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Maximizing Analytical Performance in Biomolecular Discovery with LC-MS: Focus on Psychiatric Disorders Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-03-01 Bradley J. Smith, Paul C. Guest, Daniel Martins-de-Souza
In this review, we discuss the cutting-edge developments in mass spectrometry proteomics and metabolomics that have brought improvements for the identification of new disease-based biomarkers. A special focus is placed on psychiatric disorders, for example, schizophrenia, because they are considered to be not a single disease entity but rather a spectrum of disorders with many overlapping symptoms
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Toward Unrivaled Chromatographic Resolving Power in Proteomics: Design and Development of Comprehensive Spatial Three-Dimensional Liquid-Phase Separation Technology Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-03-01 Sebastiaan Eeltink, Jelle De Vos, Gert Desmet
Spatial comprehensive three-dimensional chromatography (3D-LC) offers an innovative approach to achieve unprecedented resolving power in terms of peak capacity and sample throughput. This advanced technique separates components within a 3D separation space, where orthogonal retention mechanisms are incorporated. The parallel development of the second- and third-dimension stages effectively overcomes
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Label-Free Optical Technologies to Enhance Noninvasive Endoscopic Imaging of Early-Stage Cancers Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-03-01 Shuang Chang, Halina Krzyzanowska, Audrey K. Bowden
White light endoscopic imaging allows for the examination of internal human organs and is essential in the detection and treatment of early-stage cancers. To facilitate diagnosis of precancerous changes and early-stage cancers, label-free optical technologies that provide enhanced malignancy-specific contrast and depth information have been extensively researched. The rapid development of technology
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Emerging Areas in Undergraduate Analytical Chemistry Education: Microfluidics, Microcontrollers, and Chemometrics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-03-01 Amber M. Hupp, Michelle L. Kovarik, Daniel A. McCurry
Analytical chemistry is a fast-paced field with frequent introduction of new techniques via research labs; however, incorporation of new techniques into academic curricula lags their adoption in research and industry. This review describes the recent educational literature on microfluidics, microcontrollers, and chemometrics in the undergraduate analytical chemistry curriculum. Each section highlights
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Raman and Surface-Enhanced Raman Scattering Detection in Flowing Solutions for Complex Mixture Analysis Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-02-21 Monika Poonia, Courtney J. Morder, Hannah C. Schorr, Zachary D. Schultz
Raman scattering provides a chemical-specific and label-free method for identifying and quantifying molecules in flowing solutions. This review provides a comprehensive examination of the application of Raman spectroscopy and surface-enhanced Raman scattering (SERS) to flowing liquid samples. We summarize developments in online and at-line detection using Raman and SERS analysis, including the design
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Nonlinear Electrokinetic Methods of Particles and Cells Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-02-16 Blanca H. Lapizco-Encinas
Nonlinear electrokinetic phenomena offer label-free, portable, and robust approaches for particle and cell assessment, including selective enrichment, separation, sorting, and characterization. The field of electrokinetics has evolved substantially since the first separation reports by Arne Tiselius in the 1930s. The last century witnessed major advances in the understanding of the weak-field theory
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The Present and Future Landscapes of Molecular Diagnostics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2024-02-16 Justin C. Rolando, Arek V. Melkonian, David R. Walt
Nucleic acid testing is the cornerstone of modern molecular diagnostics. This review describes the current status and future directions of molecular diagnostics, focusing on four major techniques: polymerase chain reaction (PCR), next-generation sequencing (NGS), isothermal amplification methods such as recombinase polymerase amplification (RPA) and loop-mediated isothermal amplification (LAMP), and
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Emerging Chemical Methods for Petroleum and Petroleum-Derived Dissolved Organic Matter Following the Deepwater Horizon Oil Spill Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Phoebe Zito, David C. Podgorski, Matthew A. Tarr
Despite the fact that oil chemistry and oils spills have been studied for many years, there are still emerging techniques and unknown processes to be explored. The 2010 Deepwater Horizon oil spill in the Gulf of Mexico resulted in a revival of oil spill research across a wide range of fields. These studies provided many new insights, but unanswered questions remain. Over 1,000 journal articles related
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Nanoparticles for Interrogation of Cell Signaling Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Seonik Lee, Mengchi Jiao, Zihan Zhang, Yan Yu
Cell functions rely on signal transduction—the cascades of molecular interactions and biochemical reactions that relay extracellular signals to the cell interior. Dissecting principles governing the signal transduction process is critical for the fundamental understanding of cell physiology and the development of biomedical interventions. The complexity of cell signaling is, however, beyond what is
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Gels in Microscale Electrophoresis Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Lisa A. Holland, Laura D. Casto-Boggess
Gel matrices are fundamental to electrophoresis analyses of biopolymers in microscale channels. Both capillary gel and microchannel gel electrophoresis systems have produced fundamental advances in the scientific community. These analytical techniques remain as foundational tools in bioanalytical chemistry and are indispensable in the field of biotherapeutics. This review summarizes the current state
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Recent Advances in Single-Molecule Tracking and Imaging Techniques Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Trung Duc Nguyen, Yuan-I Chen, Limin H. Chen, Hsin-Chih Yeh
Since the early 1990s, single-molecule detection in solution at room temperature has enabled direct observation of single biomolecules at work in real time and under physiological conditions, providing insights into complex biological systems that the traditional ensemble methods cannot offer. In particular, recent advances in single-molecule tracking techniques allow researchers to follow individual
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Sensors for Coastal and Ocean Monitoring Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Ciprian Briciu-Burghina, Sean Power, Adrian Delgado, Fiona Regan
In situ water monitoring sensors are critical to gain an understanding of ocean biochemistry and ecosystem health. They enable the collection of high-frequency data and capture ecosystem spatial and temporal changes, which in turn facilitate long-term global predictions. They are used as decision support tools in emergency situations and for risk mitigation, pollution source tracking, and regulatory
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Microfluidics for Biofilm Studies Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-06-14 Lu Yuan, Hervé Straub, Liubov Shishaeva, Qun Ren
Biofilms are multicellular communities held together by a self-produced extracellular matrix and exhibit a set of properties that distinguish them from free-living bacteria. Biofilms are exposed to a variety of mechanical and chemical cues resulting from fluid motion and mass transport. Microfluidics provides the precise control of hydrodynamic and physicochemical microenvironments to study biofilms
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Photoluminescence Probes in Data-Enabled Sensing Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-26 Claudia Von Suskil, Micaih J. Murray, Dipak B. Sanap, Sharon L. Neal
This review summarizes the current status of development in photoluminescent probes, multidimensional photoluminescence detection, and multivariate data analysis methods. It then highlights reports featuring multivariate analysis of multidimensional measurements of photoluminescent probes published between June 2015 and June 2022, emphasizing work in the last 5 years. Important trends include the development
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Electrochemical Imaging of Interfaces in Energy Storage via Scanning Probe Methods: Techniques, Applications, and Prospects Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-17 Abhiroop Mishra, Dipobrato Sarbapalli, Oliver Rodríguez, Joaquín Rodríguez-López
Developing a deeper understanding of dynamic chemical, electronic, and morphological changes at interfaces is key to solving practical issues in electrochemical energy storage systems (EESSs). To unravel this complexity, an assortment of tools with distinct capabilities and spatiotemporal resolutions have been used to creatively visualize interfacial processes as they occur. This review highlights
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Low-Cost Microfluidic Systems for Detection of Neglected Tropical Diseases Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-17 Kemilly M.P. Pinheiro, Bárbara G.S. Guinati, Nikaele S. Moreira, Wendell K.T. Coltro
Neglected tropical diseases (NTDs) affect tropical and subtropical countries and are caused by viruses, bacteria, protozoa, and helminths. These kinds of diseases spread quickly due to the tropical climate and limited access to clean water, sanitation, and health care, which make exposed people more vulnerable. NTDs are reported to be difficult and inefficient to diagnose. As mentioned, most NTDs occur
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Digital Histopathology by Infrared Spectroscopic Imaging Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-17 Rohit Bhargava
Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra, enabling a comprehensive measurement of the chemical makeup and heterogeneity of biological tissues. Combining this novel contrast mechanism in microscopy with the use of artificial intelligence can transform the practice of histopathology, which currently relies largely on human examination of morphologic
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Efficient Validation Strategies in Environmental Analytical Chemistry: A Focus on Organic Micropollutants in Water Samples Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-17 Félix Hernández, David Fabregat-Safont, Marina Campos-Mañas, José Benito Quintana
This article critically reviews analytical method validation and quality control applied to the environmental chemistry field. The review focuses on the determination of organic micropollutants (OMPs), specifically emerging contaminants and pesticides, in the aquatic environment. The analytical technique considered is (gas and liquid) chromatography coupled to mass spectrometry (MS), including high-resolution
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Beginner's Guide to Micro- and Nanoscale Electrochemical Additive Manufacturing Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-17 Julian Hengsteler, Karuna Aurel Kanes, Liaisan Khasanova, Dmitry Momotenko
Electrochemical additive manufacturing is an advanced microfabrication technology capable of producing features of almost unlimited geometrical complexity. A unique combination of the capacity to process conductive materials, design freedom, and micro- to nanoscale resolution offered by these electrochemical techniques promises tremendous opportunities for a multitude of future applications spanning
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CRISPR-Based Biosensing Strategies: Technical Development and Application Prospects Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-05 Tian Tian, Xiaoming Zhou
Biosensing based on CRISPR-Cas systems is a young but rapidly evolving technology. The unprecedented properties of the CRISPR-Cas system provide an innovative tool for developing new-generation biosensing strategies. To date, a series of nucleic acid and non-nucleic acid detection methods have been developed based on the CRISPR platform. In this review, we first introduce the core biochemical properties
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A Connected World: System-Level Support Through Biosensors Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-04-05 Eric S. McLamore, Shoumen P.A. Datta
The goal of protecting the health of future generations is a blueprint for future biosensor design. Systems-level decision support requires that biosensors provide meaningful service to society. In this review, we summarize recent developments in cyber physical systems and biosensors connected with decision support. We identify key processes and practices that may guide the establishment of connections
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Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-03-31 Benjamin P. Zercher, Theresa A. Gozzo, AnneClaire Wageman, Matthew F. Bush
Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution
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Advances and Emerging Medical Applications of Direct Mass Spectrometry Technologies for Tissue Analysis Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-03-21 Mary E. King, Monica Lin, Meredith Spradlin, Livia S. Eberlin
Offering superb speed, chemical specificity, and analytical sensitivity, direct mass spectrometry (MS) technologies are highly amenable for the molecular analysis of complex tissues to aid in disease characterization and help identify new diagnostic, prognostic, and predictive markers. By enabling detection of clinically actionable molecular profiles from tissues and cells, direct MS technologies have
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Wearable Microfluidics for Continuous Assay Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-03-08 Pei-Heng Lin, Hsin-Hua Nien, Bor-Ran Li
The development of wearable devices provides approaches for the realization of self-health care. Easily carried wearable devices allow individual health monitoring at any place whenever necessary. There are various interesting monitoring targets, including body motion, organ pressure, and biomarkers. An efficient use of space in one small device is a promising resolution to increase the functions of
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Label-Free Electrochemical Methods for Disease Detection Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-02-28 Kira L. Rahn, Umesha Peramune, Tianyi Zhang, Robbyn K. Anand
Label-free electrochemical biosensing leverages the advantages of label-free techniques, low cost, and fewer user steps, with the sensitivity and portability of electrochemical analysis. In this review, we identify four label-free electrochemical biosensing mechanisms: ( a) blocking the electrode surface, ( b) allowing greater access to the electrode surface, ( c) changing the intercalation or electrostatic
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Enhanced Multiplexing Technology for Proteomics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-02-28 Bailey L. Bowser, Renã A.S. Robinson
The identification of thousands of proteins and their relative levels of expression has furthered understanding of biological processes and disease and stimulated new systems biology hypotheses. Quantitative proteomics workflows that rely on analytical assays such as mass spectrometry have facilitated high-throughput measurements of proteins partially due to multiplexing. Multiplexing allows proteome
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Nondestructive 3D Pathology with Light-Sheet Fluorescence Microscopy for Translational Research and Clinical Assays Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2023-02-28 Jonathan T.C. Liu, Adam K. Glaser, Chetan Poudel, Joshua C. Vaughan
In recent years, there has been a revived appreciation for the importance of spatial context and morphological phenotypes for both understanding disease progression and guiding treatment decisions. Compared with conventional 2D histopathology, which is the current gold standard of medical diagnostics, nondestructive 3D pathology offers researchers and clinicians the ability to visualize orders of magnitude
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Oxygen Measurement in Microdevices Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-06-13 Samantha M. Grist, Kevin L. Bennewith, Karen C. Cheung
Oxygen plays a fundamental role in respiration and metabolism, and quantifying oxygen levels is essential in many environmental, industrial, and research settings. Microdevices facilitate the study of dynamic, oxygen-dependent effects in real time. This review is organized around the key needs for oxygen measurement in microdevices, including integrability into microfabricated systems; sensor dynamic
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Saliva Diagnostics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-06-13 Taichiro Nonaka, David T.W. Wong
Cancer remains one of the leading causes of death, and early detection of this disease is crucial for increasing survival rates. Although cancer can be diagnosed following tissue biopsy, the biopsy procedure is invasive; liquid biopsy provides an alternative that is more comfortable for the patient. While blood, urine, and cerebral spinal fluid can all be used as a source of liquid biopsy, saliva is
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Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-24 Eduardo A. De La Toba, Sara E. Bell, Elena V. Romanova, Jonathan V. Sweedler
Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are differentially regulated in a multitude of neurological, metabolic, and mental disorders. Mass spectrometry (MS) has evolved to become a powerful technique for measuring
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Label-Free Super-Resolution Imaging Techniques Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-22 Ryan E. Leighton, Ariel M. Alperstein, Renee R. Frontiera
Biological and material samples contain nanoscale heterogeneities that are unresolvable with conventional microscopy techniques. Super-resolution fluorescence methods can break the optical diffraction limit to observe these features, but they require samples to be fluorescently labeled. Over the past decade, progress has been made toward developing super-resolution techniques that do not require the
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Analysis of Mitochondria by Single-Organelle Resolution Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-19 Angelika B. Harbauer, Annika Schneider, Dirk Wohlleber
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within different cell populations of a tissue but also within the same cell. Dysfunction or altered function affects the organelle itself and may also lead to malignancies
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Quantitative Stimulated Raman Scattering Microscopy: Promises and Pitfalls Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-18 Bryce Manifold, Dan Fu
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a powerful chemical imaging tool that shows promise in numerous biological and biomedical applications. The spectroscopic capability of SRS enables identification and tracking of specific molecules or classes of molecules, often without labeling. SRS microscopy also has the hallmark advantage of signal strength that
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Analytical Chemistry Throughout This Solar System Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-18 Kenneth Marshall Seaton, Morgan Leigh Cable, Amanda Michelle Stockton
One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in situ measurements, is inherently constrained by the analytical (often chemical) techniques we employ in these endeavors. The past 50 years of planetary science missions
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Developing FRET Networks for Sensing Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-18 W. Russ Algar, Katherine D. Krause
Förster resonance energy transfer (FRET) is a widely used fluorescence-based sensing mechanism. To date, most implementations of FRET sensors have relied on a discrete donor-acceptor pair for detection of each analytical target. FRET networks are an emerging concept in which target recognition perturbs a set of interconnected FRET pathways between multiple emitters. Here, we review the energy transfer
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Probing and Visualizing Interfacial Charge at Surfaces in Aqueous Solution Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-09 Giada Caniglia, Gözde Tezcan, Gabriel N. Meloni, Patrick R. Unwin, Christine Kranz
Surface charge density and distribution play an important role in almost all interfacial processes, influencing, for example, adsorption, colloidal stability, functional material activity, electrochemical processes, corrosion, nanoparticle toxicity, and cellular processes such as signaling, absorption, and adhesion. Understanding the heterogeneity in, and distribution of, surface and interfacial charge
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Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-26 JingJing Zhang, Tian Lan, Yi Lu
For many years, numerous efforts have been focused on the development of sensitive, selective, and practical sensors for environmental monitoring, food safety, and medical diagnostic applications. However, the transition from innovative research to commercial success is relatively sparse. In this review, we identify four scientific barriers and one technical barrier to developing successful sensors
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Technologies for Frugal and Sensitive Point-of-Care Immunoassays Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-26 David S. Kinnamon, Jacob T. Heggestad, Jason Liu, Ashutosh Chilkoti
Immunoassays are a powerful tool for sensitive and quantitative analysis of a wide range of biomolecular analytes in the clinic and in research laboratories. However, enzyme-linked immunosorbent assay (ELISA)—the gold-standard assay—requires significant user intervention, time, and clinical resources, making its deployment at the point-of-care (POC) impractical. Researchers have made great strides
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Emerging Optical Microscopy Techniques for Electrochemistry Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-26 Jean-François Lemineur, Hui Wang, Wei Wang, Frédéric Kanoufi
An optical microscope is probably the most intuitive, simple, and commonly used instrument to observe objects and discuss behaviors through images. Although the idea of imaging electrochemical processes operando by optical microscopy was initiated 40 years ago, it was not until significant progress was made in the last two decades in advanced optical microscopy or plasmonics that it could become a
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Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-25 JingJing Zhang,Tian Lan,Yi Lu
For many years, numerous efforts have been focused on the development of sensitive, selective, and practical sensors for environmental monitoring, food safety, and medical diagnostic applications. However, the transition from innovative research to commercial success is relatively sparse. In this review, we identify four scientific barriers and one technical barrier to developing successful sensors
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Technologies for Frugal and Sensitive Point-of-Care Immunoassays. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-25 David S Kinnamon,Jacob T Heggestad,Jason Liu,Ashutosh Chilkoti
Immunoassays are a powerful tool for sensitive and quantitative analysis of a wide range of biomolecular analytes in the clinic and in research laboratories. However, enzyme-linked immunosorbent assay (ELISA)-the gold-standard assay-requires significant user intervention, time, and clinical resources, making its deployment at the point-of-care (POC) impractical. Researchers have made great strides
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Emerging Optical Microscopy Techniques for Electrochemistry. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-25 Jean-François Lemineur,Hui Wang,Wei Wang,Frédéric Kanoufi
An optical microscope is probably the most intuitive, simple, and commonly used instrument to observe objects and discuss behaviors through images. Although the idea of imaging electrochemical processes operando by optical microscopy was initiated 40 years ago, it was not until significant progress was made in the last two decades in advanced optical microscopy or plasmonics that it could become a
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Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-24 Eduardo A De La Toba,Sara E Bell,Elena V Romanova,Jonathan V Sweedler
Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are differentially regulated in a multitude of neurological, metabolic, and mental disorders. Mass spectrometry (MS) has evolved to become a powerful technique for measuring
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Analysis of Mitochondria by Single-Organelle Resolution. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-18 Angelika B Harbauer,Annika Schneider,Dirk Wohlleber
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within different cell populations of a tissue but also within the same cell. Dysfunction or altered function affects the organelle itself and may also lead to malignancies
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Analytical Chemistry Throughout This Solar System. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-17 Kenneth Marshall Seaton,Morgan Leigh Cable,Amanda Michelle Stockton
One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in situ measurements, is inherently constrained by the analytical (often chemical) techniques we employ in these endeavors. The past 50 years of planetary science missions
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Quantitative Stimulated Raman Scattering Microscopy: Promises and Pitfalls. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-17 Bryce Manifold,Dan Fu
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a powerful chemical imaging tool that shows promise in numerous biological and biomedical applications. The spectroscopic capability of SRS enables identification and tracking of specific molecules or classes of molecules, often without labeling. SRS microscopy also has the hallmark advantage of signal strength that
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Surface Analysis Techniques in Forensic Science: Successes, Challenges, and Opportunities for Operational Deployment Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-15 Melanie J. Bailey, Marcel de Puit, Francesco Saverio Romolo
Surface analysis techniques have rapidly evolved in the last decade. Some of these are already routinely used in forensics, such as for the detection of gunshot residue or for glass analysis. Some surface analysis approaches are attractive for their portability to the crime scene. Others can be very helpful in forensic laboratories owing to their high spatial resolution, analyte coverage, speed, and
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Surface Analysis Techniques in Forensic Science: Successes, Challenges, and Opportunities for Operational Deployment. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-02-15 Melanie J Bailey,Marcel de Puit,Francesco Saverio Romolo
Surface analysis techniques have rapidly evolved in the last decade. Some of these are already routinely used in forensics, such as for the detection of gunshot residue or for glass analysis. Some surface analysis approaches are attractive for their portability to the crime scene. Others can be very helpful in forensic laboratories owing to their high spatial resolution, analyte coverage, speed, and
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Probing and Visualizing Interfacial Charge at Surfaces in Aqueous Solution. Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2022-03-08 Giada Caniglia,Gözde Tezcan,Gabriel N Meloni,Patrick R Unwin,Christine Kranz
Surface charge density and distribution play an important role in almost all interfacial processes, influencing, for example, adsorption, colloidal stability, functional material activity, electrochemical processes, corrosion, nanoparticle toxicity, and cellular processes such as signaling, absorption, and adhesion. Understanding the heterogeneity in, and distribution of, surface and interfacial charge
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Environmental Aspects of Oxide Nanoparticles: Probing Oxide Nanoparticle Surface Processes Under Different Environmental Conditions Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Izaac Sit, Haibin Wu, Vicki H. Grassian
Surface chemistry affects the physiochemical properties of nanoparticles in a variety of ways. Therefore, there is great interest in understanding how nanoparticle surfaces evolve under different environmental conditions of pH and temperature. Here, we discuss the use of vibrational spectroscopy as a tool that allows for in situ observations of oxide nanoparticle surfaces and their evolution due to
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Current Challenges and Recent Developments in Mass Spectrometry–Based Metabolomics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Stephanie L. Collins, Imhoi Koo, Jeffrey M. Peters, Philip B. Smith, Andrew D. Patterson
High-resolution mass spectrometry (MS) has advanced the study of metabolism in living systems by allowing many metabolites to be measured in a single experiment. Although improvements in mass detector sensitivity have facilitated the detection of greater numbers of analytes, compound identification strategies, feature reduction software, and data sharing have not kept up with the influx of MS data
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Clinical Chemistry for Developing Countries: Mass Spectrometry Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Suji Lee, Kavyasree Chintalapudi, Abraham K. Badu-Tawiah
Early disease diagnosis is necessary to enable timely interventions. Implementation of this vital task in the developing world is challenging owing to limited resources. Diagnostic approaches developed for resource-limited settings have often involved colorimetric tests (based on immunoassays) due to their low cost. Unfortunately, the performance/sensitivity of such simplistic tests are often limited
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Glycan Labeling and Analysis in Cells and In Vivo Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Bo Cheng, Qi Tang, Che Zhang, Xing Chen
As one of the major types of biomacromolecules in the cell, glycans play essential functional roles in various biological processes. Compared with proteins and nucleic acids, the analysis of glycans in situ has been more challenging. Herein we review recent advances in the development of methods and strategies for labeling, imaging, and profiling of glycans in cells and in vivo. Cellular glycans can
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Noncontact Nanoscale Imaging of Cells Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 David Klenerman, Yuri Korchev, Pavel Novak, Andrew Shevchuk
The reduction in ion current as a fine pipette approaches a cell surface allows the cell surface topography to be imaged, with nanoscale resolution, without contact with the delicate cell surface. A variety of different methods have been developed and refined to scan the topography of the dynamic cell surface at high resolution and speed. Measurement of cell topography can be complemented by performing
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The Role of Raman Spectroscopy Within Quantitative Metabolomics Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Cassio Lima, Howbeer Muhamadali, Royston Goodacre
Ninety-four years have passed since the discovery of the Raman effect, and there are currently more than 25 different types of Raman-based techniques. The past two decades have witnessed the blossoming of Raman spectroscopy as a powerful physicochemical technique with broad applications within the life sciences. In this review, we critique the use of Raman spectroscopy as a tool for quantitative metabolomics
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Biochemical Sensing with Nanoplasmonic Architectures: We Know How but Do We Know Why? Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Andreas Dahlin
Here, the research field of nanoplasmonic sensors is placed under scrutiny, with focus on affinity-based detection using refractive index changes. This review describes how nanostructured plasmonic sensors can deliver unique advantages compared to the established surface plasmon resonance technique, where a planar metal surface is used. At the same time, it shows that these features are actually only
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New Advances and Applications in Field-Flow Fractionation Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Christine L. Plavchak, William C. Smith, Carmen R.M. Bria, S. Kim Ratanathanawongs Williams
Field-flow fractionation (FFF) is a family of techniques that was created especially for separating and characterizing macromolecules, nanoparticles, and micrometer-sized analytes. It is coming of age as new nanomaterials, polymers, composites, and biohybrids with remarkable properties are introduced and new analytical challenges arise due to synthesis heterogeneities and the motivation to correlate
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Aqueous Two-Phase Systems and Microfluidics for Microscale Assays and Analytical Measurements Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Tasdiq Ahmed, Cameron Yamanishi, Taisuke Kojima, Shuichi Takayama
Phase separation is a common occurrence in nature. Synthetic and natural polymers, salts, ionic liquids, surfactants, and biomacromolecules phase separate in water, resulting in an aqueous two-phase system (ATPS). This review discusses the properties, handling, and uses of ATPSs. These systems have been used for protein, nucleic acid, virus, and cell purification and have in recent years found new
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Analytical Technologies for Liquid Biopsy of Subcellular Materials Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Camila D.M. Campos, Katie Childers, Sachindra S.T. Gamage, Harshani Wijerathne, Zheng Zhao, Steven A. Soper
Liquid biopsy markers, which can be secured from a simple blood draw or other biological samples, are used to manage a variety of diseases and even monitor for bacterial or viral infections. Although there are several different types of liquid biopsy markers, the subcellular ones, including cell-free DNA, microRNA, extracellular vesicles, and viral particles, are evolving in terms of their utility
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Recent Advances in Microfluidically Spun Microfibers for Tissue Engineering and Drug Delivery Applications Annu. Rev. Anal. Chem. (IF 8.0) Pub Date : 2021-07-27 Joseph Scott Magnani, Reza Montazami, Nicole N. Hashemi
In recent years, the unique and tunable properties of microfluidically spun microfibers have led to tremendous advancements for the field of biomedical engineering, which have been applied to areas such as tissue engineering, wound dressing, and drug delivery, as well as cell encapsulation and cell seeding. In this article, we analyze the most recent advances in microfluidics and microfluidically spun