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Systems biology of B cells in COVID-19 Semin. Immunol. (IF 7.8) Pub Date : 2024-03-14 Matthew C. Woodruff, Caterina E. Faliti, Ignacio Sanz
The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. Particularly in the area of B cell biology, tremendous efforts in both
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Systems analysis of innate and adaptive immunity in Long COVID Semin. Immunol. (IF 7.8) Pub Date : 2024-03-08 Michael J. Peluso, Mohamed Abdel-Mohsen, Timothy J. Henrich, Nadia R. Roan
Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the management of Long COVID (LC), an infection-associated chronic condition that has been estimated to affect 5–20% of individuals following SARS-CoV-2 infection, remains challenging due to our limited understanding
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Introduction to the special issue: B cells in cancer immunosurveillance Semin. Immunol. (IF 7.8) Pub Date : 2024-03-05 Jose R. Conejo-Garcia, Paulo C. Rodriguez
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Toolkit for mapping the clonal landscape of tumor-infiltrating B cells Semin. Immunol. (IF 7.8) Pub Date : 2024-01-31 E.O. Serebrovskaya, E.A. Bryushkova, D.K. Lukyanov, N.V. Mushenkova, D.M. Chudakov, M.A. Turchaninova
Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor - in distinct cancers, subcohorts and individual patients - is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up
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Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond Semin. Immunol. (IF 7.8) Pub Date : 2024-01-24 Evangelos Andreakos
Type I and type III interferons (IFNs) constitute a key antiviral defense systems of the body, inducing viral resistance to cells and mediating diverse innate and adaptive immune functions. Defective type I and type III IFN responses have recently emerged as the 'Achilles heel' in COVID-19, with such patients developing severe disease and exhibiting a high risk for critical pneumonia and death. Here
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To die or not to die: Gasdermins in intestinal health and disease Semin. Immunol. (IF 7.8) Pub Date : 2024-01-16 Zhaoyu Lin, Qianyue Chen, Hai-Bin Ruan
Intestinal homeostasis is achieved by the balance among intestinal epithelium, immune cells, and gut microbiota. Gasdermins (GSDMs), a family of membrane pore forming proteins, can trigger rapid inflammatory cell death in the gut, mainly pyroptosis and NETosis. Importantly, there is increasing literature on the non-cell lytic roles of GSDMs in intestinal homeostasis and disease. While GSDMA is low
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Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases Semin. Immunol. (IF 7.8) Pub Date : 2024-01-13 Susana G. Rodrigues, Schalk van der Merwe, Aleksander Krag, Reiner Wiest
Abstract not available
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Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy Semin. Immunol. (IF 7.8) Pub Date : 2023-11-29 Christine Moussion, Lélia Delamarre
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major histocompatibility complex class I molecules for presentation to CD8+ T cells. This process, called cross-presentation, is essential for initiating
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Introduction to the special issue: Antigen cross-presentation Semin. Immunol. (IF 7.8) Pub Date : 2023-11-08 Peter van Endert
Abstract not available
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Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis Semin. Immunol. (IF 7.8) Pub Date : 2023-11-06 Léonie Dejas, Karin Santoni, Etienne Meunier, Mohamed Lamkanfi
Neutrophils are among the most abundant immune cells, representing about 50%− 70% of all circulating leukocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play an essential role in host defense against infections. They exert microbicidal activity through a variety of specialized effector mechanisms, including phagocytosis, production of reactive oxygen species, degranulation and
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Regulatory T cells in allergic inflammation Semin. Immunol. (IF 7.8) Pub Date : 2023-10-12 Mehdi Benamar, Qian Chen, Monica Martinez-Blanco, Talal A. Chatila
Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially
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Chemical modulation of gasdermin D activity: Therapeutic implications and consequences Semin. Immunol. (IF 7.8) Pub Date : 2023-10-08 Bowen Zhou, Derek W. Abbott
The gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most well-studied member gasdermin D can be proteolyzed, typically by caspases, to generate an active pore-forming N-terminal domain. At least well-studied three pharmacological inhibitors (necrosulfonamide, disulfiram, dimethyl fumarate) since 2018 have
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The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions Semin. Immunol. (IF 7.8) Pub Date : 2023-10-04 Duygu Yazici, Ismail Ogulur, Yagiz Pat, Huseyn Babayev, Elena Barletta, Sena Ardicli, Manal Bel imam, Mengting Huang, Jana Koch, Manru Li, Debbie Maurer, Urszula Radzikowska, Pattraporn Satitsuksanoa, Stephan R. Schneider, Na Sun, Stephan Traidl, Alexandra Wallimann, Sebastian Wawrocki, Damir Zhakparov, Danielle Fehr, Cezmi A. Akdis
Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing to the current pandemic in allergic, autoimmune and metabolic diseases. The "Epithelial Barrier Theory" postulates that these diseases are exacerbated by persistent periepithelial inflammation (epithelitis) triggered by exposure to a wide range of epithelial barrier-damaging
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The noncanonical inflammasome-induced pyroptosis and septic shock. Semin. Immunol. (IF 7.8) Pub Date : 2023-09-29 Junru Wu,Jingjing Cai,Yiting Tang,Ben Lu
Sepsis remains one of the most common and lethal conditions globally. Currently, no proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth understanding of the pathogenesis of sepsis is needed to propel the discovery of effective treatment. Recently attention to sepsis has intensified because of a growing recognition of a non-canonical inflammasome-triggered lytic
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The immunology and cell biology of T cell aging. Semin. Immunol. (IF 7.8) Pub Date : 2023-09-28 Jörg J Goronzy,Nan-Ping Weng
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Beyond youth: Understanding CAR T cell fitness in the context of immunological aging Semin. Immunol. (IF 7.8) Pub Date : 2023-09-18 Julia Han Noll, Bruce L. Levine, Carl H. June, Joseph A. Fraietta
Population aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular
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Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS Semin. Immunol. (IF 7.8) Pub Date : 2023-09-15 Djamel Nehar-Belaid, Mark Sokolowski, Sathyabaarathi Ravichandran, Jacques Banchereau, Damien Chaussabel, Duygu Ucar
Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical
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Epigenetic and transcriptional control of gasdermins Semin. Immunol. (IF 7.8) Pub Date : 2023-09-11 Cristhian Cadena, Opher S. Kornfeld, Bettina L. Lee, Nobuhiko Kayagaki
Cells undergo an inflammatory programmed lytic cell death called ‘pyroptosis’ (with the Greek roots ‘fiery’), often featuring morphological hallmarks such as large ballooning protrusions and subsequent bursting. Originally described as a caspase-1-dependent cell death in response to bacterial infection, pyroptosis has since been re-defined in 2018 as a cell death dependent on plasma membrane pores
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Proteostasis in T cell aging Semin. Immunol. (IF 7.8) Pub Date : 2023-09-12 A. Elisabeth Gressler, Houfu Leng, Heidi Zinecker, Anna Katharina Simon
Aging leads to a decline in immune cell function, which leaves the organism vulnerable to infections and age-related multimorbidities. One major player of the adaptive immune response are T cells, and recent studies argue for a major role of disturbed proteostasis contributing to reduced function of these cells upon aging. Proteostasis refers to the state of a healthy, balanced proteome in the cell
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Better safe than sorry: Naive T-cell dynamics in healthy ageing Semin. Immunol. (IF 7.8) Pub Date : 2023-09-14 Rob J. de Boer, Kiki Tesselaar, José A.M. Borghans
It is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible
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Thymus aging and immune reconstitution, progresses and challenges Semin. Immunol. (IF 7.8) Pub Date : 2023-08-31 Yue Ru Li, Juan Carlos Zúñiga-Pflücker
Thymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prominent feature of immune senescence. The thymus undergoes rapid growth during fetal and neonatal development, peaks in size before puberty and then begins to undergo a decrease in cellularity with age. Dramatic changes occur with age-associated thymic involution. The most prominent
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The paradox of aging: Aging-related shifts in T cell function and metabolism Semin. Immunol. (IF 7.8) Pub Date : 2023-08-31 Kylie M. Quinn, Daniela M. Vicencio, Nicole L. La Gruta
T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct cellular metabolic states. The ability of T cells to readily transition between metabolic states enables flexibility to meet the changing energy demands defined by distinct effector states or T cell lineages. Immune aging is characterized, in part, by the loss of naïve T cells, accumulation of senescent
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T cell control of SARS-CoV-2: When, which, and where? Semin. Immunol. (IF 7.8) Pub Date : 2023-08-29 Mariana O. Diniz, Mala K. Maini, Leo Swadling
Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider
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Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging Semin. Immunol. (IF 7.8) Pub Date : 2023-08-29 Sandip Ashok Sonar, Makiko Watanabe, Janko Ž. Nikolich
Aging is characterized by progressive loss of organ and tissue function, and the immune system is no exception to that inevitable principle. Of all the age-related changes in the body, reduction of the size of, and naïve T (Tn) cell output from, the thymus occurs earliest, being prominent already before or by the time of puberty. Therefore, to preserve immunity against new infections, over much of
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Gasdermins and cancers Semin. Immunol. (IF 7.8) Pub Date : 2023-08-28 Junwei Hou, Tiansheng Li, Jung-Mao Hsu, Xin Zhang, Mien-Chie Hung
The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which
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Enteric neuro-immune interactions in intestinal health and disease Semin. Immunol. (IF 7.8) Pub Date : 2023-08-25 Lies van Baarle, Michelle Stakenborg, Gianluca Matteoli
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Accumulation of immune-suppressive CD4 + T cells in aging – tempering inflammaging at the expense of immunity Semin. Immunol. (IF 7.8) Pub Date : 2023-08-24 Alyssa L. Thomas, Alzbeta Godarova, Joseph A. Wayman, Emily R. Miraldi, David A. Hildeman, Claire A. Chougnet
The 'immune risk profile' has been shown to predict mortality in the elderly, highlighting the need to better understand age-related immune dysfunction. While aging leads to many defects affecting all arms of the immune system, this review is focused on the accrual of immuno-suppressive CD4 + T cell populations, including FoxP3 + regulatory T cells, and subsets of IL-10-producing T follicular helper
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The role of caspase-8 in inflammatory signalling and pyroptotic cell death Semin. Immunol. (IF 7.8) Pub Date : 2023-08-23 Jiyi Pang, James E. Vince
The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8, a cysteine-aspartic acid protease typically associated with activating caspase-3 and − 7 to induce apoptosis. However, recent research has revealed that caspase-8 also plays a role in regulating the lytic gasdermin
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T cell control of inflammaging Semin. Immunol. (IF 7.8) Pub Date : 2023-08-21 Irina Shchukina, Pavla Bohacova, Maxim N. Artyomov
T cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation – a hallmark
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Aging of lymphoid stromal architecture impacts immune responses Semin. Immunol. (IF 7.8) Pub Date : 2023-08-10 Jessica N. Lancaster
The secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A growing body of research suggests that the aged tissue microenvironment can contribute to decreased immune function, independent of intrinsic changes to hematopoietic cells with age. Stromal cells impart structural integrity, facilitate fluid transport
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Epithelial inflammasomes, gasdermins, and mucosal inflammation – Lessons from Salmonella and Shigella infected mice Semin. Immunol. (IF 7.8) Pub Date : 2023-08-08 Ersin Gül, Stefan A. Fattinger, Mikael E. Sellin, Wolf-Dietrich Hardt
Besides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion
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Immune aging – A mechanism in autoimmune disease Semin. Immunol. (IF 7.8) Pub Date : 2023-08-04 Yanyan Zheng, Qingxiang Liu, Jorg J. Goronzy, Cornelia M. Weyand
Evidence is emerging that the process of immune aging is a mechanism leading to autoimmunity. Over lifetime, the immune system adapts to profound changes in hematopoiesis and lymphogenesis, and progressively restructures in face of an ever-expanding exposome. Older adults fail to generate adequate immune responses against microbial infections and tumors, but accumulate aged T cells, B cells and myeloid
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Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging Semin. Immunol. (IF 7.8) Pub Date : 2023-08-01 Ayako Kurioka, Paul Klenerman
Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non-polymorphic antigen presenting molecules and rapid effector functions that are pre-programmed during their development. Here we review current knowledge
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Inflammasomes as regulators of non-infectious disease Semin. Immunol. (IF 7.8) Pub Date : 2023-07-26 Daniel Okin, Jonathan C. Kagan
Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components
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Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions Semin. Immunol. (IF 7.8) Pub Date : 2023-07-27 Nan-ping Weng
A vast array of αβ T cell receptors (TCRs) is generated during T cell development in the thymus through V(D)J recombination, which involves the rearrangement of multiple V, D, and J genes and the pairing of α and β chains. These diverse TCRs provide protection to the human body against a multitude of foreign pathogens and internal cancer cells. The entirety of TCRs present in an individual's T cells
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T cell fate decisions during memory cell generation with aging Semin. Immunol. (IF 7.8) Pub Date : 2023-07-24 Ines Sturmlechner, Abhinav Jain, Yunmei Mu, Cornelia M. Weyand, Jörg J. Goronzy
The defense against infectious diseases, either through natural immunity or after vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T cells are at the center of memory T cell generation during primary responses. Upon activation, they undergo a complex, highly regulated differentiation process towards different functional states. Naïve T cells maintained into
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Microbial gasdermins: More than a billion years of pyroptotic-like cell death Semin. Immunol. (IF 7.8) Pub Date : 2023-07-20
In the recent past, the concept of immunity has been extended to eukaryotic and prokaryotic microorganisms, like fungi and bacteria. The latest findings have drawn remarkable evolutionary parallels between metazoan and microbial defense-related genes, unveiling a growing number of shared transkingdom components of immune systems. One such component is the gasdermin family of pore-forming proteins –
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Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire Semin. Immunol. (IF 7.8) Pub Date : 2023-07-19
Pyroptosis is a form of programmed cell death associated with activation of inflammasomes and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the plasma membrane), and selective release of proinflammatory mediators. Induction of pyroptosis results in amplification of inflammation, contributing to the pathogenesis of chronic cardiovascular diseases such as atherosclerosis
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The gut mucus network: A dynamic liaison between microbes and the immune system Semin. Immunol. (IF 7.8) Pub Date : 2023-07-19
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Unconventional protein secretion by gasdermin pores Semin. Immunol. (IF 7.8) Pub Date : 2023-07-18
Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which coordinate host defense and inflammatory responses
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Mitochondria during T cell aging Semin. Immunol. (IF 7.8) Pub Date : 2023-07-18
Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is characterized by alterations of the mitochondrial DNA, reduced respiratory capacity, decreased mitochondrial membrane potential and increased reactive oxygen species production. These primary alterations disrupt other interconnected and important mitochondrial-related processes such as metabolism, mitochondrial
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B cells and the intestinal microbiome in time, space and place Semin. Immunol. (IF 7.8) Pub Date : 2023-07-18
The gut immune system is shaped by the continuous interaction with the microbiota. Here we dissect temporal, spatial and contextual layers of gut B cell responses. The microbiota impacts on the selection of the developing pool of pre-immune B cells that serves as substrate for B cell activation, expansion and differentiation. However, various aspects of the gut B cell response display unique features
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Pyroptosis and the cellular consequences of gasdermin pores Semin. Immunol. (IF 7.8) Pub Date : 2023-07-10 Hanna C. Huston, Marisa J. Anderson, Susan L. Fink
The family of gasdermin proteins plays a key role in the host response against external and internal pathogenic signals by mediating the form of inflammatory regulated cell death known as pyroptosis. One of the most well-studied gasdermins within innate immunity is gasdermin D, which is cleaved, oligomerizes, and forms plasma membrane pores. Gasdermin D pores lead to a number of downstream cellular
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Pyroptosis in defense against intracellular bacteria Semin. Immunol. (IF 7.8) Pub Date : 2023-07-08 Lupeng Li, Mary S. Dickinson, Jörn Coers, Edward A. Miao
Pathogenic microbes invade the human body and trigger a host immune response to defend against the infection. In response, host-adapted pathogens employ numerous virulence strategies to overcome host defense mechanisms. As a result, the interaction between the host and pathogen is a dynamic process that shapes the evolution of the host's immune response. Among the immune responses against intracellular
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Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases Semin. Immunol. (IF 7.8) Pub Date : 2023-07-04 Jeremy A. O’Sullivan, Bradford A. Youngblood, Robert P. Schleimer, Bruce S. Bochner
Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged by specific ligands or ligand-mimicking molecules. As a result, Siglec engagement is now of interest as a strategy to therapeutically dampen unwanted cellular responses. When considering allergic inflammation, human
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The gut-brain vascular axis in neuroinflammation Semin. Immunol. (IF 7.8) Pub Date : 2023-07-07 Sara Carloni, Maria Rescigno
The multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well as of distal organs, including the central nervous system. Microbial dysbiosis is reported in several inflammatory intestinal diseases characterized by the impairment of the gut epithelial and vascular barriers, defined as leaky gut, and it is reported
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Pyroptosis modulation by bacterial effector proteins Semin. Immunol. (IF 7.8) Pub Date : 2023-07-03 Qiyao Chai, Zehui Lei, Cui Hua Liu
Pyroptosis is a proinflammatory form of programmed cell death featured with membrane pore formation that causes cellular swelling and allows the release of intracellular inflammatory mediators. This cell death process is elicited by the activation of the pore-forming proteins named gasdermins, and is intricately orchestrated by diverse regulatory factors in mammalian hosts to exert a prompt immune
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Contributions of the early-life microbiome to childhood atopy and asthma development Semin. Immunol. (IF 7.8) Pub Date : 2023-06-26 Holly Steininger, Jacqueline Moltzau-Anderson, Susan V. Lynch
The rapid rise in atopy and asthma in industrialized nations has led to the identification of early life environmental factors that promote these conditions and spurred research into how such exposures may mediate the trajectory to childhood disease development. Over the past decade, the human microbiome has emerged as a key determinant of human health. This is largely due to the increasing appreciation
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Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination Semin. Immunol. (IF 7.8) Pub Date : 2023-06-26 Michelle A. Linterman
Vaccination is an excellent strategy to limit the morbidity and mortality associated with infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by inducing the germinal centre response, an intricate immune reaction that produces memory B cells and long-lived antibody-secreting plasma cells that provide protection against (re)infection. The magnitude and quality of
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Harnessing the power of oncolytic virotherapy and tertiary lymphoid structures to amplify antitumor immune responses in cancer patients Semin. Immunol. (IF 7.8) Pub Date : 2023-06-23 Ana Houel, Johann Foloppe, Marie-Caroline Dieu-Nosjean
Tertiary lymphoid structures (TLS) are ectopic aggregates of immune cells that develop in non-lymphoid tissues under persistent inflammation. Since their presence has been associated with a better prognosis in cancer patients, modulating TLS formation is being part of new challenges in immunotherapy. Although mechanisms underlying TLS genesis are still not fully understood, different strategies have
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Pyroptosis-induced inflammation and tissue damage Semin. Immunol. (IF 7.8) Pub Date : 2023-06-21 Swathy O. Vasudevan, Bharat Behl, Vijay A. Rathinam
Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-forming proteins. The cleavage of gasdermins by specific proteases enables their pore-forming activity. The activation of the prototype member of the gasdermin family, gasdermin D (GSDMD), is linked to innate immune monitoring by inflammasomes. Additional gasdermins such as GSDMA, GSDMB, GSDMC, and GSDME are activated
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Introduction to the Special Issue: The Immunopeptidome Semin. Immunol. (IF 7.8) Pub Date : 2023-06-20 Étienne Caron, Claude Perreault
Abstract not available
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T follicular helper cells in cancer, tertiary lymphoid structures, and beyond Semin. Immunol. (IF 7.8) Pub Date : 2023-06-19 Can Cui, Joseph Craft, Nikhil S. Joshi
With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in
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Immune responses to SARS-CoV-2 infection and vaccination in children Semin. Immunol. (IF 7.8) Pub Date : 2023-06-20 Petter Brodin
During the three years since SARS-CoV-2 infections were first described a wealth of information has been gathered about viral variants and their changing properties, the disease presentations they elicit and how the many vaccines developed in record time protect from COVID-19 severe disease in different populations. A general theme throughout the pandemic has been the observation that children and
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Pyroptosis: A road to next-generation cancer immunotherapy Semin. Immunol. (IF 7.8) Pub Date : 2023-06-09 Yiliang Fang, Yaxing Tang, Bo Huang
The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity, especially by mobilizing tumor-reactive CD8+T cells. Pyroptosis, programmed lytic cell death mediated by gasdermin (GSDM), results in the release of cellular antigens, damage-associated molecular patterns (DAMPs) and cytokines. Therefore, pyroptotic tumor cell-derived tumor antigens and DAMPs not only reverse
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How mass spectrometric interrogation of MHC class I ligandomes has advanced our understanding of immune responses to viruses Semin. Immunol. (IF 7.8) Pub Date : 2023-06-03 Nicola Ternette, Eleni Adamopoulou, Anthony W. Purcell
Abstract not available
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Systems analysis of human innate immunity in COVID-19 Semin. Immunol. (IF 7.8) Pub Date : 2023-05-22 Sophie Müller, Joachim L. Schultze
Recent developments in sequencing technologies, the computer and data sciences, as well as increasingly high-throughput immunological measurements have made it possible to derive holistic views on pathophysiological processes of disease and treatment effects directly in humans. We and others have illustrated that incredibly predictive data for immune cell function can be generated by single cell multi-omics
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From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease Semin. Immunol. (IF 7.8) Pub Date : 2023-05-19 Donata Vercelli
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Targeting dendritic cells to advance cross-presentation and vaccination outcomes Semin. Immunol. (IF 7.8) Pub Date : 2023-05-09 Christophe Macri, Devi Jenika, Cassandra Ouslinis, Justine D. Mintern
Dendritic cells (DCs) are a complex network of specialised antigen-presenting cells that are critical initiators of adaptive immunity. Targeting antigen directly to DCs in situ is a vaccination strategy that selectively delivers antigen to receptors expressed by DC subtypes. This approach exploits specific DC subset functions of antigen uptake and presentation. Here, we review DC-targeted vaccination