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ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-18 Rui-Mo Zhao, Qin-Fang Zhang, Xiao-Li Tian, Jia-Jia Chen, Xiao-Qi Yu, Ji Zhang
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Therapeutic Effect of a Novel M1 Macrophage-Targeted Nanodrug in Chronic Periodontitis Mice Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-13 Qiuye Chen, Yunshan Zhao, Chen Xie, Shiwang Wu, Weizhen Ji, Xu Xiao, Xu Zheng
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Drug Delivery Angle for Various Atherosclerosis and Aneurysm Percentages of the Carotid Artery Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-13 Ali Amani, Amir Hamzeh Farajollahi
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Nuclear Localization Signal Enhances the Targeting and Therapeutic Efficacy of a Porphyrin-Based Molecular Cargo: A Systemic In Vitro and Ex Vivo Evaluation Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-13 Naveen Kumar, Amit K. Sharma, Mohini Guleria, Sandeep B. Shelar, Avik Chakraborty, Sutapa Rakshit, Soumi Kolay, Drishty Satpati, Tapas Das
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Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-12 Dan Sun, Xiao Du, Xinyu Cao, Bingyu Wu, Shanshan Li, Yongmei Zhao, Tianqing Liu, Lixing Xu, Haiqin Huang
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Second Near-Infrared Macrophage-Biomimetic Nanoprobes for Photoacoustic Imaging of Neuroinflammation Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-11 Yingying Pan, Jingqin Chen, Yuling Zhang, Yaguang Ren, Zhifeng Wu, Qiang Xue, Silue Zeng, Chihua Fang, Hai Zhang, Lingyan Zhang, Chengbo Liu, Jie Zeng
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Nebulization and In Vitro Upper Airway Deposition of Liposomal Carrier Systems Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-11 Ondrej Mišík, Jana Kejíková, Ondřej Cejpek, Milan Malý, Adam Jugl, Miloslav Bělka, Filip Mravec, František Lízal
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Dissolution Mechanisms of Amorphous Solid Dispersions: Application of Ternary Phase Diagrams To Explain Release Behavior Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-12 Alexandru Deac, Christian Luebbert, Qingqing Qi, Reagan M. Courtney, Anura S. Indulkar, Yi Gao, Geoff G. Z. Zhang, Gabriele Sadowski, Lynne S. Taylor
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Correction to “Insights into the Structure of Sucralfate by Advanced Solid- and Liquid-State NMR” Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-12 Chaithanya Hareendran, Sapna Ravindranathan, T. G. Ajithkumar
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Targeted Delivery of Catalase and Photosensitizer Ce6 by a Tumor-Specific Aptamer Is Effective against Bladder Cancer In Vivo Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-11 Yang Zhang, Ru Jia, Xiaoyi Wang, Yixuan Zhang, Jinhui Wu, Quansheng Yu, Qiang Lv, Chao Yan, Pengchao Li
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Deciphering the Lexicon of Protein Targets: A Review on Multifaceted Drug Discovery in the Era of Artificial Intelligence Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-11 Suvendu Nandi, Soumyadeep Bhaduri, Debraj Das, Priya Ghosh, Mahitosh Mandal, Pralay Mitra
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KRAS Mutation Detection with (2S,4R)-4-[18F]FGln for Noninvasive PDAC Diagnosis Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-08 Song Liu, Futao Liu, Xingguo Hou, Qian Zhang, Ya’nan Ren, Hua Zhu, Zhi Yang, Xiaoxia Xu
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Multimodal Theranostic Nanoparticles for Necrosis Targeting, Fluorescence/SPECT Imaging, and Radiotherapy of Residual Tumors after Hepatocellular Carcinoma Ablation Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-07 Han Bao, Ning Wang, Song Chen, Yang Wang, Haibo Shao, Yicheng Ni, Yukang Li, Xian Liu, Xiangjun Han
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18F-Labeled Amidobenzimidazole Analogue for Visualizing STING Expression in Tumor Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-06 Jianyang Fang, Jingru Zhang, Lingxin Meng, Huifeng Li, Dongsheng Xia, Yaoxuan Wang, Hao Chen, Zhenhuan Liao, Rongqiang Zhuang, Yesen Li, Xianzhong Zhang, Zhide Guo
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Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-05 Tejal Akbar, Pavel Gershkovich, Konstantinos Stamatopoulos, Penny A. Gowland, Snow Stolnik, James Butler, Luca Marciani
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Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-05 Mitra Pirhaghi, Fatemeh Mamashli, Faezeh Moosavi-Movahedi, Payam Arghavani, Ahmad Amiri, Bagher Davaeil, Mahya Mohammad-Zaheri, Zahra Mousavi-Jarrahi, Deepak Sharma, Ülo Langel, Daniel Erik Otzen, Ali Akbar Saboury
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Correction to “Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability” Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-05 Kieran Moore, Sébastien Grégoire, Joan Eilstein, M. Begoña Delgado-Charro, Richard H. Guy
The units of In vitro CVT,0 and In vivo CVT,0 in Table 3 should both be μmol mL–1. The results, discussions, and conclusions in the original article are not affected by this correction. This article has not yet been cited by other publications.
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Effect of Annealing on Visible-Bubble Formation and Stability Profiles of Freeze-Dried High Concentration Omalizumab Formulations Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-03-02 Han Gao, Xin-Zhe Ge, Jia-Wei Liu, Si-Tao Wang, Jie Xu, Wei-Jie Fang
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Therapeutic Polymer-Based Cannabidiol Formulation: Tackling Neuroinflammation Associated with Ischemic Events in the Brain Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-27 Merari Tumin Chevalier, Mansoor Al-Waeel, Amir M. Alsharabasy, Ana Lúcia Rebelo, Sergio Martin-Saldaña, Abhay Pandit
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Thermoresponsive Polymeric Hydromorphone Prodrug Provides Sustained Local Analgesia without Apparent Adverse Effects Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-27 Zhenshan Jia, Xin Wei, Ningrong Chen, Xiaoke Xu, Gang Zhao, Xin Fu, Hanjun Wang, Mary B. Goldring, Steven R. Goldring, Dong Wang
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Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-29 Nancy H.C. Loos, Margarida L. Ferreira Martins, Jamie Rijmers, Daniëlle de Jong, Maria C. Lebre, Matthijs Tibben, Jos H. Beijnen, Alfred H. Schinkel
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Impact of Excipient Extraction and Buffer Exchange on Recombinant Monoclonal Antibody Stability Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-29 Deepika Sarin, Kunal Krishna, M. Reza Nejadnik, Raj Suryanarayanan, Anurag S. Rathore
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Sex-Dependent Changes to the Intestinal and Hepatic Abundance of Drug Transporters and Metabolizing Enzymes in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-28 Liam M. Koehn, Joel R. Steele, Ralf B. Schittenhelm, Bradley J. Turner, Joseph A. Nicolazzo
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Quantifying Protein Shape to Elucidate Its Influence on Solution Viscosity in High-Concentration Electrolyte Solutions Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-27 Zhou Tian, Xuling Jiang, Zhidong Chen, Chengnan Huang, Feng Qian
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Irreversible Electroporation-Induced Inflammation Facilitates Neutrophil-Mediated Drug Delivery to Enhance Pancreatic Cancer Therapy Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-27 Teng Huang, Xiaofei Wen, Yuxuan Liang, Xiao Liu, Jun Zhao, Xin Long
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Sialic Acid Conjugate-Modified Cationic Liposomal Paclitaxel for Targeted Therapy of Lung Metastasis in Breast Cancer: What a Difference the Cation Content Makes Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-26 Wenliang Sun, Chao Han, Ruirui Ge, Xiaotong Jiang, Yu Wang, Yingchao Han, Ning Wang, Yanzhi Song, Mingshi Yang, Guoliang Chen, Yihui Deng
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Optimizing Nonsink Dissolution Testing for Amorphous Solid Dispersions: Exploring Sample Handling Variables Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-28 Lucas José de Alencar Danda, Alane Rafaela de Carvalho Amaral, José Lamartine Soares-Sobrinho, Monica Felts de La Roca Soares
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Influence of Nucleation on Relaxation, Molecular Cooperativity, and Physical Stability of Celecoxib Glass Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-24 Xue Han, Kexin Dai, Kohsaku Kawakami
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Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-23 Kelly Schwinghamer, Stacey Line, Devin B. Tesar, Donald W. Miller, Sreedhara Alavattam, Teruna J. Siahaan
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Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-23 Vaibhavi Meghraj Desai, Mahima Choudhary, Rajdeep Chowdhury, Gautam Singhvi
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Noninvasive Evaluation of Tumoral PD-L1 Using a Novel 99mTc-Labeled Nanobody Tracer with Rapid Renal Clearance Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-23 Biao Hu, Xiaopan Ma, Linqing Shi, Tianyu Liu, Liqiang Li, Meinan Yao, Chenzhen Li, Bing Jia
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Eutectic Resolves Lysolipid Paradox in Thermoresponsive Liposomes Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-21 Daniel Eckhardt, Enrico F. Semeraro, Jessica Steigenberger, Johannes Schnur, Louma Kalie, Ulrich Massing, Georg Pabst, Heiko Heerklotz
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Adapting Deep Learning QSPR Models to Specific Drug Discovery Projects Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-19 Andrin Fluetsch, Elena Di Lascio, Grégori Gerebtzoff, Raquel Rodríguez-Pérez
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Correlating Surface Activity with Interface-Induced Aggregation in a High-Concentration mAb Solution Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-22 Estephanie L. N. Escobar, Valerie P. Griffin, Prajnaparamita Dhar
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Impact of Glycosylation on Protein–Protein Self-Interactions of Monoclonal Antibodies Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-22 Veerabhadraiah Palakollu, Lily Motabar, Christopher J. Roberts
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Self-Delivery Nanomedicines Reverse Thermal Resistance to Enhance Tumor Mild-Temperature Photothermal Therapy Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-21 Jinmei Lai, Qunying Shi, Yongqi Xie, Yinyin Zhu, Shiyu Liang, Yi Chen, Jiali Yuan, Lihan Liu
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Closing the Gap between Experiment and Simulation─A Holistic Study on the Complexation of Small Interfering RNAs with Polyethylenimine Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-19 Jonas Binder, Joshua Winkeljann, Katharina Steinegger, Lara Trnovec, Daria Orekhova, Jonas Zähringer, Andreas Hörner, Valentin Fell, Philip Tinnefeld, Benjamin Winkeljann, Wolfgang Frieß, Olivia M. Merkel
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Where Might Artificial Intelligence Be Going in Pharmaceutical Development? Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-20 Tibo Duran, Bodhisattwa Chaudhuri
At present, with its gain in popularity and widespread utilization, almost all scientific fields are being influenced by the revolution in artificial intelligence (AI). Consequently, many industries are being transformed, signaling a new era. In the past few years, the progress of AI in academic and industrial settings has been notably propelled by the implementation of machine learning (ML) techniques
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Large Unilamellar Vesicles of Phosphatidic Acid Reduce the Toxicity of α-Synuclein Fibrils Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-19 Abid Ali, Aidan P. Holman, Axell Rodriguez, Kiryl Zhaliazka, Luke Osborne, Dmitry Kurouski
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Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-19 Huirong Li, Beibei Liang, Xiaoqing Gao, Ying Peng, Qingzhu Liu, Ling Qiu, Jianguo Lin
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In Situ Monitoring of Competitive Coformer Exchange Reaction by 1H MAS Solid-State NMR Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-19 Chaithanya Hareendran, Bashir Alsirawan, Anant Paradkar, T. G. Ajithkumar
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PDGFRβ-Antagonistic Affibody-Mediated Tumor-Targeted Tumor Necrosis Factor-Alpha for Enhanced Radiotherapy in Lung Cancer Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-16 Xiaohui Tang, Jie Chen, Zhenxiong Zhao, Jie Liu, Ranfei Yu, Kunlong Zhao, Fei Wang, Yang Li, Baoqing Tian, Dandan Yuan, Yuguo Liu, Qing Fan
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Optimizing Oxygen-Production Kinetics of Manganese Dioxide Nanoparticles Improves Hypoxia Reversal and Survival in Mice with Bone Metastases Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-16 David A. Murphy, Daniela Osteicochea, Aidan Atkins, Caitlin Sannes, Zachary McClarnon, Isaac M. Adjei
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Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-16 Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe
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Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-15 Luís H. S. Queiroz, Ranna S. Barros, Francisco F. de Sousa, Mateus R. Lage, Mafalda C. Sarraguça, Paulo R. S. Ribeiro
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Self-Delivery Nanoplatform Based on Amphiphilic Apoptosis Peptide for Precise Mitochondria-Targeting Photothermal Therapy Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-14 Xin Wan, Wensong Wang, Yutian Zhou, Xiaoyu Ma, Meng Guan, Fan Liu, Si Chen, Jin-Xuan Fan, Guo-Ping Yan
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Near UV Photodegradation Mechanisms of Amino Acid Excipients: Formation of the Carbon Dioxide Radical Anion from Aspartate and Fe(III) Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-13 Yilue Zhang, Yaqi Wu, Christian Schöneich
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Unraveling the Microscopic Mechanism of Molecular Ion Interaction with Monoclonal Antibodies: Impact on Protein Aggregation Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-12 Suman Saurabh, Qinkun Zhang, John M. Seddon, Jian R. Lu, Cavan Kalonia, Fernando Bresme
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Dexamethasone Pretreatment Potentiates a Folic Acid-Functionalized Delivery System for Enhanced Lung Cancer Therapy Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-12 Ying Zhao, Changhao Jia, Zhixin Yao, Gang Chen, Gui Huang, Hui Li, Linghong Lu, Taiwei Jin, Yan Tang, Zengyan Zhu, Xuenong Zhang
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Small Molecule–Drug Conjugates Emerge as a New Promising Approach for Cancer Treatment Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-12 Tiansi Wang, Meichai Li, Ruting Wei, Xinyu Wang, Zhizhe Lin, Jianming Chen, Xin Wu
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Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid Dispersions Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-12 Pradnya Bapat, Shubhajit Paul, Yin-Chao Tseng, Lynne S. Taylor
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Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying─Comparison of In Vitro and In Vivo Performance Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-12 Eduard Trenkenschuh, Simone M. Blattner, David Hirsh, Ragna Hoffmann, Christian Luebbert, Kerstin Schaefer
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Nanoencapsulation of MDM2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-09 Anas Abed, Michelle K. Greene, Alhareth A. Alsa’d, Andrea Lees, Andrew Hindley, Daniel B Longley, Simon S McDade, Christopher J. Scott
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Electrostatically Mediated Attractive Self-Interactions and Reversible Self-Association of Fc-Fusion Proteins Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-09 James K. Forder, Veerabhadraiah Palakollu, Sudeep Adhikari, Marco A. Blanco, Mehabaw Getahun Derebe, Heidi M. Ferguson, Suman A. Luthra, Erik V. Munsell, Christopher J. Roberts
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Bimetallic Gold/Silver and Bioactive Camptothecin Hybrid Nanoparticles for Eradication of Cancer Stem Cells in a Combination Manner Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-09 Honglei Zhan, Yulong Lv, Ruiyu Shen, Chaoyue Li, Miao Li, Yahong Li
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A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-09 Aida Maaz, Ian S. Blagbrough, Paul A. De Bank
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Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose–Brain Drug Delivery Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-08 Esraa Taha, Amro Shetta, Samia A. Nour, Marianne J. Naguib, Wael Mamdouh
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Insights into the Structure of Sucralfate by Advanced Solid- and Liquid-State NMR Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-08 Chaithanya Hareendran, Sapna Ravindranathan, T. G. Ajithkumar
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Nanocrystal-Loaded Lipid Carriers for Improved Oral Absorption and Anticancer Efficacy of Etoposide: Formulation Development, Transport Mechanism, In Vitro and In Vivo Evaluation Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-08 Yue Wang, Ping Wang, Haiyan Li, Xiaoran Han, Haibin Zhu, Xiangqun Jin
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Evaluating CD133 as a Radiotheranostic Target in Small-Cell Lung Cancer Mol. Pharmaceutics (IF 4.9) Pub Date : 2024-02-08 Samantha M. Sarrett, Cindy Rodriguez, Samantha Delaney, Meena M. Hosny, Joni Sebastiano, Ana Santos-Coquillat, Outi M. Keinänen, Lukas M. Carter, Kristin J. Lastwika, Paul D. Lampe, Brian M. Zeglis