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Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF-κB/p38MAPK signaling pathway modulation Exp. Gerontol. (IF 3.9) Pub Date : 2024-05-01 Ding Zhang, Hongling Qin, Wei Chen, Junjun Xiang, Minghe Jiang, Ling Zhang, Keqing Zhou, Yueqiang Hu
Stroke is a debilitating condition with high morbidity, disability, and mortality that significantly affects the quality of life of patients. In China, the WenYang FuYuan recipe is widely used to treat ischemic stroke. However, the underlying mechanism remains unknown, so exploring the potential mechanism of action of this formula is of great practical significance for stroke treatment. This study
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Association between increased and decreased gut microbiota abundance and Parkinson's disease: A systematic review and subgroup meta-analysis Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-29 Fusheng Bai, Lin You, Hongyan Lei, Xinming Li
The objective of the study was to systematically investigate the association between gut microbiota (GM) abundance and Parkinson's disease (PD). PubMed, Medline, Cochrane Library and other literature datebase platforms were searched for eligible studies in the English-language from conception to March 1, 2024. Studies evaluating the association between GM and PD were included. The results of the included
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TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-29 Yipu Zhao, Zhengjie Wu
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterised by irreversible airflow limitation. The elderly are a vulnerable population for developing COPD. With the growth of age, physiological degenerative changes occur in the thorax, bronchus, lung and vascular wall, which can lead to age-related physiological attenuation of lung function in the elderly, so
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Oral frailty is associated with mortality independently of physical and psychological frailty among older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-27 Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Keiichi Yokoyama, Yosuke Yamada, Takeshi Kikutani, Mitsuyoshi Yoshida, Motohiko Miyachi, Misaka Kimura
Although oral frailty is independently associated with an increased risk of mortality, evidence for the usefulness of screening tools for oral frailty is less than that for physical frailty screening tools. We aimed to investigate the relationship between oral frailty and mortality in older adults. This prospective cohort study included 11,374 adults aged ≥65 years, who provided valid responses to
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Effects of moderate intensity training and lithium on spatial learning and memory in a rat model: The role of SIRT3 and PGC1-α expression levels and brain-derived neurotropic factor Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-27 Elham Shoghi, Tahereh Safari, Abolfazl Parsi-Moud, Ilia Mirzaei, Nahid Sepehri Rad, Mohadeseh Chahkandi
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Relationship between serum uric acid and sarcopenia in geriatric heart failure patients with preserved ejection fraction Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-26 Miao Lu, Yansong Li, Yiting Pan, Yinzhang Ding, Kai Wang, Di Xu
Heart failure with preserved ejection fraction (HFpEF) presents a serious risk to human health. The increased prevalence of sarcopenia in the HFpEF population has a negative impact on patient prognosis. Uric acid (UA) is the byproduct of purine metabolism and is harmful to the cardiovascular system. This study aims to establish the potential relationship between sarcopenia and serum UA in HFpEF patients
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Genetically determined type 1 diabetes mellitus and risk of osteoporosis Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-22 Ting Cheng, Jia-Lin Hou, Zi-Yi Han, Xin-Lei Geng, Yao-Chen Zhang, Ke-Yi Fan, Liu Liu, He-Yi Zhang, Yue-Hong Huo, Xiao-Feng Li, Sheng-Xiao Zhang
Observational evidence suggests that type 1 diabetes mellitus (T1DM) is associated with the risk of osteoporosis (OP). Nevertheless, it is not apparent whether these correlations indicate a causal relationship. To elucidate the causal relationship, a two-sample Mendelian randomization (MR) analysis was performed. T1DM data was obtained from the large genome-wide association study (GWAS), in which 6683
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Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-19 Yashwant Ayalasomayajula, Anagha Hesaraghatta, Neha Dantuluri, Jenna Yassine, Faizan Saleem, Hussein Mansour, Chayapatou Chayawatto, Nishank Rangarajan, Sashank Rangarajan, Smrithi Krishnan, Siva Kumar Panguluri
Oxygen supplementation is a widely used treatment for ICU patients. However, it can lead to hyperoxia, which in turn can result in oxidative stress, cardiac remodeling, and even mortality. This paper expands upon previous research conducted by our lab to establish time-dependent cardiac changes under hyperoxia. In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure
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The effect of tamoxifen on estradiol, SHBG, IGF-1, and CRP in women with breast cancer or at risk of developing breast cancer: a meta-analysis of randomized controlled trials Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-19 XingDa Li, XueJiao Hou, Benjamin Hernández-Wolters, Kousalya Prabahar, Hamed Kord-Varkaneh, Bo Mei
The effects of tamoxifen on the serum levels of hormones and acute phase reactants have been studied previously, but study results have been inconsistent, especially in women with breast cancer. Hence, we conducted this meta-analysis of randomized controlled trials (RCTs) to try to clarify the effects of tamoxifen on estradiol, insulin-like growth factor 1 (IGF-1), sex hormone binding globulin (SHBG)
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The associations of daytime napping and motoric cognitive risk syndrome: Findings from the China Health and Retirement Longitudinal Study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-19 Lixing Zhou, Yan Zhang, Meiling Ge, Gongchang Zhang, Rui Cheng, Yixin Liu, Xiaoli Chen, Xiaolei Liu, Birong Dong
Motoric cognitive risk syndrome (MCR), characterized by subjective cognitive complaints and slow gait in older populations, is associated with sleep duration. However, the association between MCR and daytime nap duration has not been thoroughly explored. Baseline data from the China Health and Retirement Longitudinal Study (CHARLS) were used in this study. MCR was defined as the coexistence of subjective
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LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-18 Yonghui Wang, Zhuo Li, Jiwen Li, Chao Sun
Long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) is involved in the progression of Parkinson's disease (PD), but the specific regulatory role needs further exploration. This study showed that the expression of NEAT1 was upregulated in the cerebrospinal fluid (CSF) and peripheral blood of patients with different stages of PD. 1-Methyl-4-phenylpyridine (MPP)-treated PC 12 cells were
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A nationwide study on immunosenescence biomarkers profile in older adults: ELSI-Brazil Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-18 Maria Luiza Lima-Silva, Karen Cecília Lima Torres, Juliana Vaz de Melo Mambrini, Nathalia Coimbra Brot, Sara Oliveira Santos, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Maria Fernanda Lima-Costa, Sérgio Viana Peixoto
Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as “Inflammaging.” Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing
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Comparison of ultrasound-guided microwave ablation, laser ablation, and radiofrequency ablation for the treatment of elderly patients with benign thyroid nodules: A meta-analysis Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-18 Ying Qian, Zheng Li, Chunyun Fan, Yong Huang
A new minimally invasive technique, ultrasound-guided thermal ablation has become one of the treatment methods for benign thyroid nodules. This study aims to evaluate the efficacy and safety of laser ablation (LA), radiofrequency ablation (RFA), and microwave ablation (MWA) in the treatment of elderly patients with benign thyroid nodules. PubMed, Web of Science, and Cochrane Library were searched for
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The characteristics of the body mass frequency index in dysmobility syndrome: A pilot study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-17 Wen Sun, Peige Wang, Yongfang Zhao
With the advancement of global aging, there has been an increase in patients with dysmobility syndrome (DS), often accompanied by osteoporosis, sarcopenia, and sarcopenic obesity. The objective of this study was to evaluate the application value of the body mass frequency index (BMFI) in older patients with DS by comprehensively analyzing the differences in BMFI between community-dwelling older subjects
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Cardiorespiratory fitness mediates the relationship between depressive symptomatology and cognition in older but not younger adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-15 Catarina Barros, Adriana Sampaio, Diego Pinal
Aging is commonly associated with emotional, physical, and cognitive changes, with the latter, particularly affecting executive functioning. Further, such changes may interact. For instance, depressive symptomatology is a known risk factor for developing cognitive deficits, especially at older ages. In contrast, an active lifestyle, reflected in high cardiorespiratory fitness (CRF) levels, has proven
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Age-related changes in muscle coordination patterns of stepping responses to recover from loss of balance Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-15 Wouter H.A. Staring, Sarah Zandvliet, Digna de Kam, Teodoro Solis-Escalante, Alexander C.H. Geurts, Vivian Weerdesteyn
Reactive stepping capacity to recover from a loss of balance declines with aging, which increases the risk of falling. To gain insight into the underlying mechanisms, we investigated whether muscle coordination patterns of reactive stepping differed between healthy young and older individuals. We performed a cross-sectional study between 15 healthy young and 14 healthy older adults. They recovered
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Home-based resistance training performed at either fast or slow speeds improves power output in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Kosuke Hirata, Mari Ito, Yuta Nomura, Chiho Kawashima, Tsukasa Yoshida, Yosuke Yamada, Neale A. Tillin, Geoffrey A. Power, Ryota Akagi
We investigated the effect of an unsupervised, body mass- home-based resistance training program in older adults performed at either a fast or slow contractile speed on changes to muscle-power, -volume, -architecture, and fatigue resistance of the knee extensors. Thirty-two male older adults (age 65–88 years) were separated into 1) fast-speed exercise (Fast-group), 2) slow-speed exercise (Slow-group)
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The effect of age and sex on peak oxygen uptake during upper and lower body exercise: A systematic review Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 M.J. Price, P.M. Smith, L.M. Bottoms, M.W. Hill
Large scale population norms for peak oxygen uptake (VO) during cycle ergometry (CE) have been published for men and women across a wide range of ages. Although upper body functional capacity has an important role in activities of daily living far less is known regarding the effect of age and sex on upper body functional capacity (i.e. arm crank ergometry; ACE). The aim of this review was to determine
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Stretch-shortening cycles protect against the age-related loss of power generation in rat single muscle fibres Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Makenna A. Patterson, Avery Hinks, Binta S. Njai, Benjamin E. Dalton, Emma F. Hubbard, Geoffrey A. Power
Aging is associated with impaired strength and power during isometric and shortening contractions, however, during lengthening (i.e., eccentric) contractions, strength is maintained. During daily movements, muscles undergo stretch-shortening cycles (SSCs). It is unclear whether the age-related maintenance of eccentric strength offsets age-related impairments in power generation during SSCs owing to
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Higher blood biochemistry-based biological age developed by advanced deep learning techniques is associated with frailty in geriatric rehabilitation inpatients: RESORT Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-13 Lihuan Guan, Camilla S.L. Tuttle, Fedor Galkin, Alex Zhavoronkov, Andrea B. Maier
Accelerated biological ageing is a major underlying mechanism of frailty development. This study aimed to investigate if the biological age measured by a blood biochemistry-based ageing clock is associated with frailty in geriatric rehabilitation inpatients. Within the REStORing health of acutely unwell adulTs (RESORT) cohort, patients' biological age was measured by an ageing clock based on completed
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The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Su-ting Jiang, Shu-ying Lian, Yao-huan Sun, Mei-bo Pan, Bin Wang, Hui Wang, Jun Hua, Yi-chen Wang, Qiu-ling Wang, Yin-feng Dong
The beneficial effect of social interaction in mitigating the incidence of post-stroke depression (PSD) and ameliorating depressive symptoms has been consistently demonstrated through preclinical and clinical studies. However, the underlying relationship with oxytocin requires further investigation. In light of this, the present study aimed to explore the protective effect of pair housing on the development
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QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Jinfang Dou, Xin'ai Zhang, Chaoqun Hu, Yuqian Gao, Yue Zhao, Murong Hei, Zhimiao Wang, Nan Guo, Haiyan Zhu
The onset of Alzheimer's disease is related to neuron damage caused by massive deposition of Aβ in the brain. Recent studies suggest that excessive Aβ in the brain mainly comes from peripheral blood, and BBB is the key to regulate Aβ in and out of the brain. In this study, we explored the pathogenesis of AD from the perspective of Aβ transport through the BBB and the effect of QKL injection in AD mice
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Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-12 Haoran Peng, Longyu Wu, Siyuan Chen, Shaopu Wu, Xiaoxue Shi, Jianjun Ma, Hongqi Yang, Xue Li
Lymphocyte antigen 96 () plays an important role in innate immunity and has been reported to be associated with various neurological diseases. However, its role in Parkinson's disease (PD) remains unclear. Transcriptome data from a total of 49 patients with PD and 34 healthy controls were downloaded from the Gene Expression Omnibus (GEO) database to analyse the expression pattern of and its relationship
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PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-11 Yimin Fu, Lei Tao, Xiaojun Wang, Binyou Wang, Weilin Qin, Lei Song
Mitochondrial dysregulation in skeletal myocytes is considered a major factor in aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) on Sestrin2-mediated mechanistic target of rapamycin complex 1 (mTORC1) in aged skeletal muscles. C2C12 myoblasts were stimulated by 50 μM 7β-hydroxycholesterol (7β-OHC) to observe
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Age and sex mediated effects of estrogen and Β3-adrenergic receptor on cardiovascular pathophysiology Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-08 Graziamaria Corbi, Marika Comegna, Caterina Vinciguerra, Alessio Capasso, Luigi Onorato, Alfonso Maria Salucci, Antonio Rapacciuolo, Alessandro Cannavo
Sex differences are consistently identified in determining the prevalence, manifestation, and response to therapies in several systemic disorders, including those affecting the cardiovascular (CV), skeletal muscle, and nervous system. Interestingly, such differences are often more noticeable as we age. For example, premenopausal women experience a lower risk of CV disease than men of the same age.
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Association between Triglyceride-glucose index and sarcopenia in China: A nationally representative cohort study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-08 Yong Chen, Chongwu Liu, Mingdong Hu
The relationship between sarcopenia and insulin resistance (IR) has seldom been reported. Triglyceride-glucose (TyG) index, a new IR indicator, has gained traction as a prognostic tool for many diseases. We aimed to investigate whether the level of TyG index was related to the incidence of sarcopenia. A total of 1819 participants above 60 without sarcopenia at baseline were included from the China
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Relationship between quadriceps femoris echotexture biomarkers and muscle strength and physical function in older adults with heart failure with preserved ejection fraction Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-06 Iván José Fuentes-Abolafio, Michele Ricci, María Rosa Bernal-López, Ricardo Gómez-Huelgas, Antonio Ignacio Cuesta-Vargas, Luis Miguel Pérez-Belmonte
Muscle wasting is pronounced in patients with heart failure with preserved ejection fraction (HFpEF). The quadriceps femoris echotexture biomarkers assessed by ultrasound (US) have not been studied in these patients. To describe echotexture biomarkers assessed by the US and to assess their relationship with sex, age, body mass index (BMI), self-reported outcomes, muscle strength and physical function
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Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-05 Yibao Wei, Junfeng Kang, Zhenyuan Ma, Taiyang Liao, Peng Wu, Peimin Wang, Zhengquan Huang
Osteoporotic osteoarthritis (OP-OA) is a severe pathological form of OA, urgently requiring precise management strategies and more efficient interventions. Emodin (Emo), an effective ingredient found in the traditional Chinese medicine rhubarb, has been dEmonstrated to promote osteogenesis and inhibit extracellular matrix degradation. In this study, we aimed to investigate the interventional effects
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Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-02 Svetlana Ukraintseva, Arseniy P. Yashkin, Igor Akushevich, Konstantin Arbeev, Hongzhe Duan, Galina Gorbunova, Eric Stallard, Anatoliy Yashin
Diverse pathogens (viral, bacterial, fungal) have been associated with Alzheimer's disease (AD) and related traits in various studies. This suggests that compromised immunity, rather than specific microbes, may play a role in AD by increasing an individual's vulnerability to various infections, which could contribute to neurodegeneration. If true, then vaccines that have heterologous effects on immunity
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The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes Exp. Gerontol. (IF 3.9) Pub Date : 2024-04-01 Robert G. Memelink, Rose Njemini, Minse J.J. de Bos Kuil, Suzan Wopereis, Johan de Vogel-van den Bosch, Josje D. Schoufour, Michael Tieland, Peter J.M. Weijs, Ivan Bautmans
Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption
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Microbiome interactions with different risk factors in development of myocardial infarction Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-27 Manisha Bijla, Sunil Kumar Saini, Ajai Kumar Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
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Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-23 Yong-Fang Fu, Yi-Xun Guo, Shi-Hui Xia, Ting-Ting Zhou, Yun-Chao Zhao, Zhen-Hua Jia, Yan Zhang
Active vitamin D analog eldecalcitol is clinically applied in treatment of postmenopausal osteoporosis. This study aims to determine the role of eldecalcitol in the protection of osteocytes from senescence and the associated ferroptosis. The MLO-Y4 osteocytes were exposed to D-gal inducing senescence. The ovariectomized (OVX) mice treated with D-gal using as an aging inducer were intraperitoneally
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Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-23 Zhiyuan Wang, Bin Han, Jianjiao Qi, Xuelei Cao, Huali Gu, Jinping Sun
Vascular cognitive impairment (VCI) has become a common disease-causing cognitive deficit in humans, second only to Alzheimer's Disease (AD). Chuanzhitongluo capsule (CZTL) is a Traditional Chinese Medicine (TCM) preparation known for its effective protection against cerebral ischemia. However, its potential to ameliorate VCI remains unclear. This study aimed to investigate the cognitive improvement
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Circulating cytokines and vascular dementia: A bi-directional Mendelian randomization study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-22 Yuge Xia, Zhirui Xu, Yicong Zhang, Dongli Jiang, Yunyi Zhu, Xiaolun Liang, Rui Sun
Inflammatory responses are associated with the development of vascular dementia (VaD). Circulating cytokines modulate the inflammatory response and are important for the immune system. To further elucidate the role of the immune system in VaD, we used Mendelian randomization (MR) to comprehensively and bi-directionally assess the role of circulating cytokines in VaD.
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Corrigendum to “Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults” [Exp. Gerontol. 181 (2023) 112278] Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Yujiro Asano, Taishi Tsuji, Tomohiro Okura
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Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43 Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Jing Xia, Yang Tan, Congli Mao, Wenting Shen, Ying Zhao
To explore the mechanism by which Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury (TBI). The oxygen -glucose deprivation/recovery (OGD/R) cell model was constructed to simulate the pathological state of astrocytes in a TBI environment. The viability of astrocytes was measured by CCK-8, and the cytoskeleton changes were observed by Phalloidin- TRITC staining
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Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Steven P. Winesett, Sudeshna A. Chatterjee, Brianne Borgia, Brigette A. Cox, Kelly A. Hawkins, Jon W. Miles, Clayton W. Swanson, Julia T. Choi, Rachael D. Seidler, Emily J. Fox, David J. Clark
Walking performance and cognitive function demonstrate strong associations in older adults, with both declining with advancing age. Walking requires the use of cognitive resources, particularly in complex environments like stepping over obstacles. A commonly implemented approach for measuring the cognitive control of walking is a dual-task walking assessment, in which walking is combined with a second
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Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-19 Samira Nemati, Zohreh Zavvari-Oskuye, Soleyman Bafadam, Behnaz Mokhtari, Reza Badalzadeh, Abedin Vakili
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Pulmonary function and trajectories of cognitive decline in aging population Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-18 Albert J. Ksinan, Andrea Dalecká, Tatyana Court, Hynek Pikhart, Martin Bobák
The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pulmonary function and the trajectories of cognitive decline using prospective population-based SHARE data from 14 countries
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Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-16 Zhongwu Su, Yi Liu, Weijian Zhang, Wenhui Liang, Yuyan Chen, Jinyuan Cao, Yu Liu, Yiqing Zheng, Qi Li
Age-related hearing loss (ARHL) is the most common sensory disorder associated with human aging. Chronic inflammation is supposed to be an important contributor to ARHL. Yet, the underlying mechanisms of developing cochlear inflammation are still not well understood. In this study, we found that the inflammation, endoplasmic reticulum (ER) stress and necroptosis signalings are activated in the cochlea
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Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-15 Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming Hu
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The mediating role of lower body muscle strength and IGF-1 level in the relationship between age and cognition. A MIDUS substudy Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-14 Evrim Gökçe, Navin Kaushal, Theo Fontanille, Tudor Vrinceanu, Kathia Saillant, Wouter A J Vints, Thomas Freret, Antoine Gauthier, Louis Bherer, Antoine Langeard
Aging is a natural process associated with a decline in cognition. However, the mediating effect of physical function and circulating myokines on this relationship has yet to be fully clarified. This study investigated how muscle strength and circulating insulin-like growth factor-1 (IGF-1) levels mediate the relationship between age and cognitive functions. A total of 1255 participants aged 25–74 years
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Parental age at death is associated with age at first birth in offspring Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-14 Anna Thalén, Anders Ledberg
People age at different rates and the available evidence suggests that the rate of aging is partly inherited from previous generations. This heterogeneity in aging is evident already in midlife, but to what extent aging is associated with the timing of events earlier in life is not fully known. Here we aim to shed light on this topic by investigating the trade-off between reproduction and aging postulated
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Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-12 Youngju Choi, Keisei Kosaki, Nobuhiko Akazawa, Koichiro Tanahashi, Seiji Maeda
Although sleep quality and physical activity (PA) may influence on arterial stiffness, the combined effects of these two factors on arterial stiffness remain unknown. A total of 103 healthy middle-aged and older men and women (aged 50–83 years) with no history of cardiovascular disease and depression were included in this study. Arterial stiffness was measured using carotid-femoral pulse wave velocity
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CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-11 Xia Lin, Lingqun Mao, Qiuyue Chen, Tianyu Wang, Taotao Tao, Luping Pan
Dysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the role of circHIVP2 in Parkinson's disease (PD) and its molecular mechanism is not well understood. 127 patients with PD and 85 healthy people were enrolled. RT-qPCR was employed to examine the levels of circHIVEP2. ROC curve to explore the diagnostic. Mpp induced the SH-SY5Y to construct
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Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-10 Dan-Qian Chen, Hao-Jun Zhang, Wen Zhang, Kai Feng, Hui Liu, Hai-Ling Zhao, Ping Li
Diabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide, and leads to high morbidity and mortality. Emerging evidences have revealed gut microbiota dysbiosis and related metabolism dysfunction play a dominant role in DKD progression and treatment through modulating inflammation. Our previous studies showed that Tangshen Formula (TSF)
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p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6 Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Ying Cheng, Man Zhang, Rong Xu, Lingli Fu, Mei Xue, Chaofei Xu, Chao Tang, Ting Fang, Xiaohuan Liu, Bei Sun, Liming Chen
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only promotes the development of diabetes and its complications, but also aggravates the occurrence of senescence. Previous studies have shown that DR is associated with senescence, but the specific mechanism has not been fully elucidated. Here, we first detected the differentially expressed
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Kaempferol: Paving the path for advanced treatments in aging-related diseases Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-08 Md Sadique Hussain, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Gaurav Gupta, Moyad Shahwan, Neelima Kukreti, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has emerged as a promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, and pharmacokinetics, and highlights its potential therapeutic utility against
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Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Qingrong Ouyang, Lei Xu, Yunwei Zhang, Luwen Huang, Yang Du, Ming Yu
Chronic Post-Stroke Fatigue (PSF) is a common and persistent complications among ischemic stroke survivors. The serum glycated hemoglobin (HbA1c) level, as it is known has emerged as a critical risk factor for Acute Ischemic Stroke (AIS) and post-stroke cognitive and emotional impairment. However, no studies have been conducted on the link between HbA1c and PSF. Therefore, this study aims to estimate
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Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-06 Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Xue Bai, Hong Xiang, Yangjing Li, Hongmei Wang
Sarcopenia is a harmful condition common among older adults for which no treatment is available. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor inducible 14 (FN14) are known to play important roles in the pathogenesis of sarcopenia. This study investigated alterations in methylation in and to identify potential targets for the managing sarcopenia
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Path analysis to identify factors influencing osteoporosis: A cross-sectional study Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-05 Qiaofeng Chen, Jie Chen, Rongdong Zeng, Jianhui Shi
Osteoporosis is characterized by low bone mass and deterioration of bone tissue, which is influenced by both environmental factors and nutritional metabolism. The relationship between biochemical indicators and bone mineral density (BMD) is intricate and involves complex mechanisms. Path analysis, a statistical method that investigates causal relationships and the strength of associations among multiple
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Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates Exp. Gerontol. (IF 3.9) Pub Date : 2024-03-02 James B. Hengenius, Rebecca Ehrenkranz, Xiaonan Zhu, Nancy W. Glynn, Theodore J. Huppert, Caterina Rosano
Declining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neural substrates are not known. We examined brain resting state connectivity in relation to declining self-reported energy levels (SEL) and occurrence of fatigue over time. We examined resting-state functional MRI in 272 community dwelling older adults participating in the Health Aging and
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The role of mitochondrial quality control mechanisms in chondrocyte senescence Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-27 Tianlei Zhao, Dawei Niu, Yancheng Chen, Peiliang Fu
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte senescence. In hypoxia and hypodextrose environment, chondrocytes heavily rely on glycolysis for energy metabolism. Mitochondria, acting as the regulatory
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Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Nan Wang, Weihao Rong, Yimin Xie, Shuang Chen, Zhipeng Xi, Rongrong Deng
Intervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative diseases (SDD) and stands as a primary contributor to both low back pain (LBP) and disability. The progression of IVDD is linked to structural and functional alterations in tissues, where an imbalance in the inflammatory microenvironment can induce extracellular matrix (ECM) degradation, senescence
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Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-22 Olli-Pekka Mattila, Taina Rantanen, Merja Rantakokko, Laura Karavirta, Neil Cronin, Timo Rantalainen
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Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Fatma Ben Waer, Dan Iulian Alexe, Mariam Lahiani, Rubén Sanchez-Gomez, Fatma Chaari, Cristina Ioana Alexe, Dragos Ioan Tohanean, Haithem Rebai, Teodora Mihaela Iconomescu, Laurențiu Gabriel Talaghir, Sonia Sahli
The current study aimed to compare the effects of Pilates versus Zumba training on postural performance in middle-aged postmenopausal women. Fifty-seven eligible women, aged between 50 and 60 years, were randomized into three groups: Zumba (ZG) group, Pilates (PG) group or control (CG) group. Postural control was assessed using a force platform under 4 sensory manipulation conditions: on firm and foam
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Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-20 Gustavo Z. Schaun, Matthias Gumpenberger, Leonie Konermann, Alexandra Graf, Peter Raidl, Barbara Wessner, Robert Csapo
Age-associated remodeling processes affect the intramuscular connective tissue (IMCT) network, which may significantly impair muscle function. Thus, we aimed to test whether including exercises shown to efficiently target the IMCT to a conventional resistance exercise intervention (CONV) would result in greater functional gains as compared to CONV alone. Fifty-three men and women (66.2 ± 3.3 years)
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Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-17 Chiara Ceolin, Marina De Rui, Cristina Simonato, Margherita Vergadoro, Sara Cazzavillan, Vittorio Acunto, Mario Virgilio Papa, Giulia Salerno Trapella, Bruno Micael Zanforlini, Chiara Curreri, Anna Bertocco, Maria Devita, Alessandra Coin, Giuseppe Sergi
Coronavirus Disease-2019 (COVID-19), driven by the SARS-CoV-2 virus, has disproportionately affected the elderly, with comorbidities like sarcopenia worsening prognosis. Considering the significant impact of RNA vaccines on survival rates in this population, our objective is to investigate the impact of vaccination on the survival of hospitalized elderly patients with COVID-19, considering the presence
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Does excess body weight accelerate immune aging? Exp. Gerontol. (IF 3.9) Pub Date : 2024-02-15 Anna Tylutka, Barbara Morawin, Łukasz Walas, Agnieszka Zembron-Lacny
Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion in T lymphocytes. Therefore, the study was designed to explain whether excess body mass in older individuals affected the disproportion in numbers of T lymphocytes and whether