显示样式:     当前分类: 医药    当前期刊: Pharmacological Reviews    加入关注    导出
我的关注
我的收藏
您暂时未登录!
登录
  • International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
    Pharmacol. Rev. (IF 17.893) Pub Date : 2017-10-01
    Csaba Szabo,Andreas Papapetropoulos,Eliot H. Ohlstein,ASSOCIATE EDITOR,Csaba Szabo,Andreas Papapetropoulos,Csaba Szabo,Andreas Papapetropoulos
    更新日期:2017-10-05
  • Chemical Tools for Studying Lipid-Binding Class A G Protein–Coupled Receptors
    Pharmacol. Rev. (IF 17.893) Pub Date : 2017-07-01
    Anna Cooper,Sameek Singh,Sarah Hook,Joel D. A. Tyndall,Andrea J. Vernall,Stephen P. H. Alexander,ASSOCIATE EDITOR,Anna Cooper,Sameek Singh,Sarah Hook,Joel D. A. Tyndall,Andrea J. Vernall,Anna Cooper,Sameek Singh,Sarah Hook,Joel D. A. Tyndall,Andrea J. Vernall

    Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid, leukotriene, bile acid, and platelet-activating factor receptor families are class A G protein–coupled receptors with endogenous lipid ligands. Pharmacological tools are crucial for studying these receptors and addressing the many unanswered questions surrounding expression of these receptors in normal and diseased tissues. An inherent challenge for developing tools for these lipid receptors is balancing the often lipophilic requirements of the receptor-binding pharmacophore with favorable physicochemical properties to optimize highly specific binding. In this study, we review the radioligands, fluorescent ligands, covalent ligands, and antibodies that have been used to study these lipid-binding receptors. For each tool type, the characteristics and design rationale along with in vitro and in vivo applications are detailed.

    更新日期:2017-08-24
  • Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology
    Pharmacol. Rev. (IF 17.893) Pub Date : 2017-04-01
    Marco Pirazzini,Ornella Rossetto,Roberto Eleopra,Cesare Montecucco,Jeffrey M. Witkin,ASSOCIATE EDITOR,Marco Pirazzini,Ornella Rossetto,Roberto Eleopra,Cesare Montecucco,Marco Pirazzini,Ornella Rossetto,Roberto Eleopra,Cesare Montecucco
    更新日期:2017-08-24
  • Systems Chronotherapeutics
    Pharmacol. Rev. (IF 17.893) Pub Date : 2017-04-01
    Annabelle Ballesta,Pasquale F. Innominato,Robert Dallmann,David A. Rand,Francis A. Lévi,Stephanie W. Watts,ASSOCIATE EDITOR,Annabelle Ballesta,Pasquale F. Innominato,Robert Dallmann,David A. Rand,Francis A. Lévi,Annabelle Ballesta,Pasquale F. Innominato,Robert Dallmann,David A. Rand,Francis A. Lévi
    更新日期:2017-08-24
  • International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases
    Pharmacol. Rev. (IF 17.893) Pub Date : 2017-04-01
    Carmen W. Dessauer,Val J. Watts,Rennolds S. Ostrom,Marco Conti,Stefan Dove,Roland Seifert,Eliot H. Ohlstein,ASSOCIATE EDITOR,Carmen W. Dessauer,Val J. Watts,Rennolds S. Ostrom,Marco Conti,Stefan Dove,Roland Seifert,Carmen W. Dessauer,Val J. Watts,Rennolds S. Ostrom,Marco Conti,Stefan Dove,Roland Seifert
    更新日期:2017-08-24
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
所有期刊列表A-Z