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Comparison of different scores as predictors of mechanical ventilation and intensive care unit admission in acute theophylline poisoning. Toxicol. Res. (IF 2.1) Pub Date : 2023-10-03 Ghada Attia Sagah,Alshaimma Mahmoud Elmansy
Background Theophylline is commonly used to control respiratory diseases, especially in developing countries. Theophylline has a narrowed therapeutic index, and its toxicity is associated with morbidity and mortality. Physicians should be aware of the early prediction of the need for intensive care unit admission (ICU) and mechanical ventilation (MV). Aim This study aimed to assess the power of the
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The potential role of upregulated PARP-1/RIPK1 expressions in amikacin-induced oxidative damage and nephrotoxicity in Wistar rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-10-03 Amera Abd El Latif,Abo Elnasr A Zahra,AlShimaa Badr,Zizy I Elbialy,Abdullah A A Alghamdi,Norah A Althobaiti,Doaa H Assar,Tarek Kamal Abouzed
This study aimed to investigate the gene expression levels associated with nephrotoxic action of amikacin, as well as the post-treatment effect of diuretics on its nephrotoxic effects. Sixty male rats were divided equally into six groups, including the control group receiving saline intra-peritoneally (ip), and the five treated groups including therapeutic and double therapeutic dose groups, injected
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Toxicity assessment and DNA repair kinetics in HEK293 cells exposed to environmentally relevant concentrations of Glyphosate (Roundup® Control Max). Toxicol. Res. (IF 2.1) Pub Date : 2023-09-30 Dardo Roma,Maria Eugenia Cecchini,María Paula Tonini,Virginia Capella,Delia Aiassa,Nancy Rodriguez,Fernando Mañas
Glyphosate is a systemic, non-selective, pre and post-emergence wide range herbicide. In 2015, IARC classified Glyphosate as "a probable carcinogenic agent for humans". The aim of this study was to evaluate the cytotoxicity and genotoxicity of the commercial formulation of glyphosate (Roundup® Control Max) at environmentally relevant concentrations and measure the potential effect of this herbicide
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Diagnostic accuracy of carboxyhemoglobin saturation with pulse CO-oximetry in patients with carbon monoxide poisoning. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-29 Arzu Babacan
Objective Carboxyhemoglobin saturation (SpCO)with pulse CO-oximetry is an alternative method in CO poisoning; however, the correlation of it with blood carboxyhemoglobin level (COHb) is still debated.The study aimed to evaluate the correlation between SpCO and venous COHb level and factors associated with the diagnostic accuracy of SpCO. Material and methods SpCO and venous COHb levels of patients
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Nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) with repercussions toward apoptosis, necrosis, and cancer necrosis factor (TNF-α) at nano-biointerfaces. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-29 Rajiv Kumar,Bhupender S Chhikara,Simge Er Zeybekler,Dhruv Sanjay Gupta,Ginpreet Kaur,Mitrabasu Chhillar,Anil K Aggarwal,Abbas Rahdar
Introduction Apoptosis, necrosis, and cancer necrosis factor (TNF-a) are all impacted by the nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) at nano-biointerfaces. The creation of multi-functional nanoparticles has had a considerable impact on the transport of drugs and genes, nanotheranostics (in-vivo imaging, concurrent diagnostics), interventions for external
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Fullerene C60 protects against 7,12-dimethylbenz [a] anthracene (DMBA) induced-pancreatic damage via NF-κB and Nrf-2/HO-1 axis in rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-26 Seda Beyaz,Abdullah Aslan,Ozlem Gok,Ibrahim Hanifi Ozercan,Can Ali Agca
The objective of this investigation was to investigate the protective effects of fullerene C60 nanoparticle against pancreatic damage experimentally induced by 7,12-dimethylbenz [a] anthracene (DMBA) in female rats. Fullerene C60 nanoparticle was administered to rats 5 times a week by oral gavage (o.g) at 1.7 mg/kg bw 7 days after DMBA administration. 60 Wistar albino female rats divided to four groups;
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DNA methylome profiling in occupational radon exposure miners using an Illumina Infinium Methylation EPIC BeadChip. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-23 Pinhua Zhang,Yunyun Wu,Chunnan Piao,Yanchao Song,Yanfang Zhao,Yumin Lyu,Quanfu Sun,Jianxiang Liu
Background A causal relationship between occupational radon exposure in underground miners and lung cancer risk has been demonstrated through large cohort epidemiological studies. However, the mechanisms by which radon exposure causes adverse effects on lung tissue remain unclear. Epigenetic alterations such as DNA methylation may provide new insights into interactions at molecular levels induced by
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The protective effects of date seeds, in either conventional or nanoformulation, against bisphenol A-induced testicular toxicity: involvement of testicular expression of CYP11A1, Nrf-2 and Bax/Bcl-2 ratio. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-23 Dina M M H El-Kossi,Shawky S Ibrahim,Kamel M A Hassanin,Nashwa Hamad,Noha A Rashed,Heba I Elkhouly,Ahmed Abdel-Wahab
Background Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), is ubiquitous in our environment and poses a significant threat to male fertility. Date seeds (DSs) are used in folk medicine due to their antioxidant activity. Aim The purpose of this study was to assess the beneficial effects of DSs, whether in powder or nanoparticle form, against BPA-induced testicular oxidative challenges and
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Dexamethasone-induced mitochondrial ROS-mediated inhibition of AMPK activity facilitates osteoblast necroptosis. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-23 Yingchao Shen,Bo Jiang,Wei Lu,Bin Luo,Yuan Zhou,Guiying Qian
Long-term or high-dose glucocorticoid use can lead to serious orthopedic complications, including femoral head necrosis. Both basic and clinical studies have shown that high doses dexamethasone (Dex) can directly induce osteoblasts death. This study investigated the mechanism underlying Dex induced osteoblast death. In this study, we showed that Dex induces osteoblast necroptosis, rather than apoptosis
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Effects of Rosmarinus officinalis L. (Laminaceae) essential oil on adult and larvae of Drosophila melanogaster. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-21 Aline Lucca Pedroso,Miryane Knapp Schonwald,Cristiane Lenz Dalla Corte,Felix Alexandre Antunes Soares,Adriane Sperança,Benhur Godoi,Nélson Rodrigues de Carvalho
Rosmarinus officinalis (Lamiaceae family), also known as "alecrim," is a perennial herb, typical of the Mediterranean region and widely distributed in Brazilian territory. Despite having demonstrated several properties of human interest, insecticide/larvicidal effect of essential oil from R. officinalis on insects remains unclear. In this study, we tested the effects of R. officinalis essential oil
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Testicular tissue response following a 90-day subchronic exposure to HTP aerosols and cigarette smoke in rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-20 Hongjuan Wang,Yushan Tian,Yaning Fu,Shuhao Ma,Xiaoxiao Xu,Wenming Wang,Fengjun Lu,Xianmei Li,Pengxia Feng,Shulei Han,Huan Chen,Hongwei Hou,Qingyuan Hu,Chuan Liu
Background Researches have shown that chronic inhalation of cigarette smoke (CS) disrupts male reproductive system, but it is unclear about the mechanisms behind reproductive damages by tobacco toxicants in male rats. This study was designed to explore the effects of heated tobacco products (HTP) aerosols and CS exposure on the testicular health of rats. Materials and Methods Experiments were performed
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Melatonin treatment prevents carbon-tetrachloride induced rat brain injury. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-20 Nikola M Stojanović,Aleksandra Maslovarić,Ivana Mihajlović,Aleksandar Marković,Pavle J Randjelović,Dušan Sokolović
Introduction Herein the neuroprotective properties of melatonin, a highly effective antioxidant, administered in a single dose 50 mg/kg intraperitoneally, were investigated in the brain tissue of Wistar rats acutely exposed to the toxin carbon-tetrachloride (1 mL/kg, intraperitoneally). Methods To assess the degree of whole encephalic mass damage, biochemical parameters related to lipid and protein
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Insight into the negative effect and lipid profile alterations in liver of mice exposed to methylimidazolium ionic liquids, a novel "green" solvent. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-19 Ming Li,Zhunan Xia,Shiyi Chen,Xin Liu,Qiao Wang,Yan Liu,Yongning Wu,Sheng Wen,Zhiyong Gong
Background Ionic liquids (ILs) have been recognized as potential environmentally friendly solvents; however, their potential toxicity to living organisms warrants thorough investigation, particularly for novel-generation ILs in mammalian models. Methods In this study, we examined the hepatic effects and disruption of lipid metabolism in mice exposed to 1-heptyl-3-methylimidazolium chloride (C7[MIM]Cl)
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A nomogram proposal for early prediction of intensive care unit admission in patients with acute antipsychotic poisoning. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-19 Doaa M El-Gharbawy,Ibrahim Ali Kabbash,Mona M Ghonem
Background Early identification of antipsychotic poisoned patients who may have a potential risk for intensive care unit (ICU) admission is crucial especially when resources are limited. Nomograms were previously used as a practical tool to predict prognosis and planning the treatment of some diseases including some poisoning conditions. However, they were not previously investigated in antipsychotic
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Metabolic disturbance and transcriptomic changes induced by methyl triclosan in human hepatocyte L02 cells. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-13 Jing An,Yuting Yi,Jingjing Jiang,Weiwei Yao,Guofa Ren,Yu Shang
PURPOSE Methyl triclosan (MTCS) is one of the biomethylated by-products of triclosan (TCS). With the increasing use of TCS, the adverse effects of MTCS have attracted extensive attention in recent years. The purpose of this study was to investigate the cytotoxicity of MTCS and to explore the underlining mechanism using human hepatocyte L02 cells as in vitro model. RESULTS The cytotoxicity results revealed
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Involvement of functional senescence in efavirenz-induced toxicity in fruit fly. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-09 Walter Mdekera Iorjiim,Simeon Omale,Samuel Ede,Chinelo Vera Ugokwe,Taiwo Emmanuel Alemika
Background We aimed in this article to assess the likeliness of efavirenz to induce functional senescence in Drosophila melanogaster (fruit fly). Methods Ten different concentrations of EFV were mixed with fly food and fed to 3-day-old flies orally for a 7 day LC50 calculation. Drug concentrations from LC50 were selected for a 28 day survival to determine the duration of treatment for behavioral and
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Assessing the potential molecular mechanism of arsenite-induced skin cell senescence. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-09 Sufei Du,Fan Yang,Liping Wu,Dexiu Hu,Yuhong Zhang,Maoyuan Gong,Yang Yang,Xingcan Yang,Qibing Zeng
Arsenic exposure is a public health concern worldwide. Skin damage, as a typical lesion of arsenic exposure, the mechanism is still unknown. Studies have found that cellular senescence plays a key role in arsenic-induced skin damage, and the previous research found that the ERK/CEBPB signaling pathway may be an important molecular event of arsenic-induced skin cell senescence, but its specific mechanism
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Comparative oxidative damages induced by silver nanoparticles with different sizes and coatings in Caenorhabditis elegans. Toxicol. Res. (IF 2.1) Pub Date : 2023-09-06 Shuyan Niu,Junjun Wang,Xiaoru Chang,Mengting Shang,Menghao Guo,Zuoyi Sun,Yunjing Li,Yuying Xue
Silver nanoparticles (AgNPs) are widely used in many commercial and medical products. Serious concerns are paid on their adverse potentials to the environment and human health. In this study, toxic effects and oxidative stress induced by AgNPs with different sizes and coatings (20 nm AgNPs, 20 nm polyvinylpyrrolidone (PVP) -AgNPs and 50 nm AgNPs) in Caenorhabditis elegans (C. elegans) were investigated
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Polystyrene microplastic alters the redox state and arsenic metabolization in the freshwater bivalve Limnoperna fortunei. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-29 Silvana Manske Nunes,Marcelo Estrella Josende,Daniele Fattorini,Francesco Regoli,José Maria Monserrat,Juliane Ventura-Lima
Most organisms possess the capacity to metabolize arsenic (As) accumulating compounds to less toxic forms, thus minimizing the adverse effect induced by this metalloid. However, other contaminants may to interfere with As metabolism, contributing to the accumulation of more toxic compounds. Microplastics (MPs) are omnipresent in aquatic environment and may induce toxicological effects (alone or in
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Mitigative potential of rhoifolin against cisplatin prompted testicular toxicity: biochemical, spermatogenic and histological based analysis. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-26 Faria Saher,Muhammad Umar Ijaz,Ali Hamza,Qurat Ul Ain,Muhammad Faisal Hayat,Tayyaba Afsar,Ali Almajwal,Huma Shafique,Suhail Razak
Rhoifolin (ROF) is a naturally occurring flavonoid compound with diverse pharmacological and therapeutic benefits. The current investigation was designed to evaluate the curative potential of Rhoifolin (ROF) against Cisplatin (CP) induced testicular damage. Mature male albino rats (n = 48) were randomly distributed into 4 equal groups: control, CP (10 mg/kg), CP + ROF (10 mg/kg + 20 mg/kg) and ROF
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Clinical observation of liposomal doxorubicin on liver and renal function in patients with breast cancer. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-26 Mingliang Li,Ling Wang,Jie Du
Background Doxorubicin has become the first-line antitumor drug clinically, but severely limited by multiple side effects, especially cardiotoxicity. Liposomal doxorubicin therefore replaced traditional doxorubicin for low toxicity and high efficiency. Previous studies have suggested liver and kidney may be the main organs affected by liposomal doxorubicin. Due to insufficient clinical evidence, we
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The synthetic cannabinoid 5F-MDMB-PICA enhances the metabolic activity and angiogenesis in human brain microvascular endothelial cells by upregulation of VEGF, ANG-1, and ANG-2. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-23 Laith Naser Al-Eitan,Saif Zuhair Alahmad,Mohd Fahmi Munib ElMotasem,Mansour Abdullah Alghamdi
Brain angiogenesis, the formation of new blood vessels from existing brain vasculature, has been previously associated with neural plasticity and addictive behaviors related to substances. Synthetic cannabinoids (SCs) have become increasingly popular due to their ability to mimic the effects of cannabis, offering high potency and easy accessibility. In the current study, we reveal that the SC 5F-MDMB-PICA
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2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing atypical ultrasonic vocalization in infant mice. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-23 Eiki Kimura,Go Suzuki,Naoto Uramaru,Masaki Kakeyama,Fumihiko Maekawa
Epidemiological and experimental studies indicate that maternal exposure to environmental pollutants impairs the cognitive and motor functions of offspring in humans and laboratory animals. Infant ultrasonic vocalizations (USVs), the communicative behavior of pups toward caregivers, are impaired in rodent models of neurodevelopmental disorders, suggesting a useful method to evaluate the developmental
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Anti-inflammatory and antioxidative effects of elderberry diet in the rat model of seizure: a behavioral and histological investigation on the hippocampus. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-18 Amir-Hossein Bayat,Neda Eskandari,Mojtaba Sani,Farid Fotouhi,Zahra Shenasandeh,Sara Saeidikhoo,Razieh Rohani,Mohammadamin Sabbagh Alvani,Mohammadreza Mafi Balani,Mahdi Eskandarian Boroujeni,Mohammad-Amin Abdollahifar,Faezeh Tajari,Abbas Aliaghaei,Meysam Hassani Moghaddam
The present study was designed to evaluate whether elderberry (EB) effectively reduces inflammation and oxidative stress in hippocampal cells to modify seizure damage. Seizure was induced in rats by the injection of pentylenetetrazol (PTZ). In the Seizure + EB group, EB powder was added to the rats' routine diet for eight consecutive weeks. The study included several behavioral tests, immunohistopathology
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Hexaconazole exposure disrupt acetylcholinesterase, leading to mental illness. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-18 Abuzer Ali,Sayed Aliul Hasan Abdi,Amena Ali,Wasim Ahmad
Hexaconazole is widely used in agricultural work, and it has been observed that it has potential to disrupt endocrine function and it has also capacity of bioaccumulation. In this study, we examined how the hexaconazole disrupts the usual balance of acetylcholinesterase. It has been already reported that heavy pesticide exposures may be a reason for several mental illnesses because these pesticides
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Role of mitochondrial disruption and oxidative stress in plasticizer phthalate-induced cytotoxicity to human bone osteoblasts. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-10 Ekramy Mahmoud Elmorsy,Ayat Al-Ghafari,Huda Al Doghaither
Phthalates are frequently utilized in a wide range of products such as plasticizers with reported negative effects on bones. The current study evaluated the effect of butyl cyclohexyl phthalate on the human osteoblasts via different assays. MTT and lactate dehydrogenase assays were used to examine the in-vitro cytotoxic effect of butyl cyclohexyl phthalate on human bone osteoblasts in concentrations
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Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-07 Lanyi Huang,Jingbin Xu,Kaiqian Duan,Tuya Bao,Yu Cheng,Haimin Zhang,Yong Zhang,Yingwei Lin,Fasheng Li
Background Epidemiological inquiry reveals that neuroinflammation and mitochondrial dysfunction caused by PM2.5 exposure are associated with Alzheimer's disease. Nevertheless, the molecular mechanisms of mitochondrial dynamics and neuroinflammation induced by PM2.5 exposure remain elusive. In this study, our objective was to explore the impact of PM2.5 on mitochondrial dynamics and neuroinflammation
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Comparison of nickel oxide nano and microparticles toxicity in rat liver: molecular, biochemical, and histopathological study. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-01 Caglar Adiguzel,Hatice Karaboduk,Fatma Gokce Apaydin,Suna Kalender,Yusuf Kalender
The unique properties of nickel oxide nanoparticles distinguish it from classical nickel compounds, increasing its use in agriculture, industry, and many industrial areas. The aim of this study is to investigate the possible toxicity of nickel oxide and nickel oxide nanoparticles in the liver. For this purpose, Wistar rats were given nickel oxide and nickel oxide nanoparticles orally, intraperitoneally
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Plasma neurofilament light chain as a potential biomarker of neurodegeneration in murine brain. Toxicol. Res. (IF 2.1) Pub Date : 2023-08-01 Tomoya Sano,Yasushi Masuda,Hironobu Yasuno,Tadahiro Shinozawa,Takeshi Watanabe
Reliable fluid biomarkers for evaluating neurotoxicity have yet to be established. However, recent studies have reported neurofilament light chain as a fluid biomarker of several neurodegenerative disorders. In this study, we investigated changes in the cerebrospinal fluid and plasma levels of neurofilament light chain in mice treated with trimethyltin as a neurotoxicant. Trimethyltin diluted with
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Study of food toxicology of toxins artificially introduced into the food or fruits. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-27 Saurabh Dilip Bhandare,Sarika Shivaji Malode
A recent incidence reported in NEWS media of artificial fruits ripening agent's toxic to health and killed several seasonal fruit eaters because of the toxicity of the fruit introduced with such toxic ripening agents that affect adversely on health of humans and animals both consumers equivalently have been highlighted in this study.
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Metformin and Aspirin: Anticancer effects on A549 and PC3 cancer cells and the mechanisms of action. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-24 Farzaneh Motafeghi,Romina Shahsavari,Parham Mortazavi,Aysan Babaei,Pouria SamadiMojaveri,Omid Abed Khojasteh,Mohammad Shokrzadeh
Metformin exerts its anticancer effect through two mechanisms, directly affecting the tumor and indirectly reducing systemic insulin levels. The anticancer effects of aspirin occur by inhibiting Cyclooxygenase (COX)-2. COX-2 is absent in many cell types under normal conditions and increases under pathological conditions such as cancer. This study aims to investigate the effect of metformin and aspirin
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The synthetic dye malachite green found in food induces cytotoxicity and genotoxicity in four different mammalian cell lines from distinct tissuesw. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-24 Andryo O de Almada Vilhena,Karina M M Lima,Luana F C de Azevedo,Jorge D Rissino,Augusto C P de Souza,Cleusa Y Nagamachi,Julio C Pieczarka
Malachite green (MG) is a synthetic dye that uses ranges from its application as a tissue dye to that as an antiparasitic in aquaculture. Several studies have reported the presence of this compound in food dyes and in the meat of fish raised in captivity for human consumption, suggesting risks both for the end user and for as those who handle these products because of MG toxic properties described
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Protective impacts of Withania somnifera leaf extract from Taif area against diclofenac induced hepato-renal toxicity: role of antioxidants, inflammation, apoptosis, and anti-oxidative stress biomarkers. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-22 Mohamed Mohamed Soliman,Ahmed M Elshehawei,Saed Althobaiti,Samy M Sayed
Current study examined the boosting impacts of Withania somnifera leaf extract from Taif area (high-altitude area) against hepatic and renal toxicity induced by diclofenac in experimental rats. Withania is highly grown on Taif area as environmental herb with multiple functions. Diclofenac is non-steroidal medication used for treatment of pain but over dose has severe side effects. Thirty-two adult
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Study on the mechanism of PM2.5 affecting Th1/Th2 immune imbalance through the notch signaling pathway in asthmatic mice. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-17 Ji-Rong Wu,Zheng He,Hai-Rong Bao,Xiao-Li Zeng,Xiao-Ju Liu
Some research has shown that PM2.5 causes Th1/Th2 immune imbalance and aggravates asthma. However, the exact mechanism of PM2.5 causing aggravation of asthma remains unclear. The purpose of this study was to investigate whether exposure to PM2.5 exacerbates Th1/Th2 immune imbalance through the Notch signaling pathway. Eight-week-old SPF female BALF/c mice were sensitized by ovalbumin to establish an
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HM-chromanone alleviates hyperglycemia and inflammation in mice with endotoxin-induced insulin resistance. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-15 Ha J Lim,Jae E Park,Ji S Han
This study was designed to investigate whether (E)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone alleviates inflammation and hyperglycemia in mice with endotoxin-induced insulin resistance. (E)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone (10, 30, and 50 mg/kg bodyweight) was orally pre-administered to C57BL/6 J mice. An hour later, lipopolysaccharides (20 mg/kg bodyweight) was administered
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Zerumbone attenuates the excessive proliferation of keratinocytes in psoriasis mice through regulating NLRP3/NF-κB pathway. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-14 Jin Lin,Yimiao Fang,Yi Cao,Lili Ma,Maocan Tao,Xiao Wang,Yuanyuan Li,Lijun Qing
Psoriasis is a common chronic disease, and existing treatment regimens often exhibit certain toxicities and side effects. Zerumbone (Zer) may possess therapeutic effect, and the objective of this study is to investigate the effect of Zer on psoriasis. A mouse model of psoriasis was established using imiquimod cream, and the role of Zer on the pathological alterations in psoriatic mouse skin was evaluated
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HM-chromanone isolated from Portulaca oleracea L. alleviates insulin resistance and inhibits gluconeogenesis by regulating palmitate-induced activation of ROS/JNK in HepG2 cells. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-10 Jae Eun Park,Ji Sook Han
Oxidative stress is a major cause of hepatic insulin resistance. This study investigated whether (E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HM-chromanone), a homoisoflavonoid compound isolated from Portulaca oleracea L., alleviates insulin resistance and inhibits gluconeogenesis by reducing palmitate (PA)-induced reactive oxygen species (ROS)/c-Jun NH2-terminal kinase (JNK) activation
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Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-06 Danting Wan,Zihao Zhu,Jie Zhou,Zhengzheng Deng,Pengyuan Lei,Qi Liu,Xiaoya Sun,Bo Huang
Background The protective effects of astragaloside IV (ASIV) on various diseases are well known, but its potential impact on radiation-induced bystander effect (RIBE) has remained unclear. Objective This study aimed to explore the protective mechanism of ASIV against oxidative damage caused by RIBE in LO2 cells. Methods To construct the RIBE model, the conditioned medium from HepG2 cells irradiated
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Physicians' perspectives on different therapeutic approaches for aluminum phosphide poisoning and their relevant outcomes. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-03 Zahraa K Sobh,Maha Ghanem,Marwa Kholief
Background Aluminum phosphide is a highly toxic pesticide that results in high mortality. To date, there is neither a definitive antidote nor a unified protocol for managing acute aluminum phosphide poisoning. Objectives This cross-sectional questionnaire-based study aims to explore different management approaches and rely on the expertise of Egyptian medical professionals to enhance the prognosis
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Clinical and demographic features with outcome predictors of adult patients with acute intoxication admitted to a medical intensive care unit in the Mediterranean part of Croatia. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-03 Vedran Kovacic,Lukas Kvartuc,Marijana Mikacic,Ivan Jerkovic,Tanja Ilic Begovic,Marina Maras,Jurica Nazlic
Background The objective of the study was to assess the demographics, clinical parameters, and outcome of acute intoxications among adult patients admitted to a medical intensive care unit in southern Croatia. Materials and Methods An observational retrospective study was conducted over a 1-year period. The subjects were patients admitted to the intensive care unit for acute poisoning. Results In all
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Investigation of oxidative stress status and apoptotic markers of juvenile trout exposed to arsenic toxicity. Toxicol. Res. (IF 2.1) Pub Date : 2023-07-03 Hasan Saç,Aslı Ç Yeltekin
Arsenic is one of the most abundant elements on earth. Arsenic, also called metalloid, is used as a raw material in many industries. Arsenic causes the acceleration of free radical production in the body and the resulting oxidative stress. In juvenile trout, the interactions of arsenic with metacomposition, biochemical analysis, and apoptosis stimuli were investigated. Results were demonstrated by
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Body mass index as a predictor of the outcomes of acute clozapine toxicity: a cross-sectional study. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-30 Ghada A Sagah,Manar M Fayed
Acute antipsychotic overdose is frequently reported nowadays. Clozapine is one of the atypical agents that are highly lipophilic, highly protein-bound, has a large volume of distribution, and accumulates in the brain and other tissues. Obesity is an essential factor controlling patients' treatment and clinical course. The current study aimed to study the prognostic value of body mass index (BMI) in
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Phage display technology for fabricating a recombinant monoclonal ScFv antibody against tetanus toxin. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-30 Hamideh Rouhani Nejad,Jalil Fallah Mehrabadi,Pardis Saeedi,Saeed Zanganeh
Tetanus is a specific infectious disease, often associated with lower immunization in developing countries and catastrophic events (such as earthquakes). Millions of people, especially children, die every year from tetanus disease. Therefore, it is necessary to devise a rapid and sensitive detection method for tetanus toxin to ensure an early diagnosis and clinical treatment of tetanus. The current
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Cytotoxicity screening of Thymus vulgaris L. in breast cancer: in vitro study. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-26 Nazmiye Bıtgen,Gozde Ozge Onder,Munevver Baran,Arzu Yay
Breast cancer is one of the leading causes of cancer-related deaths due to its aggressive course. There is an increasing need for alternative therapy strategies, including herbal medications, to treat the disease because of its high incidence. Medicinal plants, such as Thymus vulgaris L. (T. vulgaris), have recently attracted great interest due to the antitumor properties of their extracts. The purpose
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Synergistic toxicity of 2,4-dichlorophenoxyacetic acid and arsenic alters biomarkers in rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-24 Hasan Huseyin Demirel,Fahriye Zemheri-Navruz,İsmail Kucukkurt,Damla Arslan-Acaroz,Ali Tureyen,Sinan Ince
2,4-dichlorophenoxyacetic acid (2,4-D) and arsenic cause severe and extensive biological toxicity in organisms. However, their interactions and toxic mechanisms in co-exposure remain to be fully elucidated. In this study, 28 four-week-old female rats were divided into four groups and exposed to 100 mg/L arsenic or/and 600 mg/L 2,4-D through drinking water for a period of 28 days. As a result, it was
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High-throughput transcriptome sequencing reveals the protective role of adenosine receptor-related genes in paraquat-exposed Caenorhabditis elegans. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-21 Lingmei Ma,Chunyan Ling,Shuning Hu,Sudan Ye,Chun Chen
This study sought to identify the genes associated with adenosine's protective action against paraquat (PQ)-induced oxidative stress via the adenosine receptor (ADOR-1) in Caenorhabditis elegans (C. elegans). The C. elegans was divided into 3 groups-2 groups exposed to PQ, one in presence, and one in absence of adenosine-and a control group that was not treated. Each group's total RNA was extracted
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Using science to respond to public exposures from chemical hazards during emergencies in England. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-14 Graham J Urquhart,Matthew Symington,Kerry Foxall,Henrietta Harrison,Ovnair Sepai
This paper describes how toxicological considerations are an essential component of acute chemical incident response, and how the UK Health Security Agency (UKHSA), as Category 1 responders under the Civil Contingencies Act (2004), provide that expert, authoritative, and timely advice to protect people from exposure to harmful substances. Background information about the general response to emergencies
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Casein and pea enriched high-protein diet attenuates arsenic provoked apoptosis in testicles of adult rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-14 Sagnik Biswas,Priyankar Pal,Rubia Mondal,Prabir Kumar Mukhopadhyay
Arsenic toxicity is a major health issue that also threats male reproductive system leading to impairment of fertility. The antioxidant capacity of casein and pea enriched formulated high-protein diet (FHPD) is found to be effective in different toxicity management. The present study was endeavored to investigate the mitigatory aspect of FHPD on arsenic stimulated testicular apoptosis. Adult male rats
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Gallic acid: a polyphenolic compound potentiates the therapeutic efficacy of cisplatin in human breast cancer cells. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-06 S Shruthi,Kamalesh D Mumbrekar,B S Satish Rao,Bhasker K Shenoy
Gallic acid (GA) is a natural polyhydroxyphenolic compound with antioxidant, antimutagenic, anti-inflammatory, and antineoplastic activities. Cisplatin (CPT) is a platinum-based chemotherapeutic drug, and it is the treatment of choice for breast, ovarian, testicular, head, and neck cancers. However, the use of anticancer drugs has undesirable effects on patients due to associated toxicities. Thus,
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Correction to: Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. Toxicol. Res. (IF 2.1) Pub Date : 2023-06-05
[This corrects the article DOI: 10.1039/c9tx00002j.].
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Dissecting the effects of paraquat-induced pulmonary injury in rats using UPLC-Q-TOF-MS/MS-based metabonomics. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-31 Xiehong Liu,Chi Li,Changmiao Hou,Yu Jiang,Fang Chen,Yimin Zhu,Lianhong Zou
Objective Paraquat (PQ) is a toxic compound that selectively accumulates in the lungs, inducing severe pulmonary inflammation and fibrosis. However, data on the metabolomic changes induced by the PQ remain scant. This study aimed to determine the metabolic changes in Sprague-Dawley rats subjected to PQ using UPLC-Q-TOF-MS/MS. Methods We established groups of PQ-induced pulmonary injury rats for 14
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Interaction of mercury species with proteins: towards possible mechanism of mercurial toxicology. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-30 Sharmin Akther Rupa,Md Abdul Majed Patwary,Mohammed Mahbubul Matin,William Emmanuel Ghann,Jamal Uddin,Mohsin Kazi
The nature of the binding of mercurials (organic and inorganic) and their subsequent transformations in biological systems is a matter of great debate as several different hypotheses have been proposed and none of them has been conclusively proven to explain the characteristics of Hg binding with the proteins. Thus, the chemical nature of Hg-protein binding through the possible transportation mechanism
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Tectorigenin relieved sepsis-induced myocardial ferroptosis by inhibiting the expression of Smad3. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-30 Xiaowei Fang,Wei Fu,Bing Zou,Fei Zhang
Background Myocardial injury is a serious consequence of sepsis that contributes to high rates of death. Currently, the pathophysiology of cardiac damage in sepsis is still unknown, and treatment approaches are limited. Methods The sepsis mouse model was established inducing by Lipopolysaccharide (LPS) in vivo and Tectorigenin was pretreated to explore whether it contributed to alleviated myocardial
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Cardioprotective role of the coenzyme Q10 and coconut oil in acute aluminum phosphide poisoning: a randomized controlled clinical trial. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-27 Rasha E Elsharkawy,Mona M Ghonem,Ghada N El-Sarnagawy,Ayman A Nagy,Mona M Heshmat
Aluminum phosphide (ALP)-induced cardiotoxicity is a major cause of high mortality rates. As there is no specific antidote, restoring cardiac hemodynamics is the cornerstone for saving patients. Based on oxidative stress theory in acute ALP poisoning, we examined the cardioprotective role of coconut oil and Coenzyme Q10 (COQ10) in ALP poisoning, focusing on their antioxidant capacity. This study was
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Assessing the effect of N-oxidation on the mutagenicity of 1-pyrazolines using the Ames assay. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-23 Keiko Inami,Motofumi Miura,Masafumi Yoshida,Masataka Mochizuki
N-Nitrosamines are well known as environmental carcinogens. We have reported that N-nitroso-N-methylbutylamine was oxidized by Fe2+-Cu2+-H2O2 to 5-methyl-5-nitro-1-pyrazoline, a direct-acting N-oxide. 1-Pyrazolines have not been reported to exhibit genotoxicity. In this study, we investigated the effect of N-oxidation on the mutagenicity of 1-pyrazolines using the Ames assay. The mutagenicity of 5
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The ameliorative effects of quercetin and curcumin against subacute nephrotoxicity of fipronil induced in Wistar rats. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-22 Meltem Uzunhisarcikli,Fatma Gokce Apaydin,Hatice Bas,Yusuf Kalender
Fipronil is a phenylpyrazole insecticide that is widely used in agricultural, veterinary, and public health fields for controlling a wide variety of insect species and it is an environmentally potent toxic substance. Curcumin and quercetin, which are well-known natural antioxidants, are widely used to prevent the harmful effects of free radicals on biological systems. The present study aimed to determine
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The therapeutic benefit of antioxidants on the outcome of acute aluminum phosphide poisoning: a systemic review and meta-analysis. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-18 Zahraa K Sobh,Asmaa Abd-Elhameed
This systematic review and meta-analysis pool evidence available from clinical trials to verify the effect of antioxidants on the outcome of acute aluminum phosphide (AlP) poisoning. A systematic review complied with "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" (PRISMA) Protocols. Meta-analysis was conducted on 10 studies that fulfill eligibility criteria. Four antioxidants
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High-fat diet promotes multiple binges-induced liver injury via promoting hepatic macrophage proinflammatory polarization. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-15 Yi-Ran Wang,Na Xie,Yan-Jing Zhang,Lin Wang,Zhan Sun,Tao Zeng
High-fat diet (HFD) and ethanol could synergistically induce liver damage, but the underlying mechanisms remain to be elucidated. M1-polarized macrophages have been demonstrated to be key players in ethanol-induced liver damage. The current study was designed to investigate whether hepatic steatosis could promote ethanol-induced liver injury by promoting liver macrophage M1 polarization. In the in
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Evaluation of various scoring systems as predictors of the need for intensive care unit admission and other adverse outcomes among patients with acute clozapine poisoning. Toxicol. Res. (IF 2.1) Pub Date : 2023-05-04 Heba I Lashin,Asmaa F Sharif
Acute clozapine poisoning (ACP) is frequently reported worldwide. We evaluated the efficacy of the Poison Severity Score (PSS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Rapid Emergency Medicine Score (REMS), and Modified Early Warning Score (MEWS) as predictors for intensive care unit (ICU) admission, mechanical ventilation (MV), mortality, and length of hospital stay in
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Hsa_circ_0084003 modulates glycolysis and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma through targeting hsa-miR-143-3p/DNMT3A axis. Toxicol. Res. (IF 2.1) Pub Date : 2023-04-29 Kaiqiong Wang,Zhiju Chen,Xin Qiao,Jinfang Zheng
Pancreatic ductal adenocarcinoma, one of the deadliest tumors of the digestive tract, is a difficult and invasive malignancy. Current treatment for pancreatic ductal adenocarcinoma mainly depends on surgery combined with radiotherapy and chemotherapy, which, however, often resulting in questionable curative effect. Therefore, new targeted therapies are needed in future treatment. We first interfered