate clinical management
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IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma Cytokine (IF 3.8) Pub Date : 2024-03-12 I.P. Shilovskiy, A.A. Nikolskii, E.D. Timotievich, V.I. Kovchina, L.I. Vishnyakova, K.V. Yumashev, K.V. Vinogradova, M.M. Kaganova, V.E. Brylina, V.V. Tyulyubaev, T.E. Rusak, M.E. Dyneva, O.M. Kurbacheva, D.A. Kudlay, M.R. Khaitov
Neutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 – a Th2-cytokine regulates neutrophil
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Expression of monocyte chemokine receptors in diabetes after non-surgical periodontal treatment: A pilot study Cytokine (IF 3.8) Pub Date : 2024-03-11 Danielle Borges Germano, Ana Luíza Pereira Assunção Silveira, Yeon Jung Kim, Jônatas Bussador do Amaral, Marina Tiemi Shio, Luiz Henrique da Silva Nali, Carlos Eduardo dos Santos Ferreira, Alexandre Miyahira, Francisco Antonio Helfenstein Fonseca, André Luis Lacerda Bachi, Débora Pallos, Carolina Nunes França
The aim of this study was to evaluate the effect of non-surgical periodontal treatment in the expression of chemokine receptors, in individuals with Periodontitis, associated or not with Diabetes. Pilot study, which included patients (n = 45) with Periodontitis, associated (n = 25) or not (n = 20) with Diabetes, submitted to the non-surgical periodontal treatment for one month. The expression of chemokine
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Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS/NLRP3/IL-1β signaling pathway Cytokine (IF 3.8) Pub Date : 2024-03-11 Jia-Jie Tan, Yuan-Feng Dai, Fan Wang, Ze-Hong Lv, Li-Jun Huang, Ling-Yi Peng, Xiang-Ping Li
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CD4+ Foxp3+ Regulatory T-cells in Modulating Inflammatory Microenvironment in Chronic Rhinosinusitis with Nasal Polyps: Progress and Future Prospect Cytokine (IF 3.8) Pub Date : 2024-03-07 Nur Najwa Farahin M Yusoff, Suhana Ahmad, Wan Faiziah Wan Abdul Rahman, Rohimah Mohamud, Jennifer C.Boer, Magdalena Plebanski, Baharudin Abdullah, Xin Chen, Tengku Ahmad Damitri Al-Astani Tengku Din
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune
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Cytokine storm in human monkeypox: A possible involvement of purinergic signaling Cytokine (IF 3.8) Pub Date : 2024-03-05 Gilnei Bruno da Silva, Geórgia de Carvalho Braga, Júlia Leão Batista Simões, Aniela Pinto Kempka, Margarete Dulce Bagatini
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence
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Plasmatic profiles of cytokines/chemokines, glial fibrillary acidic protein (GFAP) and MRI brain damage in neonates with hypoxic ischemic encephalopathy (HIE) Cytokine (IF 3.8) Pub Date : 2024-03-04 Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia–ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging
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Cancer energy reprogramming and the immune responses Cytokine (IF 3.8) Pub Date : 2024-03-02 Xingxing Yuan, Serge Yannick Ouedraogo, Muhammed Trawally, Yurong Tan, Ousman Bajinka
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Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression Cytokine (IF 3.8) Pub Date : 2024-03-02 Samaneh mollazadeh, Mahmoud Mahmoudi, Mojgan Mohammadi, Ramiar Kamal Kheder, Hussein Nasiri Mahallati, Salime Sarbaz Haghighi, Elnaz Masoumi, Zahra Javanmardi, Seyed-Alireza Esmaeili
The SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), leads to severe pathogenicity and high mortality among different communities around the world. Therefore, it is important to understand the mechanisms of virus pathogenesis and the immune system's response to prevent the further spread of this virus. This study was aimed to evaluate the relationship between the serum level of interleukin
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Th2-predominant immune response underlies the pathogenesis of Dengue Cytokine (IF 3.8) Pub Date : 2024-03-01 Dipesh Kale, Ashish Kumar Vyas, Girish Chandra Bhatt, Ashvini Kumar Yadav, Anirudh K. Singh, Shashwati Nema, Debasis Biswas
Dengue is a rapidly emerging pandemic-prone disease, whose manifestations range from asymptomatic infection to life-threatening complications like Dengue Hemorrhagic Fever and Dengue Shock Syndrome. This study investigates and compares the immune response in clinically defined cohorts of Dengue with and without warning signs, with the aim of identifying immunological correlates of clinical disease
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Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD Cytokine (IF 3.8) Pub Date : 2024-02-27 Linyang Ge, Nan Wang, Zi Chen, Shuanglan Xu, Linfu Zhou
The pathogenesis and treatment strategies for chronic obstructive pulmonary disease (COPD) require further exploration. Abnormal neutrophil inflammation and the overexpression of neutrophil extracellular traps (NETs) are closely associated with acute exacerbations of COPD (AECOPD). Siglec-9, a specific receptor expressed on neutrophils that inhibits their function, prompted us to investigate its relationship
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Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia Cytokine (IF 3.8) Pub Date : 2024-02-27 Luis Fernando Viana Furtado, William Pereira Alves, Vivian Jordania da Silva, Élida Mara Leite Rabelo
Over the years, there has been progress in understanding the molecular aspects of iron metabolism and erythropoiesis. However, despite research conducted both in laboratories and living organisms, there are still unanswered questions due to the complex nature of these fields. In this study we investigated the effects of hookworm infection on iron metabolism and how the hosts response to anemia is affected