样式: 排序: IF: - GO 导出 标记为已读
-
Greater methylation of the IL-6 promoter region is associated with decreased integrity of the corpus callosum in schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-05-04 Anna Michalczyk, Ernest Tyburski, Piotr Podwalski, Katarzyna Waszczuk, Krzysztof Rudkowski, Jolanta Kucharska-Mazur, Monika Mak, Katarzyna Rek-Owodziń, Piotr Plichta, Maksymilian Bielecki, Wojciech Andrusewicz, Elżbieta Cecerska-Heryć, Agnieszka Samochowiec, Błażej Misiak, Leszek Sagan, Jerzy Samochowiec
Schizophrenia is associated with chronic subclinical inflammation and decreased integrity of the corpus callosum (CC). Our previous study showed associations between peripheral IL-6 levels and the integrity of the CC. Epigenetic studies show associations between methylation of the genes related to immunological processes and integrity of the CC. To investigate correlations between methylation status
-
The relationship between event-related potential components and suicide risk in major depressive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-05-03 Xiaobo Zhou, Zhonghua Lin, Jingwen Liu, Minjing Xiang, Xia Deng, Zhili Zou
Suicide is a serious global issue, with major depressive disorder (MDD) being a significant risk factor for suicidal thoughts and behaviors. There is an urgent need to determine whether event-related potential components (ERPs) could be used as an indicator to assess suicidal risk. From 2020 to 2023, 258 participants in total were recruited into the study. All participants were divided into four groups:
-
Diminished representational momentum for physical states in patients with depressive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-05-03 Xiangyi Zhou, Jiamin Zhu, Yuke Yao, Xiaohuanghao Yang, Zhihua Shen, Yongguang Wang
The representational momentum for physical state changes refers to the fact that we remember objects as more changed in physical state than they actually were. It has been well documented that depressive disorder is associated with impairment of time perception. Thus, the present work was conducted with the aim to investigate the representational momentum for physical state changes in patients with
-
Perspective taking as a transdiagnostic risk factor for interpersonal dysfunction J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-05-03 Chloe C. Hudson, Emily M. Bowers, Thröstur Björgvinsson, Courtney Beard
Numerous psychiatric populations have demonstrated reduced tendency to adopt others’ perspectives relative to those without psychiatric illness; yet, the clinical implications of these deficits remain unclear. We examined whether impairments in perspective-taking are prospectively associated with symptom severity and functional outcomes in an acute psychiatric sample. We hypothesized that poorer perspective-taking
-
Mismatch Negativity in Schizophrenia, Unaffected First-degree Relatives, and Healthy Controls J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-05-03 Anushree Bose, Sri Mahavir Agarwal, Hema Nawani, Venkataram Shivakumar, Vanteemar S. Sreeraj, Janardhanan C. Narayanaswamy, Devvarta Kumar, Ganesan Venkatasubramanian
Mismatch negativity (MMN) amplitude is attenuated in schizophrenia patients (SZ). However, variability in illness course among SZ samples and types of deviant stimuli used in MMN paradigms have contributed to inconsistent findings across studies. Though MMN is suggested to be impaired in schizotypy, the potential link between the two is yet to be systematically examined in unaffected first-degree relatives
-
Peak alpha frequency and electroencephalographic microstates are correlated with aggression in schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-29 Michael Murphy, Ricardo E. Carrión, Jose Rubio, Anil K. Malhotra
Large scale retrospective studies have shown an association between schizophrenia and risk of violence. Overall, this increase in risk is small and does not justify or support stigmatizing public perceptions or media depictions of people with schizophrenia. Nonetheless, in some situations, some symptoms of schizophrenia can increase the risk of violent behavior. Prediction of this behavior would allow
-
Profiles of mental illness in college students and associated factors: A latent class analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-27 Jaqueline Galdino Albuquerque Perrelli, Rodrigo García-Cerde, Pollyanna Fausta Pimentel de Medeiros, Zila M. Sanchez
Mental illness among university students poses a pressing challenge for educational institutions, urging the need for strategies that foster health and mitigate mental distress, with an emphasis on preventing suicide. Our study sought to discern the profiles of mental illness among college students and explore the factors associated with them. We examined data from 918 students at a Brazilian Federal
-
Neurological soft signs as trait markers of a subset of patients with obsessive-compulsive disorder with low insight and altered cognitive abilities J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-26 Damien Doolub, Nicolas Vibert, Fabiano Botta, Ali Razmkon, Cédric Bouquet, Issa Wassouf, Bruno Millet, Ghina Harika-Germaneau, Nematollah Jaafari
Neurological soft signs (NSS) are subtle motor control impairments that include involuntary movements and abnormalities of motor coordination, sensory integration and lateralization. They engage different brain networks, including the prefrontal networks that support the higher cognitive functions that are dysfunctional in obsessive-compulsive disorder (OCD). This study investigated the relationships
-
The experience sampling methodology in psychosis risk states: A systematic review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-26 Bogna Bogudzińska, Arkadiusz Jaworski, Aleksandra Zajdel, Katarzyna Skrzypek, Błażej Misiak
The experience sampling method (ESM) is a structured diary technique, which is used to assess thoughts, mood and appraise subjective experiences in daily life. It has been recognized as a useful tool for understanding the characteristics, dynamics, and underlying mechanisms of prodromal symptoms of psychosis. The present systematic review aimed to provide a qualitative synthesis of findings provided
-
Increased cell-free DNA is associated with oxidative damage in patients with schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-26 Shuhui Li, Jie Jiang, Wenli Zhu, Dandan Wang, Chaoqing Dong, Yangying Bu, Juan Zhang, Daiyutong Gao, Xiaowen Hu, Chunling Wan
Cell-free DNA (cfDNA) has been found to be elevated in patients with schizophrenia (SZ), potentially derived from activated apoptosis, but the underlying mechanisms remain unknown. Moreover, whether the concentrations of cfDNA are altered with disease stage has not been investigated, which limits its clinical application as an auxiliary diagnostic marker for SZ. Using an improved fluorescence correlation
-
A new mouse model of depression induced by chronic restraint stress combined with lipopolysaccharide J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-26 Liqin Ying, Huijun Zheng, Jiahao Zhu, Xiaolin Liang, Hao Liu, Wei Cui
-
Frequent sauna bathing and psychosis: Interrelationship with cardiorespiratory fitness J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-25 Setor K. Kunutsor, Jussi Kauhanen, Jari A. Laukkanen
Frequent sauna bathing and higher cardiorespiratory fitness (CRF) levels may play a role in reducing the risk of mental disorders such as psychosis, however, data on their joint contributions is scanty. We aimed to investigate the interplay between sauna bathing, CRF and psychosis risk using a population-based prospective study. Self-reported frequency of sauna bathing (FSB) and CRF measured by respiratory
-
Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-24 D. Hen-Shoval, T. Indig-Naimer, L. Moshe, N.M. Kogan, H. Zaidan, I. Gaisler-Salomon, E. Okun, R. Mechoulam, G. Shoval, G. Zalsman, A. Weller
Major depressive disorder (MDD) stands as a significant cause of disability globally. Cannabidiolic Acid-Methyl Ester (CBDA-ME) (EPM-301, HU-580), a derivative of Cannabidiol, demonstrates immediate antidepressant-like effects, yet it has undergone only minimal evaluation in psychopharmacology. Our goal was to investigate the behavioral and potential molecular mechanisms associated with the chronic
-
Not missing at random: Missing data are associated with clinical status and trajectories in an electronic monitoring longitudinal study of bipolar disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-24 Ramzi Halabi, Benoit H. Mulsant, Martin Alda, Alexandra DeShaw, Arend Hintze, Muhammad I. Husain, Claire O'Donovan, Rachel Patterson, Abigail Ortiz
There is limited information on the association between participants' clinical status or trajectories and missing data in electronic monitoring studies of bipolar disorder (BD). We collected self-ratings scales and sensor data in 145 adults with BD. Using a new metric, Missing Data Ratio (MDR), we assessed missing self-rating data and sensor data monitoring activity and sleep. Missing data were lowest
-
Reward responsivity and habit formation in the co-occurrence of restrictive eating and nonsuicidal self-injury J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Soo-Eun Lee, Daniel Valerio Montero, Ashley Sanico, Ann F. Haynos
Dysfunctions in reward and/or habit formation have been proposed as factors contributing individually to the maintenance of restrictive eating and nonsuicidal self-injury (NSSI). However, despite the high comorbidity between these behaviors, the associations between reward and habit formation in their co-occurrence remains unclear. This study examined self-reported reward responsivity and habit strength
-
Personality nuances and risk of dementia: Evidence from two longitudinal studies J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Yannick Stephan, Angelina R. Sutin, René Mõttus, Martina Luchetti, Damaris Aschwanden, Antonio Terracciano
Personality traits are broad constructs composed of nuances, operationalized by personality items, that can provide a more granular understanding of personality associations with health outcomes. This study examined the associations between personality nuances and incident dementia and evaluated whether nuances associations replicate across two samples. Health and Retirement Study (HRS, N = 11,400)
-
Deployment-related toxic exposures are associated with worsening mental and physical health after military service: Results from a self-report screening of veterans deployed after 9/11 J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Kyle J. Bourassa, H. Ryan Wagner, Tate F. Halverson, Allison E. Ashley-Koch, Jean Beckham, Melanie E. Garrett, VA Mid Atlantic MIRECC Workgroup, Nathan A. Kimbrel, Jennifer C. Naylor
Exposure to toxins—such as heavy metals and air pollution—can result in poor health and wellbeing. Recent scientific and media attention has highlighted negative health outcomes associated with toxic exposures for U.S. military personnel deployed overseas. Despite established health risks, less empirical work has examined whether deployment-related toxic exposures are associated with declines in mental
-
Hidden dangers: Does multisensory impairments accompanying visual impairment increase dementia risk J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Xiaojuan Shi, Yueping Wu, Huihui wang, Xiaoxue He, Xue Zhang, Lining Pu, Degong Pan, Jiangping Li
Growing evidence suggests that sensory impairment, particularly in the form of visual impairment, may contribute to the development of dementia. However, it remains unclear whether experiencing concurrent visual impairment in combination with other types of multisensory impairments may further increase this risk. The study used data from the UK Biobank cohort study, which recruited 500,000 adults.
-
The relationship between anxiety symptoms and disturbances in biological rhythms in patients with depression J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Binxun Jiang, Ningning Li, Xiaobo Xue, Linlin Wang, Liu Hong, Chuangxin Wu, Junyu Zhang, Xuelin Chao, Wenfei Li, Wen Liu, Leping Huang, Yiyun Liu, Sijia Zhang, Yuhui Qin, Xujuan Li, Zuowei Wang
Biological rhythms denote the cyclical patterns of life activities anchored to a 24-hour cycle. Research shows that depression exhibits disturbances in biological rhythms. Yet, the relationship between these biological rhythms and concomitant anxiety symptoms is insufficiently investigated in structured clinical assessments. This multicenter study, carried out in four Chinese hospitals, comprehensively
-
Association between maternal depression symptoms and child telomere length J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-23 Caroline G. Walker, Zaneta M. Thayer, Emma J. Marks, Kien N. Ly, Avinesh Pillai, Karen Waldie, Lisa Underwood, Russell G. Snell, Sarah D. Knowles, Jane E. Cha, Susan M.B. Morton
-
Adult ADHD and pathological narcissism: A retrospective-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-21 Miguel Duarte, Martin Blay, Roland Hasler, Eleonore Pham, Rosetta Nicastro, Marlène Jan, Martin Debbané, Nader Perroud
Adult attention deficit hyperactivity disorder (ADHD) is often associated with personality pathology. However, only few studies have been conducted on the link between ADHD and pathological narcissism (PN), with or without a diagnosis of narcissistic personality disorder (NPD). In order to fill this gap, PN and NPD were assessed in 164 subjects suffering from ADHD, with several other measures including
-
Reply to “Letter to the Editor: The relationship between inflammatory markers early adversity and major depressive disorder is still an open question.” J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-19 Lawrence Maayan, Michal Maayan
-
Anxiety-, and depression-like behavior following short-term finasteride administration is associated with impaired synaptic plasticity and cognitive behavior in male rats J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-18 R.B. Sasibhushana, B.S. Shankaranarayana Rao, Bettadapura N. Srikumar
Finasteride, a 5α-Reductase inhibitor, is used to treat male pattern baldness and benign prostatic hyperplasia. Several clinical studies show that chronic finasteride treatment induces persistent depression, suicidal thoughts and cognitive impairment and these symptoms are persistent even after its withdrawal. Previous results from our lab showed that repeated administration of finasteride for six
-
Interventions targeting emotion regulation: A systematic umbrella review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-18 Luigi F. Saccaro, Alexis Giff, Maurilio Menduni De Rossi, Camille Piguet
Emotion dysregulation (ED), the difficulty in modulating which emotions are felt, and when and how they are expressed or experienced, has been implicated in an array of psychological disorders. Despite potentially different manifestations depending on the disorder, this symptom is emerging as a transdiagnostic construct that can and should be targeted early, given the associations with various maladaptive
-
Sleep Delta power, age, and sex effects in treatment-resistant depression J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-17 Nadia S. Hejazi, Wallace C. Duncan Jr., Mina Kheirkhah, Amanda Kowalczyk, Brady Riedner, Mark Oppenheimer, Reza Momenan, Qiaoping Yuan, Mike Kerich, David Goldman, Carlos A. Zarate Jr.
Electroencephalographic (EEG) deficits in slow wave activity or Delta power (0.5–4 Hz) indicate disturbed sleep homeostasis and are hallmarks of depression. Sleep homeostasis is linked to restorative sleep and potential antidepressant response via non-rapid eye movement (NREM) slow wave sleep (SWS) during which neurons undergo essential repair and rejuvenation. Decreased Low Delta power (0.5–2 Hz)
-
Positive mental health accounts for the relationship between insomnia symptoms and suicide-related outcomes J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-17 Julia Brailovskaia, Tobias Teismann, Jürgen Margraf
Insomnia symptoms have been shown to be associated with suicide ideation/behavior. However, the underlying mechanism is unclear and studies on protective factors that might mitigate the association between sleep-related problems and suicide ideation/behavior are largely missing. On this background the aim of the current study was to investigate, whether positive mental health (PMH) accounts for the
-
Effects of a novel, brief psychological therapy (Managing Unusual Sensory Experiences) for hallucinations in first episode psychosis (MUSE FEP): Findings from an exploratory randomised controlled trial J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-16 Robert Dudley, Guy Dodgson, Stephanie Common, Emmanuel Ogundimu, James Liley, Lucy O'Grady, Florence Watson, Christopher Gibbs, Bronia Arnott, Charles Fernyhough, Ben Alderson-Day, Charlotte Aynsworth
Hallucinations are a common feature of psychosis, yet access to effective psychological treatment is limited. The Managing Unusual Sensory Experiences for First-Episode-Psychosis (MUSE-FEP) trial aimed to establish the feasibility and acceptability of a brief, hallucination-specific, digitally provided treatment, delivered by a non-specialist workforce for people with psychosis. MUSE uses psychoeducation
-
Inter-identity amnesia in dissociative identity disorder resolved: A behavioural and neurobiological study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-16 Lora I. Dimitrova, Andrew J. Lawrence, Eline M. Vissia, Sima Chalavi, Andreana F. Kakouris, Dick J. Veltman, Antje A.T.S. Reinders
Dissociative identity disorder (DID) is characterised by, among others, subjectively reported inter-identity amnesia, reflecting compromised information transfer between dissociative identity states. Studies have found conflicting results regarding memory transfer between dissociative identity states. Here, we investigated inter-identity amnesia in individuals with DID using self-relevant, subject
-
Genetically identified mediators associated with increased risk of stroke and cardiovascular disease in individuals with autism spectrum disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-16 Tianyu Jin, Wei Huang, Qiongyi Pang, Zheng Cao, Dalin Xing, Shunyuan Guo, Tong Zhang
Growing evidence suggested that individuals with autism spectrum disorder (ASD) associated with stroke and cardiovascular disease (CVD). However, the causal association between ASD and the risk of stroke and CVD remains unclear. To validate this, we performed two-sample Mendelian randomization (MR) and two-step mediation MR analyses, using relevant genetic variants sourced from the largest genome-wide
-
Evaluating the efficacy and mechanisms of a ketogenic diet as adjunctive treatment for people with treatment-resistant depression: A protocol for a randomised controlled trial J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-15 Min Gao, Megan Kirk, Eva Lash, Heather Knight, Moscho Michalopoulou, Nicola Guess, Michael Browning, Scott Weich, Philip Burnet, Susan A. Jebb, Richard Stevens, Paul Aveyard
One-third of people with depression do not respond to antidepressants, and, after two adequate courses of antidepressants, are classified as having treatment-resistant depression (TRD). Some case reports suggest that ketogenic diets (KDs) may improve some mental illnesses, and preclinical data indicate that KDs can influence brain reward signalling, anhedonia, cortisol, and gut microbiome which are
-
A prospective study on EEG default mode network associated with subsequent posttraumatic stress disorder following sexual assault J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-15 Su Mi Park, Jun-Young Lee, Jung-Seok Choi, Hee Yeon Jung
This study aimed to explore the predictors of posttraumatic stress disorder (PTSD) in women who have recently experienced sexual assault, by examining psychological and neurophysiological factors using a prospective design with resting-state electroencephalogram (EEG) functional connectivity. The study enrolled 33 women who had been recently traumatized by sexual assault and conducted assessments within
-
Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-14 Richard J. Macatee, Mallory J. Cannon, Brandon S. Schermitzler, Thomas J. Preston, Kaveh Afshar
Biological sex differences in Cannabis Use Disorder (CUD) progression, cannabis withdrawal severity, and pharmacotherapy response have been reported, suggesting that CUD mechanisms may differ by sex. Drug cue reactivity is an established predictor of drug use behavior, but the literature on sex differences in drug cue reactivity is mixed, including in CUD. One possible moderator of sex differences
-
The influence of chronic inflammation on the illnesscourse of bipolar disorder: A longitudinal study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-13 Robert Queissner, Frederike T. Fellendorf, Nina Dalkner, Susanne A. Bengesser, Alexander Maget, Armin Birner, Martina Platzer, Bernd Reininghaus, Alfred Häussl, Elena Schönthaler, Adelina Tmava-Berisha, Melanie Lenger, Eva Z. Reininghaus
C-reactive protein (CRP) is a systemic inflammatory marker, which indicates systemic inflammatory processes It is involved in different inflammatory processes of the body and is a reliable marker for the general inflammatory state of the body. High sensitive CRP seems to play a key role as a state and trait marker of bipolar disorder (BD). In the current study, we tried to determine the long-term effect
-
Comparative efficacy of different interventions on executive function in adolescents with internet use disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-13 Peisheng Ma, Zhongliang Xia, Yunbo Zhao, Yu Zhao
The formation and relapse of Internet use disorder (IUD) are related to the decline in executive function. Previous studies have indicated that exercise intervention and high-definition transcranial direct current stimulation (HD-tDCS) can improve the cognitive abilities of adolescents with IUD. However, the combined intervention's impact on executive function in these adolescents remains unclear.
-
PTSD, distress and substance use in the aftermath of October 7th, 2023, terror attacks in Southern Israel J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-13 Daniel Feingold, Yuval Neria, Dana Tzur Bitan
The October 7th, 2023, terror attacks in Israel were characterized by a scope and magnitude not previously known to Israeli citizens. The aim of this study was to examine the prevalence and correlates of posttraumatic stress disorder (PTSD), emotional distress and use of addictive substances among Israeli adults, approximately one month following the attacks. PTSD was assessed with the Posttraumatic
-
Lifestyle modification as intervention for seasonal affective disorder: A systematic review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-12 Max Rothenberg, Barbara Nussbaumer-Streit, Edda Pjrek, Dietmar Winkler
Bright light therapy (BLT) and pharmacological therapies currently represent the first line treatments for patients with seasonal affective disorder (SAD). Lifestyle modifications offer a diverse field of additional intervention options. Since it is unclear, if lifestyle modifications are effective in SAD patients, this systematic review aims to synthesize the current evidence on their effectiveness
-
A randomized controlled trial on COGITO, a free self-help smartphone app to enhance mental well-being J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Steffen Moritz, Dominik Paweł Grudzień, Łukasz Gawęda, Adrianna Aleksandrowicz, Ryan Balzan, Athif Shaffy, Alina Bruhns, Swantje Marie Borsutzky, Lara Rolvien
Smartphone apps may help to prevent the transition from minor to severe mental health problems. We compared a free self-help smartphone app (COGITO; ) against a wait-list condition for the improvement of self-esteem and depression. The Rosenberg Self-Esteem Scale represented the primary outcome in this controlled trial. The final sample (n = 213) was randomly assigned to either the app or to the control
-
Pharmacogenetic intervention improves treatment outcomes in Chinese adult men with schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Ying Qin, Yanjing Liu, Jingwen Zhao, Yong Yang, Hui Xiang, Tianwei Gao, Chengchen Huang
To investigate the clinical application value of pharmacogenetic testing in individualized drug therapy for adult male patients with schizophrenia. A total of 186 adult patients with schizophrenia were enrolled and randomised into the pharmacogenetic (PGx) intervention group and the standard care group. In the PGx intervention group, PGx testing was performed, and the medication regimen was adjusted
-
Efficacy of EMDR for early intervention after a traumatic event: A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Anna Torres-Giménez, Cristina Garcia-Gibert, Estel Gelabert, Aïda Mallorquí, Xavier Segu, Alba Roca-Lecumberri, Amparo Martínez, Yolanda Giménez, Bàrbara Sureda
Eye Movement Desensitization and Reprocessing (EMDR) is a well-established psychological therapy for the treatment of post-traumatic stress disorder, based on the recommendations of clinical practice guidelines. However, these guidelines are not as consistent in recommending EMDR interventions for the early treatment of post-traumatic symptoms. The main objective of this review is to evaluate the effectiveness
-
Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Ying Liu, Lu Chen, Lin Lin, Caijuan Xu, Yifan Xiong, Huiwen Qiu, Xinyu Li, Sixin Li, Hui Cao
Depressive disorders are widely debilitating psychiatric disease. Despite the considerable progress in the field of depression therapy, extensive research spanning many decades has failed to uncover pathogenic pathways that might aid in the creation of long-acting and rapid-acting antidepressants. Consequently, it is imperative to reconsider existing approaches and explore other targets to improve
-
Psychiatric diagnoses, somatic disorders, and emergency dispatches among individuals who used a national suicide crisis line J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-10 Peter C. Britton, Kipling M. Bohnert, Lauren M. Denneson, Dara Ganoczy, Mark A. Ilgen
Crisis line responders initiate emergency dispatches by activating 911 or other local emergency services when individuals are determined to be at imminent risk for undesired outcomes. This study examined the association of characteristics, psychiatric diagnoses, and somatic symptoms with emergency dispatches in a national sample. Veterans Crisis Line data were used to identify contacts (i.e., calls
-
Efficacy of Esketamine among patients with treatment resistant depression in a ‘real world' health-care setting in Israel J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-10 Lior Dvorak, Esther Bloemhof-Bris, Assaf Shelef, Dania Halperin, Gay Wexler, Ortal Talmon, Kfir Feffer
One in five people will likely suffer from major depressive disorder (MDD) during their life. Thirty percent of those with MDD will experience Treatment Resistant Depression (TRD), which is characterized by a failure to respond to two adequately administered trials of antidepressants. Esketamine is a rapidly acting intranasal antidepressant. Present-day Esketamine research has limited data in real-world
-
The characteristics and clinical outcomes of a pluripotent high-risk group with the potential to develop a diverse range of psychiatric disorders J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Tae Young Lee, Hyunju Lee, Junhee Lee, Yunna Lee, Sang Jin Rhee, Dong Yeon Park, Myung Jae Paek, Eun Young Kim, Euitae Kim, Sungwon Roh, Hee Yeon Jung, Minah Kim, Se Hyun Kim, Yong Min Ahn, Kyooseob Ha, Jun Soo Kwon
Recent studies have indicated that clinical high risk for psychosis (CHR-P) is highly specific for psychotic disorders other than pluripotential to various serious mental illnesses. However, not all CHR-P develop psychotic disorder only, and psychosis can occur in non-psychotic disorders as well. Our prospective cohort study aims to investigate the characteristics and clinical outcomes of a pluripotent
-
Mild differences in the role of somatic symptoms in depression networks in pregnancy and postpartum: A comparison with women outside peripartum J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Petra Pátková Daňsová, Edita Chvojka, Hynek Cígler, Lenka Lacinová
Depression is one of the most prevalent mental ailments in pregnancy. Many authors have discussed the appropriateness of somatic symptoms for depression assessment in pregnancy and postpartum. However, no study has examined the role of somatic symptoms in networks of pregnant and postpartum women compared to women outside peripartum. Here, we show that somatic symptoms are essential to depression assessment
-
Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Kate Walsh, Nicole Short, Yin Yao Ji, Xin Ming An, Kristen D. Witkemper, Megan Lechner, Kathy Bell, Jenny Black, Jennie Buchanan, Jeffrey Ho, Gordon Reed, Melissa Platt, Ralph Riviello, Sandra L. Martin, Israel Liberzon, Sheila A.M. Rauch, Kenneth Bollen, Samuel A. McLean
This study aims to develop and validate a brief bedside tool to screen women survivors presenting for emergency care following sexual assault for risk of persistent elevated posttraumatic stress symptoms (PTSS) six months after assault. Participants were 547 cisgender women sexual assault survivors who presented to one of 13 sexual assault nurse examiner (SANE) programs for medical care within 72 h
-
Network meta-analysis of the effects of different cognitive trainings on the cognitive function of patients with mild cognitive impairment J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Ji-Wei Chen, Wen-Qian Du, Kun Zhu
Examining the relationship between the responses of a number of different cognitive trainings on cognitive functioning in middle-aged and elderly patients with mild cognitive impairment. Randomized controlled experimental studies published publicly from the time of inception to October 30, 2023 were searched through Web of Science, PubMed, Embase, and Cochrane library databases. Traditional and network
-
An examination of the potential core symptoms of posttraumatic stress disorder: What is integral after removing general psychopathology & distress? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-06 Alexander Puhalla, Connor Sullivan, Kathleen Chard, Benjamin Dickstein, Charles W. Hoge
Many confirmatory factor analyses (CFA) have examined the structure of posttraumatic stress disorder (PTSD) with some suggesting increased complexity (i.e., 6+ factors), while others suggesting a more refined structure (i.e., 2-factors). These competing PTSD structures may be due to conflation of non-trauma specific symptoms that have been added overtime. However, none of these studies examined if
-
Influence of CYP2C19 and CYP2D6 on side effects of aripiprazole and risperidone: A systematic review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-06 Emma de Brabander, Kristian Kleine Schaars, Therese van Amelsvoort, The PSY-PGx Consortium, Monika Budde, Urs Heilbronner, Allan H. Young, Mario Juruena, Eduard Vieta, Natalia E. Fares-Otero, Martien J. Kas, Markus Nöthen, Alexandra Philipsen, Laura L. Kilarski, Jonathan Laatsch, Moritz J. Rossner, Sven P. Wichert, Ramona Moldovan, Noam Shomron, Thomas G. Schulze, Roger Man King Ng, Nigel Olisa, Erik
Variability in hepatic cytochrome P450 (CYP) enzymes such as 2C19 and 2D6 may influence side-effect and efficacy outcomes for antipsychotics. Aripiprazole and risperidone are two commonly prescribed antipsychotics, metabolized primarily through CYP2D6. Here, we aimed to provide an overview of the effect of CYP2C19 and CYP2D6 on side-effects of aripiprazole and risperidone, and expand on existing literature
-
The capacity of cognitive tests to detect generalized anxiety disorder (GAD): A pilot study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Axel Baussay, Laura Di Lodovico, Daphnee Poupon, Matthieu Doublet, Nicolas Ramoz, Philibert Duriez, Philip Gorwood
Cognitive impairment remains understudied in generalized anxiety disorder (GAD), despite the high prevalence and substantial burden associated with this disorder. We aimed to assess cognitive impairment in patients with GAD and evaluate the ability of cognitive tests to detect this disorder. Because of its high rate of comorbidity, we also examined how other anxiety disorders and current major depressive
-
Incidence of post-COVID psychiatric disorders according to the periods of SARS-CoV-2 variant dominance: The LIFE study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Fumiko Murata, Megumi Maeda, Keitaro Murayama, Tomohiro Nakao, Haruhisa Fukuda
This retrospective cohort study examined the incidence of post-COVID psychiatric disorders in older adults according to hospitalization status and SARS-CoV-2 variant period in Japan. Claims data, COVID-19 case-related information, and vaccination records were obtained from three Japanese municipalities. We identified individuals aged ≥65 years who had COVID-19 or other respiratory tract infection (RTI)
-
Genetic influences on testosterone and PTSD J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Shannon E. Cusack, Adam X. Maihofer, Daniel Bustamante, Ananda B. Amstadter, Laramie E. Duncan
Females are twice as likely to experience PTSD as compared to males. Although sex differences in prevalence are well-established, little is known about why such sex differences occur. Biological factors that vary with sex, including sex hormone production, may contribute to these differences. Considerable evidence links sex hormones, such as testosterone, to PTSD risk though less is known about the
-
Sex-specific associations of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in patients with drug-naïve schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Meijuan Li, Xiaoli Wang, Siying Kong, Yuying Qiu, Changyong Jiang, Wei Sun, Shu Yang, Lijie Ji, Yonghui Zhang, Jie Li
This present study aimed to investigate the sex-specific association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in drug-naïve schizophrenia patients for the first time. A total of 204 participants in this study, including 137 drug-naïve schizophrenia (DNS) patients and 67 healthy controls (HCs). All participants completed the Measurements and Treatment Research to Improve
-
An exploratory study of the prevalence and adverse associations of in-school traditional bullying and cyberbullying among adolescents in Connecticut J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Yasna Rostam-Abadi, Elina A. Stefanovics, Zu Wei Zhai, Marc N. Potenza
Bullying, traditional or cyber, among adolescents, is a public health concern. In this study, we explored frequencies and correlates of different forms of bullying among Connecticut high-school students. Youth Risk Behavior Survey data from 2019 from Connecticut adolescents (N = 1814) were used. χ tests and survey-weighted logistic regressions examined relationships between bullying subgroups (in-school
-
ADHD, sleep, chronotype and health in a large cohort of Dutch nurses J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-03 M. Michielsen, M.N. Böhmer, R.C.H. Vermeulen, J.J. Vlaanderen, A.T.F. Beekman, J.J.S. Kooij
-
Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-03 Mengdi Jin, Mengtong Xie, Yane Liu, Haideng Song, Min Zhang, Weizhen Li, Xinwei Li, Ningning Jia, Lin Dong, Qingxing Lu, Fengyu Xue, Lijuan Yan, Qiong Yu
Schizophrenia (SCZ) represents a set of enduring mental illnesses whose underlying etiology remains elusive, posing a significant challenge to public health. Previous studies have shown that the neurodevelopmental process involving small molecules such as miRNA and mRNA is one of the etiological hypotheses of SCZ. We identified and verified that miR-30e-3p and ABI1 can be used as biomarkers in peripheral
-
Trauma-informed behavioral supports (TIBS) for inpatient treatment of individuals who experience BPD J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-02 Erika R. Carr, Jane E.M. Carter, Marc Hillbrand
Trauma-Informed Behavioral Supports (TIBS) is a novel treatment approach targeting aggression against self or against others in individuals who experience borderline personality disorder (BPD). It is based on applied behavior analysis and uses a person-centered and trauma-informed framework. People with BPD hospitalized because of concerning behaviors, [aggression to others, verbal aggression (e.g
-
An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-29 Divya Ramakrishnan, Luis C. Farhat, Edoardo F.Q. Vattimo, Jessica L.S. Levine, Jessica A. Johnson, Bekir B. Artukoglu, Angeli Landeros-Weisenberger, Abraham Zangen, Antoine Pelissolo, Carlos A. de B. Pereira, Christian Rück, Daniel L.C. Costa, David Mataix-Cols, David Shannahoff-Khalsa, David F. Tolin, Elham Zarean, Elisabeth Meyer, Emily R. Hawken, Eric A. Storch, Erik Andersson, Euripedes C. Miguel
Expert consensus operationalized treatment response and remission in obsessive-compulsive disorder (OCD) as a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) reduction ≥35% and score ≤12 with ≤2 on Clinical Global Impressions Improvement (CGI-I) and Severity (CGI-S) scales, respectively. However, there has been scant empirical evidence supporting these definitions. We conducted a systematic review and
-
Psychomotor retardation: What about the partial responders to magnetic transcranial stimulation in treatment resistant depression ? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-29 Alison Robin, Véronique Thomas-Ollivier, Anne Sauvaget, Morgane Pere, Samuel Bulteau
Psychomotor retardation is a core clinical component of Major Depressive Disorder responsible for disability and is known as a treatment response marker of biological treatments for depression. Our objective was to describe cognitive and motoric measures changes during a treatment by repetitive Transcranial Magnetic Stimulation (rTMS) within the THETAD-DEP trial for treatment-resistant depression (TRD)
-
Association of somatic comorbidity and treatment adherence in patients with psychotic disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 J. Leijala, O. Kampman, J. Suvisaari, S. Eskelinen
Increased risk for somatic comorbidity in individuals with schizophrenia has been well established. In addition, psychiatric patients with somatic illnesses are more likely to have more psychiatric readmissions. Increased burden of treatment related to chronic somatic comorbidities may be associated with lower adherence to psychiatric medication. Cross-sectional study of 275 patients with schizophrenia
-
Peripheral inflammation is associated with impaired sadness recognition in euthymic bipolar patients J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 Chih-Yu Chang, Hui Hua Chang, Cheng Ying Wu, Ying Tsung Tsai, Tsung-Hua Lu, Wei Hung Chang, Chia-Fen Hsu, Po See Chen, Huai-Hsuan Tseng
Inflammation impairs cognitive function in healthy individuals and people with psychiatric disorders, such as bipolar disorder (BD). This effect may also impact emotion recognition, a fundamental element of social cognition. Our study aimed to investigate the relationships between pro-inflammatory cytokines and emotion recognition in euthymic BD patients and healthy controls (HCs). We recruited forty-four