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Highly sensitive miRNA-21 detection with enzyme-free cascade amplification biosensor Talanta (IF 6.1) Pub Date : 2024-03-15 Qiuyan Huang, Kun Wang, Yuan Wang
In this study, we present an enzyme-free fluorescence biosensor for the highly sensitive detection of miRNA-21, a crucial biomarker in clinical diagnosis. Our innovative approach combines catalytic hairpin assembly (CHA) and entropy-driven amplification into a cascade amplification strategy. MicroRNA initiates the catalytic hairpin assembly reaction, liberating the trigger region needed for the entropy-driven
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A signal-switchable photoelectrochemical biosensor for ultrasensitive detection of long non-coding RNA in cancer cells Talanta (IF 6.1) Pub Date : 2024-03-15 Yuling Li, Li-e Liu, Hangchen Han, Xinxin Yuan, Jiangying Ji, Linsheng Xue, Yongjun Wu, Ruiying Yang
Long non-coding RNA (LncRNA) as an emerging tumor biomarker plays a key factor in the early diagnosis of cancer. Herein, an innovative signal-switchable photoelectrochemical (PEC) biosensor based on ZrO@CuO bimetallic oxides and T7 Exo-assisted signal amplification is reported for the ultrasensitive and selective detection of lncRNA (HOX gene antisense intergenic RNA, HOTAIR) in cancer cells. Firstly
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Preparation of MIL-101(Cr)–NH2@TAPB-DVA-COF based membrane solid-phase extraction for efficient enrichment and sensitive determination of trace aromatic disinfection by-products in juice drinks Talanta (IF 6.1) Pub Date : 2024-03-14 Xueyun Wei, Zhuomin Zhang, Gongke Li
Aromatic disinfection by-products (DBPs) have garnered considerable interest in recent years for their potential carcinogenicity. However, efficient separation and enrichment of DBPs in complex samples is a challenge due to the extremely low content of aromatic DBPs and the complexity of sample matrices. In this study, a MIL-101(Cr)–NH@TAPB-DVA-COF hybrid material was prepared as the enrichment medium
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Predictive models for sensory score and physicochemical composition of Yuezhou Longjing tea using near-infrared spectroscopy and data fusion Talanta (IF 6.1) Pub Date : 2024-03-14 Yong Chen, Mengqi Guo, Kai Chen, Jiang Xinfeng, Zezhong Ding, Haowen Zhang, Min Lu, Dandan Qi, Chunwang Dong
In this study, NIR quantitative prediction model was established for sensory score and physicochemical components of different varieties and quality grades of Yuezhou Longjing tea. Firstly, L, a, b color factors and diffuse reflection spectral data are collected for each sample. Subsequently, the original spectrum is preprocessed. Three techniques for selecting variables, CARS, BOSS, and SPA, were
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In vitro detection of circulating tumor cells using the nicking endonuclease-assisted lanthanide metal luminescence amplification strategy Talanta (IF 6.1) Pub Date : 2024-03-14 Xuekang Wang, Yating Zeng, Nanhang Zhu, Yue Yu, Qiangying Yi, Yao Wu
The in vitro detection of circulating tumor cells (CTCs) has been proven as a vital method for early diagnosis and evaluation of cancer metastasis, since the existence and number fluctuation of CTCs have shown close correlation with clinical outcomes. However, it remains difficult and technically challenging to realize accurate CTCs detection, due to the rarity of CTCs in the blood samples with complex
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Pyridine appended pyrimidine bis hydrazone: Zn2+/ATP detection, bioimaging and functional properties of its dinuclear Zn(II) complex Talanta (IF 6.1) Pub Date : 2024-03-14 Ottoor Anitha, Sandipan Ghorai, Thangaraj Thiruppathiraja, Humayun Amir, Abinayaselvi Murugan, Ramalingam Natarajan, Senthilkumar Lakshmipathi, Chinnuswamy Viswanathan, Mathivanan Jothi, Balasubramanian Murugesapandian
A pyridine functionalized pyrimidine-based system, was successfully synthesized, characterized, and evaluated for its remarkable selective characteristics towards Zn and ATP ions. The chemical sensing capabilities of were demonstrated through absorption, fluorescence, and NMR spectroscopic techniques. The probe exhibited outstanding sensitivity when interacting with the ions, demonstrating relatively
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An intelligent wearable artificial pancreas patch based on a microtube glucose sensor and an ultrasonic insulin pump Talanta (IF 6.1) Pub Date : 2024-03-14 Xiaojin Luo, Jiaye Xie, Li Yang, Yue Cui
In order to improve the living standards of diabetes patients and reduce the negative health effects of this disease, the medical community has been actively searching for more effective treatments. In recent years, an artificial pancreas has emerged as an important approach to managing diabetes. Despite these recent advances, meeting the requirements for miniaturized size, accurate sensing and large-volume
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Fabrication of a 96-electrode array using carbon dioxide laser ablation Talanta (IF 6.1) Pub Date : 2024-03-13 Supatinee Kongkaew, Yudtapum Thipwimonmas, Mareeyam Hayeeabu, Warakorn Limbut
The 96 laser-induced multigraphene electrode (96 L-MGE) integrated microwell plate (96 L-MGE-MP) is described. Each cell includes separate working, auxiliary, and reference electrodes, and the array sits on a poly-methyl methacrylate (PMMA) well. The 96 electrochemical cells were fabricated by laser ablation of polyimide adhesive tape, which created laser-induced graphene electrodes (L-GE). The microwell
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Integration of a hamper pad on test strips for improved sensitivity of carbendazim detection Talanta (IF 6.1) Pub Date : 2024-03-13 Pumnatthiga Makkala, Sirowan Ruantip, Anumart Buakeaw, Sudkate Chaiyo, Nanthika Khongchareonporn
Lateral flow immunoassays (LFIAs) are widely used to determine carbendazim (CBZ) residues in food products due to their advantages of low cost, ease and rapid use, on-site detection capability. However, conventional LFIAs have low detection sensitivity. Although improvements have been made to increase the sensitivity, it is not sufficient. Here, a hamper pad, polyvinyl alcohol coated on a nitrocellulose
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A hydrodynamic-based dual-function microfluidic chip for high throughput discriminating tumor cells Talanta (IF 6.1) Pub Date : 2024-03-13 Yu-Jia Wei, Xing Wei, Xuan Zhang, Cheng-Xing Wu, Ji-Ying Cai, Ming-Li Chen, Jian-Hua Wang
A hydrodynamic-based microfluidic chip consisted of two function units that could not only separate tumor cells (TCs) from whole blood but also remove residual blood cells was designed. The separation of TCs was achieved by a straight contraction-expansion array (CEA) microchannel on the front end of the chip. The addition of contractive structure brought a micro-vortex like Dean vortex that promoted
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Corrigendum to “Lateral flow immunoassay (LFIA) for dengue diagnosis: Recent progress and prospect”, [Talanta, 2024, 267, 125268] Talanta (IF 6.1) Pub Date : 2024-03-13 Ziting Ma, Jinnian Guo, Lu Jiang, Suqing Zhao
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Highly selective and sensitive molecularly imprinted sensors for the electrochemical assay of quercetin in methanol extracts of Rubus sanctus and Fragaria vesca Talanta (IF 6.1) Pub Date : 2024-03-12 M. Mesud Hurkul, Ahmet Cetinkaya, Seyda Yayla, S. Irem Kaya, Fatma Budak, Kenan Can Tok, Mehmet Gumustas, Lokman Uzun, Sibel A. Ozkan
Quercetin (QUE) is a powerful antioxidant and one of the common phenolic compounds found in plants, vegetables, and fruits, which has shown many pharmacological activities. The complex nature of the matrix in which QUE is found and its importance and potential uses in diverse applications force the researchers to develop selective and sensitive sensors. In the present work, a novel molecularly imprinted
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Geographical discrimination of Paw San rice cultivated in different regions of Myanmar using near-infrared spectroscopy, headspace-gas chromatography-ion mobility spectrometry and chemometrics Talanta (IF 6.1) Pub Date : 2024-03-12 Saw Thantar, Alina Mihailova, Marivil D. Islam, Florence Maxwell, Islam Hamed, Christina Vlachou, Simon D. Kelly
Paw San rice, also known as “Myanmar pearl rice”, is considered the highest quality rice in Myanmar. There are considerable differences in terms of the premium commercial value of Paw San rice, which is an incentive for fraud, e.g. adulteration with cheaper rice varieties or mislabelling its geographical origin. Shwe Bo District is one of the most popular rice growing areas in the Sagaing region of
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Integrating of analytical techniques with enzyme-mimicking nanomaterials for the fabrication of microfluidic systems for biomedical analysis Talanta (IF 6.1) Pub Date : 2024-03-12 Sherzod Shukhratovich Abdullaev, Raed H Althomali, Ahmad Raza Khan, Hijran Sanaan Jabbar, Munther abosoda, Ali Alsaalamy, Saurabh Aggarwal, Yasser Fakri Mustafa, Ibrahim Hammoud Khlewee, Abeer mhussan jabbar
Bioanalysis faces challenges in achieving fast, reliable, and point-of-care (POC) determination methods for timely diagnosis and prognosis of diseases. POC devices often display lower sensitivity compared to laboratory-based methods, limiting their ability to quantify low concentrations of target analytes. To enhance sensitivity, the synthesis of new materials and improvement of the efficiency of the
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Glutathione ligand self-assembly enables luminescence from Au15 nanoclusters for highly sensitive and selective monitoring of blood Pb(II) ions Talanta (IF 6.1) Pub Date : 2024-03-11 Chang Yuan, Zhanjun Guo, Shubo Tian, Ningning Song, Minmin Liang
Lead Pb(II) ions is a cumulative toxicant that impacts several biological systems and poses severe harm to young children. Accurate Pb(II) ions monitoring is thus of paramount importance. Here, we present the synthesis and application of glutathione-capped Au nanoclusters (Au(SG)) as a luminescence probe for the accurate and selective monitoring of blood Pb(II). The introduction of Pb(II) ions triggers
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Online water vapor removal membrane inlet mass spectrometer for high-sensitivity detection of dissolved methane Talanta (IF 6.1) Pub Date : 2024-03-11 Han Wang, Changjie Liu, Haiyun Song, Haobin Wang, Yupeng Cheng, Youjiang Liu, Chilai Chen
Underwater mass spectrometry is characterized by excellent consistency, strong specificity, and the ability to simultaneously detect multiple substances, making it a valuable tool in research fields such as aquatic ecosystems, hydrothermal vents, and the global carbon cycle. Nevertheless, current underwater mass spectrometry encounters challenges stemming from the high-water vapor content, constituting
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Ultrasensitive protein and exosome analysis based on a rolling circle amplification assisted-CRISPR/Cas12a strategy Talanta (IF 6.1) Pub Date : 2024-03-11 Jingjing Shi, Chao Lei, Wenjiao Fan, Yuanyuan Sun, Chenghui Liu
CRISPR/Cas12a system has attracted extensive concern in biosensing due to its high specificity and programmability. Nevertheless, existing Cas12a-based assays mainly focus on nucleic acid detection and have limitations in non-nucleic acid biomarker analysis. To broaden the application prospect of the CRISPR/Cas technology, a cascade Cas12a biosensing platform is reported by combining dual-functionalized
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On-site extraction using a 3D printed device coated with Zn/Co-ZIF-derived carbon followed by an on-line SIA-HPLC-FL system for fluoroquinolones determination in wastewater Talanta (IF 6.1) Pub Date : 2024-03-11 D. Barzallo, A. Están, N. Crespí, C. Palomino, G. Turnes, E. Palacio, L. Ferrer
A 3D printed device covered with Zn/Co-ZIF-derived carbon allows the on-site extraction of fluoroquinolones (FQs) from wastewater, avoiding the sample transportation to the laboratory, and the subsequent elution, separation and determination using an on-line flow system based on sequential injection analysis (SIA) coupled to HPLC-FL. Several parameters that affect the extraction efficiency and desorption
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Exploring the mechanism of contact-dependent cell-cell communication on chemosensitivity based on single-cell high-throughput drug screening platform Talanta (IF 6.1) Pub Date : 2024-03-11 Yue Jiang, Xuelian Ren, Guobin Liu, Shulei Chen, Ming Hao, Xinran Deng, He Huang, Kun Liu
High-throughput drug screening (HTDS) has significantly reduced the time and cost of new drug development. Nonetheless, contact-dependent cell-cell communication (CDCCC) may impact the chemosensitivity of tumour cells. There is a pressing need for low-cost single-cell HTDS platforms, alongside a deep comprehension of the mechanisms by which CDCCC affects drug efficacy, to fully unveil the efficacy
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Intra-nanoparticle plasmonic nanogap based spatial-confinement SERS analysis of polypeptides Talanta (IF 6.1) Pub Date : 2024-03-09 Ruili Li, Yuyang Hu, Xiaotong Sun, Zhipeng Zhang, Kecen Chen, Qi Liu, Xiaoqing Chen
Sensing and characterizing water-soluble polypeptides are essential in various biological applications. However, detecting polypeptides using Surface-Enhanced Raman Scattering (SERS) remains a challenge due to the dominance of aromatic amino acid residues and backbones in the signal, which hinders the detection of non-aromatic amino acid residues. Herein, intra-nanoparticle plasmonic nanogap were designed
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Ag-carbon dots with peroxidase-like activity for colorimetric and SERS dual mode detection of glucose and glutathione Talanta (IF 6.1) Pub Date : 2024-03-09 Lv Haiyang, Liu Guantong, Zhang Nan, Yang Zhanye, Jv Xinge, Zhao Bing, Yuan Tian
Currently, nanozymes have made important research progress in the fields of catalysis, biosensing and tumor therapy, but most of nanozymes sensing systems are single-mode detection, which are easily affected by environment and operation, so it is crucial to construct nanozymes sensing system with dual-signal detection to obtain a more stable and reliable performance. In this paper, Ag-carbon dots (Ag-CDs)
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A fluorescent probe for detecting H2O2 and delivering H2S in lysosomes and its application in maintaining the redox environments Talanta (IF 6.1) Pub Date : 2024-03-08 Chen Xu, Yukun Zhang, Mingguang Ren, Keyin Liu, Qin Wu, Chunling Zhang, Shoujuan Wang, Fangong Kong
Hydrogen peroxide (HO) is a reactive oxygen species (ROS) that can be used as a marker for the occurrence of oxidative stress in the organism. Lysosomes serve as intracellular digestive sites, and when the concentration of HO in them is abnormal, lysosomal function is often impaired, leading to the development of diseases. Hydrogen sulfide (HS) acts as a gaseous signaling molecule that scavenges HO
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Quantum dots (QDs) attached magnetic beads (MBs) for on-chip efficient capture and detection of bacteria in ready-to-eat (RTE) foods Talanta (IF 6.1) Pub Date : 2024-03-08 Yunxing Li, Yihong Xu, Winnie C. Soko, Hongyan Bi
In this study, we established a versatile and simple magnetic-assisted microfluidic method for fast bacterial detection. Quantum dots (QDs) were loaded onto magnetic beads (MBs) to construct performance enhanced on-chip capture of bacteria. (), as a model bacterium was studied. CdSe QDs were deposited onto the surface of FeO MBs through layer-by-layer self-assembly to enhance the loading of antibodies
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Fluorescent DNA-Silver nanoclusters in food safety detection: From synthesis to application Talanta (IF 6.1) Pub Date : 2024-03-08 Bingxuan Zhou, Imran Mahmood Khan, Xiaowei Ding, Sobia Niazi, Yin Zhang, Zhouping Wang
In recent years, the conventional preparation of silver nanoclusters (AgNCs) has attracted much attention due to their ultra-small size, tunable fluorescence, easy-to-engineer, as well as biocompatible material. Moreover, its great affinity towards cytosine bases on single-stranded DNA has led to the construction of biosensors, especially aptamers, for a broad variety of applications in food safety
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Deep-learning assisted zwitterionic magnetic immunochromatographic assays for multiplex diagnosis of biomarkers Talanta (IF 6.1) Pub Date : 2024-03-07 Guan Liu, Junhao Wang, Jiulin Wang, Xinyuan Cui, Kan Wang, Mingrui Chen, Ziyang Yang, Ang Gao, Yulan Shen, Qian Zhang, Guo Gao, Daxiang Cui
Magnetic nanoparticle (MNP)-based immunochromatographic tests (ICTs) display long-term stability and an enhanced capability for multiplex biomarker detection, surpassing conventional gold nanoparticles (AuNPs) and fluorescence-based ICTs. In this study, we innovatively developed zwitterionic silica-coated MNPs (MNP@Si-Zwit/COOH) with outstanding antifouling capabilities and effectively utilised them
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Mo5N6 nanosheets for fluorescent quenching and target recognition: Highly selectively sensing of sodium hexametaphosphate Talanta (IF 6.1) Pub Date : 2024-03-07 Wenying Huang, Yali Wu, Chunqiu Xia, Liangqia Guo
Typical fluorescent biosensors use fluorescently labeled ssDNA for target recognition and nanomaterials for signal transduction. Herein, we propose a reverse sensing strategy that MoN nanosheets are used for target recognition while fluorescein (FAM)-labeled ssDNA only serves for signal generation. We discover that MoN nanosheets show high fluorescence quenching ability (>95%) and selective recognition
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Binary-amplifying electrochemiluminescence sensor for sensitive assay of catechol and luteolin based on HKUST-1 derived CuO nanoneedles as a novel luminophore Talanta (IF 6.1) Pub Date : 2024-03-07 Beibei Wang, Wenrui Zhao, Lin Wang, Kai Kang, Xianrui Li, Duo Zhang, Jujie Ren, Xueping Ji
Herein, a highly novel and effective electrochemiluminescence (ECL) sensor based on metal-organic framework (MOF, HKUST-1) derived CuO nanoneedles (HKUST-1 derived CuO NNs), gold nanoparticles (AuNPs) and TiO was developed for ultrasensitive detection of catechol and luteolin. The HKUST-1 derived CuO NNs were employed as luminophore for the first time, which were successfully fabricated by using HKUST-1
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Advancing amyotrophic lateral sclerosis disease diagnosis: A lab-on-chip electrochemical immunosensor for ultra-sensitive TDP-43 protein detection and monitoring in serum patients’ Talanta (IF 6.1) Pub Date : 2024-03-06 Antonio Turco, Elisabetta Primiceri, Maria Serena Chiriacò, Velia La Pesa, Francesco Ferrara, Nilo Riva, Angelo Quattrini, Alessandro Romano, Giuseppe Maruccio
The global increase in population aging has led to a rise in neurodegenerative diseases (NDs), posing significant challenges to public health. Developing selective and specific biomarkers for early diagnosis and drug development is crucial addressing the growing burden of NDs. In this context, the RNA-binding protein TDP-43 has emerged as a promising biomarker for amyotrophic lateral sclerosis (ALS)
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Surface plasmon resonance-enhanced photoelectrochemical immunoassay with Cu-doped porous Bi2WO6 nanosheets Talanta (IF 6.1) Pub Date : 2024-03-06 Haiyang Wang, Dianyong Tang, Xin Wang, Xinyu Wan, Dianping Tang
The development of rapid screening sensing platforms to improve pre-screening mechanisms in community healthcare is necessary to meet the significant need for portable testing in biomarker diagnostics. Here, we designed a portable smartphone-based photoelectrochemical (PEC) immunoassay for carcinoembryonic antigen (CEA) detection using Cu-doped ultrathin porous BiWO (CuBWO) nanosheets as the photoactive
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Short bridging and partial derivatization synergistically modified β-cyclodextrin bonded chiral stationary phases for improved enantioseparation Talanta (IF 6.1) Pub Date : 2024-03-06 Xinyu Liu, Chang Liu, Jianhao Zhou, Xueru Zhao, Youqing Shen, Hailin Cong, Bing Yu
β-Cyclodextrin (β-CD) and its derivatives have been widely employed in the field of chiral separation, but they are still faced the limitation of low enantioselectivity and complex processes. Derivatization with functional molecules or preparation as bridging dimers are the two main modifications for β-CD to obtain chiral recognition compounds. Herein, a partially derived bridged β-CD (CPI-EBCD) bonded
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Field-effect transistor biosensor with signal amplification by ternary initiation complexes for detection of wide-range RNA concentration Talanta (IF 6.1) Pub Date : 2024-03-06 Hiroki Hayashi, Akihiro Enami, Hiroto Fujita, Shigeki Kuroiwa, Keishi Ohashi, Masayasu Kuwahara, Tetsuya Osaka, Toshiyuki Momma
Electrical detection of RNAs using transistor-based biosensors has attracted attention as a strategy for medical diagnosis and environmental monitoring. Herein, we demonstrated a proof-of-concept for specific, sensitive, and label-free RNA detection using a field-effect transistor (FET) biosensor with signal amplification by ternary initiation complexes (SATIC), which is an isothermal one-step nucleic
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Electrochemical detection of bacterial endotoxin lipopolysaccharide (LPS) on gold electrode modified with DAL-PEG-DK5-PEG-OH - Antimicrobial peptide conjugate Talanta (IF 6.1) Pub Date : 2024-03-05 Paulina Kosikowska-Adamus, Anna Golda, Jacek Ryl, Magdalena Pilarczyk-Żurek, Grzegorz Bereta, Tadeusz Ossowski, Adam Lesner, Joanna Kozieł, Adam Prahl, Paweł Niedziałkowski
This work describes fabrication of gold electrodes modified with peptide conjugate DAL-PEG-DK5-PEG-OH that enables ultra-sensitive detection of lipopolysaccharide (LPS) isolated from the reference strain of O26:B6. The initial step of the established procedure implies immobilization of the fully protected DAL-PEG-DK5-PEG-OH peptide on the surface of the gold electrode previously modified by cysteamine
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Research progress of human key DNA and RNA methylation-related enzymes assay Talanta (IF 6.1) Pub Date : 2024-03-05 Tiantian Ma, Qiongwen Zhang, Shuying Zhang, Dan Yue, Fanting Wang, Yujie Ren, Hengmiao Zhang, Yinuo Wang, Yongjun Wu, Li-e Liu, Fei Yu
Gene methylation-related enzymes (GMREs) are disfunction and aberrantly expressed in a variety of cancers, such as lung, gastric, and pancreatic cancers and have important implications for human health. Therefore,it is critical for early diagnosis and therapy of tumor to develop strategies that allow rapid and sensitive quantitative and qualitative detection of GMREs. With the development of modern
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Development of double-layer poly (amino acid) modified electrochemical sensor for sensitive and direct detection of betamethasone in cosmetics Talanta (IF 6.1) Pub Date : 2024-03-05 Yirong Ma, Xinran Wei, Jiameng Xu, Shuhua Ji, Fan Yang, Aiguo Zeng, Yunzhe Li, Jiliang Cao, Jia Zhang, Zhimin Luo, Qiang Fu
Screening for illegal use of glucocorticoids (GCs) in cosmetics by electrochemical methods is extremely challenging due to the poor electrochemical activity of GCs. In this study, poly-L-Serine/poly-Taurine modified electrode (P(Tau)/P(L-Ser)/GCE) was prepared for sensitive and direct determination of betamethasone in cosmetics by a simple two-step electropolymerization reaction. The relevant parameters
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Electroextraction of methylene blue from aqueous environmental samples using paper points coupled with hollow fiber membranes Talanta (IF 6.1) Pub Date : 2024-03-05 Ricardo Mathias Orlando, Miloš Dvořák, Pavel Kubáň
This article introduces a novel approach by coupling paper points with hollow fiber membrane for electroextraction (PP–HF-EE). The method was innovatively applied to extract methylene blue (MB) from large water volumes (up to 580 mL). A comprehensive study of six key parameters – organic filter, acceptor and donor phase composition, extraction time, applied voltage, and sample volume – was conducted
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High-resolution performance of pillar[6]arene functionalized with imidazolium ionic liquids for gas chromatography Talanta (IF 6.1) Pub Date : 2024-03-05 Tao Sun, Yanli Song, YuanYuan Zhang, Mengyi Ba, Wen Li, Zhiqiang Cai, Shaoqiang Hu, Xianming Liu, Shusheng Zhang
Pillar[]arenes (P[]A, = 5–10) have attracted much attention because of their highly symmetric pillar-shaped architecture with -electron rich cavity. Nevertheless, the use of ionic liquid functionalized P[]A in chromatography has not been reported up to data. This work reports the investigation of the imidazolium ionic liquids functionalized pillar[6]arene (P6A-C10-IM-C8[NTf]) as the stationary phase
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Ratiometric electrochemical immunoassay based on 2D Co/Fe MOF decorated with toluidine blue and Fc-labeled Schiff base for accurate assay of alpha-fetoprotein in clinical serum Talanta (IF 6.1) Pub Date : 2024-03-05 He-Nan Sun, Miao Wang, Hong-Sheng Tan, Hui-Ping Liu, Mingjun Liu, Shan-Shan Li
The high level of alpha-fetoprotein (AFP) expression is closely related to hepatocellular carcinoma (HCC). Herein, a dual signal ratiometric electrochemical immunosensor based on chitosan-ferrocenecarboxaldehyde-spindle gold (Chit-Fc-SAu) and Co/Fe metal-organic framework-toluidine blue/polydopamine (Co/Fe MOF-TB/PDA) was proposed for quantitative analysis of AFP. Specifically, Chit-Fc-SAu worked as
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Aptamer-mediated double strand displacement amplification with microchip electrophoresis for ultrasensitive detection of Salmonella typhimurium Talanta (IF 6.1) Pub Date : 2024-03-05 Yuqi Lu, Qihui Xie, Jingyi Chen, Zhaohui Chu, Fan Zhang, Qingjiang Wang
Rapid and quantitative detection of foodborne bacteria is of great significance to public health. In this work, an aptamer-mediated double strand displacement amplification (SDA) strategy was first explored to couple with microchip electrophoresis (MCE) for rapid and ultrasensitive detection of (). In double-SDA, a bacteria-identified probe consisting of the aptamer (Apt) and trigger sequence (Tr)
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Detection and adsorption of 2-methyl-4-chlorophenoxyacetic acid in vegetables via dual-functional molecularly imprinted polymer doping with carbon dot Talanta (IF 6.1) Pub Date : 2024-03-04 Haiping Wang, Yi Xu, Qingyan Bai, Shujuan Ma, Chunmiao Bo, Junjie Ou
2-Methyl-4-chlorophenoxyacetic acid (MCPA) is one of the most widely used herbicides, so adsorption and detection of MCPA in the environment is critical. Blue fluorescent carbon dot (CD) was synthesized from citric acid and urea, which could be quenched by MCPA. Herein, bifunctional molecularly imprinted polymer (CD@MIP) was prepared on monodisperse poly (glycidyl methacrylate--ethylene glycol dimethacrylate)
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Nanosensor based approaches for quantitative detection of heparin Talanta (IF 6.1) Pub Date : 2024-03-04 Aakanksha Pathak, Nishchay Verma, Shweta Tripathi, Amit Mishra, Krishna Mohan Poluri
Heparin, being a widely employed anticoagulant in numerus clinical complications, requires strict quantification and qualitative screening to ensure the safety of patients from potential threat of thrombocytopenia. However, the intricacy of heparin's chemical structures and low abundance hinders the precise monitoring of its level and quality in clinical settings. Conventional laboratory assays have
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Sulfur defect–engineered Bi2S3–x/In2S3–y mediated signal enhancement of photoelectrochemical sensor for lead ions detection Talanta (IF 6.1) Pub Date : 2024-03-04 Xiang Ren, Man Wang, Jingui Chen, Jinxiu Zhao, Huan Wang, Dan Wu, Rui Xu, Yong Zhang, Huangxian Ju, Qin Wei
Lead ions (Pb) are heavy metal ions that are harmful to living organisms and ecosystems. It is important to realize sensitive detection of Pb in the environment. In this study, a signal enhancement photoelectrochemical (PEC) sensor with high sensitivity was constructed for the detection of Pb. Firstly, to obtain excellent electron transfer performance, sulfur defect–engineered BiS/InS mediated signal
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Metal-organic framework (MOF)-based biosensors for miRNA detection Talanta (IF 6.1) Pub Date : 2024-03-03 Leila Gorgani, Maedeh Mohammadi, Ghasem Najafpour Darzi, Jahan Bakhsh Raoof
MicroRNAs (miRNAs) play several crucial roles in the physiological and pathological processes of the human body. They are considered as important biomarkers for the diagnosis of various disorders. Thus, rapid, sensitive, selective, and affordable detection of miRNAs is of great importance. However, the small size, low abundance, and highly similar sequences of miRNAs impose major challenges to their
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Aptamer inhibitor selection of SpyCas9 through CE-SELEX Talanta (IF 6.1) Pub Date : 2024-03-02 Ge Yang, Huimin Wang, Guangyu Jiang, Liping Zhao, Feng Qu
CRISPR/Cas9 is a natural immune system of archaea and bacteria, which has been widely used in gene editing. In order to better control and improve the accuracy and safety of the system, inhibitors for SpyCas9 as “switches” have been selected for several years. The available inhibitors currently are all natural polypeptides inhibitors derived from phages, except one small molecule inhibitor. These natural
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Determining pyroxasulfone herbicide in honey samples using liquid-liquid extraction with low temperature purification (LLE-LTP) Talanta (IF 6.1) Pub Date : 2024-03-02 Luma Soares Costa, Carolina Freitas Schettino, Lázaro Chaves Sicupira, Gevany Paulino de Pinho, Flaviano Oliveira Silvério
Pyroxasulfone is a selective, systemic, pre-emergence herbicide which acts to inhibit weeds in potato, coffee, sugar cane, eucalyptus, and soybean plantations, among others. This active ingredient was classified by Brazilian legislation as a very dangerous product for the environment, and to date there are no studies involving the development of extraction methods for monitoring this compound in environmental
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Regulating valence states of CuFe-PBA for the simultaneous electrochemical detection of Cd2+, Pb2+ and Hg2+ in food application Talanta (IF 6.1) Pub Date : 2024-03-02 Shan Jin, Jianxiang Pang, Fanpeng Ma, Yikun Cheng, Yunfei Shen, Zemao Xiao, Long Chen
Prussian blue analogues, as prospective electrode materials, play a crucial role in detecting heavy metal ions (HMIs), a process closely related to their electron transfer capacities and active surfaces. Here, etched copper-iron Prussian blue analogues (CuFe-PBA) are synthesized through a combination of flash nanoprecipitation (FNP) and an alkali etching process. Furthermore, this study investigates
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Sustainable beeswax modified cellulose paper for the determination of tricyclic antidepressants in biofluids Talanta (IF 6.1) Pub Date : 2024-03-01 Marisol González-Bermúdez, Ángela I. López-Lorente, Rafael Lucena, Soledad Cárdenas
This article describes the synthesis of sorptive phases for bioanalysis based on the modification of cellulose paper with natural beeswax as sorbent, resulting in a substrate completely renewable and sustainable. The preparation of the sorptive phases consisted of the dissolution of beeswax in hexane, followed by its drop-casting on cellulose paper and subsequent evaporation of the solvent. The beeswax
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A reusable screen-printed carbon electrode-based aptasensor for the determination of chloramphenicol in food and environment samples Talanta (IF 6.1) Pub Date : 2024-03-01 Krittapas Kaewnu, Supatinee Kongkaew, Sasimanas Unajak, Atittaya Hoihuan, Chutikarn Jaengphop, Proespichaya Kanatharana, Panote Thavarungkul, Warakorn Limbut
An electrochemical aptasensor was developed for the determination of chloramphenicol (CAP) in fresh foods and food products. The aptasensor was developed using Prussian blue (PB) and chitosan (CS) film. PB acts as a redox probe for detection and CS acts as a sorption material. The aptamer (Apt) was immobilized on a screen-printed carbon electrode (SPCE) modified with gold nanoparticles (AuNPs). Under
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Double-enhanced sandwich electrochemiluminescence aptasensor based on g-C3N4–Au-luminol nanocomposites and ZnCuS nanosheets for highly sensitive detection of mucin 1 Talanta (IF 6.1) Pub Date : 2024-03-01 Kaida Kuang, Yao Lu, Yang Chen, Pei Zhang, Nengqin Jia
The traditional luminol electrochemiluminescence (ECL) sensing suffers from low signal response and instability issues. Here, an Au/ZnCuS double-enhanced -CN-supported luminol ECL aptasensor is constructed for the sensitive detection of human mucin 1 (MUC1). In this platform, -CN of a large specific surface area is beneficial to load more luminol illuminants. Au nanoparticles promote the decomposition
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Sweat as a source of non-invasive biomarkers for clinical diagnosis: An overview Talanta (IF 6.1) Pub Date : 2024-03-01 Zhiliang Zhang, Zhanhong Li, Kunchen Wei, Zehui Cao, Zhigang Zhu, Rui Chen
Sweat has excellent potential as one of the sources of non-invasive biomarkers for clinical diagnosis. It is relatively easy to collect and process and may contain different disease-specific markers and drug metabolites, making it ideal for various clinical applications. This article discusses the anatomy of sweat glands and their role in sweat production, as well as the history and development of
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High enrichment and measurement of heterocyclic aromatic hydrocarbons from environmental waters with magnetic resorcinol-formaldehyde nanocomposites coupled with high performance liquid chromatography Talanta (IF 6.1) Pub Date : 2024-03-01 Yayan Tong, Yalin Wu, Linchun Nie, Liushan Jiang, Qingxiang Zhou
Heterocyclic aromatic hydrocarbons are concerned pollutants with carcinogenic toxicity, which exist universally in various environmental matrices and have great harm to environmental and human health. In present work, magnetic resorcinol-formaldehyde composites (FeO@SiO@R–F) were fabricated via aldol condensation reaction under alkaline condition. The prepared magnetic materials were examined and analyzed
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Quantitative detecting low concentration polystyrene nanoplastics in aquatic environments via an Ag/Nb2CTx (MXene) SERS substrate Talanta (IF 6.1) Pub Date : 2024-03-01 Lekai Chang, Shuli Bai, Ping Wei, Xingyue Gao, Jinfeng Dong, Bingpu Zhou, Chao Peng, Jianbo Jia, Tiangang Luan
In this study, the plasmonic Ag nanoparticles (Ag NPs) were uniformly anchored on the high conductivity NbC (MXene) nanosheets to construct an Ag/NbC substrate for surface-enhanced Raman spectroscopy (SERS) detection of polystyrene (PS) nanoplastics. The KI addition (0.15 mol/L), the volume ratio between substrate colloid and nanoplastic suspension (2:1), and the mass ratio of NbC in substrate (14%)
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Advancing mass spectrometry-based chemical imaging: A noncontact continuous flow surface probe in mass spectrometry for enhanced signal detection and spatial resolution Talanta (IF 6.1) Pub Date : 2024-03-01 Abdil Ozdemir, Jung-Lee Lin, Mustafa Gulfen, Chung-Hsuan Chen
A new method has been developed for mass spectrometric imaging of small molecules and proteins on tissue or in thinly sliced materials. A laser desorption Venturi electrospray ionization-mass spectrometer was developed for molecular imaging. This method combines laser desorption (LD) and electrospray ionization (ESI) systems before a mass spectrometer (MS). To carry out laser desorption, samples are
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Multiplexed electrochemical nucleic acid sensor based on visible light-mediated metal-free thiol-yne click reaction for simultaneous detection of different nucleic acid targets Talanta (IF 6.1) Pub Date : 2024-03-01 Jinlong Fan, Hanlin Gong, Fan Wang, Li Wang, Yongsheng Yu, Danqing Liu, Weiwei Yang
Simultaneous detection of multiple tumor biomarkers with a simple and low-cost assay is crucial for early cancer detection and diagnosis. Herein, we presented a low-cost and simple assay for multiplexed detection of tumor biomarkers using a spatially separated electrodes strategy. The sensor is fabricated based on a metal-free thiol-yne click reaction, which is mediated by visible light, on commercially
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Scalable synthesis of Au@CeO2 nanozyme for development of colorimetric lateral flow immunochromatographic assay to sensitively detect heart-type fatty acid binding protein Talanta (IF 6.1) Pub Date : 2024-03-01 Haodong Wang, Minghong Jian, Jiwen Fan, Yuquan He, Zhenxin Wang
Nanozymes with core@shell nanostructure are considered promising biolabeling materials for their multifunctional properties. In this work, a simple one-pot strategy has been proposed for scalable synthesis of gold@cerium dioxide core@shell nanoparticles (Au@CeO NPs) with strong localized surface plasmon resonance (LSPR) absorption and high peroxidase-like catalytic activity by redox reactions of Ce
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Green infant formula analysis: Optimizing headspace solid-phase microextraction of carbonyl compounds associated with lipid peroxidation using GC-MS and pentafluorophenylhydrazine derivatization Talanta (IF 6.1) Pub Date : 2024-03-01 Jorge A. Custodio-Mendoza, Ana Lopez Blanco, Ana M. Ares-Fuentes, Antonia M. Carro Díaz
The refinement and optimization of a method combining headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) was successfully performed for the first time to determine seven carbonyl and dicarbonyl compounds, including glyoxal, methylglyoxal, dimethylglyoxal, and malondialdehyde in infant formulae, related to lipid peroxidation. HS-SPME was utilized for simultaneous
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A novel laccase-like Cu-MOF for colorimetric differentiation and detection of phenolic compounds Talanta (IF 6.1) Pub Date : 2024-03-01 Ziyi Gao, Jianping Guan, Meng Wang, Shenghong Liu, Kecen Chen, Qi Liu, Xiaoqing Chen
The development of convenient, fast, and cost-effective methods for differentiating and detecting common organic pollutant phenols has become increasingly important for environmental and food safety. In this study, a copper metal-organic framework (Cu-MOF) with flower-like morphology was synthesized using 2-methylimidazole (2-MI) as ligands. The Cu-MOF was designed to mimic the natural laccase active
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Essential spectral pixels-based improvement of UMAP classifying hyperspectral imaging data to identify minor compounds in food matrix Talanta (IF 6.1) Pub Date : 2024-02-29 Xiangdong Qing, Guiying Lu, Xiaohua Zhang, Qingling Chen, Xiaohong Zhou, Wei He, Ling Xu, Jin Zhang
Classifying big data in hyperspectral imaging (HSI) can be challenging when minor (low-concentrated) compounds are present in actual samples, as for chemical additives and adulterants in food matrix. Herein, we propose a new strategy to classify HSI data for the identification of adulterants in food material for the first time. This strategy is based on the selection of essential spectral pixels of
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Electrochemical bioplatform to manage alpha-gal syndrome by tracking the carbohydrate allergen in meat Talanta (IF 6.1) Pub Date : 2024-02-29 Víctor Ruiz-Valdepeñas Montiel, María Gamella, Marina Blázquez-García, Verónica Serafín, Elena Molina, José M. Pingarrón, Sara Benedé, Susana Campuzano
This work presents the first bioplatform described to date for the determination of galactose-α-1,3-galactose (α-Gal), a non-primate mammalian oligosaccharide responsible for almost all cases of red meat allergy. The bioplatform is based on the implementation of an indirect competitive immunoassay and enzymatic labeling with the enzyme horseradish peroxidase (HRP) built on the surface of magnetic microparticles
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Combining recombinase polymerase amplification with tyrosine modified 2′-deoxyuridine-5′-triphosphate for direct voltammetric detection of double-stranded DNA: Application to potato pathogen Dickeya solani Talanta (IF 6.1) Pub Date : 2024-02-29 Elena V. Suprun, Svetlana A. Khmeleva, Insaf F. Duskaev, Konstantin G. Ptitsyn, Leonid K. Kurbatov, Valeriy E. Shershov, Viktoriya E. Kuznetsova, Sergey A. Lapa, Alexander V. Chudinov, Sergey P. Radko
The approach based on a combination of isothermal recombinase polymerase amplification (RPA), 2′-deoxyuridine-5′-triphosphate modified with tyrosine aromatic group (dUTP-Y1), and direct voltammetric detection of RPA product carrying electroactive labels was successfully applied to the potato pathogen The artificial nucleotide dUTP-Y1 demonstrated a good compatibility with RPA, enabling by targeting
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Modification strategies for semiconductor metal oxide nanomaterials applied to chemiresistive NOx gas sensors: A review Talanta (IF 6.1) Pub Date : 2024-02-29 Jiaxin Lv, Chaoneng Zhang, Guangfei Qu, Keheng Pan, Jin Qin, Kunling Wei, Yuqi Liang
Semiconductor metal oxides (SMOs) nanomaterials are a category of sensing materials that are widely applied to chemiresistive NO gas sensors. However, there is much space to improve the sensing performance of SMOs nanomaterials. Therefore, how to improve the sensing performance of SMOs nanomaterials for NO gases has always attracted the interest of researchers. Up to now, there are few reviews focus