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Reply to Wang et al., “Ample evidence for the presence of HSV-1 LAT in non-neuronal ganglionic cells of mice and humans” J. Virol. (IF 5.4) Pub Date : 2024-05-03 Werner J. D. Ouwendijk, Pavitra Roychoudhury, Anthony L. Cunningham, Keith R. Jerome, David M. Koelle, Paul R. Kinchington, Ian Mohr, Angus C. Wilson, Georges M. G. M. Verjans, Daniel P. Depledge
In their letter regarding our recent article entitled “Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice” (1), the authors notably rephrase their original claim (2) that “HSV-1 can establish latency in non-neuronal cells” to “non-neuronal cells contain LAT.” The original statement remains unsupported. Importantly,
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Correction for Lin et al., “Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Promotes the Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma via Metastatic Tumor Antigen 1 and Mechanistic Target of Rapamycin Signaling Induction” J. Virol. (IF 5.4) Pub Date : 2024-05-03 Zhe Lin, Xin Wan, Runqiu Jiang, Lei Deng, Yun Gao, Junwei Tang, Yu Yang, Wei Zhao, Xin Yan, Kun Yao, Beicheng Sun, Yun Chen
Volume 88, no. 20, p. 11872–11885, 2014, https://doi.org/10.1128/jvi.01867-14. Page 11875, Fig. 2B: Due to an error in rearranging the figure in the final version, the Vimentin panel of Fig. 2B is an inadvertent duplicate of the E-cadherin panel of Fig. 5B. The Vimentin panel of Fig. 2B should appear as shown in this correction.
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Ample evidence for the presence of HSV-1 LAT in non-neuronal ganglionic cells of mice and humans J. Virol. (IF 5.4) Pub Date : 2024-05-03 Shaohui WangXueying SongAlex RajewskiChintda SantiskulvongHomayon Ghiasi1Department of Surgery, Center for Neurobiology and Vaccine Development, Ophthalmology Research, Cedars-Sinai Medical Center, Los Angeles, California, USA2Applied Genomics, Computation, and Translational Core, Cedars-Sinai Medical Center, Los Angeles, California, USA, Felicia Goodrum
Journal of Virology, Ahead of Print.
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KSHV genome harbors both constitutive and lytically induced enhancers J. Virol. (IF 5.4) Pub Date : 2024-05-02 Nilabja Roy ChowdhuryVyacheslav GurevichMeir Shamay1Daniella Lee Casper Laboratory in Viral Oncology, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel, Jae U. Jung
Journal of Virology, Ahead of Print.
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Tripartite motif 2b (trim2b) restricts spring viremia of carp virus by degrading viral proteins and negative regulators NLRP12-like receptors J. Virol. (IF 5.4) Pub Date : 2024-05-02 Hong Fang, Xiao Man Wu, Si Yao Zheng, Ming Xian Chang
Spring viremia of carp virus (SVCV) is a lethal freshwater pathogen that causes high mortality in cyprinid fish. In the present study, we identified zebrafish trim2b, NLRP12-L1, and NLRP12-L2 as potential pattern recognition receptors (PRRs) for sensing ...
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Novel insights into the host cell glycan binding profile of human metapneumovirus J. Virol. (IF 5.4) Pub Date : 2024-05-01 Annelies Van Den Bergh, Benjamin Bailly, Patrice Guillon, Mark von Itzstein, Larissa Dirr
All cells are decorated with a dense coat of sugars that makes a sugar code. Many respiratory viruses exploit this sugar code by binding to these sugars to cause infection. Human metapneumovirus is a leading cause for acute respiratory tract infections. ...
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Pharmacological activation of TLR7 exerts inhibition on the replication of EV-D68 in respiratory cells J. Virol. (IF 5.4) Pub Date : 2024-05-01 Huili LiYuehan HuangQingran YangZhe ZhangSiyu ShenHaoran GuoWei Wei1Institute of Virology and AIDS Research, First Hospital, Jilin University, Changchun, Jilin, China2Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, First Hospital, Jilin University, Changchun, Jilin, China, Rebecca Ellis Dutch
Journal of Virology, Ahead of Print.
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Correction for Samsa et al., “Uncoupling cis-Acting RNA Elements from Coding Sequences Revealed a Requirement of the N-Terminal Region of Dengue Virus Capsid Protein in Virus Particle Formation” J. Virol. (IF 5.4) Pub Date : 2024-04-25 Marcelo M. Samsa, Juan A. Mondotte, Julio J. Caramelo, Andrea V. Gamarnik
Volume 86, no. 2, p. 1046–1058, 2012, https://doi.org/10.1128/jvi.05431-11. Figure 7 should appear as shown in this correction. In the far right panels, the image for Mut Nt2 was an inadvertent duplication of the image for Mut Nt1. This likely happened because the two images are almost identical.
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Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells J. Virol. (IF 5.4) Pub Date : 2024-04-25 Arvin T. Persaud, Jasmin Khela, Claire Fernandes, Deepa Chaphekar, Jonathan Burnie, Vera A. Tang, Che C. Colpitts, Christina Guzzo
HIV-1 establishes a lifelong infection accompanied by numerous immunological changes. Inflammation of the gut epithelia, exacerbated by the loss of mucosal T cells and cytokine dysregulation, persists during HIV-1 infection. Feeding back into this loop of ...
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Structural morphing in the viral portal vertex of bacteriophage lambda J. Virol. (IF 5.4) Pub Date : 2024-04-25 Zhiwei GuKexun WuJiawei Wang1State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China, Kristin N. Parent
Journal of Virology, Ahead of Print.
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InsPection of electron density maps supports wrongly modeled hexakisphosphate (InsP6) bound to African swine fever mRNA-decapping enzyme g5Rp J. Virol. (IF 5.4) Pub Date : 2024-04-24 Marc Graille
In April 2022, a paper entitled “Structural Insight into Molecular Inhibitory Mechanism of InsP6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp” was published in the Journal of Virology (1). In this article, the authors focus on the g5Rp Nudix hydrolase from African swine fever virus (ASFV), the causative agent of swine infection. This enzyme is endowed with a diphosphoinositol polyphosphate
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Japanese encephalitis virus NS1 and NS1’ proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication J. Virol. (IF 5.4) Pub Date : 2024-04-24 Shengda XieXiaoxiao YangXingmiao YangZiyu CaoNing WeiXinxin LinMiaolei ShiRuibing Cao1MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Mark T. Heise
Journal of Virology, Ahead of Print.
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Harnessing the power of IFN for therapeutic approaches to COVID-19 J. Virol. (IF 5.4) Pub Date : 2024-04-23 Elise G. VioxSteven E. BosingerDaniel C. DouekGideon SchreiberMirko Paiardini1Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA2Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA3Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia
Journal of Virology, Ahead of Print.
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A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection J. Virol. (IF 5.4) Pub Date : 2024-04-23 Luke F. Domanico, Gary P. Dunn, Oren Kobiler, Matthew P. Taylor
Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen that infects approximately 67% of the global human population. HSV-1 invades the peripheral nervous system, where latent HSV-1 infection persists within the host for life. Immunological ...
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The TRAF3-DYRK1A-RAD54L2 complex maintains ACE2 expression to promote SARS-CoV-2 infection J. Virol. (IF 5.4) Pub Date : 2024-04-23 Dexin Mao, Shufeng Liu, An Thanh Phan, Stephanie Renner, Yan Sun, Tony T. Wang, Yiping Zhu
The expression of ACE2 is essential for the entry of SARS-CoV-2 into host cells. We identify a new complex—the TDR complex—that acts to maintain the abundance of ACE2 in host cells. The identification and characterization of the TDR complex provide new ...
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Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restriction J. Virol. (IF 5.4) Pub Date : 2024-04-23 Melissa R. Budicini, Valerie J. Rodriguez-Irizarry, Robert W. Maples, Julie K. Pfeiffer
Viruses infect specific species and cell types, which is dictated by the expression of host factors required for viral entry as well as downstream replication steps. Murine norovirus (MNV) infects mouse cells, but not human cells. However, human cells ...
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Second Correction for Shin et al., “Histone Deacetylase Classes I and II Regulate Kaposi’s Sarcoma-Associated Herpesvirus Reactivation” J. Virol. (IF 5.4) Pub Date : 2024-04-22 Hye Jin ShinJennifer DeCotiisMario GironDiana PalmeriDavid M. Lukac
Journal of Virology, Ahead of Print.
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A tetravalent dengue virus-like particle vaccine induces high levels of neutralizing antibodies and reduces dengue replication in non-human primates J. Virol. (IF 5.4) Pub Date : 2024-04-22 Daniel ThoresenKenta MatsudaAkane UrakamiMya Myat Ngwe TunTakushi NomuraMeng Ling MoiYuri WatanabeMomoko IshikawaTrang Thi Thu HauHiroyuki YamamotoYuriko SuzakiYasushi AmiJonathan F. SmithTetsuro MatanoKouichi MoritaWataru Akahata1VLP Therapeutics, Inc., Gaithersburg, Maryland, USA2Department of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan3Department
Journal of Virology, Ahead of Print.
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Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication J. Virol. (IF 5.4) Pub Date : 2024-04-19 Cason R. KingMackenzie J. DodgeKatelyn M. MacNeilTanner M. TessierJoe S. MymrykAndrew Mehle1Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA2Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada3Division of Protective Immunity, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA4Department
Journal of Virology, Ahead of Print.
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OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway J. Virol. (IF 5.4) Pub Date : 2024-04-19 Suyan Wang, Zhuangzhuang Xu, Yongzhen Liu, Mengmeng Yu, Tao Zhang, Peng Liu, Xiaole Qi, Yuntong Chen, Lingzhai Meng, Ru Guo, Li Zhang, Wenrui Fan, Li Gao, Yulu Duan, Yanping Zhang, Hongyu Cui, Yulong Gao
OASL (2´,5´-oligadenylate synthetase-like protein) exhibits broad-spectrum antiviral effects against single-stranded RNA viruses in mammals, potentially serving as a promising target for novel antiviral strategies. However, its role in inhibiting the ...
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Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity J. Virol. (IF 5.4) Pub Date : 2024-04-19 Yingqi Liu, Yidan Qin, Bingbing Yang, Hongmei Zheng, Songlin Qiao, Zhong Luo, Rui Li
Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) axis plays a vital role in counteracting alphaherpesvirus infections. Alphaherpesviruses exploit various strategies for antagonizing cGAS-STING-mediated antiviral immune responses. ...
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Identification of a membrane-associated element (MAE) in the C-terminal region of SARS-CoV-2 nsp6 that is essential for viral replication J. Virol. (IF 5.4) Pub Date : 2024-04-19 Yuying HanZhenghong YuanZhigang Yi1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, and Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China2Shanghai Public Health Clinical Center, Fudan University, Shanghai, China, Tom Gallagher
Journal of Virology, Ahead of Print.
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Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection J. Virol. (IF 5.4) Pub Date : 2024-04-18 Yi He, Chang Miao, Shiping Yang, Changhao Xu, Yuwei Liu, Xi Zhu, Yiping Wen, Rui Wu, Qin Zhao, Xiaobo Huang, Qigui Yan, Yifei Lang, Shan Zhao, Yiping Wang, Xinfeng Han, Sanjie Cao, Yajie Hu, Senyan Du
In this study, we aimed to investigate the impact of glycoconjugate sialic acids on mosquito infection with Japanese encephalitis virus (JEV). Our findings demonstrate that sialic acids play a crucial role in enhancing JEV infection by facilitating the ...
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Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells J. Virol. (IF 5.4) Pub Date : 2024-04-17 Juliette Bougon, Eileigh Kadijk, Lucie Gallot-Lavallee, Bruce A. Curtis, Matthew Landers, John M. Archibald, Denys A. Khaperskyy
Respiratory viruses including the influenza A virus continue to cause annual epidemics with high morbidity and mortality due to the limited effectiveness of vaccines and antiviral drugs. Among the strategies evolved by viruses to evade immune responses is ...
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The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype J. Virol. (IF 5.4) Pub Date : 2024-04-17 Anja SchollmeierMichael BasicMirco GlitscherEberhard Hildt1Division of Virology, Paul Ehrlich Institute, Langen, Germany, J.-H. James Ou
Journal of Virology, Ahead of Print.
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A devastating blow: personal reflections on Argentina’s scientific decline J. Virol. (IF 5.4) Pub Date : 2024-04-16 Daniel R. Perez
As a scientist who honed my skills in Argentina, the recent government decision to defund the National Scientific and Technical Research Council (CONICET) and the National Institute of Agricultural Technology (INTA) feels like a personal gut punch. It is a devastating blow not just to scientific progress, but to Argentina’s future.
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NS7a of SADS-CoV promotes viral infection via inducing apoptosis to suppress type III interferon production J. Virol. (IF 5.4) Pub Date : 2024-04-16 Xiaowei Wang, Wenjing Qiu, Guangli Hu, Xiaoyuan Diao, Yunfei Li, Yue Li, Peng Li, Yufang Liu, Yongtong Feng, Chunyi Xue, Yongchang Cao, Zhichao Xu
Over the last 20 years, multiple animal-originated coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), middle east respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2, have caused millions of deaths, seriously ...
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Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution J. Virol. (IF 5.4) Pub Date : 2024-04-16 Kosuke TakadaYasuko OrbaYurie KidaJiaqi WuChikako OnoYoshiharu MatsuuraSo NakagawaHirofumi SawaTokiko Watanabe1Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan2Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan3International Collaboration Unit, Research Center for Zoonosis
Journal of Virology, Ahead of Print.
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Epitopes of an antibody that neutralizes a wide range of SARS-CoV-2 variants in a conserved subdomain 1 of the spike protein J. Virol. (IF 5.4) Pub Date : 2024-04-16 Hanako Ishimaru, Mitsuhiro Nishimura, Hideki Shigematsu, Maria Istiqomah Marini, Natsumi Hasegawa, Rei Takamiya, Sachiyo Iwata, Yasuko Mori
Novel severe acute respiratory syndrome coronavirus 2 variants with immune evasion ability are still repeatedly emerging, nonetheless, a part of immunity developed in responding to the antigen of earlier variants retains efficacy against recent variants ...
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The role of HPV11 E7 in modulating STING-dependent interferon β response in recurrent respiratory papillomatosis J. Virol. (IF 5.4) Pub Date : 2024-04-16 Lijuan Chen, Huiying Hu, Yufei Pan, Yuanyuan Lu, Mengyuan Zhao, Yun Zhao, Lixin Wang, Kai Liu, Zhenkun Yu
Surgical tumor reduction is the most common treatment for recurrent respiratory papillomatosis (RRP). One of the characteristics of RRP is its persistent recurrence, and multiple surgeries are usually required to control the symptoms. Recently, some ...
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Virological, innate, and adaptive immune profiles shaped by variation in route and age of host in murine cytomegalovirus infection J. Virol. (IF 5.4) Pub Date : 2024-04-15 Christopher P. CoplenMladen JergovicElana L. TernerChristine M. BradshawJennifer L. UhrlaubJanko Ž. Nikolich1Department of Immunobiology, University of Arizona College of Medicine – Tucson, Tucson, Arizona, USA2University of Arizona Center on Aging, University of Arizona College of Medicine – Tucson, Tucson, Arizona, USA, Anna Ruth Cliffe
Journal of Virology, Ahead of Print.
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Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19 J. Virol. (IF 5.4) Pub Date : 2024-04-09 Adrianus C. M. BoonTraci L. BrickerEthan J. FritchSarah R. LeistKendra GullyRalph S. BaricRachel L. GrahamBrigid V. TroanMatthew MahoneyJames W. Janetka1Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA2Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA3Department of
Journal of Virology, Ahead of Print.
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Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies J. Virol. (IF 5.4) Pub Date : 2024-04-09 Tomomi Kimura-SomeyaKazushige KatsuraMiyuki Kato-MurayamaToshiaki HosakaTomomi Uchikubo-KamoKentaro IharaKazuharu HanadaShin SatoKazutaka MurayamaMichiyo KataokaMikako ShirouzuYuichi Someya1RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan2Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, Japan3Department of Pathology, National Institute of Infectious
Journal of Virology, Ahead of Print.
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Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2 J. Virol. (IF 5.4) Pub Date : 2024-04-09 Ruirui YangPu HanPengcheng HanDedong LiRunchu ZhaoSheng NiuKefang LiuShihua LiWen-Xia TianGeorge Fu Gao1College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China2CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China3School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China4College
Journal of Virology, Ahead of Print.
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Novel mutation N588 residue in the NS1 protein of feline parvovirus greatly augments viral replication J. Virol. (IF 5.4) Pub Date : 2024-04-09 Lisha LiZirui LiuRui LiangMengfang YangYuanyuan YanYuzhou JiaoZhe JiaoXiaoshuai HuMengxia LiZhou ShenGuiqing Peng1State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China2Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Colin R.
Journal of Virology, Ahead of Print.
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Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection J. Virol. (IF 5.4) Pub Date : 2024-04-09 Hemeng BuShengnan ZhangPingchao LiZijian LiuYichu LiuZhixia LiXinglong LiuZhi WangLiqiang FengLing ChenLinbing Qu1State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China2University of Chinese Academy of Sciences, Beijing, China, Paul G. Thomas
Journal of Virology, Ahead of Print.
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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses J. Virol. (IF 5.4) Pub Date : 2024-04-09 Xuechao TangSufen LiJinzhu ZhouXianyu BianJianxin WangNan HanXuejiao ZhuRan TaoWei WangMin SunPeng LiXuehan ZhangBin Li1Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agricultural and Rural Affairs, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry
Journal of Virology, Ahead of Print.
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Deep profiling of potential substrate atlas of porcine epidemic diarrhea virus 3C-like protease J. Virol. (IF 5.4) Pub Date : 2024-04-09 Junwei Zhou, Peng Sun, Yuanqing Wang, Runhui Qiu, Zhixiang Yang, Jiahui Guo, Zhuang Li, Shaobo Xiao, Liurong Fang
Coronaviruses (CoVs) are major pathogens that infect humans and animals. The 3C-like protease (3CLpro) encoded by CoV not only cleaves the CoV polyproteins but also degrades host proteins and is considered an attractive target for the development of anti-...
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Japanese encephalitis virus NS1 and NS1′ protein disrupts the blood-brain barrier through macrophage migration inhibitory factor-mediated autophagy J. Virol. (IF 5.4) Pub Date : 2024-04-09 Luping Zhang, Xiaowei Nan, Dengyuan Zhou, Xugang Wang, Shuo Zhu, Qiuyan Li, Fan Jia, Bibo Zhu, Youhui Si, Shengbo Cao, Jing Ye
Japanese encephalitis (JE) is a significant viral encephalitis worldwide, caused by the JE virus (JEV). In some patients, the virus cannot be cleared in time, leading to the breach of the blood-brain barrier (BBB) and invasion of the central nervous ...
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VP2 mediates the release of the feline calicivirus RNA genome by puncturing the endosome membrane of infected cells J. Virol. (IF 5.4) Pub Date : 2024-04-09 Weiyao SunMing WangZhibin ShiPengfei WangJinhui WangBingchen DuShida WangZhenzhao SunZaisi LiuLili WeiDecheng YangXijun HeJingfei Wang1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Christiane E. Wobus
Journal of Virology, Ahead of Print.
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Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4+ and CD8+ T cells and protects against recurrent genital herpes J. Virol. (IF 5.4) Pub Date : 2024-04-08 Afshana QuadiriSwayam PrakashNisha Rajeswari DhanushkodiMahmoud SingerLatifa ZayouAmin Mohammed ShaikMiyo SunBerfin SuzerLauren Su Lin LauAmruth ChilukurriHawa VahedHubert SchaeferLbachir BenMohamed1Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA2Department of Vaccines and Immunotherapies, TechImmune
Journal of Virology, Ahead of Print.
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Indirect CD4+ T cell protection against mouse gamma-herpesvirus infection via interferon gamma J. Virol. (IF 5.4) Pub Date : 2024-04-05 Wanxiaojie XieKimberley BruceGabrielle T. BelzHelen E. FarrellPhilip G. Stevenson1School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia2The University of Queensland Frazer Institute, Brisbane, Queensland, Australia, Anna Ruth Cliffe
Journal of Virology, Ahead of Print.
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Inhibition of the RLR signaling pathway by SARS-CoV-2 ORF7b is mediated by MAVS and abrogated by ORF7b-homologous interfering peptide J. Virol. (IF 5.4) Pub Date : 2024-04-04 Xiao XiaoYanan FuWanling YouCongcong HuangFeng ZengXinsheng GuXiaoguang SunJian LiQiwei ZhangWeixing DuGong ChengZhixin LiuLong Liu1Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China2Institute of Virology, Shiyan Key Laboratory of Virology, Hubei University of Medicine, Shiyan, China3Hubei Key Laboratory of Embryonic Stem
Journal of Virology, Ahead of Print.
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Systematic review and meta-analysis of genome-wide pooled CRISPR screens to identify host factors involved in influenza A virus infection J. Virol. (IF 5.4) Pub Date : 2024-04-03 Annabel MaesAlexander BotzkiJanick MathysFrancis ImpensXavier Saelens1VIB Center for Medical Biotechnology, VIB, Ghent, Belgium2Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium3Janssen Pharmaceutica NV, Beerse, Belgium4VIB Technology Training, VIB, Ghent, Belgium5Department of Biomolecular Medicine, Ghent University, Ghent, Belgium6VIB Proteomics Core, VIB, Ghent, Belgium
Journal of Virology, Ahead of Print.
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Identification of a short sequence motif in the influenza A virus pathogenicity factor PB1-F2 required for inhibition of human NLRP3 J. Virol. (IF 5.4) Pub Date : 2024-04-03 Filo SilvaInês Boal-CarvalhoNathalia WilliamsMehdi ChabertChengyue NiuDalila HedhiliHélèna CholtusNicolas LiaudetNadia GaïaWolfram KarenovicsPatrice FrancoisMirco Schmolke1Department of Microbiology and Molecular Medicine, Medical Faculty, University of Geneva, Geneva, Switzerland2Bioimaging Core Facility, Medical Faculty, University of Geneva, Geneva, Switzerland3Genomic Research Laboratory, Division
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Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination J. Virol. (IF 5.4) Pub Date : 2024-04-03 Nathalie MantelFabienne Piras-DouceEmilie ChautardErnesto Marcos-LopezCaroline L. BodinhamAntonio CosmaVirginie CourtoisNina DhoogeSylviane GautheronStefan H. E. KaufmannKathleen PizzoferroDavid J. M. LewisFrédéric MartinonAnke PagnonFranck RaynalNathalie Dereuddre-BosquetRoger Le Grand1Research and Development, Sanofi, Marcy L'Etoile, France2Université Paris-Saclay, INSERM, CEA, Center for Immunology
Journal of Virology, Ahead of Print.
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Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells J. Virol. (IF 5.4) Pub Date : 2024-04-03 Kathryn M. MooreAdam-Nicolas PelletierStacey LappAmanda MetzGregory K. TharpMichelle LeeSwati Sharma BhasinManoj BhasinRafick-Pierre SékalySteven E. BosingerMehul S. Suthar1Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA2Emory Vaccine Center, Atlanta, Georgia, USA3Emory National Primate Research Center, Atlanta, Georgia, USA4RPM Bioinfo Solutions, Blainville, Quebec
Journal of Virology, Ahead of Print.
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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease J. Virol. (IF 5.4) Pub Date : 2024-04-02 Sham NambulliNicolas EscriouLinda J. RennickMatthew J. DemersNatasha L. Tilston‑LunelAnita K. McElroyDominique J. BarbeauNicholas A. CrosslandRyan M. HoehlSabrina SchraufAlexander G. WhiteH. Jacob BorishJaime A. TomkoLonnie J. FryeCharles A. ScangaJoAnne L. FlynnAnnette MartinChristiane GerkeAmy L. HartmanW. Paul Duprex1Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh
Journal of Virology, Ahead of Print.
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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model J. Virol. (IF 5.4) Pub Date : 2024-04-02 Jérémy BrunetZaineb ChouchaMarion GransagneHouda TabbalMin-Wen KuJulian BuchrieserPriyanka FernandesDamien BatalieJodie LopezLaurence MaEvelyne DufourEmeline SimonDavid HardyStéphane PetresFrançoise GuinetHelene Strick-MarchandMarc MonotPierre CharneauLaleh MajlessiW. Paul DuprexChristiane GerkeAnnette MartinNicolas Escriou1Institut Pasteur, Université Paris Cité, Département de Santé Globale, Paris
Journal of Virology, Ahead of Print.
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The Ca2+-dependent phosphatase calcineurin dephosphorylates TBK1 to suppress antiviral innate immunity J. Virol. (IF 5.4) Pub Date : 2024-04-02 Yang Qu, Siyuan Wang, Hui Jiang, Qingyi Wang, Ying Liao, Xusheng Qiu, Lei Tan, Cuiping Song, Chan Ding, Yingjie Sun, Zengqi Yang
Viral infections disrupt intracellular Ca2+ homeostasis, which affects the regulation of various host processes to create conditions that are conducive for their own proliferation, including the host immune response. The mechanism by which viruses trigger ...
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Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II J. Virol. (IF 5.4) Pub Date : 2024-04-02 Jeremy KeownAlaa BaazaouiMarek ŠebestaRichard ŠteflLoïc CarriqueErvin FodorJonathan M. Grimes1Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, United Kingdom2Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom3CEITEC–Central European Institute of Technology, Masaryk University, Brno, Czechia4National Centre for Biomolecular Research
Journal of Virology, Ahead of Print.
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Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila J. Virol. (IF 5.4) Pub Date : 2024-04-02 Qiqi Rong, Zhichong Xi, Dongyang Guo, Wen Xu, Liqin Zhang, Qingfa Wu
Viral infections pose a severe threat to human health, marked by high pathogenicity and mortality rates. Innate antiviral pathways, such as Toll, Imd, and JAK-STAT, are generally conserved across insects and mammals. Recently, the multi-functionality of ...
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Establishment of replication-competent vesicular stomatitis virus recapitulating SADS-CoV entry J. Virol. (IF 5.4) Pub Date : 2024-04-01 Zihui ZhuYutong HanMingli GongBo SunRong ZhangQiang Ding1Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China2Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China3SXMU-Tsinghua Collaborative Innovation
Journal of Virology, Ahead of Print.
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A CRM1-dependent nuclear export signal in Autographa californica multiple nucleopolyhedrovirus Ac93 is important for the formation of intranuclear microvesicles J. Virol. (IF 5.4) Pub Date : 2024-04-01 Guoqing Chen, Jing Yang, Yihong Wu, Haoran Wang, Xinxin Zhang, Guozhong Feng
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) Ac93 is important for the formation of intranuclear microvesicles. However, how the baculovirus manipulates Ac93 for the formation of intranuclear microvesicles is unclear. In this study, we ...
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PDCD4 restricts PRRSV replication in an eIF4A-dependent manner and is antagonized by the viral nonstructural protein 9 J. Virol. (IF 5.4) Pub Date : 2024-04-01 Ruiping WeiXiaoxiao ZhangXiaoying WangLu LiYajie FuYaosheng ChenXiaohong LiuChunhe Guo1State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China, Rebecca Ellis Dutch
Journal of Virology, Ahead of Print.
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Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release J. Virol. (IF 5.4) Pub Date : 2024-03-29 Yamin ShengYingying DengXiaoxuan LiPinpin JiXuwen SunBaoyuan LiuJiahong ZhuJiakai ZhaoYuchen NanEn-Min ZhouJulian A. HiscoxJames P. StewartYani SunQin Zhao1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China2Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University
Journal of Virology, Ahead of Print.
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Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection J. Virol. (IF 5.4) Pub Date : 2024-03-28 Yi-Jung HuangTian-Lu ChengYen-Tseng WangChien-Shu ChenYu-Ling LeuChih-Shiang ChangCheng-Han HoShi-Wei ChaoChia-Tse LiChih-Hung Chuang1Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan2Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan3Department of Biomedical Science
Journal of Virology, Ahead of Print.
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Correction for Querbes et al., “A JC Virus-Induced Signal Is Required for Infection of Glial Cells by a Clathrin- and eps15-Dependent Pathway” J. Virol. (IF 5.4) Pub Date : 2024-03-26 W. Querbes, A. Benmerah, D. Tosoni, P. P. Di Fiore, Walter J. Atwood
Volume 78, no. 1, p. 250–256, 2004, https://doi.org/10.1128/jvi.78.1.250-256.2004. The authors wish to correct the scientific record relating to Fig. 1 and 2 of the above-referenced paper, where four panels of control images within Fig. 1A and 2A were not described sufficiently in the figure legends and appear to be duplicates. This omission, which we have now corrected, had no bearing on the conclusions
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Correction for Nebenzahl-Sharon et al., “An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein” J. Virol. (IF 5.4) Pub Date : 2024-03-26 Keren Nebenzahl-Sharon, Rakefet Sharf, Jana Amer, Hassan Shalata, Hanan Khoury-Haddad, Sook-Young Sohn, Nabieh Ayoub, Patrick Hearing, Tamar Kleinberger
Volume 93, no. 19, e02253-18, 2019, https://doi.org/10.1128/jvi.02253-18. The following statement was omitted from Acknowledgments. “This research was also supported in part by the Israel Cancer Association, with the generous assistance of the ICA Switzerland friends.”
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Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity J. Virol. (IF 5.4) Pub Date : 2024-03-26 Yi-Chin Fan, Jo-Mei Chen, Yi-Ying Chen, Yuan-Dun Ke, Gwong-Jen J. Chang, Shyan-Song Chiou
Introduction of mutations into the fusion loop is one potential strategy for generating safe dengue and Zika vaccines by reducing the risk of severe dengue following subsequent infections, and for constructing live-attenuated vaccine candidates against ...