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Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-18 Marco Bertolini, Lorena Mendive-Tapia, Ouldouz Ghashghaei, Abigail Reese, Charles Lochenie, Anna M. Schoepf, Miquel Sintes, Karolina Tokarczyk, Zandile Nare, Andrew D. Scott, Stephen R. Knight, Advait R. Aithal, Amit Sachdeva, Rodolfo Lavilla, Marc Vendrell
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Machine Learning Assisted Hit Prioritization for High Throughput Screening in Drug Discovery ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-15 Davide Boldini, Lukas Friedrich, Daniel Kuhn, Stephan A. Sieber
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“Blue Light, Camera, Action!” ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-13 Paul O’Callaghan, Olof Idevall-Hagren
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Pyrazinone Biosynthesis and Signaling─Myxo Style ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-12 Jeffrey D. Rudolf, Sandra Loesgen
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Reversibly Sticking Metals and Graphite to Hydrogels and Tissues ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-13 Wenhao Xu, Faraz A. Burni, Srinivasa R. Raghavan
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Sequence- and Structure-Specific tRNA Dihydrouridylation by hDUS2 ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-12 Jingwei Ji, Nathan J. Yu, Ralph E. Kleiner
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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-11 Miroslav Kosar, Roman C. Sarott, David A. Sykes, Alexander E. G. Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L. Z. Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J. Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J. McCormick, Tian Hua, Christian W. Gruber, Dmitry B. Veprintsev, James A. Frank, Uwe Grether, Erick M. Carreira
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Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-06 Nicholas L. Truex, Somesh Mohapatra, Mariane Melo, Jacob Rodriguez, Na Li, Wuhbet Abraham, Deborah Sementa, Faycal Touti, Derin B. Keskin, Catherine J. Wu, Darrell J. Irvine, Rafael Gómez-Bombarelli, Bradley L. Pentelute
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ZeoSyn: A Comprehensive Zeolite Synthesis Dataset Enabling Machine-Learning Rationalization of Hydrothermal Parameters ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-06 Elton Pan, Soonhyoung Kwon, Zach Jensen, Mingrou Xie, Rafael Gómez-Bombarelli, Manuel Moliner, Yuriy Román-Leshkov, Elsa Olivetti
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Molecular Deformation Is a Key Factor in Screening Aggregation Inhibitor for Intrinsically Disordered Protein Tau ACS Cent. Sci. (IF 18.2) Pub Date : 2024-03-05 Keke Chai, Jian Yang, Ying Tu, Junjie Wu, Kang Fang, Shuo Shi, Tianming Yao
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Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-29 Ye Wang, Katherine J. Torma, Joshua B. Pyser, Paul M. Zimmerman, Alison R. H. Narayan
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Electronic Excited States from Physically Constrained Machine Learning ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-29 Edoardo Cignoni, Divya Suman, Jigyasa Nigam, Lorenzo Cupellini, Benedetta Mennucci, Michele Ceriotti
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Synthesis and Single Crystal X-ray Diffraction Structure of an Indium Arsenide Nanocluster ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-28 Soren F. Sandeno, Sebastian M. Krajewski, Ryan A. Beck, Werner Kaminsky, Xiaosong Li, Brandi M. Cossairt
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Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-27 Anna Charalampidou, Thomas Nehls, Christian Meyners, Satish Gandhesiri, Sebastian Pomplun, Bradley L. Pentelute, Frederik Lermyte, Felix Hausch
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Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-27 Peng-Hsun Chase Chen, Xuejiao Shirley Guo, Hanyuan Eric Zhang, Gopal K. Dubey, Zhi Zachary Geng, Carol A. Fierke, Shiqing Xu, J. Trae Hampton, Wenshe Ray Liu
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Dynamic Manipulation of Droplets on Liquid-Infused Surfaces Using Photoresponsive Surfactant ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-27 Xichen Liang, Kseniia M. Karnaukh, Lei Zhao, Serena Seshadri, Austin J. DuBose, Sophia J. Bailey, Qixuan Cao, Marielle Cooper, Hao Xu, Michael Haggmark, Matthew E. Helgeson, Michael Gordon, Paolo Luzzatto-Fegiz, Javier Read de Alaniz, Yangying Zhu
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A Conversation with Leslie Schoop ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-27 Sam Lemonick
Solid-state chemist describes debunking claims that LK-99 was a room-temperature superconductor.
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Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-26 Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, Nathanael S. Gray
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A Novel Molten Salt Mediated Synthesis of Mesoporous Metal Oxides with High Crystallization ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-26 Dongsheng Ma, Hanpeng Lu, Yu Zhou, Shuaihu Jiang, Duan Wang, Qin Yue
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Interfacial Charge Transfer Regulates Photoredox Catalysis ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-25 Chen Ye, De-Shan Zhang, Bin Chen, Chen-Ho Tung, Li-Zhu Wu
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Mannosylated STING Agonist Drugamers for Dendritic Cell-Mediated Cancer Immunotherapy ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-23 Dinh Chuong Nguyen, Kefan Song, Simbarashe Jokonya, Omeed Yazdani, Drew L. Sellers, Yonghui Wang, ABM Zakaria, Suzie H. Pun, Patrick S. Stayton
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A Multidisciplinary Structural Approach to the Identification of the Haemophilus influenzae Type b Capsular Polysaccharide Protective Epitope ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-22 Francesca Nonne, Lucia Dello Iacono, Sara Bertuzzi, Luca Unione, Daniela Proietti, Nathalie Norais, Immaculada Margarit, Roberto Adamo, Jesús Jiménez-Barbero, Filippo Carboni, Maria Rosaria Romano
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Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-21 Jian Zou, Zuo-Cheng Qiu, Qiang-Qiang Yu, Jia-Ming Wu, Yong-Heng Wang, Ke-Da Shi, Yi-Fang Li, Rong-Rong He, Ling Qin, Xin-Sheng Yao, Xin-Luan Wang, Hao Gao
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Unraveling and Resolving the Inconsistencies in Tafel Analysis for Hydrogen Evolution Reactions ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-20 Chengzhang Wan, Yansong Ling, Sibo Wang, Heting Pu, Yu Huang, Xiangfeng Duan
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A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug Discovery ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-20 Arnaud Gaudry, Marco Pagni, Florence Mehl, Sébastien Moretti, Luis-Manuel Quiros-Guerrero, Luca Cappelletti, Adriano Rutz, Marcel Kaiser, Laurence Marcourt, Emerson Ferreira Queiroz, Jean-Robert Ioset, Antonio Grondin, Bruno David, Jean-Luc Wolfender, Pierre-Marie Allard
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Electrochemical Synthesis of Sound: Hearing the Electrochemical Double Layer ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-19 Megan Kelly, Bill Yan, Christine Lucky, Marcel Schreier
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Natural Product Synthesis in the 21st Century: Beyond the Mountain Top ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-14 Ryan A. Shenvi
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The Challenges of Working with Legacy NMRs ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-14 Celia Arnaud
Nearly a decade after Agilent stopped making the instruments, researchers work to keep old systems running.
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Stabilizing the Catalyst Layer for Durable and High Performance Alkaline Membrane Fuel Cells and Water Electrolyzers ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-15 Chuan Hu, Hyun Woo Kang, Seung Won Jung, Xiaohua Zhang, Young Jun Lee, Na Yoon Kang, Chi Hoon Park, Young Moo Lee
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A Conversation with Loreto Paulino Jr. ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-15 Robin Meadows
After finishing college in Guam, Paulino went straight to Alaska to investigate how beavers are changing the Arctic.
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Protein Structure-Based Organic Chemistry-Driven Ligand Design from Ultralarge Chemical Spaces ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-13 François Sindt, Anthony Seyller, Merveille Eguida, Didier Rognan
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Spiro-strain Takes Chemiluminescence to Flash-Mode ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-15 Sujit Kumar Das, Ankona Datta
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Archaea-Inspired Switchable Nanochannels for On-Demand Lithium Detection by pH Activation ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-13 Yang Liu, Yongchao Qian, Lin Fu, Congcong Zhu, Xin Li, Qingchen Wang, Haoyang Ling, Huaqing Du, Shengyang Zhou, Xiang-Yu Kong, Lei Jiang, Liping Wen
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Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-10 Huang Chen, Aiwu Bian, Wenbo Zhou, Ying Miao, Jiangnan Ye, Jiahui Li, Peng He, Qiansen Zhang, Yue Sun, Zhenliang Sun, Chaowen Ti, Yihua Chen, Zhengfang Yi, Mingyao Liu
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From Functional Fatty Acids to Potent and Selective Natural-Product-Inspired Mimetics via Conformational Profiling ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-12 Lauren E. Markham, Thomas Koelblen, Harry R. Chobanian, Ariele Viacava Follis, Thomas P. Burris, Glenn C. Micalizio
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Deciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-07 Le-Le Zhu, Qingyu Yang, De-Gao Wang, Luo Niu, Zhuo Pan, Shengying Li, Yue-Zhong Li, Wei Zhang, Changsheng Wu
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A Unified Description of Salt Effects on the Liquid–Liquid Phase Separation of Proteins ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-08 Chao Duan, Rui Wang
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Zoogeochemists Measure How Muddy Animals Change Their Environments’ Chemistry ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-08 Robin Donovan
As climate change accelerates, small populations are influencing ecosystems more than they used to.
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Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-07 Cristina Di Carluccio, Linda Cerofolini, Miguel Moreira, Frédéric Rosu, Luis Padilla-Cortés, Giulia Roxana Gheorghita, Zhuojia Xu, Abhishek Santra, Hai Yu, Shinji Yokoyama, Taylor E. Gray, Chris D. St. Laurent, Yoshiyuki Manabe, Xi Chen, Koichi Fukase, Matthew S. Macauley, Antonio Molinaro, Tiehai Li, Barbara A. Bensing, Roberta Marchetti, Valérie Gabelica, Marco Fragai, Alba Silipo
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Metals in Cancer Research: Beyond Platinum Metallodrugs ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-07 Angela Casini, Alexander Pöthig
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Discovery of a Monoclonal Antibody That Targets Cell-Surface Pseudaminic Acid of Acinetobacter baumannii with Direct Bactericidal Effect ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-07 Xuemei Yang, Ruohan Wei, Han Liu, Tongyao Wei, Ping Zeng, Yan Chu Cheung, Heng Heng, Edward Waichi Chan, Xuechen Li, Sheng Chen
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Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-05 Jason Yang, Francesca-Zhoufan Li, Frances H. Arnold
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Machine Learning to Develop Peptide Catalysts─Successes, Limitations, and Opportunities ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-05 Tobias Schnitzer, Martin Schnurr, Andrew F. Zahrt, Nader Sakhaee, Scott E. Denmark, Helma Wennemers
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Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex ACS Cent. Sci. (IF 18.2) Pub Date : 2024-02-01 Meranda M. Masse, Rachel B. Hutchinson, Christopher E. Morgan, Heather J. Allaman, Hongqing Guan, Edward W. Yu, Silvia Cavagnero
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Ultralow Background Membrane Editors for Spatiotemporal Control of Phosphatidic Acid Metabolism and Signaling ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-30 Xiang-Ling Li, Reika Tei, Masaaki Uematsu, Jeremy M. Baskin
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Construction of Layer-Blocked Covalent Organic Framework Heterogenous Films via Surface-Initiated Polycondensations with Strongly Enhanced Photocatalytic Properties ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-29 Yuxiang Zhao, Shengfei Li, Guangen Fu, Haoyong Yang, Shengxu Li, Daheng Wu, Tao Zhang
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Creation of Cationic Polymeric Nanotrap Featuring High Anion Density and Exceptional Alkaline Stability for Highly Efficient Pertechnetate Removal from Nuclear Waste Streams ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-31 Bin Wang, Jie Li, Hongliang Huang, Bin Liang, Yin Zhang, Long Chen, Kui Tan, Zhifang Chai, Shuao Wang, Joshua T. Wright, Robert W. Meulenberg, Shengqian Ma
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High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-30 Saaya Hario, Giang N. T. Le, Hikaru Sugimoto, Kei Takahashi-Yamashiro, Suguru Nishinami, Hirofumi Toda, Selene Li, Jonathan S. Marvin, Shinya Kuroda, Mikhail Drobizhev, Takuya Terai, Yusuke Nasu, Robert E. Campbell
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Exploring Chemical Space Using Ab Initio Hyperreactor Dynamics ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-30 Alexandra Stan-Bernhardt, Liubov Glinkina, Andreas Hulm, Christian Ochsenfeld
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Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-29 Ivy A. Guan, Joanna S. T. Liu, Renata C. Sawyer, Xiang Li, Wanting Jiao, Yannasittha Jiramongkol, Mark D. White, Lejla Hagimola, Freda H. Passam, Denise P. Tran, Xiaoming Liu, Simone M. Schoenwaelder, Shaun P. Jackson, Richard J. Payne, Xuyu Liu
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Silanol-Assisted High-Yield Nanofabrication of SnO2 Single Crystals with Highly Tunable and Ordered Mesoporosity ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-29 Shoukang Xiao, Li Wang, Ze Qin, Xiao Chen, Liyu Chen, Yingwei Li, Kui Shen
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Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-27 Haiyang Su, Yuanlin Song, Shouzhi Yang, Ziyue Zhang, Yao Shen, Lan Yu, Shujing Chen, Lei Gao, Cuicui Chen, Dongni Hou, Xinping Wei, Xuedong Ma, Pengyu Huang, Dejun Sun, Jian Zhou, Kun Qian
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Cellular Repair of Synthetic Analogs of Oxidative DNA Damage Reveals a Key Structure–Activity Relationship of the Cancer-Associated MUTYH DNA Repair Glycosylase ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-26 Savannah G. Conlon, Cindy Khuu, Carlos H. Trasviña-Arenas, Tian Xia, Michelle L. Hamm, Alan G. Raetz, Sheila S. David
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Correction to “Quantification and Mapping of Alkylation in the Human Genome Reveal Single Nucleotide Resolution Precursors of Mutational Signatures” ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-25 Yang Jiang, Cécile Mingard, Sabrina M. Huber, Vakil Takhaveev, Maureen McKeague, Seiichiro Kizaki, Mirjam Schneider, Nathalie Ziegler, Vera Hürlimann, Julia Hoeng, Nicolas Sierro, Nikolai V. Ivanov, Shana J. Sturla
The funding statement is amended to clarify the independent nature of projects from which results are reported in the article: We acknowledge funding from Philip Morris International and funding from the Swiss National Science Foundation (185020, 186332), which funded independent research projects. This article has not yet been cited by other publications.
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Celebrating the 10th Anniversary of ACS Central Science ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-24 Carolyn R. Bertozzi, Kirk S. Schanze
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Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7 ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-24 Yating Liu, Mengkun Yan, Minghui Wang, Shiwei Luo, Shasha Wang, Yawen Luo, Zhuojia Xu, Wenjing Ma, Liuqing Wen, Tiehai Li
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A Layered Organic Cathode for High-Energy, Fast-Charging, and Long-Lasting Li-Ion Batteries ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-18 Tianyang Chen, Harish Banda, Jiande Wang, Julius J. Oppenheim, Alessandro Franceschi, Mircea Dincǎ
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Highly Enantioselective Catalysis by Enzyme Encapsulated in Metal Azolate Frameworks with Micelle-Controlled Pore Sizes ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-18 Hao Ren, Jian Yuan, Yi-Ming Li, Wen-Jing Li, Yi-Hang Guo, Yi-Bo Zhang, Bing-Hao Wang, Kaili Ma, Lu Peng, Guping Hu, Wen-Qi Wang, Hailong He, Lien-Yang Chou, Ming-Hua Zeng, Yue-Biao Zhang, Lin Cheng
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Hydrogen–Deuterium Exchange Mass Spectrometry Identifies Local and Long-Distance Interactions within the Multicomponent Radical SAM Enzyme, PqqE ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-17 Wen Zhu, Anthony T. Iavarone, Judith P. Klinman
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Pseudo-Luciferase Activity of the SARS-CoV-2 Spike Protein for Cypridina Luciferin ACS Cent. Sci. (IF 18.2) Pub Date : 2024-01-17 Ryo Nishihara, Hisham M. Dokainish, Yoshiki Kihara, Hiroki Ashiba, Yuji Sugita, Ryoji Kurita