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Optogenetic stimulation of medial septal glutamatergic neurons modulates theta-gamma coupling in the hippocampus Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-04-27 Elena Dmitrieva, Anton Malkov
Hippocampal cross-frequency theta-gamma coupling (TGC) is a basic mechanism for information processing, retrieval, and consolidation of long-term and working memory. While the role of entorhinal afferents in the modulation of hippocampal TGC is widely accepted, the influence of other main input to the hippocampus, from the medial septal area (MSA, the pacemaker of the hippocampal theta rhythm) is poorly
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Perceived stress and renewal: The effects of long-term stress on the renewal effect Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-04-04 Borja Nevado, James Byron Nelson
Two online experiments evaluated the relationship between long-term stress, as measured with the Perceived Stress Scale-10, and the Renewal Effect. In the first experiment renewal was assessed with a behavioral suppression task in a science-fiction based video game. Participants learned to suppress mouse clicking during a signal for an upcoming attack to avoid losing points. The signal was first paired
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Central amygdala contributes to stimulus facilitation and pre-stimulus vigilance during cerebellar learning Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-04-04 Sean J. Farley, John H. Freeman
Our previous studies found that the central amygdala (CeA) modulates cerebellum-dependent eyeblink conditioning (EBC) using muscimol inactivation. We also found that CeA inactivation decreases cerebellar neuronal activity during the conditional stimulus (CS) from the start of training. Based on these findings, we hypothesized that the CeA facilitates CS input to the cerebellum. The current study tested
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Infralimbic cortex plays a similar role in the punishment and extinction of instrumental behavior Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-04-04 Matthew C. Broomer, Mark E. Bouton
Learning to stop responding is a fundamental process in instrumental learning. Animals may learn to stop responding under a variety of conditions that include punishment—where the response earns an aversive stimulus in addition to a reinforcer—and extinction—where a reinforced response now earns nothing at all. Recent research suggests that punishment and extinction may be related manifestations of
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Bayesian reinforcement learning: A basic overview Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-04-03 Pyungwon Kang, Philippe N. Tobler, Peter Dayan
We and other animals learn because there is some aspect of the world about which we are uncertain. This uncertainty arises from initial ignorance, and from changes in the world that we do not perfectly know; the uncertainty often becomes evident when our predictions about the world are found to be erroneous. The Rescorla-Wagner learning rule, which specifies one way that prediction errors can occasion
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Impaired free recall of neutral but not negative material tested 105 min after cortisol administration Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-03-28 Daniela Barros Rodrigues, Despina Antypa, Ulrike Rimmele
Pharmacological studies have consistently shown memory retrieval impairment after administration of cortisol, particularly pronounced for emotional laboratory material (i.e. list of emotional words). However, it is unclear how pharmacological elevation of cortisol affects memory retrieval of ecologically-relevant emotional material (i.e. similar to a newspaper article about an emotional event). In
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Variation in the effectiveness of reinforcement and nonreinforcement in generating different conditioned behaviors Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-03-23 Victor Navarro, Dominic M. Dwyer, Robert C. Honey
Rat autoshaping procedures generate two readily measurable conditioned responses: During lever presentations that have previously signaled food, rats approach the food well (called goal-tracking) and interact with the lever itself (called sign-tracking). We investigated how reinforced and nonreinforced trials affect the overall and temporal distributions of these two responses across 10-second lever
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Emotional modulation of memorability in mnemonic discrimination Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-02-28 Fernanda Morales-Calva, Stephanie L. Leal
Although elements such as emotion may serve to enhance or impair memory for images, some images are consistently remembered or forgotten by most people, an intrinsic characteristic of images known as memorability. Memorability explains some of the variability in memory performance, however, the underlying mechanisms of memorability remain unclear. It is known that emotional valence can increase the
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Social evaluative stress enhances central detail memory, reduces false memory, and results in intrusive memories that last for days Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-02-24 Mercedes L. Stanek, Kayla M. Boaz, Chloe N. Cordes, Taylor D. Niese, Kristen E. Long, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Boyd R. Rorabaugh, Phillip R. Zoladz
Few studies have quantified what an individual remembers about a laboratory-controlled stressor. Here, we aimed to replicate previous work by using a modified version of the Trier Social Stress Test (TSST) to quantify participant memory for a stressful experience. We also aimed to extend this work by quantifying false and intrusive memories that ensued. One hundred and seven participants were exposed
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tDCS of right-hemispheric Wernicke’s area homologue affects contextual learning of novel lexicon Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-02-23 Daria Gnedykh, Diana Tsvetova, Nadezhda Mkrtychian, Evgeny Blagovechtchenski, Svetlana Kostromina, Yury Shtyrov
Numerous studies have shown robust evidence of the right hemisphere’s involvement in the language function, for instance in the processing of intonation, grammar, word meanings, metaphors, etc. However, its role in lexicon acquisition remains obscure. We applied transcranial direct current stimulation (tDCS) over the right-hemispheric homologue of Wernicke’s area to assess its putative involvement
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The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-02-23 Amanda M. Leonetti, Isabella R. Galluzzo, Timothy A.D. McLean, Gilda Stefanelli, Fiona Ramnaraign, Samuel Holm, Stephen M. Winston, Isaiah L. Reeves, Mark A. Brimble, Brandon J. Walters
Formation of long-term memories requires learning-induced changes in both transcription and translation. Epitranscriptomic modifications of RNA recently emerged as critical regulators of RNA dynamics, whereby adenosine methylation (m6A) regulates translation, mRNA stability, mRNA localization, and memory formation. Prior work demonstrated a pro-memory phenotype of m6A, as loss of m6A impairs and loss
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Long-term calorie restriction prevented memory impairment in middle-aged male mice and increased a marker of DNA oxidative stress in hippocampal dentate gyrus Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-02-07 Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara dos Anjos Rosário, Jose Ivo Araújo Beserra-Filho, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveira
Calorie restriction (CR) is a non-invasive and economic approachknown to increase healthspan and life expectancy, through a decrease in oxidative stress, an increase in neurotrophins, among other benefits. However, it is not clear whether its benefit could be noted earlier, as at the beginning of middle-age. Hence, weaimed to determine whether six months of long-term CR, from early adulthood to the
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BDNF-dependent signaling in the olfactory bulb modulates social recognition memory in mice Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-01-17 Caio M. de Castro, Ana F. Almeida-Santos, Lara M.Z. Mansk, Laura F. Jaimes, Martín Cammarota, Grace S. Pereira
An operative olfactory bulb (OB) is critical to social recognition memory (SRM) in rodents, which involves identifying conspecifics. Furthermore, OB also allocates synaptic plasticity events related to olfactory memories in their intricate neural circuit. Here, we asked whether the OB is a target for brain-derived neurotrophic factor (BDNF), a well-known mediator of plasticity and memory. Adult ICR-CD1
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Dynamic regulation of corticostriatal glutamatergic synaptic expression during reversal learning in male mice Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-01-17 Jayapriya Chandrasekaran, Kevin K. Caldwell, Jonathan L. Brigman
Behavioral flexibility, one of the core executive functions of the brain, has been shown to be an essential skill for survival across species. Corticostriatal circuits play a critical role in mediating behavioral flexibility. The molecular mechanisms underlying these processes are still unclear. Here, we measured how synaptic glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
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CCR5 regulates Aβ1-42-induced learning and memory deficits in mice Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-01-11 Hou-Yuan Huang, Shelbi Salinas, Jessica Cornell, Iquo-Bella Udoh, Yang Shen, Miou Zhou
C–C chemokine receptor 5 (CCR5) is a chemokine receptor involved in immune responses and a co-receptor for HIV infection. Recently, CCR5 has also been reported to play a role in synaptic plasticity, learning and memory, and cognitive deficits associated with normal aging, traumatic brain injury (TBI), and HIV-associated neurocognitive disorder (HAND). In contrast, the role of CCR5 in cognitive deficits
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Corrigendum to “Reminder-dependent alterations in long-term declarative memory expression” [Neurobiol. Learn. Mem. 206 (2023) 107858] Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2024-01-05 Kai Rong Tay, Francesca Bolt, Hei Ting Wong, Svetlina Vasileva, Jonathan Lee
Abstract not available
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Conditioned inhibition of fear and reward in male and female rats Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-12-20 Jamie N. Krueger, Nupur N. Patel, Kevin Shim, Ka Ng, Susan Sangha
Stimuli in our environment are not always associated with an outcome. Some of these stimuli, depending on how they are presented, may gain inhibitory value or simply be ignored. If experienced in the presence of other cues predictive of appetitive or aversive outcomes, they typically gain inhibitory value and become predictive cues indicating the absence of appetitive or aversive outcomes. In this
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Environmental enrichment improves cognitive function, learning, memory and anxiety-related behaviours in rodent models of dementia: Implications for future study Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-12-14 Siti Norhafizah Mohd Sahini, Nurul Aqmar Mohd Nor Hazalin, Bettadapura N. Srikumar, Hanish Singh Jayasingh Chellammal, Gurmeet Kaur Surindar Singh
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The effects of extinction and an explicitly unpaired treatment on the reinforcing properties of a Pavlovian conditioned stimulus Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-12-09 Nicholas G.W. Kennedy, Nathan M. Holmes, Lily W.T. Peng, R. Frederick Westbrook
This series of experiments examined the effects of extinction and an explicitly unpaired treatment on the ability of a conditioned stimulus (CS) to function as a reinforcer. Rats were trained to lever press for food, exposed to pairings of a noise CS and food, and, finally, tested for their willingness to lever press for the CS in the absence of the food. Experiment 1 provided a demonstration of conditioned
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OFC neurons do not represent the negative value of a conditioned inhibitor Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-30 Guillem R. Esber, Alexandra Usypchuk, Gurpreet Kaur Saini, Mickael Deroche, Mihaela D. Iordanova, Geoffrey Schoenbaum
The orbitofrontal cortex (OFC) is often proposed to function as a value integrator; however, alternative accounts focus on its role in representing associative structures that specify the probability and sensory identity of future outcomes. These two accounts make different predictions about how this area should respond to conditioned inhibitors of reward, since in the former, neural activity should
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Ghrelin receptor antagonism and satiety attenuate Pavlovian-instrumental transfer Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-23 Zachary J. Pierce-Messick, Ashleigh K. Brink, T. Anna Vo, Laura H. Corbit
Animals rely on learned cues to guide their behaviour for rewards such as food. The Pavlovian-instrumental transfer (PIT) task can be used to investigate the influence of Pavlovian stimuli on instrumental responding. Ghrelin, an orexigenic peptide, and its receptor, growth hormone secretagogue receptor 1A (GHS-R1A), has received growing interest for its role in reward-motivated learning and behaviours
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The influence of learning history on anterograde interference Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-22 E. De La Fontaine, R. Hamel, J.F. Lepage, P.M. Bernier
Classically interpreted as a competition between opposite memories (A vs B), anterograde interference (AI) also emerges in the absence of competing memories (A vs A), suggesting that mechanisms other than those involved in memory competition contribute to AI. To investigate this, we tested the hypothesis that extending motor practice would enhance a first memory, but come at the cost of reduced learning
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Basolateral amygdala corticotropin releasing factor receptor 2 interacts with nonmuscle myosin II to destabilize memory in males Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-22 Madalyn Hafenbreidel, Surya Pandey, Sherri B. Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B. Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D. Cameron, Gavin Rumbaugh, Courtney A. Miller
Preclinical studies show that inhibiting the actin motor ATPase nonmuscle myosin II (NMII) with blebbistatin (Blebb) in the basolateral amgydala (BLA) depolymerizes actin, resulting in an immediate, retrieval-independent disruption of methamphetamine (METH)-associated memory in male and female adult and adolescent rodents. The effect is highly selective, as NMII inhibition has no effect in other relevant
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Dissociable role of the basolateral complex of the amygdala in the acquisition and extinction of conditioned fear following reproductive experience in female rats Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-22 Kelly A. Kershaw, Jodie E. Pestana, Madison Brooke, Luisa Saavedra Cardona, Bronwyn M. Graham
In female rats and humans, reproductive experience (i.e., pregnancy) alters the behavioral, hormonal and molecular substrates of fear extinction. Here, we assessed whether the role of a central neural substrate of fear extinction, the basolateral amygdala (BLA), also changes following reproductive experience. Nulliparous (virgin) and primiparous (one prior pregnancy) female rats received infusions
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Reminder-dependent alterations in long-term declarative memory expression Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-07 Kai Rong Tay, Francesca Bolt, Hei Ting Wong, Svetlina Vasileva, Jonathan Lee
The reminder of a previously-learned memory can render that memory vulnerable to disruption or change in expression. Such memory alterations have been viewed as supportive of the framework of memory reconsolidation. However, alternative interpretations and inconsistencies in the replication of fundamental findings have raised questions particularly in the domain of human declarative memory. Here we
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The emergence of task-relevant representations in a nonlinear decision-making task Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-10 N. Menghi, F. Silvestrin, L. Pascolini, W. Penny
This paper describes the relationship between performance in a decision-making task and the emergence of task-relevant representations. Participants learnt two tasks in which the appropriate response depended on multiple relevant stimuli and the underlying stimulus-outcome associations were governed by a latent feature that participants could discover. We divided participants into good and bad performers
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Electrophysiological evidence for context reinstatement effects on object recognition memory Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-07 Jingwen Miao, Michael Weigl, Nuo Kong, Min-Fang Zhao, Axel Mecklinger, Zhiwei Zheng, Juan Li
Reinstating the context present at encoding during the test phase generally enhances recognition memory compared with changing the context when specific item–context associations are established during encoding. However, it remains unclear whether context reinstatement improves the performance in differentiating between old and similar items in recognition memory tests and what underlying cognitive
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The anterior medial hippocampus contributes to both recall and familiarity-based memory for scenes Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-07 J. Gardette, E. Cousin, P. Hot
The hippocampus is usually associated with recall memory, whereas its contribution to familiarity-based memory is debated. Growing evidence support the idea that this structure participates to any cognitive process performed on scene representations. In parallel, differences in functional specialisation and cortical connectivity were found across the longitudinal and transverse axes of the hippocampus
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Differential effects of acute stress on spatial learning and memory in the open-field tower maze across the female estrous cycle Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-11-07 Olga Lipatova, Matthew M. Campolattaro, Blakely K. Lockhart, Mariam B. Hammad
The purpose of the present investigation was to test how acute stress and levels of circulating estrogens together influence acquisition and retention of spatial learning, as well as explorative behaviors in female rats. We used the hippocampus-dependent Open-field Tower Maze (OFTM) task to assess acquisition followed by a retention test (reacquisition) that was given 48 h later. Immediately prior
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Cortisol decreases activation in extinction related brain areas resulting in an impaired recall of context-dependent extinction memory Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-20 Alina Nostadt, Christian J. Merz, Oliver T. Wolf, Martin Tegenthoff, Silke Lissek
Conditioned responding gradually stops during successful extinction learning. The renewal effect is defined as the recovery of a extinguished conditioned response when the context of extinction is different from acquisition. The stress hormone cortisol is known to have an influence on extinction memory and associative learning. Different effects of cortisol on behaviour and brain activity have been
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Differential effects of acute cardiovascular exercise on explicit and implicit motor memory: The moderating effects of fitness level Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-21 J. Cristini, V.S. Kraft, B. De las Heras, L. Rodrigues, Z. Parwanta, J. Hermsdörfer, S. Steib, M. Roig
A single bout of cardiovascular exercise (CE) performed after practice can facilitate the consolidation of motor memory. However, the effect is variable and may be modulated by different factors such as the motor task’s or participant’s characteristics and level of awareness during encoding (implicit vs explicit learning). This study examines the effects of acute CE on the consolidation of motor sequences
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Synergistic photoactivation of VTA-catecholaminergic and BLA-glutamatergic projections induces long-term potentiation in the insular cortex Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-20 Luis F. Rodríguez-Durán, Diana L. López-Ibarra, Gabriela Herrera-Xithe, Federico Bermúdez-Rattoni, Daniel Osorio-Gómez, Martha L. Escobar
The presentation of novel stimuli induces a reliable dopamine release in the insular cortex (IC) from the ventral tegmental area (VTA). The novel stimuli could be associated with motivational and emotional signals induced by cortical glutamate release from the basolateral amygdala (BLA). Dopamine and glutamate are essential for acquiring and maintaining behavioral tasks, including visual and taste
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Developmental Changes in Functional Connectivity between the Prefrontal Cortex and Amygdala following Fear Extinction Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-20 K.S. Zimmermann, R. Richardson, K.D. Baker
The amygdala and prefrontal cortex (PFC) undergo dramatic changes in structure, function, and regional connectivity in early life, ultimately stabilizing in early adulthood. Pathways between these two structures underlie many forms of emotional learning, including the extinction of conditioned fear. Here we sought to characterize changes in extinction-related medial PFC (mPFC)→ amygdala functional
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The 5-HT1A receptor agonist 8-OH-DPAT modulates motor/exploratory activity, recognition memory and dopamine transporter binding in the dorsal and ventral striatum Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-20 Susanne Nikolaus, Owen Y. Chao, Markus Beu, Jan Henke, Christina Antke, An-Li Wang, Benedetta Fazari, Eduards Mamlins, Joseph P. Huston, Frederik L. Giesel
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Individual differences in information processing during sleep and wake predict sleep-based memory consolidation of complex rules Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-15 Madison Richter, Zachariah R. Cross, Ina Bornkessel-Schlesewsky
Memory is critical for many cognitive functions, from remembering facts, to learning complex environmental rules. While memory encoding occurs during wake, memory consolidation is associated with sleep-related neural activity. Further, research suggests that individual differences in alpha frequency during wake (∼7 – 13 Hz) modulate memory processes, with higher individual alpha frequency (IAF) associated
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Alternated emotional working memory in individuals with subclinical insomnia disorder: An electrophysiological study Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-14 Siyu Li, Taotao Ru, Meiheng He, Qingwei Chen, Xue Luo, Guofu Zhou
The deleterious effects of sleep loss on sleep-dependent memory and emotional function have been documented in the current literature. Yet, the effects of insomnia-induced chronic sleep disturbance on emotional short-term memory have been scarcely investigated. Twenty-one participants with subclinical insomnia disorder (SID) and 20 healthy participants (healthy control, HC) performed a delayed recognition
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Acute single non-sedative doses of NOP receptor agonists affect acquisition of object location memory but repeated high doses do not induce long-lasting deficits Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-11 Flora D'Oliveira da Silva, Nurulain T. Zaveri, Lionel Moulédous
The Nociceptin/Orphanin FQ (N/OFQ) system has been shown to modulate various aspects of long-term memory. It is therefore important to study the effects on memory impairment by nociceptin receptor (NOP) agonists under preclinical development. In the present study, we investigated the effect of systemic injection of two small molecule selective NOP agonists, AT-202 and AT-524, in the object location
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Incidental learning of faces during threat: No evidence for enhanced physiological responses to former threat identities Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-11 Sabine Schellhaas, Christian Schmahl, Florian Bublatzky
Remembering an unfamiliar person and the contextual conditions of that encounter is important for adaptive future behavior, especially in a potentially dangerous situation. Initiating defensive behavior in the presence of former dangerous circumstances can be crucial. Recent studies showed selective electrocortical processing of faces that were previously seen in a threat context compared to a safety
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Brief environmental enrichment elicits metaplasticity on the insular cortex in vivo and reduces the strength of conditioned taste aversion Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-05 Beatriz Gutiérrez-Vera, Salma E. Reyes-García, Martha L. Escobar
Environmental enrichment (EE) is known to improve memory and cognition and modulate the impact of aversive stimuli in animals, promoting the development of resilience to stressful situations. Likewise, it is known that EE can modulate synaptic plasticity as is the case of long-term potentiation (LTP). These findings have been described initially in ex vivo preparations, suggesting that the effects
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When stress enhances memory encoding: The beneficial effects of changing context Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-09 Cameron Riddell, Andrew P. Yonelinas, Grant S. Shields
The effects of acute stress on memory encoding are complex, and we do not yet know all of the conditions that can determine whether stress at encoding improves or impairs memory. Recent work has found that changing contexts between encoding and stress can abolish the effects of post-encoding stress on memory, suggesting that context may play an important role in the effects of stress on memory. However
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Sex difference in the facilitation of fear learning by prior fear conditioning Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-05 Kehinde E. Cole, Ryan G. Parsons
There is now ample evidence that the strength and underlying mechanisms of memory formation can be drastically altered by prior experience. However, the prior work using rodent models on this topic has used only males as subjects, and as a result, we do know whether or not the effects of prior experience on subsequent learning are similar in both sexes. As a first step towards addressing this shortcoming
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Effects of early-life stress on probabilistic reversal learning and response perseverance in young adults Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-05 Corinna Y. Franco, Barbara J. Knowlton
Early life stress (ELS), including experiences with abuse and neglect, are related to several negative health outcomes in adulthood. One area that has received attention is the increased rate of substance abuse disorder in individuals who had experienced ELS. Given the critical role habitual behavior in the development of substance abuse, ELS may affect the trajectory of neural development such that
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Behavioral and genetic architecture of fear conditioning and related phenotypes Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-10-05 D. Zeid, L.R. Seemiller, D.A. Wagstaff, T.J. Gould
Contextual fear conditioning is a form of Pavlovian learning during which an organism learns to fear previously neutral stimuli following their close temporal presentation with an aversive stimulus. In mouse models, freezing behavior is typically used to quantify learned fear. This dependent variable is the sum of multiple processes, including associative/configural learning, fear and anxiety, and
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How associations become behavior Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-29 Stefano Ghirlanda, Magnus Enquist
The Rescorla and Wagner (1972) model is the first mathematical theory to explain associative learning in the presence of multiple stimuli. Its main theoretical construct is that of associative strength, but this is connected to behavior only loosely. We propose a model in which behavior is described by a collection of Poisson processes, each with a rate proportional to an associative strength. The
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Successful alpha neurofeedback training enhances working memory updating and event-related potential activity Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-26 Lu Shen, Yali Jiang, Feng Wan, Yixuan Ku, Wenya Nan
Neurofeedback (NF) is a promising method to self-regulate human brain activity for cognition enhancement. Due to the unclear results of alpha NF training on working memory updating as well as the impact of feedback modality on NF learning, this study aimed to understand further the underlying neural mechanism of alpha NF training effects on working memory updating, where the NF learning was also compared
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Ventral hippocampal projections to infralimbic cortex and basolateral amygdala are differentially activated by contextual fear and extinction recall Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-25 Emma T. Brockway, Sarah Simon, Michael R. Drew
Fear and extinction learning are thought to generate distinct and competing memory representations in the hippocampus. How these memory representations modulate the expression of appropriate behavioral responses remains unclear. To investigate this question, we used cholera toxin B subunit to retrolabel ventral hippocampal (vHPC) neurons projecting to the infralimbic cortex (IL) and basolateral amygdala
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Corticosterone injection into the basolateral amygdala before and after memory reactivation impairs the subsequent expression of fear memory in rats: An interaction of glucocorticoids and β-adrenoceptors Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-19 Abbas Ali Vafaei, Maryam Nazari, Samira Omoumi, Ali Rashidy-Pour, Payman Raise-Abdullahi
Abstract Glucocorticoid administration, before or after fear memory reactivation, impairs subsequent fear memory expression, but the underlying mechanisms are not well understood. The present study examined the role of basolateral amygdala (BLA) β-adrenoceptors in the effects of intra-BLA corticosterone injection on fear memory in rats. Bilateral cannulae were implanted in the BLA of Wistar male rats
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Acute exercise performed before and after motor practice enhances the positive effects on motor memory consolidation Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-21 Lasse Jespersen, Katrine Matlok Maes, Nicoline Ardenkjær-Skinnerup, Marc Roig, Jonas Rud Bjørndal, Mikkel Malling Beck, Jesper Lundbye-Jensen
Performing a single bout of exercise can enhance motor learning and long-term retention of motor skills. Parameters such as the intensity and when the exercise bout is performed in relation to skill practice (i.e., timing) likely influence the effectiveness. However, it is still not fully understood how exercise should be administered to maximize its effects and how exercise interacts with distinct
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Increased hippocampal CREB phosphorylation after retrieval of remote contextual fear memories in Carioca high-conditioned freezing rats Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-18 Fernanda Nunes, Bruna Lotufo Denucci, Yury Velho Martins Lages, Sílvia Maisonnette, Thomas Eichenberg Krahe, Antonio Pedro Mello Cruz, J. Landeira-Fernandez
The participation of the hippocampal formation in consolidation and reconsolidation of contextual fear memories has been widely recognized and known to be dependent on the activation of the cAMP response element (CRE) binding protein (CREB) pathway. Recent findings have challenged the prevailing view that over time contextual fear memories migrate to neocortical circuits and no longer require the hippocampus
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Stress effects on spatial memory retrieval and brain c-Fos expression pattern in adults are modulated by early nicotine exposure Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-18 José L. Solano, Carlos Novoa, Marisol R. Lamprea, Leonardo A. Ortega
The cognitive effects of nicotine are linked to persistent modifications in extended neural systems that regulate cognitive and emotional processes, and these changes occur during development. Additionally, acute stress has modulatory effects on cognition that involve broad neural systems and can be influenced by prior environmental challenges. The effects of nicotine and stress may be interconnected
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The contextual fear conditioning consolidation depends on the functional interaction of the dorsal subiculum and basolateral amygdala in rats Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-08 Márcio Braga de Melo, Vanessa Manchim Favaro, Maria Gabriela Menezes Oliveira
Fear conditioning tasks enable us to explore the neural basis of adaptative and maladaptive behaviors related to aversive memories. Recently, we provided the first evidence of the dorsal subiculum (DSub) involvement in contextual fear conditioning (CFC) consolidation by showing that the post-training bilateral NMDA (N-methyl-D-aspartate) receptor blockade in DSub impaired the performance of animals
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Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-10 Thomas G. Adams, Benjamin Kelmendi, Jamilah R. George, Jennifer Forte, Troy J.J. Hubert, Hannah Wild, Colton S. Rippey, Christopher Pittenger
Exposure-based therapies for anxiety and related disorders are believed to depend on fear extinction learning and corresponding changes in extinction circuitry. Frontopolar multifocal transcranial direct current stimulation (tDCS) has been shown to improve therapeutic safety learning during in vivo exposure and may modulate functional connectivity of networks implicated in fear processing and inhibition
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Predictive learning by a burst-dependent learning rule Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-09 G. William Chapman, Michael E. Hasselmo
Humans and other animals are able to quickly generalize latent dynamics of spatiotemporal sequences, often from a minimal number of previous experiences. Additionally, internal representations of external stimuli must remain stable, even in the presence of sensory noise, in order to be useful for informing behavior. In contrast, typical machine learning approaches require many thousands of samples
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Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-04 Brandon K. Hayes, Amritha Harikumar, Lorena A. Ferguson, Eva E. Dicker, Bryan T. Denny, Stephanie L. Leal
Individuals with depression exhibit dysfunctional emotion regulation, general episodic memory deficits, and a negativity bias, where negative experiences are better remembered. Recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation – a computation that processes experiences with overlapping
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Activating M1 muscarinic cholinergic receptors induces destabilization of resistant contextual fear memories in rats Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-09-04 Karim H. Abouelnaga, Andrew E. Huff, Olivia S. O'Neill, William S. Messer, Boyer D. Winters
Destabilization of previously consolidated memories places them in a labile state in which they are open to modification. However, strongly encoded fear memories tend to be destabilization-resistant and the conditions required to destabilize such memories remain poorly understood. Our lab has previously shown that exposure to salient novel contextual cues during memory reactivation can destabilize
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Neurocognitive predictors of food memory in healthy adults – A preregistered analysis Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-08-23 Ronja Thieleking, Evelyn Medawar, Arno Villringer, Frauke Beyer, A. Veronica Witte
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Stress, associative learning, and decision-making Neurobiol. Learn. Mem. (IF 2.7) Pub Date : 2023-08-19 Jacqueline Giovanniello, Christian Bravo-Rivera, Amiel Rosenkranz, K. Matthew Lattal
Exposure to acute and chronic stress has significant effects on the basic mechanisms of associative learning and memory. Stress can both impair and enhance associative learning depending on type, intensity, and persistence of the stressor, the subject’s sex, the context that the stress and behavior is experienced in, and the type of associative learning taking place. In some cases, stress can cause