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Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic review and meta-analysis Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-02-16 Yea Jin Youn, Seungyeon Kim, Hyun-Jeong Jeong, Young-Mi Ah, Yun Mi Yu
[Display omitted]
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Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer’s and Parkinson’s disease Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-02-11 Niklas Reich, Christian Hölscher
Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels, neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective effects in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Thus, we review the physiological function and therapeutic potential of CCK. The neuropeptide facilitates hippocampal glutamate release and gates GABAergic basket cell activity
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Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-20 Alexandra Donovan, Shervin Assari, Christine Grella, Magda Shaheen, Linda Richter, Theodore C. Friedman
Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a child’s development. ELS is associated with substance use and mental health problems. This narrative literature review focuses on sex and gender differences in the effects of ELS on 1) adolescent neuroendocrine development; 2) pubertal brain maturation; and 3) development of internalizing symptoms and subsequent
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The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-04 MacKenzie R. Peltier, Terril L. Verplaetse, Margaret Altemus, Yasmin Zakiniaeiz, Elizabeth A. Ralevski, Yann S. Mineur, Ralitza Gueorguieva, Marina R. Picciotto, Kelly P. Cosgrove, Ismene Petrakis, Sherry A. McKee
Rates of alcohol use disorder (AUD) are increasing in men and women and there are high rates of concurrent posttraumatic stress disorder (PTSD) and AUD. AUD and PTSD synergistically increase symptomatology and negatively affect treatment outcomes; however, there are very limited pharmacological treatments for PTSD/AUD. Neurosteroids have been implicated in the underlying neurobiological mechanisms
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Modulatory role of neurosteroidogenesis in the spinal cord during peripheral nerve injury-induced chronic pain Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-03 Ayikoe-Guy Mensah-Nyagan, Laurence Meyer, Christine Patte-Mensah
The brain and spinal cord (SC) are both targeted by various hormones, including steroid hormones. However, investigations of the modulatory role of hormones on neurobiological functions usually focus only on the brain. The SC received little attention although this structure pivotally controls motor and sensory functions. Here, we critically reviewed key data showing that the process of neurosteroid
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The role of stress in perinatal depression and anxiety – A systematic review Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-03 MA. Schalla, A. Stengel
Perinatal depression (PND) and anxiety affect around 20% of women, but available pharmacotherapy is not sufficiently effective in 20–60% of them, indicating a need for better understanding of these diseases. Since stress is a significant risk factor for PND, the aim was to examine the role of biological, environmental and psychological stress in PND and anxiety through a systematic literature search
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Electroencephalography findings in menstrually-related mood disorders: A critical review Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-02 Elisavet Kaltsouni, Felix Schmidt, Rachel G. Zsido, Allison Eriksson, Julia Sacher, Inger Sundström-Poromaa, Rachael L. Sumner, Erika Comasco
The female reproductive years are characterized by fluctuations in ovarian hormones across the menstrual cycle, which have the potential to modulate neurophysiological and behavioral dynamics. Menstrually-related mood disorders (MRMDs) comprise cognitive-affective or somatic symptoms that are thought to be triggered by the rapid fluctuations in ovarian hormones in the luteal phase of the menstrual
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Sex differences in cortisol levels in depression: A systematic review and meta-analysis Front. Neuroendocrin. (IF 7.4) Pub Date : 2024-01-02 Rui Wang, Lydia Kogler, Birgit Derntl
Higher prevalence of depression in females might be associated with sex-specific cortisol levels. Evidence exists that cortisol levels differ between healthy females and males, however a sex-specific association in depression has not been systematically assessed. Thus, the current study quantifies the existing literature on different cortisol parameters, i.e., basal cortisol, hair cortisol, cortisol
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POST-FINASTERIDE SYNDROME AND POST-SSRI SEXUAL DYSFUNCTION: TWO CLINICAL CONDITIONS APPARENTLY DISTANT, BUT VERY CLOSE Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-11-21 Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Roberto Cosimo Melcangi
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Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-11-21 Monique Vallée
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Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-11-21 Lin Zhang, Dick F. Swaab
Bipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical
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Testosterone’s Role in Modulating Human Behaviors Relevant to Mating and Parenting Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-11-14 Francesca R. Luberti, Justin M. Carré
Testosterone (T) is linked to human mating and parenting. Here, we comprehensively reviewed evidence on whether, in men and women, 1) basal T levels are related to mating and parenting behaviors, 2) T responds to reproduction-relevant cues, 3) acute changes in T map onto subsequent mating and parenting behaviors, and 4) single-dose exogenous T administration causally affects mating and parenting behaviors
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Symptoms of mental disorders and oral contraception use: A systematic review and meta-analysis Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-11-14 Mathilda Z. Kraft, Philine Rojczyk, Thomas Weiss, Birgit Derntl, Zora Kikinis, Ilona Croy, Carina Heller
Worldwide, over 150 million adolescent and adult women use oral contraceptives (OC). An association between OC-use and the emergence of symptoms of mental disorders has been suggested. This systematic review and meta-analysis provide an overview of published research regarding symptoms of mental disorders in association with OC-use, factoring the influence of OC types, age of first-use, duration of
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Sex and gender in health research: Intersectionality matters Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-10-30 Sivaniya Subramaniapillai, Liisa A.M. Galea, Gillian Einstein, Ann-Marie G. de Lange
Research policies aiming to integrate sex and gender in scientific studies are receiving increased attention in academia. Incorporating these policies into health research is essential for improving targeted and equitable healthcare outcomes, by considering both disparities and similarities between individuals relating to sex and gender. Although these efforts are both urgent and critical, only an
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The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-10-04 Shameena Bake, Siara K. Rouzer, Shruti Mavuri, Rajesh C. Miranda, Amanda H. Mahnke
Prenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical
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Neuroestradiol and neuronal development: Not an exclusive male tale anymore Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-09-07 Luis M. Garcia-Segura, Pablo Méndez, M. Angeles Arevalo, Iñigo Azcoitia
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Androgen action on myogenesis throughout the lifespan; comparison with neurogenesis Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-09-03 Sabrina Tzivia Barsky, Douglas Ashley Monks
Androgens’ pleiotropic actions in promoting sex differences present not only a challenge to providing a comprehensive account of their function, but also an opportunity to gain insights by comparing androgenic actions across organ systems. Although often overlooked by neuroscientists, skeletal muscle is another androgen-responsive organ system which shares with the nervous system properties of electrochemical
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Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-28 Gregg Duester
It is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
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A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-22 Jordan C. Barone, Mitchell P. Butler, Ashley Ross, Anna Patterson, Melissa Wagner-Schuman, Tory A. Eisenlohr-Moul
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Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-21 Jacques Balthazart
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Focus on fentanyl in females: Sex and gender differences in the physiological and behavioral effects of fentanyl Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-18 Kaitlyn M. Little, Therese A Kosten
The prevalence of opioid use disorder and overdose continues to harm the U.S. population and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs. Gender differences in the effects of fentanyl are not well understood. The present article reviews evidence for gender and sex differences in the physiological and behavioral effects of fentanyl in humans and animals. Biological
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Stress and gonadal steroid influences on alcohol drinking and withdrawal, with focus on animal models in females Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-08 Deborah A. Finn
Sexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in
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Aversion-associated drug and alcohol seeking in females Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-07 Miranda E. Arnold, Jesse R. Schank
Compulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research
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Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-08-04 Raquel Santos-Toscano, Maria Angeles Arevalo, Luis Miguel Garcia-Segura, Daniela Grassi, Natalia Lagunas
Substance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic
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Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-07-27 Cathryn A. Cutia, Catherine A. Christian-Hinman
Gonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary–gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant
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Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-07-19 Águeda Castro-Quintas, Helena Palma-Gudiel, Nerea San Martín-González, Javier R. Caso, Juan C. Leza, Lourdes Fañanás
Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children
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The historical progression of positron emission tomography research in neuroendocrinology Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-07-07 Jason Bini
The rapid and continual development of a number of radiopharmaceuticals targeting different receptor, enzyme and small molecule systems has fostered Positron Emission Tomography (PET) imaging of endocrine system actions in vivo in the human brain for several decades. PET radioligands have been developed to measure changes that are regulated by hormone action (e.g., glucose metabolism, cerebral blood
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Impact of ectopic fat on brain structure and cognitive function:A systematic review and meta-analysis from observational studies Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-07-04 Zhi-Hui Song, Jing Liu, Xiao-Feng Wang, Rafael Simó, Chao Zhang, Jian-Bo Zhou
Ectopic fat, defined as a specific organ or compartment with the accumulation of fat tissue surrounding organs, is highly associated with obesity which has been identified as a risk factor for cognitive impairment and dementia. However, the relationship between ectopic fat and changes in brain structure or cognition is yet to be elucidated. Here, we investigated the effects of ectopic fat on brain
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Women’s use of alcohol: Neurobiobehavioral concomitants and consequences Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-06-01 Sara Jo Nixon, Christian C. Garcia, Ben Lewis
In this narrative review, we draw from historical and contemporary literature to explore the impact of alcohol consumption on brain and behavior among women. We examine three domains: 1) the impact of alcohol use disorder (AUD) on neurobiobehavioral outcomes, 2) its impact on social cognition/emotion processing, and 3) alcohol’s acute effects in older women. There is compelling evidence of alcohol-related
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Vitamin D status and cognitive performance in community-dwelling adults: A dose-response meta-analysis of observational studies Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-06-01 Janis D. Harse, Ross J. Marriott, Kun Zhu, Kevin Murray, Romola S. Bucks
Low vitamin D status is linked with poorer cognition in adults while findings in relation to high levels are mixed. We performed a systematic review and meta-analyses to examine dose–response associations between 25-hydroxyvitamin D (25OHD) levels and cognitive performance in community-dwelling adults. Thirty-eight observational studies were included in dose–response meta-analyses. Positive, nonlinear
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The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-05-21 Gregory H. Jones, Omar F. Pinjari, Courtney M. Vecera, Kacy Smith, Anita Barrera, Rodrigo Machado-Vieira
Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory
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Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-05-20 E.L. Gräfe, H.M.O. Reid, I. Shkolnikov, K. Conway, A. Kit, C. Acosta, B.R. Christie
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Neuroendocrine mechanisms contributing to the coevolution of sociality and communication Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-05-20 Megan K. Freiler, G. Troy Smith
Communication is inherently social, so signaling systems should evolve with social systems. The ‘social complexity hypothesis’ posits that social complexity necessitates communicative complexity and is generally supported in vocalizing mammals. This hypothesis, however, has seldom been tested outside the acoustic modality, and comparisons across studies are confounded by varying definitions of complexity
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Fast neurotransmitter identity of MCH neurons: Do contents depend on context? Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-05-05 B.G. Beekly, A. Rupp, C.R. Burgess, C.F. Elias
Hypothalamic melanin-concentrating hormone (MCH) neurons participate in many fundamental neuroendocrine processes. While some of their effects can be attributed to MCH itself, others appear to depend on co-released neurotransmitters. Historically, the subject of fast neurotransmitter co-release from MCH neurons has been contentious, with data to support MCH neurons releasing GABA, glutamate, both,
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Hormonal contraception and cognition: Considering the influence of endogenous ovarian hormones and genes for clinical translation Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-04-20 Laura Gravelsins, Sophia Zhao, Gillian Einstein
Despite the well-known influence of ovarian hormones on the brain and widespread use of hormonal contraception (HC) since the 1960s, our knowledge of HC’s cognitive effects remains limited. To date, the cognitive findings have been inconsistent. In order to establish what might make HC studies more consistent, we surveyed the literature on HCs and cognition to determine whether studies considered HC
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Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-04-13 Jill M. Daniel, Sarah H. Lindsey, Ricardo Mostany, Laura A. Schrader, Andrea Zsombok
Research in preclinical models indicates that estrogens are neuroprotective and positively impact cognitive aging. However, clinical data are equivocal as to the benefits of menopausal estrogen therapy to the brain and cognition. Pre-existing cardiometabolic disease may modulate mechanisms by which estrogens act, potentially reducing or reversing protections they provide against cognitive decline.
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Stress in adolescence as a first hit in stress-related disease development: Timing and context are crucial Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-03-29 Giulia F. Mancini, Onno C. Meijer, Patrizia Campolongo
The two-hit stress model predicts that exposure to stress at two different time-points in life may increase or decrease the risk of developing stress-related disorders later in life. Most studies based on the two-hit stress model have investigated early postnatal stress as the first hit with adult stress as the second hit. Adolescence, however, represents another highly sensitive developmental window
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Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-04-02 Marc Ten-Blanco, África Flores, Luigia Cristino, Inmaculada Pereda-Pérez, Fernando Berrendero
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic neurons that have extensive projections throughout the central nervous system and bind two different G protein-coupled receptors (OX1R and OX2R). Since its discovery in 1998, the orexin system has gained the interest of the scientific community as a potential therapeutic target for the treatment of different pathological
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The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-03-06 Xiaoli Liao, Miao Chen, Yamin Li
Objective The present study aimed to systematically and quantitatively review evidence derived from both postmortem brain and PET studies to explore the pathological role of glia induced neuroinflammation in the pathogenesis of ASD, and discuss the implications of these findings in relation to disease pathogenesis and therapeutic strategies. Method An online databases search was performed to collate
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Editorial overview: Hormonal contraceptives and the brain: A call for translational research Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-02-16 Jesse M. Lacasse, Nafissa Ismail, Natalie C. Tronson
Abstract not available
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The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-02-10 Lindsey Mountcastle, Melissa Zajdel, Taylor Robinson, Krystyna R. Keller, Shani Gelles, Alicia A. Livinski, Bijal Kikani, Dawn E. Lea, Laura M. Koehly
Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for
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The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-02-08 Yi Ren, Aisouda Savadlou, Soobin Park, Paul Siska, Jonathan R. Epp, Derya Sargin
Alzheimer’s Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. Treatments aimed at improving pathology in AD remain ineffective to stop disease progression. This makes the detection of the early intervention strategies to reduce future disease risk extremely important. Isolation and loneliness have been identified among the major risk factors for
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Progesterone and contraceptive progestin actions on the brain: A systematic review of animal studies and comparison to human neuroimaging studies Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-02-08 Belinda Pletzer, Katharina Winkler-Crepaz, Katharina Maria Hillerer
In this review we systematically summarize the effects of progesterone and synthetic progestins on neurogenesis, synaptogenesis, myelination and six neurotransmitter systems. Several parallels between progesterone and older generation progestin actions emerged, suggesting actions via progesterone receptors. However, existing results suggest a general lack of knowledge regarding the effects of currently
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The importance of translationally evaluating steroid hormone contributions to substance use Front. Neuroendocrin. (IF 7.4) Pub Date : 2023-02-07 Erin E. Maher, Ashley M. Strzelecki, Jessica J. Weafer, Cassandra D. Gipson
Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature
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Oral contraceptives and cognition: A systematic review Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-12-26 Caroline Gurvich, Isobel Nicholls, Alex Lavale, Jayashri Kulkarni
Oral contraceptives (OCs) are widely used. While the physical impacts of OCs have been well researched, there is increasing interest on potential impacts of OCs on brain, behaviour and cognition. We systematically reviewed the literature to determine the influence of OCs on cognition, including neurocognition, social cognition and emotional processing. Inclusionary criteria were: (a) premenopausal
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Hormonal contraceptives and the brain: A systematic review on 60 years of neuroimaging, EEG, and biochemical studies in humans and animals Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-12-25 Joan Y. Song, Caroline Delbourgo Patton, Renee Friedman, Lakshmi S. Mahajan, Rachel Nordlicht, Rahman Sayed, Michael L. Lipton
Hormonal contraception has been widely prescribed for decades. Although safety and efficacy are well-established, much uncertainty remains regarding brain effects of hormonal contraception. We systematically review human and animal studies on the brain effects of hormonal contraception which employed neuroimaging techniques such as MRI, PET and EEG, as well as animal studies which reported on neurotransmitter
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Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-11-18 Idy S.C. Man, Robin Shao, W.K. Hou, Shirley Xin Li, Fiona Yan Liu, Maggy Lee, Yun Kwok Wing, Suk-yu Yau, Tatia M.C. Lee
Humans experience multiple biological and emotional changes under acute stress. Adopting a multi-systemic approach, we summarized 61 studies on healthy people’s endocrinological, physiological, immunological and emotional responses to the Trier Social Stress Test. We found salivary cortisol and negative mood states were the most sensitive markers to acute stress and recovery. Biomarkers such as heart
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Estradiol and progesterone in female reward-learning, addiction, and therapeutic interventions Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-11-07 Emily N. Hilz, Hongjoo J. Lee
Sex steroid hormones like estradiol (E2) and progesterone (P4) guide the sexual organization and activation of the developing brain and control female reproductive behavior throughout the lifecycle; importantly, these hormones modulate functional activity of not just the endocrine system, but most of the nervous system including the brain reward system. The effects of E2 and P4 can be seen in the processing
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Moving beyond the mean: Promising research pathways to support a precision medicine approach to hormonal contraception Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-11-01 Sarah E. Hill, Summer Mengelkoch
Women’s psychological and behavioral responses to hormonal contraceptive (HC) treatment can be highly variable. One of the great challenges to researchers seeking to improve the experiences of women who use HCs is to identify the sources of this variability to minimize unpleasant psychobehavioral side-effects. In the following, we provide recommendations for programs of research aimed at identifying
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Combined oral contraceptives and mental health: Are adolescence and the gut-brain axis the missing links? Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-10-14 Sarah Kheloui, Andra Smith, Nafissa Ismail
Combined oral contraceptives (containing synthetic forms of estradiol and progestins) are one of the most commonly used drugs among females. However, their effects on the gut-brain axis have not been investigated to a great extent despite clear evidence that suggest bi-directional interactions between the gut microbiome and endogenous sex hormones. Moreover, oral contraceptives are prescribed during
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Oral contraceptives in the central nervous system: Basic pharmacology, methodological considerations, and current state of the field Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-10-13 Elizabeth Hampson
Millions of women around the world use combined oral contraceptives (OCs), yet surprisingly little is known about their central nervous system (CNS) effects. This article provides a short overview of the basic pharmacology of OCs, emphasizing features that may be relevant to understanding their effects in the CNS. Historical and recent findings from studies of cognitive function, mood, and negative
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Combined Oral Contraceptive Use and Risk for Binge Eating in Women: Potential Gene x Hormone Interactions Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-28 Kelly L. Klump, Alaina M. Di Dio
Extant animal and human data suggest endogenous ovarian hormones increase risk for binge eating in females, possibly via gene x hormone interactions and hormonally induced increases in genetic influences. Approximately 85% of women will take combined oral contraceptives (COCs) that mimic the riskiest hormonal milieu for binge eating (i.e., post-ovulation when both estrogen and progesterone are present)
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Review of the effects of polycystic ovary syndrome on Cognition: Looking beyond the androgen hypothesis Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-23 Mateja Perović, Katrina Wugalter, Gillian Einstein
Polycystic-ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age, and many features associated with PCOS – such as elevated androgens, insulin resistance and inflammation – are known to affect cognition. However, effects of PCOS on cognition are not well-understood. Here we review the current literature on PCOS and cognition, note the extent of PCOS symptomatology
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Hormonal Contraceptive Influences on Cognition and Psychopathology: Past Methods, Present Inferences, and Future Directions Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-22 Adriene M. Beltz
In the last decade, there has been a remarkable surge in research on the neural and behavioral correlates of hormonal contraceptive use, particularly oral contraceptive use. Questions have evolved swiftly and notably, with studies no longer revealing if hormonal contraceptives matter for the brain and behavior, but rather how, when, and for whom they matter most. Paralleling this shift, the goal of
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Structural and functional brain alterations in Cushing’s disease: A narrative review Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-17 Yi-Fan Liu, Lei Pan, Ming Feng
Neurocognitive and psychiatric symptoms are non-negligible in Cushing’s disease and are accompanied by structural and functional alterations of the brain. In this review, we have summarized multimodal neuroimaging and neurophysiological studies to highlight the current and historical understandings of the structural and functional brain alterations in Cushing’s disease. Specifically, structural studies
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Hormone-based models for comparing menstrual cycle and hormonal contraceptive effects on human resting-state functional connectivity Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-17 Kathleen V. Casto, Timothy Jordan, Nicole Petersen
Oral contraceptives (OCs) are widely used yet understudied given their potential for public health consequences. Emerging investigations scaling from single-subject, dense-sampling neuroimaging studies to population-level metrics have linked OCs to altered brain structure and function. Modeling the hypogonadal, hypergonadal, or mixed state effects of OCs in terms of their impact on hormone action in
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A tribute to Gian Carlo Panzica (17 August 1949–21 July 2022) Front. Neuroendocrin. (IF 7.4) Pub Date : 2022-09-02 Jacques Balthazart
Abstract not available