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Association between coffee and tea consumption and ovarian cancer incidence: A prospective analysis in the PLCO dataset Int. J. Cancer (IF 6.4) Pub Date : 2024-05-11 Changzhen Huang, Hualei Bu, Yuanjian Wang, Ran Chu, Wenna Zhao, Yan Liu, Han Wu, Shu Yao
Epidemiological evidence regarding the relationship between coffee and tea consumption and the risk of ovarian cancer (OC) is inconsistent. Therefore, we aimed to quantitatively investigate this topic in a large prospective cohort study. This cohort study included 24,715 individuals recruited from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trials between 1993 and 2001. The data used
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Exposure to polycyclic aromatic hydrocarbons promotes the progression of low‐grade cervical intraepithelial neoplasia: A population‐based cohort study in China Int. J. Cancer (IF 6.4) Pub Date : 2024-05-11 Meng Cui, Li Song, Rui Mao, Yuanjing Lyu, Ling Ding, Zhilian Wang, Ruixin Pei, Jiaxin Yan, Caihong Wu, Xiaoxue Li, Haixia Jia, Le Zhang, Mingxuan Zhang, Jiahao Wang, Jintao Wang
Low‐grade cervical intraepithelial neoplasia (CIN1) is an early stage of cervical cancer development. Previously, we reported that exposure to polycyclic aromatic hydrocarbons (PAHs) increases the risk of cervical precancerous lesions, especially in females with a high‐risk human papillomavirus (HR‐HPV) infection. However, the effects of PAHs on CIN1 progression remain unclear. A community‐based prospective
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Differential levels of circulating RNAs prior to endometrial cancer diagnosis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-11 Sina Rostami, Trine B. Rounge, Luca Pestarino, Robert Lyle, Renée Turzanski Fortner, Øystein Ariansen Haaland, Rolv T. Lie, Fredrik Wiklund, Tone Bjørge, Hilde Langseth
Endometrial cancer (EC) is one of the most common female cancers and there is currently no routine screening strategy for early detection. An altered abundance of circulating microRNAs (miRNAs) and other RNA classes have the potential as early cancer biomarkers. We analyzed circulating RNA levels using small RNA sequencing, targeting RNAs in the size range of 17–47 nucleotides, in EC patients with
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Cancer incidence, stage shift and survival during the 2020 COVID‐19 pandemic: A population‐based study in Belgium Int. J. Cancer (IF 6.4) Pub Date : 2024-05-10 Hanna M. Peacock, Mira Van Meensel, Bart Van Gool, Geert Silversmit, Kris Dekoninck, James D. Brierley, Liesbet Van Eycken
The COVID‐19 pandemic was associated with a profound decline in cancer diagnoses in 2020 in Belgium. Disruption in diagnostic and screening services and patient reluctance to visit health facilities led to fewer new cases and concerns that cancers may be diagnosed at more advanced stages and hence have poorer prognosis. Using data from mandatory cancer registration covering all of Belgium, we predicted
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Treatment of chronic COVID‐19 with convalescent/postvaccination plasma in patients with hematologic malignancies Int. J. Cancer (IF 6.4) Pub Date : 2024-05-09 Maike Janssen, Albrecht Leo, Cornelia Wolf, Miriam Stenzinger, Marie Bartenschlager, Juliane Brandt, Sandra Sauer, Michael Schmitt, Peter Dreger, Richard F. Schlenk, Claudia M. Denkinger, Carsten Müller‐Tidow
Immunocompromised patients are at high risk to fail clearance of SARS‐CoV‐2. Prolonged COVID‐19 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS‐CoV‐2 evolves, new variants of concern have emerged that evade available monoclonal antibodies. Moreover, antiviral therapy promotes SARS‐CoV‐2 escape mutations, particularly in immunocompromised patients
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Stereotactic radiosurgery and radiotherapy for brainstem metastases: An international multicenter analysis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-09 Felix Ehret, Daniel Rueß, Oliver Blanck, Susanne Fichte, Georgios Chatzikonstantinou, Robert Wolff, Lucas Mose, Stephan Mose, Thomas Fortmann, Ralph Lehrke, Menekse Turna, Hale Basak Caglar, Farshin Mortasawi, Martin Bleif, David Krug, Maximilian I. Ruge, Christoph Fürweger, Alexander Muacevic
Brainstem metastases (BSM) present a significant neuro‐oncological challenge, resulting in profound neurological deficits and poor survival outcomes. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) offer promising therapeutic avenues for BSM despite their precarious location. This international multicenter study investigates the efficacy and safety of SRS and FSRT
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Identifying modifiable risk factors to prevent aggressive colorectal cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-05-08 Peilu Wang, Mingyang Song, A. Heather Eliassen, Molin Wang, Andrew T. Chan, Jeffrey A. Meyerhardt, Fred K. Tabung, Xuehong Zhang, Tomotaka Ugai, Shuji Ogino, Edward L. Giovannucci
It remains unclear if pre‐diagnostic factors influence the developmental pathways of colorectal cancer (CRC) that could enhance tumor aggressiveness. This study used prospective data from 205,489 cancer‐free US health professionals to investigate the associations of 31 known or putative risk factors with the risk of aggressive CRC. Tumor aggressiveness was characterized by three endpoints: aggressive
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Autophagy in glioblastoma: A mechanistic perspective Int. J. Cancer (IF 6.4) Pub Date : 2024-05-08 Durgesh Meena, Sushmita Jha
Glioblastoma (GBM) is one of the most lethal malignancies in humans. Even after surgical resection and aggressive radio‐ or chemotherapies, patients with GBM can survive for less than 14 months. Extreme inter‐tumor and intra‐tumor heterogeneity of GBM poses a challenge for resolving recalcitrant GBM pathophysiology. GBM tumor microenvironment (TME) exhibits diverse heterogeneity in cellular composition
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The current infection with Helicobacter pylori and association with upper gastrointestinal lesions and risk of upper gastrointestinal cancer: Insights from multicenter population‐based cohort study Int. J. Cancer (IF 6.4) Pub Date : 2024-05-07 Xinxin Yan, Hongmei Zeng, He Li, Maomao Cao, Fan Yang, Siyi He, Shaoli Zhang, Yi Teng, Qianru Li, Changfa Xia, Wanqing Chen
The relationship between Helicobacter pylori (H. pylori) infection and upper gastrointestinal (UGI) cancers is complex. This multicenter, population‐based cohort study conducted in seven areas in China aimed to assess the correlation between current H. pylori infection and the severity of UGI lesions, as well as its association with the risk of gastric cancer (GC) and esophageal cancer (EC). From 2015
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Heterogeneous treatment effect of dose‐dense paclitaxel plus carboplatin therapy for advanced ovarian cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-05-07 Ayumi Taguchi, Kosuke Kato, Akiko Furusawa, Konan Hara, Kenbun Sone, Kyosuke Yamada, Hiroaki Kajiyama, Muneaki Shimada, Aikou Okamoto
A Japanese clinical trial (JGOG3016) showed that dose‐dense weekly paclitaxel in combination with carboplatin extensively prolonged overall survival (OS) in patients with advanced ovarian cancer. However, in other clinical trials, dose‐dense paclitaxel regimens were not superior to triweekly paclitaxel regimens. In this study, causal tree analysis was applied to explore subpopulations with different
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Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)‐induced phenotypes for platinum sensitivity and long‐term survival in ovarian cancer—A study from the OVCAD consortium Int. J. Cancer (IF 6.4) Pub Date : 2024-05-06 Gesa Fromhage, Eva Obermayr, Natalia Bednarz‐Knoll, Toon Van Gorp, Eva Welsch, Stephan Polterauer, Elena Ioana Braicu, Sven Mahner, Jalid Sehouli, Ignace Vergote, Nicole Concin, Stefan Kurtz, Sascha Steinbiss, Antje Torge, Robert Zeillinger, Linn Wölber, Burkhard Brandt
We analyzed variations in the epidermal growth factor receptor (EGFR) gene and 5′‐upstream region to identify potential molecular predictors of treatment response in primary epithelial ovarian cancer. Tumor tissues collected during debulking surgery from the prospective multicenter OVCAD study were investigated. Copy number variations in the human endogenous retrovirus sequence human endogenous retrovirus
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The development of brain metastases in patients with different therapeutic strategies for metastatic renal cell cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-05-04 Sophie H. A. E. Derks, Edgar L. van der Meer, Arjen Joosse, Maja J. A. de Jonge, Cleo Slagter, Joost W. Schouten, Esther Oomen‐de Hoop, Marion Smits, Martin J. van den Bent, Joost L. M. Jongen, Astrid A. M. van der Veldt
A diagnosis of brain metastasis (BM) significantly affects quality of life in patients with metastatic renal cell cancer (mRCC). Although systemic treatments have shown efficacy in mRCC, active surveillance (AS) is still commonly used in clinical practice. In this single‐center cohort study, we assessed the impact of different initial treatment strategies for metastatic RCC (mRCC) on the development
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Post‐diagnosis adiposity, physical activity, sedentary behaviour, dietary factors, supplement use and colorectal cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Konstantinos K. Tsilidis, Georgios Markozannes, Nerea Becerra‐Tomás, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Laure Dossus, Esther M. González‐Gil, Marc J. Gunter, Kate Allen, Nigel T. Brockton, Helen Croker, Vanessa L. Gordon‐Dseagu, Panagiota Mitrou, Nicole Musuwo, Martin J. Wiseman, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried
Based on the World Cancer Research Fund Global Cancer Update Programme, we performed systematic reviews and meta‐analyses to investigate the association of post‐diagnosis adiposity, physical activity, sedentary behaviour, and dietary factors with colorectal cancer prognosis. We searched PubMed and Embase until 28th February, 2022. An independent expert committee and expert panel graded the quality
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Extrachromosomal circular DNA landscape of breast cancer with lymph node metastasis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Yuhan Bao, Xiaolong Sui, Xiaofei Wang, Nina Qu, Yanjie Xie, Yizi Cong, Xiaoli Cao
Breast cancer (BC) is a complex disease with diverse manifestations, often resulting in lymph node metastasis (LNM) and impacting patient prognosis. Extrachromosomal circular DNA (eccDNA) has emerged as a key player in tumorigenesis, yet its contribution to BC LNM remains elusive. Here, we examined primary tumors and matched LNM tissues from 19 BC patients using the Circle‐Seq method. We identified
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Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Doris S. M. Chan, Margarita Cariolou, Georgios Markozannes, Katia Balducci, Rita Vieira, Sonia Kiss, Nerea Becerra‐Tomás, Dagfinn Aune, Darren C. Greenwood, Esther M. González‐Gil, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. May, Folakemi T. Odedina, Roderick Skinner, Karen Steindorf, Anne Tjønneland, Galina Velikova, Monica L. Baskin, Rajiv Chowdhury
The role of diet in colorectal cancer prognosis is not well understood and specific lifestyle recommendations are lacking. We searched for randomised controlled trials (RCTs) and longitudinal observational studies on post‐diagnosis dietary factors, supplement use and colorectal cancer survival outcomes in PubMed and Embase from inception until 28th February 2022. Random‐effects dose–response meta‐analyses
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Early‐pregnancy sex steroid and thyroid function hormones, thyroid autoimmunity, and maternal papillary thyroid cancer incidence in the Finnish Maternity Cohort Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Cari M. Kitahara, Heljä‐Marja Surcel, Roni Falk, Ruth M. Pfeiffer, Tuija Männistö, Mika Gissler, Britton Trabert
Thyroid cancer more commonly affects women than men and is the third most frequently diagnosed cancer among women of reproductive age. We conducted a nested case–control study within the Finnish Maternity Cohort to evaluate pre‐diagnostic sex steroid and thyroid function markers in relation to subsequent maternal papillary thyroid cancer. Cases (n = 605) were women ages 18–44 years, who provided an
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Post‐diagnosis adiposity, physical activity, dietary factors and cancer survival: A systematic review of the evidence base (WCRF Global Cancer Update Programme) Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Rudolf Kaaks
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Associations between eosinophils and cancer risk in the UK Biobank Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Jeanny H. Wang, Charles S. Rabkin, Eric A. Engels, Minkyo Song
Eosinophils exhibit anti‐tumor cytotoxic responses in the tumor microenvironment and may contribute to tumor immunosurveillance. To assess the relationship between circulating eosinophils and cancer risk, we analyzed data from 443,542 adults aged 38–73 in the UK Biobank, who were initially cancer‐free, had over a year of follow‐up, and baseline white blood cell count measurements. Using multivariable
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Post‐diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Georgios Markozannes, Nerea Becerra‐Tomás, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Marc J. Gunter, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. May, Folakemi T. Odedina, Roderick Skinner, Karen Steindorf, Anne Tjønneland, Galina Velikova, Monica L. Baskin, Rajiv Chowdhury, Lynette Hill, Sarah
Low physical activity and high sedentary behaviour have been clearly linked with colorectal cancer development, yet data on their potential role in colorectal cancer survival is limited. Better characterisation of these relationships is needed for the development of post‐diagnosis physical activity and sedentary behaviour guidance for colorectal cancer survivors. We searched PubMed and Embase through
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Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis Int. J. Cancer (IF 6.4) Pub Date : 2024-05-02 Nerea Becerra‐Tomás, Georgios Markozannes, Margarita Cariolou, Katia Balducci, Rita Vieira, Sonia Kiss, Dagfinn Aune, Darren C. Greenwood, Laure Dossus, Ellen Copson, Andrew G. Renehan, Martijn Bours, Wendy Demark‐Wahnefried, Melissa M. Hudson, Anne M. May, Folakemi T. Odedina, Roderick Skinner, Karen Steindorf, Anne Tjønneland, Galina Velikova, Monica L. Baskin, Rajiv Chowdhury, Lynette Hill, Sarah
The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta‐analysis on post‐diagnosis adiposity measures (body mass index [BMI], waist circumference, waist‐to‐hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random‐effects meta‐analyses were conducted when
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Human–mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model Int. J. Cancer (IF 6.4) Pub Date : 2024-05-01 Tatsuhiko Imaoka, Satoshi Tanaka, Masanori Tomita, Kazutaka Doi, Megumi Sasatani, Keiji Suzuki, Yutaka Yamada, Shizuko Kakinuma, Michiaki Kai
Mouse models are vital for assessing risk from environmental carcinogens, including ionizing radiation, yet the interspecies difference in the dose response precludes direct application of experimental evidence to humans. Herein, we take a mathematical approach to delineate the mechanism underlying the human–mouse difference in radiation‐related cancer risk. We used a multistage carcinogenesis model
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Correction to “DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells” Int. J. Cancer (IF 6.4) Pub Date : 2024-04-30
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Second primary cancer risks according to race and ethnicity among U.S. breast cancer survivors Int. J. Cancer (IF 6.4) Pub Date : 2024-04-30 Carolyn Brandt, Jacqueline B. Vo, Gretchen L. Gierach, Iona Cheng, Vanessa N. Torres, Wayne R. Lawrence, Lauren E. McCullough, Lene H. S. Veiga, Amy Berrington de González, Cody Ramin
Breast cancer survivors have an increased risk of developing second primary cancers, yet risks by race and ethnicity have not been comprehensively described. We evaluated second primary cancer risks among 717,335 women diagnosed with first primary breast cancer (aged 20–84 years and survived ≥1‐year) in the SEER registries using standardized incidence ratios (SIRs; observed/expected). SIRs were estimated
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Comprehensive genomic profiling of salivary gland carcinoma: Analysis of the Center for Cancer Genomics and Advanced Therapeutics database in Japan Int. J. Cancer (IF 6.4) Pub Date : 2024-04-30 Sho Iwaki, Daisuke Kawakita, Toshitaka Nagao, Yuichiro Tada, Yoshitaka Honma, Mizuo Ando, Takuma Matoba, Kiyoshi Minohara, Satsuki Nakano, Takayuki Murase, Shinichi Iwasaki, Hiroshi Inagaki
Comprehensive information on genetic alterations in salivary gland cancer (SGC) is limited. This study aimed to elucidate the genetic and clinical characteristics of patients with SGC using the Center for Cancer Genomics and Advanced Therapeutics (C‐CAT) database, a Japanese national genomic database. We analyzed data of 776 patients with SGC registered in the C‐CAT database between June 1, 2019, and
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The use of pembrolizumab monotherapy for the management of head and neck squamous cell carcinoma (HNSCC) in the UK Int. J. Cancer (IF 6.4) Pub Date : 2024-04-30 Ifigenia Vasiliadou, Derek Grose, Christina Wilson, Alekh Thapa, Olly Donnelly, Elsa Lee, Isla Leslie, Mahwish Karim, Andrew Hartley, Sarah Partridge, Katharine Medlow, James De Boisanger, Robert Metcalf, Andrew Williamson, Anoop Haridass, David Noble, Karen Mactier, Harriet Walter, Ning Ma, Emma De Winton, Jennifer Cohen, Lindsay Rayner, Konstantinos Geropantas, Petra Jankowska, Jessica Mason, Rafael
Pembrolizumab has received approval in the UK as first‐line monotherapy for recurrent and/or metastatic HNSCC (R/M HNSCC) following the results of the KEYNOTE‐048 trial, which demonstrated a longer overall survival (OS) in comparison to the EXTREME chemotherapy regimen in patients with a combined positive score (CPS) ≥1. In this article, we provide retrospective real‐world data on the role of pembrolizumab
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Methylation markers for anal cancer screening: A repeated cross‐sectional analysis of people living with HIV, 2015–2016 Int. J. Cancer (IF 6.4) Pub Date : 2024-04-29 Anjali Vasavada, Helen C. Stankiewicz Karita, John Lin, Jeffrey Schouten, Stephen E. Hawes, Ruanne V. Barnabas, Judith Wasserheit, Qinghua Feng, Rachel L. Winer
People living with HIV (PLWH) are at highest risk of anal cancer and will benefit from optimized screening for early disease detection. We compared host DNA methylation markers in high‐grade squamous intraepithelial lesions (HSIL) versus samples negative for intraepithelial lesions (NILM) or low‐grade intraepithelial lesions (LSIL) in PLWH. We recruited PLWH identifying as male aged ≥18 years undergoing
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Underdiagnosed cancer during COVID‐19 pandemic and return to normality Int. J. Cancer (IF 6.4) Pub Date : 2024-04-29 Antonio V. Sterpetti, Raimondo Gabriele, Immacolata Iannone, Valeria Borrelli
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Associations between pathological features and risk of metachronous colorectal cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-04-27 Ye Zhang, Aung Ko Win, Enes Makalic, Daniel D. Buchanan, Rish K. Pai, Amanda I. Phipps, Christophe Rosty, Alex Boussioutas, Amalia Karahalios, Mark A. Jenkins
Survivors of colorectal cancer (CRC) are at risk of developing another primary colorectal cancer ‐ metachronous CRC. Understanding which pathological features of the first tumour are associated with risk of metachronous CRC might help tailor existing surveillance guidelines. Population‐based CRC cases were recruited from the United States, Canada and Australia between 1997 and 2012 and followed prospectively
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Gene expression markers in peripheral blood and outcome in patients with platinum‐resistant ovarian cancer: A study of the European GANNET53 consortium Int. J. Cancer (IF 6.4) Pub Date : 2024-04-27 Eva Obermayr, Thomas Mohr, Eva Schuster, Elena Ioana Braicu, Eliane Taube, Jalid Sehouli, Ignace Vergote, Eric Pujade‐Lauraine, Isabelle Ray‐Coquard, Philipp Harter, Pauline Wimberger, Florence Joly‐Lobbedez, Sven Mahner, Ute Martha Moll, Nicole Concin, Robert Zeillinger
Disease progression is a major problem in ovarian cancer. There are very few treatment options for patients with platinum‐resistant ovarian cancer (PROC), and therefore, these patients have a particularly poor prognosis. The aim of the present study was to identify markers for monitoring the response of 123 PROC patients enrolled in the Phase I/II GANNET53 clinical trial, which evaluated the efficacy
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Subsequent malignant neoplasms after primary hematological malignancy in adult patients Int. J. Cancer (IF 6.4) Pub Date : 2024-04-26 Rosa M. Rönkkö, Aapeli O. Nevala, Janne M. Pitkäniemi, Ulla M. Wartiovaara‐Kautto, Nea K. Malila
Patients with primary hematological malignancy (HM) are at an elevated risk of subsequent malignant neoplasms (SMNs), which is a common concern after treatment of primary cancer. We identified 45,533 patients aged ≥20 years and diagnosed with primary HM in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios (SIR) and excess absolute risks per 1000
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Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium Int. J. Cancer (IF 6.4) Pub Date : 2024-04-25 Nhan Thi Ho, Sarah Krull Abe, Md. Shafiur Rahman, Rashedul Islam, Eiko Saito, Prakash C. Gupta, Mangesh S. Pednekar, Norie Sawada, Shoichiro Tsugane, Akiko Tamakoshi, Takashi Kimura, Xiao‐Ou Shu, Yu‐Tang Gao, Woon‐Puay Koh, Hui Cai, Wanqing Wen, Ritsu Sakata, Ichiro Tsuji, Reza Malekzadeh, Akram Pourshams, Seiki Kanemura, Jeongseon Kim, Yu Chen, Hidemi Ito, Isao Oze, Chisato Nagata, Keiko Wada, Yumi
There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing
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When DNA damage responses meet tumor immunity: From mechanism to therapeutic opportunity Int. J. Cancer (IF 6.4) Pub Date : 2024-04-24 Dong Pan, Qi Wang, Aihua Shen, Zhihao Qi, Chunfu Zheng, Burong Hu
DNA damage is a prevalent phenomenon in the context of cancer progression. Evidence suggests that DNA damage responses (DDR) are pivotal in overcoming tumor immune evasion. Alternatively, traditional radiotherapy and chemotherapy operate by inducing DNA damage, consequently stimulating the immune system to target tumors. The intricate interplay between signaling pathways involved in DDR and immune
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A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study Int. J. Cancer (IF 6.4) Pub Date : 2024-04-23 Mohammad L. Rahman, Xiao‐Ou Shu, Dean P. Jones, Wei Hu, Bu‐tian Ji, Batel Blechter, Jason Y. Y. Wong, Qiuyin Cai, Gong Yang, Yu‐Tang Gao, Wei Zheng, Nathaniel Rothman, Douglas Walker, Qing Lan
The etiology of lung cancer in never‐smokers remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Here, we aimed to enhance our understanding of lung cancer pathogenesis among never‐smokers using untargeted metabolomics. This nested case‐control study included 395 never‐smoking women who developed lung cancer and 395 matched never‐smoking cancer‐free
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Metabolic characterization of sphere‐derived prostate cancer stem cells reveals aberrant urea cycle in stemness maintenance Int. J. Cancer (IF 6.4) Pub Date : 2024-04-22 Yuanyuan Luo, Jiachuan Yu, Zhikun Lin, Xiaolin Wang, Jinhui Zhao, Xinyu Liu, Wangshu Qin, Guowang Xu
Alteration of cell metabolism is one of the essential characteristics of tumor growth. Cancer stem cells (CSCs) are the initiating cells of tumorigenesis, proliferation, recurrence, and other processes, and play an important role in therapeutic resistance and metastasis. Thus, identification of the metabolic profiles in prostate cancer stem cells (PCSCs) is critical to understanding prostate cancer
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Assessment of barriers to cancer screening and interventions implemented to overcome these barriers in 27 Latin American and Caribbean countries Int. J. Cancer (IF 6.4) Pub Date : 2024-04-22 Isabel Mosquera, Clara B. Barajas, Hannah Theriault, Sara Benitez Majano, Li Zhang, Mauricio Maza, Silvana Luciani, Andre L. Carvalho, Partha Basu
There is a gap in the understanding of the barriers to cancer screening participation and complying with downstream management in the Community of Latin American and Caribbean states (CELAC). Our study aimed to assess barriers across the cancer screening pathway from the health system perspective, and interventions in place to improve screening in CELAC. A standardized tool was used to collect information
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Effectiveness of self‐sampling human papillomavirus test on precancer detection and screening uptake in Japan: The ACCESS randomized controlled trial Int. J. Cancer (IF 6.4) Pub Date : 2024-04-22 Misuzu Fujita, Kengo Nagashima, Minobu Shimazu, Misae Suzuki, Ichiro Tauchi, Miwa Sakuma, Setsuko Yamamoto, Hideki Hanaoka, Makio Shozu, Nobuhide Tsuruoka, Tokuzo Kasai, Akira Hata
Japan is lagging in cervical cancer prevention. The effectiveness of a self‐sampling human papillomavirus (HPV) test, a possible measure to overcome this situation, has not yet been evaluated. A randomized controlled trial was performed to evaluate the effectiveness of a self‐sampling HPV test on detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and screening uptake. Women between
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Cancer‐associated fibroblast activation predicts progression, metastasis, and prognosis of cutaneous squamous cell carcinoma Int. J. Cancer (IF 6.4) Pub Date : 2024-04-22 Jaakko S. Knuutila, Pilvi Riihilä, Liisa Nissinen, Lauri Heiskanen, Roosa E. Kallionpää, Teijo Pellinen, Veli‐Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer and the metastatic disease is associated with poor prognosis. Cancer‐associated fibroblasts (CAFs) promote progression of cancer, but their role in cSCC is largely unknown. We examined the potential of CAF markers in the assessment of metastasis risk and prognosis of primary cSCC. We utilized multiplexed fluorescence
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Outcome of early detection approach in control of breast, cervical, and oral cancer: Experience from a rural cancer center in India Int. J. Cancer (IF 6.4) Pub Date : 2024-04-20 Atul Budukh, Tapas Dora, Sankalp Sancheti, Vikram Singh, Alok Goel, Sonali Bagal, Amandeep Kaur, Ishan Manchanda, Gurwinder Kaur, Ashish Gulia, Pankaj Chaturvedi, Rajendra Badwe
In low‐ and middle‐income countries most of the cancer patients attend the hospital at a late stage and treatment completion of these cases is challenging. The early detection program (EDP), in rural areas of Punjab state, India was initiated to identify breast, cervical, and oral cancer at an early stage by raising awareness and providing easy access to diagnosis and treatment. A total of 361 health
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ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-04-17 Yuuki Ohara, Huaitian Liu, Amanda J. Craig, Shouhui Yang, Paloma Moreno, Tiffany H. Dorsey, Helen Cawley, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, Stefan Ambs, S. Perwez Hussain
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal‐like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to the development of the aggressive basal‐like/squamous subtype. Using our integrated approach, we identified
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Beyond basics: Key mutation selection features for successful tumor‐informed ctDNA detection Int. J. Cancer (IF 6.4) Pub Date : 2024-04-16 Marijana Nesic, Mads H. Rasmussen, Tenna V. Henriksen, Christina Demuth, Amanda Frydendahl, Iver Nordentoft, Lars Dyrskjøt, Claus L. Andersen
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Association between CDK4/6 inhibitors and drug‐related osteonecrosis of the jaw: A pharmacoepidemiological study using the FDA Adverse Events Reporting System Int. J. Cancer (IF 6.4) Pub Date : 2024-04-15 Makiko Go, Yoshihiro Noguchi, Rikuto Masuda, Hiroki Asano, Michio Kimura, Eiseki Usami, Tomoaki Yoshimura
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PARP1 expression predicts PARP inhibitor sensitivity and correlates with metastatic potential and overall survival in melanoma Int. J. Cancer (IF 6.4) Pub Date : 2024-04-15 Lisa Marie Fröhlich, Ana Villar‐Miyar, Tamara Heintze, Birgit Sauer, Birgit Schittek
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Comprehensive characterization of somatic mutations associated with chimeric RNAs in human cancers Int. J. Cancer (IF 6.4) Pub Date : 2024-04-13 Yuting Wang, Meng Shu, Tianqiang Wang, Tongxin He, Jiapei Yuan, Yang Yang
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Chemotherapy versus chemotherapy plus immune checkpoint inhibitors for the first‐line treatment of unresectable thymic carcinoma: A multicenter retrospective study Int. J. Cancer (IF 6.4) Pub Date : 2024-04-12 Baishen Zhang, Yao Liu, Zhiting Chen, Jing Chen, Hui Yu, Meichen Li, Shudong Ma, Chao Cheng, Likun Chen
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Prevalence of survivors of childhood cancer based on a population‐based cancer registry in Osaka, Japan Int. J. Cancer (IF 6.4) Pub Date : 2024-04-12 Haruka Kudo, Kayo Nakata, Toshitaka Morishima, Mizuki Shimadzu Kato, Yoshihiro Kuwabara, Akihisa Sawada, Hiroyuki Fujisaki, Yoshiko Hashii, Isao Miyashiro
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Circulating microRNAs in association with pancreatic cancer risk within 5 years Int. J. Cancer (IF 6.4) Pub Date : 2024-04-11 Cong Wang, Hui Cai, Qiuyin Cai, Jie Wu, Rachael Stolzenberg‐Solomon, Xingyi Guo, Claire Zhu, Yu‐Tang Gao, Jordan Berlin, Fei Ye, Wei Zheng, Veronica Wendy Setiawan, Xiao‐Ou Shu
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Exploring the tumor genomic landscape of aggressive prostate cancer by whole‐genome sequencing of tissue or liquid biopsies Int. J. Cancer (IF 6.4) Pub Date : 2024-04-11 Simone Weiss, Philippe Lamy, Maria Rusan, Maibritt Nørgaard, Benedicte Parm Ulhøi, Michael Knudsen, Christine Gaasdal Kassentoft, Leila Farajzadeh, Jørgen Bjerggaard Jensen, Jakob Skou Pedersen, Michael Borre, Karina Dalsgaard Sørensen
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Field experience with the 8‐HPV‐type oncoprotein test for cervical cancer screening among HPV‐positive women living with and without HIV in LMICs Int. J. Cancer (IF 6.4) Pub Date : 2024-04-11 Laura Downham, Mary Luz Rol, Mathilde Forestier, Pilar Romero, Laura Mendoza, Pamela Mongelós, María Alejandra Picconi, María Celeste Colucci, Valeria Mariel Padin, Ana Paula Flores, Michael Zúñiga, Annabelle Ferrera, Yessy Cabrera, Marcela Farfan Crispín, Arianis Tatiana Ramirez, Londiwe Cele, Halimatou Diop‐Ndiaye, Dianke Samaté, Pascaline Manga, Fadimatou Bintou Thiam, Maria Isabel Rodriguez, Jyoshma
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Effects of ambient temperature, relative humidity and absolute humidity on risk of nasopharyngeal carcinoma in China Int. J. Cancer (IF 6.4) Pub Date : 2024-04-10 Wenyi Di, Jiamin Yu, Dan Zong, Yizhi Ge, Yujie Zhang, Xin Chen, Xia He
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Prognosis and immunotherapy efficacy in dMMR&MSS colorectal cancer patients and an MSI status predicting model Int. J. Cancer (IF 6.4) Pub Date : 2024-04-10 Xinhui Fu, Jinglin Huang, Junling Zhu, Xinjuan Fan, Chao Wang, Weihao Deng, Xiaoli Tan, Zhiting Chen, Yacheng Cai, Hanjie Lin, Guannan Wang, Ning Zhang, Yongmin Zhu, Ji Chen, Huanmiao Zhan, Shuhui Huang, Yongzhen Fang, Yuhua Li, Yan Huang
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Differences in survival and recurrence of colorectal cancer by stage across population-based European registries Int. J. Cancer (IF 6.4) Pub Date : 2024-04-05 Anne-Marie Bouvier, Valérie Jooste, Roberto Lillini, Rafael Marcos-Gragera, Alexander Katalinic, Paolo Giorgi Rossi, Guy Launoy, Véronique Bouvier, Marcela Guevara, Eva Ardanaz, Elisabetta Rapiti Aylward, Kaire Innos, Miguel Rodríguez Barranco, Milena Sant
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Clinical efficacy of tumor organoid‐guided cancer therapy for locally advanced unresectable or metastatic breast cancer Int. J. Cancer (IF 6.4) Pub Date : 2024-04-05 Ying‐yi Lin, Hong‐fei Gao, Hong Li, Qiong Hu, Bo‐le Du, Sheng Li, Fang‐ping Xu, Min‐yi Cheng, Jia‐chen Zou, Xing‐xing Zheng, Teng Zhu, Kun Wang
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Antibodies against high‐risk human papillomavirus proteins as markers for noncervical HPV‐related cancers in a Black South African population, according to HIV status Int. J. Cancer (IF 6.4) Pub Date : 2024-04-05 Mwiza Gideon Singini, Mazvita Muchengeti, Freddy Sitas, Wenlong Carl Chen, Jean‐Damien Combes, Tim Waterboer, Gary M. Clifford
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Trends in the incidence of colorectal cancer in sub‐Saharan Africa: A population‐based registry study Int. J. Cancer (IF 6.4) Pub Date : 2024-04-03 Laura Moen, Biying Liu, Phiona Bukirwa, Tatenda Chingonzoh, Eric Chokunonga, Anne Finesse, Ann Korir, Bojang Lamin, Cesaltina Ferreira Lorenzoni, Shyam S. Manraj, Guy N'Da, Anani Wencesl Severin Odzebe, Olufemi Ogunbiyi, Nontuthuzelo I. M. Somdyala, Magdalena Packzowski, Donald M. Parkin
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Time‐specific impact of trace metals on breast density of adolescent girls in Santiago, Chile Int. J. Cancer (IF 6.4) Pub Date : 2024-04-03 Claire E. Kim, Ana Pereira, Alexandra M. Binder, Chitra Amarasiriwardena, John A. Shepherd, Camila Corvalan, Karin B. Michels
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Indications of sustained delay of colorectal cancer diagnoses in Germany during the first 2 years of the COVID‐19 pandemic Int. J. Cancer (IF 6.4) Pub Date : 2024-04-02 Hermann Brenner, Lisa Weber, Rafael Cardoso, Thomas Heisser, Michael Hoffmeister, Bernd Holleczek
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Clinical outcomes of coronavirus disease in patients with breast cancer treated with granulocyte colony‐stimulating factor following chemotherapy: Triangulation of evidence using population‐based cohort and Mendelian randomization analyses Int. J. Cancer (IF 6.4) Pub Date : 2024-04-02 Yali Wang, Weifeng Cai, Peng He, Qindong Cai, Jinhua Huang, Shougui Liu, Minyan Chen, Lili Chen, Yuxiang Lin, Jialin Hou, Jing Li, Chengbin Fu, Zhonghua Han, Hui Han, Shunguo Lin, Chunsen Xu, Fangmeng Fu, Chuan Wang
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