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Effect of Personalized Risk-Reduction Strategies on Cognition and Dementia Risk Profile Among Older Adults: The SMARRT Randomized Clinical Trial. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-27 Kristine Yaffe,Eric Vittinghoff,Sascha Dublin,Carrie B Peltz,Lynn E Fleckenstein,Dori E Rosenberg,Deborah E Barnes,Benjamin H Balderson,Eric B Larson
Importance Modifiable risk factors are hypothesized to account for 30% to 40% of dementia; yet, few trials have demonstrated that risk-reduction interventions, especially multidomain, are efficacious. Objective To determine if a personalized, multidomain risk reduction intervention improves cognition and dementia risk profile among older adults. Design, Setting, and Participants The Systematic Multi-Domain
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Discrepancies in Estimating Excess Death by Political Party Affiliation During the COVID-19 Pandemic-Reply. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-27 Jacob Wallace,Paul Goldsmith-Pinkham,Jason L Schwartz
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Cost of Exempting Sole Orphan Drugs From Medicare Negotiation. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-27 Matthew Vogel,Olivia Zhao,William B Feldman,Amitabh Chandra,Aaron S Kesselheim,Benjamin N Rome
Importance The Inflation Reduction Act (IRA) requires Medicare to negotiate prices for some high-spending drugs but exempts drugs approved solely for the treatment of a single rare disease. Objective To estimate Medicare spending and global revenues for drugs that might have been exempt from negotiation from 2012 to 2021. Design, Setting, and Participants This cross-sectional study analyzed drugs that
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Association of Smoking Cessation and Cardiovascular, Cancer, and Respiratory Mortality. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-27 Blake Thomson,Farhad Islami
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Risk of Bleeding Following Non-Vitamin K Antagonist Oral Anticoagulant Use in Patients With Acute Ischemic Stroke Treated With Alteplase. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Tou-Yuan Tsai,Yu-Chang Liu,Wan-Ting Huang,Yu-Kang Tu,Shang-Quan Qiu,Sameer Noor,Yong-Chen Huang,Eric H Chou,Edward Chia-Cheng Lai,Huei-Kai Huang
Importance Current guidelines advise against intravenous alteplase therapy for treatment of acute ischemic stroke in patients previously treated with non-vitamin K antagonist oral anticoagulants (NOACs). Objective To evaluate the risk of bleeding and mortality after alteplase treatment for acute ischemic stroke among patients treated with NOACs compared to those not treated with NOACs. Design, Setting
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One Size Fits All-An Underappreciated Health Inequity. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Mary E Tinetti,Melissa deCardi Hladek,Deborah Ejem
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Oseltamivir May or May Not Reduce Hospitalizations-Reply. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Emily G McDonald,Ryan Hanula,Todd C Lee
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Corrections to a Meta-Analysis of Oseltamivir Use in Preventing Hospitalization for Influenza. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Todd C Lee
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Oseltamivir May or May Not Reduce Hospitalizations. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 James W Antoon,Carlos G Grijalva,Keipp Talbot
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Therapeutic Benefit From New Drugs From Pharmaceutical Companies. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Joel Lexchin
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Why Some Patients Overpay for Specialty Generic Drugs. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Francis J Crosson,Aaron S Kesselheim
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Oseltamivir May or May Not Reduce Hospitalizations. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Timothy M Uyeki,David S C Hui,Nelson Lee
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Provenance and Clinical Benefit of Medicines Introduced to the French Market, 2008 to 2018. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Leeza Osipenko,Philippe Potey,Bernardo Perez,Alexandra Kupryjanczuk,Filip Angelov,Alexandra Schuster,Elias Mossialos
Importance Both the commercial sector and academia play a vital role in medicine development. Ongoing debates exist on their contribution and the value of medicinal products entering the market. Objective To identify the provenance and clinical benefit of medicines that entered the French market between 2008 and 2018. Design and Setting In this cross-sectional study, the provenance of each medicine
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Medicare Part D Payments for Generic Imatinib From 2017 to 2023. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-20 Stacie B Dusetzina
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Widening Gender Gap in Life Expectancy in the US, 2010-2021. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 Brandon W Yan,Elizabeth Arias,Alan C Geller,Donald R Miller,Kenneth D Kochanek,Howard K Koh
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I Am Worried I Have Sciatica-What Do I Need to Know? JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 Grace Y Zhang,Michael A Incze
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Acute Myocardial Infarction Revealed by an Escape Rhythm in a Patient With Failed Sgarbossa Criteria. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 Cecilia R Varga,William M Miles,Mohammed Ruzieh
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Shift From Smoking Cigarettes to Vaping Nicotine in Young Adults. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 Brandon T Sanford,Naomi C Brownstein,Nathaniel L Baker,Amanda M Palmer,Tracy T Smith,Alana M Rojewski,Benjamin A Toll
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Giving Patients the Focused Attention They Deserve. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 James R Deming,John W Beasley,Christine A Sinsky
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Health Disinformation Use Case Highlighting the Urgent Need for Artificial Intelligence Vigilance: Weapons of Mass Disinformation. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-13 Bradley D Menz,Natansh D Modi,Michael J Sorich,Ashley M Hopkins
Importance Although artificial intelligence (AI) offers many promises across modern medicine, it may carry a significant risk for the mass generation of targeted health disinformation. This poses an urgent threat toward public health initiatives and calls for rapid attention by health care professionals, AI developers, and regulators to ensure public safety. Observations As an example, using a single
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The Natural History of Disability and Caregiving Before and After Long-Term Care Entry. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Kenneth Lam,Irena Cenzer,Cari R Levy,Dan D Matlock,Alexander K Smith,Kenneth E Covinsky
Importance Many older persons move into long-term care facilities (LTCFs) due to disability and insufficient home caregiving options. However, the extent of disability and caregiving provided around the time of entry is unknown. Objective To quantitatively describe disability and caregiving before and after LTCF entry, comparing nursing home (NH), assisted living (AL), and independent living (IL) entrants
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Overnight Stay in the Emergency Department and Mortality in Older Patients. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Melanie Roussel,Dorian Teissandier,Youri Yordanov,Frederic Balen,Marc Noizet,Karim Tazarourte,Ben Bloom,Pierre Catoire,Laurence Berard,Marine Cachanado,Tabassome Simon,Said Laribi,Yonathan Freund,,
Importance Patients in the emergency department (ED) who are waiting for hospital admission on a wheeled cot may be subject to harm. However, mortality and morbidity among older patients who spend the night in the ED while waiting for a bed in a medical ward are unknown. Objective To assess whether older adults who spend a night in the ED waiting for admission to a hospital ward are at increased risk
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Care Demands Ahead of Transitioning Into Residential Care-A Window Into Family Caregiving at Home. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Chanee D Fabius,Jennifer L Wolff,Vicki A Freedman
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The Tip of the Iceberg-Concealing of Advanced Conduction Abnormality. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Pongsakorn Buraphat,Pornanong Kurusathian,Arjbordin Winijkul
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Nonfunctional Adrenal Adenomas and Increased Risk of Mortality. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Fabio Bioletto,Ezio Ghigo,Mirko Parasiliti-Caprino
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The Risks of Being in Limbo in the Emergency Department. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Timothy S Anderson,Shoshana J Herzig
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Nonfunctional Adrenal Adenomas and Increased Risk of Mortality-Reply. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Jekaterina Patrova,Jonatan D Lindh,Henrik Falhammar
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Nonfunctional Adrenal Adenomas and Increased Risk of Mortality. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-06 Barbara Depczynski,Myron Lee,Andrea R Horvath
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Effect of a Novel Multicomponent Intervention to Improve Patient Access to Kidney Transplant and Living Kidney Donation: The EnAKT LKD Cluster Randomized Clinical Trial. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-03 Amit X Garg,Seychelle Yohanna,Kyla L Naylor,Susan Q McKenzie,Istvan Mucsi,Stephanie N Dixon,Bin Luo,Jessica M Sontrop,Mary Beaucage,Dmitri Belenko,Candice Coghlan,Rebecca Cooper,Lori Elliott,Leah Getchell,Esti Heale,Vincent Ki,Gihad Nesrallah,Rachel E Patzer,Justin Presseau,Marian Reich,Darin Treleaven,Carol Wang,Amy D Waterman,Jeffrey Zaltzman,Peter G Blake
Importance Patients with advanced chronic kidney disease (CKD) have the best chance for a longer and healthier life if they receive a kidney transplant. However, many barriers prevent patients from receiving a transplant. Objectives To evaluate the effect of a multicomponent intervention designed to target several barriers that prevent eligible patients from completing key steps toward receiving a
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Solving the Kidney Transplant Conundrum Through Systems Thinking. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-03 L Ebony Boulware
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Health Care Staff Turnover and Quality of Care at Nursing Homes. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Karen Shen,Brian E McGarry,Ashvin D Gandhi
Importance Turnover in health care staff may disrupt patient care and create operational and organizational challenges, and nursing home staff turnover rates are particularly high. Empirical evidence on the association between turnover and quality of care is limited and has typically relied on low-quality measures of turnover, small and selected samples of facilities, and comparisons across facilities
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Point-of-Care Ultrasonography in Suspected Acute Coronary Syndrome. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Karan Kalani,A Shaheer Ahmed,Enosh Katta
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Feasibility of Emulating Clinical Trials Supporting US FDA Supplemental Indication Approvals of Drugs and Biologics. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Guneet S Janda,Joshua D Wallach,Meera M Dhodapkar,Reshma Ramachandran,Joseph S Ross
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Disparities in Kidney Transplant Waitlisting Among Young Patients Without Medical Comorbidities. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 S Ali Husain,Miko E Yu,Kristen L King,Joel T Adler,Jesse D Schold,Sumit Mohan
Importance Disparities in kidney transplant referral and waitlisting contribute to disparities in kidney disease outcomes. Whether these differences are rooted in population differences in comorbidity burden is unclear. Objective To examine whether disparities in kidney transplant waitlisting were present among a young, relatively healthy cohort of patients unlikely to have medical contraindications
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Racial Disparities in Emergency Department Physical Restraint Use: A Systematic Review and Meta-Analysis. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Vidya Eswaran,Melanie F Molina,Alison R Hwong,David G Dillon,Lizbeth Alvarez,Isabel E Allen,Ralph C Wang
Importance Recent studies have demonstrated that people of color are more likely to be restrained in emergency department (ED) settings compared with other patients, but many of these studies are based at a single site or health care system, limiting their generalizability. Objective To synthesize existing literature on risk of physical restraint use in adult EDs, specifically in reference to patients
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Incidental Coronary Artery Calcium on Chest CT in Persons Without Known Atherosclerotic Cardiovascular Disease. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Matthew C Tattersall,Robyn L McClelland,Prashant Nagpal,Roderick Deaño,Michael J Blaha,James H Stein
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An Older Patient With Chest Pain-Diagnostic Traps. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Ziheng Jia,Tong Liu,Jingjin Che
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Screening for Hypertensive Disorders of Pregnancy in the US-A New Hypertensive Urgency. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Srilakshmi Mitta,Cary P Gross,Melissa A Simon
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Policies of US Companies Offering Direct-to-Consumer Laboratory Tests. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Louiza Kalokairinou,Rebekah Choi,Nina Yichen Wei,Anna Wexler
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Comparison of Hospital Online Price and Telephone Price for Shoppable Services. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Merina Thomas,James Flaherty,Jiefei Wang,Morgan Henderson,Vivian Ho,Mark Cuban,Peter Cram
Importance US hospitals are required to publicly post their prices for specified shoppable services online. However, the extent to which a hospital's prices posted online correlate with the prices they give to a telephone caller is unknown. Objective To compare hospitals' online cash prices for vaginal childbirth and brain magnetic resonance imaging (MRI) with prices offered to secret shopper callers
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Potential Discrepancies in Sensitivity of Fracture Prediction Tools-Reply. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Carolyn J Crandall,Kristine E Ensrud
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Care Ecosystem Collaborative Model and Health Care Costs in Medicare Beneficiaries With Dementia: A Secondary Analysis of a Randomized Clinical Trial. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Elan L Guterman,Rachel E Kiekhofer,Andrew J Wood,I Elaine Allen,James G Kahn,Sarah Dulaney,Jennifer J Merrilees,Kirby Lee,Winston Chiong,Stephen J Bonasera,Tamara L Braley,Lauren J Hunt,Krista L Harrison,Bruce L Miller,Katherine L Possin
Importance Collaborative dementia care programs are effective in addressing the needs of patients with dementia and their caregivers. However, attempts to consider effects on health care spending have been limited, leaving a critical gap in the conversation around value-based dementia care. Objective To determine the effect of participation in collaborative dementia care on total Medicare reimbursement
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Potential Discrepancies in Sensitivity of Fracture Prediction Tools. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Chia-Hao Hsu,Chung-Hwan Chen,Nin-Chieh Hsu
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Xuebijing Injection for Sepsis Treatment: When Will It Be Approved Outside of China? JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Tianyang Hu
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Potential Discrepancies in Sensitivity of Fracture Prediction Tools. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Xiangling Deng,Huixia Zhou,Wenchao Li
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Health Care Transparency-What You See Should Be What You Get. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Aaron S Parzuchowski,A Mark Fendrick
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Machine-Made Empathy? Why Medicine Still Needs Humans-Reply. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 John W Ayers,Mark Dredze,Davey M Smith
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How Can Palliative Care Help Me? JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Govind Warrier,Arjun Gupta,Ramy Sedhom
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Machine-Made Empathy? Why Medicine Still Needs Humans. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Alfredo Vannacci,Roberto Bonaiuti,Claudia Ravaldi
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Automated Opt-Out vs Opt-In Patient Outreach Strategies for Breast Cancer Screening: A Randomized Clinical Trial. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Leah M Marcotte,Stefanie Deeds,Chelle Wheat,Eric Gunnink,Kristen Gray,Jorge Rojas,Carolyn Finch,Karin Nelson,Ashok Reddy
Importance Optimal strategies for population-based outreach for breast cancer screening remain unknown. Objective To evaluate the effect on breast cancer screening of an opt-out automatic mammography referral strategy compared with an opt-in automated telephone message strategy. Design, Setting, and Participants This pragmatic randomized clinical trial was conducted from April 2022 to January 2023
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Machine-Made Empathy? Why Medicine Still Needs Humans. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Angelo Cadiente,Jamie Chen,Bryan Pilkington
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An Abnormal ECG Finding in a Patient With COVID-19. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Abhishek Thakur,Anish Kapil,Siddharthan Deepti
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Association of Gestational Diabetes With Subsequent Long-Term Risk of Mortality. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Yi-Xin Wang,Makiko Mitsunami,JoAnn E Manson,Audrey J Gaskins,Janet W Rich-Edwards,Liang Wang,Cuilin Zhang,Jorge E Chavarro
Importance Gestational diabetes has been associated with numerous chronic diseases. However, few studies have examined the association of gestational diabetes with long-term mortality risk. Objective To investigate the associations between gestational diabetes and long-term risks of total and cause-specific mortality. Design, Setting, and Participants This cohort study analyzed participants of the
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US Medical Student Health Insurance Coverage for Mental Health Treatment After the COVID-19 Pandemic. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Amelia E Mercado,Karissa A Chesky,Ananth V Panchamukhi,J Wesley Boyd
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Designing Effective and Appropriate Opt-Out Approaches for Patient Outreach. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Kimberly J Waddell,Shivan J Mehta
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An Interesting Wide QRS Complex Tachycardia. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Qinghua Chang,Gaopin Wang,Renguang Liu
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Testing Whether Cancer Screening Saves Lives: Implications for Randomized Clinical Trials of Multicancer Screening. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 H Gilbert Welch,Tanujit Dey
Importance Cancer screening is often promoted as a means to save lives. The question of whether cancer screening truly saves lives is becoming increasingly relevant given the growing enthusiasm for multicancer detection blood tests (ie, liquid biopsies). It is possible in randomized clinical trials for screening to reduce deaths due to the targeted cancer without reducing deaths due to all causes.
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Estimated Lifetime Gained With Cancer Screening Tests: A Meta-Analysis of Randomized Clinical Trials. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-11-01 Michael Bretthauer,Paulina Wieszczy,Magnus Løberg,Michal F Kaminski,Tarjei Fiskergård Werner,Lise M Helsingen,Yuichi Mori,Øyvind Holme,Hans-Olov Adami,Mette Kalager
Importance Cancer screening tests are promoted to save life by increasing longevity, but it is unknown whether people will live longer with commonly used cancer screening tests. Objective To estimate lifetime gained with cancer screening. Data Sources A systematic review and meta-analysis was conducted of randomized clinical trials with more than 9 years of follow-up reporting all-cause mortality and
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A Case of S1Q3T3-A Classic Nonspecific Electrocardiogram Finding. JAMA Intern. Med. (IF 39.0) Pub Date : 2023-10-30 Rohit Pillai,Jason D Matos