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Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity Cell Stem Cell (IF 23.9) Pub Date : 2024-05-08 Jun Shen, Shuzhen Lyu, Yingxi Xu, Shuo Zhang, Li Li, Jinze Li, Junli Mou, Leling Xie, Kejing Tang, Wei Wen, Xuemei Peng, Ying Yang, Yu Shi, Xinjie Li, Min Wang, Xin Li, Jianxiang Wang, Tao Cheng
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ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum Cell Stem Cell (IF 23.9) Pub Date : 2024-05-07 Catarina Martins-Costa, Andrea Wiegers, Vincent A. Pham, Jaydeep Sidhaye, Balint Doleschall, Maria Novatchkova, Thomas Lendl, Marielle Piber, Angela Peer, Paul Möseneder, Marlene Stuempflen, Siu Yu A. Chow, Rainer Seidl, Daniela Prayer, Romana Höftberger, Gregor Kasprian, Yoshiho Ikeuchi, Nina S. Corsini, Jürgen A. Knoblich
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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor Cell Stem Cell (IF 23.9) Pub Date : 2024-05-03 Tingwei Guo, Fei Pei, Mingyi Zhang, Takahiko Yamada, Jifan Feng, Junjun Jing, Thach-Vu Ho, Yang Chai
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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Thomas Mortimer, Valentina M. Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G. Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B. Koronowski, Paul Petrus, Carolina M. Greco, Stephen Forrow, Henrik Oster, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
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Unveiling the mystery of nuclear RNA homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Lin Shan, Ling-Ling Chen
How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.
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Addressing challenges for repairing adult spinal cord with insights from neonates Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Mickey E. Abraham, Joel Martin, Joseph D. Ciacci
Stem cell therapy has emerged as a promising area of scientific investigation, sparking considerable interest, especially in spinal cord injury (SCI). Sun et al.1 discover that the extracellular matrix (ECM) from the neonatal spinal cord transmits biochemical signals to endogenous axons, thus promoting axonal regeneration.
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Actin pushes open a leaky lumen Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Jia Guo, Yue Shao
Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.1 establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.
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Sox9-coordinated cellular neighborhoods generate fibrosis Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Darrian Bugg, Jennifer Davis
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
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Microbial metabolite steers intestinal stem cell fate under stress Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Shu Zhu, Wen Pan
Recently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.
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Hallmarks of cancer stemness Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Jia-Jian Loh, Stephanie Ma
Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness
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Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Dhiraj Indana, Andrei Zakharov, Youngbin Lim, Alexander R. Dunn, Nidhi Bhutani, Vivek B. Shenoy, Ovijit Chaudhuri
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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Mohammad Nazim, Chia-Ho Lin, An-Chieh Feng, Wen Xiao, Kyu-Hyeon Yeom, Mulin Li, Allison E. Daly, Xianglong Tan, Ha Vu, Jason Ernst, Michael F. Carey, Stephen T. Smale, Douglas L. Black
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Connie Eaves (May 22, 1944–March 7, 2024) Cell Stem Cell (IF 23.9) Pub Date : 2024-05-02 Ali Turhan, Franck Nicolini, François Lemoine, Laure Coulombel, Saghi Ghaffari
No Abstract
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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells Cell Stem Cell (IF 23.9) Pub Date : 2024-05-01 Huijuan Hua, Yaqi Wang, Xiaofeng Wang, Shusen Wang, Yunlu Zhou, Yinan Liu, Zhen Liang, Huixia Ren, Sufang Lu, Shuangshuang Wu, Yong Jiang, Yue Pu, Xiang Zheng, Chao Tang, Zhongyang Shen, Cheng Li, Yuanyuan Du, Hongkui Deng
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Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease Cell Stem Cell (IF 23.9) Pub Date : 2024-04-30 Biao Huang, Zipeng Zeng, Sunghyun Kim, Connor C. Fausto, Kari Koppitch, Hui Li, Zexu Li, Xi Chen, Jinjin Guo, Chennan C. Zhang, Tianyi Ma, Pedro Medina, Megan E. Schreiber, Mateo W. Xia, Ariel C. Vonk, Tianyuan Xiang, Tadrushi Patel, Yidan Li, Riana K. Parvez, Balint Der, Zhongwei Li
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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer Cell Stem Cell (IF 23.9) Pub Date : 2024-04-24 Zahir Shah, Lei Tian, Zhixin Li, Lewei Jin, Jianying Zhang, Zhenlong Li, Tasha Barr, Hejun Tang, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
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Generation of human alveolar epithelial type I cells from pluripotent stem cells Cell Stem Cell (IF 23.9) Pub Date : 2024-04-19 Claire L. Burgess, Jessie Huang, Pushpinder S. Bawa, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Lauren J. Ayers, Michael P. Morley, Apoorva Babu, Carlos Villacorta-Martin, Maria Yampolskaya, Anne Hinds, Bibek R. Thapa, Feiya Wang, Adeline Matschulat, Pankaj Mehta, Edward E. Morrisey, Xaralabos Varelas, Darrell N. Kotton
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Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence Cell Stem Cell (IF 23.9) Pub Date : 2024-04-16 Xue Han, Linqing Xing, Yantao Hong, Xuechun Zhang, Bo Hao, J. Yuyang Lu, Mengyuan Huang, Zuhui Wang, Shaoqian Ma, Ge Zhan, Tong Li, Xiaowen Hao, Yibing Tao, Guanwen Li, Shuqin Zhou, Zheng Zheng, Wen Shao, Yitian Zeng, Dacheng Ma, Wenhao Zhang, Xiaohua Shen
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Cell Stem Cell (IF 23.9) Pub Date : 2024-04-15 Osama Al-Dalahmah, Matti Lam, Julie J. McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A. Jakubiak, Rebekka Kühn, Yoon A. Kim, Maria Caterina De Rosa, Claudia A. Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Gunnar Hargus
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Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development Cell Stem Cell (IF 23.9) Pub Date : 2024-04-11 Hsueh-Fu Wu, Kenyi Saito-Diaz, Chia-Wei Huang, Jessica L. McAlpine, Dong Eun Seo, D. Sumner Magruder, Mohamed Ishan, Harrison C. Bergeron, William H. Delaney, Fabio R. Santori, Smita Krishnaswamy, Gerald W. Hart, Ya-Wen Chen, Robert J. Hogan, Hong-Xiang Liu, Natalia B. Ivanova, Nadja Zeltner
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Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques Cell Stem Cell (IF 23.9) Pub Date : 2024-04-09 Byung-Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland Mortlock, Diana Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See DeRavin, Taehoon Shin, Sogun Hong, Cynthia E. Dunbar
Abstract not available
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Patient-derived tumor-like cell clusters for personalized chemo- and immunotherapies in non-small cell lung cancer Cell Stem Cell (IF 23.9) Pub Date : 2024-04-08 Shenyi Yin, Ying Yu, Nan Wu, Minglei Zhuo, Yanmin Wang, Yanjie Niu, Yiqian Ni, Fang Hu, Cuiming Ding, Hongsheng Liu, Xinghua Cheng, Jin Peng, Juan Li, Yang He, Jiaxin Li, Junyi Wang, Hanshuo Zhang, Xiaoyu Zhai, Bing Liu, Yaqi Wang, Jianzhong Jeff Xi
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Rebuilding and rebooting immunity with stem cells Cell Stem Cell (IF 23.9) Pub Date : 2024-04-08 Laura N. Stankiewicz, Fabio M.V. Rossi, Peter W. Zandstra
Advances in modern medicine have enabled a rapid increase in lifespan and, consequently, have highlighted the immune system as a key driver of age-related disease. Immune regeneration therapies present exciting strategies to address age-related diseases by rebooting the host’s primary lymphoid tissues or rebuilding the immune system directly via biomaterials or artificial tissue. Here, we identify
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Genetic haute couture to block HIV-1 at front doors Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Petronela Ancuta
The chemokine receptors CCR5 and CXCR4 are “front doors” for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).
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The difficult translational pathway from animal models to patients Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Marina Cavazzana, Annarita Miccio
Lee et al.1 analyzed the impacts of lentiviral vector transduction and CRISPR-Cas9/homology-directed repair editing on hematopoietic stem and progenitor cell (HSPC) engraftment and clonal dynamics. The study suggests that relative to lentiviral-vector-mediated gene addition, homology-directed repair editing is inefficient in vivo and might impair the engraftment and differentiation of HSPCs.
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Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Heather M. Sosnoski, Avery D. Posey
Anti-CD19 CAR T cells were among the last decade’s scientific breakthroughs, achieving remarkable remissions in patients with B cell leukemias and lymphomas. Now, the engineered cell therapies are traversing disease indications into autoimmunity and resolving disease symptoms in patients with systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis.1
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Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Courtney E. Vishy, Chardai Thomas, Thomas Vincent, Daniel K. Crawford, Matthew M. Goddeeris, Benjamin S. Freedman
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KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Jesse D. Lai, Joshua E. Berlind, Gabriella Fricklas, Cecilia Lie, Jean-Paul Urenda, Kelsey Lam, Naomi Sta Maria, Russell Jacobs, Violeta Yu, Zhen Zhao, Justin K. Ichida
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Kenji Namoto, Clara Baader, Vanessa Orsini, Alexandro Landshammer, Eva Breuer, Kieu Trinh Dinh, Rosemarie Ungricht, Monika Pikiolek, Stephane Laurent, Bo Lu, Alexandra Aebi, Katharina Schönberger, Eric Vangrevelinghe, Olivera Evrova, Tianliang Sun, Stefano Annunziato, Julie Lachal, Emily Redmond, Louis Wang, Kristie Wetzel, Jan S. Tchorz
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A simultaneous knockout knockin genome editing strategy in HSPCs potently inhibits CCR5- and CXCR4-tropic HIV-1 infection Cell Stem Cell (IF 23.9) Pub Date : 2024-04-04 Amanda M. Dudek, William N. Feist, Elena J. Sasu, Sofia E. Luna, Kaya Ben-Efraim, Rasmus O. Bak, Alma-Martina Cepika, Matthew H. Porteus
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Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids Cell Stem Cell (IF 23.9) Pub Date : 2024-04-01 Zheng Sun, Zhenni Chen, Man Yin, Xianming Wu, Bo Guo, Xiaokang Cheng, Rui Quan, Yuting Sun, Qi Zhang, Yongheng Fan, Chen Jin, Yanyun Yin, Xianglin Hou, Weiyuan Liu, Muya Shu, Xiaoyu Xue, Ya Shi, Bing Chen, Zhifeng Xiao, Jianwu Dai, Yannan Zhao
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Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment Cell Stem Cell (IF 23.9) Pub Date : 2024-03-26 Adrian A. Epstein, Sara N. Janos, Luca Menozzi, Kelly Pegram, Vaibhav Jain, Logan C. Bisset, Joseph T. Davis, Samantha Morrison, Aswathy Shailaja, Yingqiu Guo, Agnes S. Chao, Khadar Abdi, Blaire Rikard, Junjie Yao, Simon G. Gregory, Kimberley Fisher, Rick Pittman, Al Erkanli, Kathryn E. Gustafson, Caroline W.T. Carrico, Eric J. Benner
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Autofluorescence is a biomarker of neural stem cell activation state Cell Stem Cell (IF 23.9) Pub Date : 2024-03-22 Christopher S. Morrow, Kelsey Tweed, Sabina Farhadova, Alex J. Walsh, Bo P. Lear, Avtar Roopra, Ryan D. Risgaard, Payton C. Klosa, Zachary P. Arndt, Ella R. Peterson, Michelle M. Chi, Allison G. Harris, Melissa C. Skala, Darcie L. Moore
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Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques Cell Stem Cell (IF 23.9) Pub Date : 2024-03-19 Byung-Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland Mortlock, Diana Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See DeRavin, Taehoon Shin, Sogun Hong, Cynthia E. Dunbar
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Lung repair and regeneration: Advanced models and insights into human disease Cell Stem Cell (IF 23.9) Pub Date : 2024-03-15 Maria C. Basil, Konstantinos-Dionysios Alysandratos, Darrell N. Kotton, Edward E. Morrisey
The respiratory system acts as both the primary site of gas exchange and an important sensor and barrier to the external environment. The increase in incidences of respiratory disease over the past decades has highlighted the importance of developing improved therapeutic approaches. This review will summarize recent research on the cellular complexity of the mammalian respiratory system with a focus
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Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure Cell Stem Cell (IF 23.9) Pub Date : 2024-03-07 Xiang Yuan, Jingqi Wu, Zhen Sun, Jin Cen, Yajing Shu, Chenhua Wang, Hong Li, Dongni Lin, Kun Zhang, Baihua Wu, Anil Dhawan, Ludi Zhang, Lijian Hui
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A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Jenna M. Kastenschmidt, Joseph G. Schroers-Martin, Brian J. Sworder, Suhas Sureshchandra, Michael S. Khodadoust, Chih Long Liu, Mari Olsen, David M. Kurtz, Maximilian Diehn, Lisa E. Wagar, Ash A. Alizadeh
Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect clinical outcomes. Current immunotherapeutic strategies, including antibody- and cell-based therapies, variably overcome pro-tumorigenic mechanisms for sustained disease control. Modeling the intact FL TME, with its native, syngeneic tumor-infiltrating leukocytes, is a major challenge. Here, we describe an organoid
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An iron rheostat controls hematopoietic stem cell fate Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Yun-Ruei Kao, Jiahao Chen, Rajni Kumari, Anita Ng, Aliona Zintiridou, Madhuri Tatiparthy, Yuhong Ma, Maria M. Aivalioti, Deeposree Moulik, Sriram Sundaravel, Daqian Sun, Julie A. Reisz, Juliane Grimm, Nuria Martinez-Lopez, Stephanie Stransky, Simone Sidoli, Ulrich Steidl, Rajat Singh, Angelo D’Alessandro, Britta Will
Mechanisms governing the maintenance of blood-producing hematopoietic stem and multipotent progenitor cells (HSPCs) are incompletely understood, particularly those regulating fate, ensuring long-term maintenance, and preventing aging-associated stem cell dysfunction. We uncovered a role for transitory free cytoplasmic iron as a rheostat for adult stem cell fate control. We found that HSPCs harbor comparatively
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Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Shuyong Wang, Xuan Wang, Yiran Shan, Zuolong Tan, Yuxin Su, Yannan Cao, Shuang Wang, Jiahong Dong, Jin Gu, Yunfang Wang
Liver injuries often occur in a zonated manner. However, detailed regenerative responses to such zonal injuries at cellular and molecular levels remain largely elusive. By using a fate-mapping strain, , to elucidate liver regeneration after acute pericentral injury, we found that pericentral regeneration is primarily compensated by the expansion of remaining pericentral hepatocytes, and secondarily
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Hallmarks of totipotent and pluripotent stem cell states Cell Stem Cell (IF 23.9) Pub Date : 2024-02-20 Peng Du, Jun Wu
Though totipotency and pluripotency are transient during early embryogenesis, they establish the foundation for the development of all mammals. Studying these has been challenging due to limited access and ethical constraints, particularly in humans. Recent progress has led to diverse culture adaptations of epiblast cells in the form of totipotent and pluripotent stem cells, which not only deepen our
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Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders Cell Stem Cell (IF 23.9) Pub Date : 2024-02-20 David Shin, Chang N. Kim, Jayden Ross, Kelsey M. Hennick, Sih-Rong Wu, Neha Paranjape, Rachel Leonard, Jerrick C. Wang, Matthew G. Keefe, Bryan J. Pavlovic, Kevin C. Donohue, Clara Moreau, Emilie M. Wigdor, H. Hanh Larson, Denise E. Allen, Cathryn R. Cadwell, Aparna Bhaduri, Galina Popova, Carrie E. Bearden, Alex A. Pollen, Sebastien Jacquemont, Stephan J. Sanders, David Haussler, Arun P. Wiita, Nicholas
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to study the mechanisms by which abnormalities emerge in the context of the 22q11.2 microdeletion, which confers significant genetic risk for psychiatric disorders. We investigated early stages of human thalamus development using human pluripotent stem cell-derived organoids and show that the 22q11.2 microdeletion
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Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes Cell Stem Cell (IF 23.9) Pub Date : 2024-02-15 Kavita Raniga, Aishah Nasir, Nguyen T.N. Vo, Ravi Vaidyanathan, Sarah Dickerson, Simon Hilcove, Diogo Mosqueira, Gary R. Mirams, Peter Clements, Ryan Hicks, Amy Pointon, Will Stebbeds, Jo Francis, Chris Denning
Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have prompted their therapeutic application and utilization for evaluating potential cardiovascular safety liabilities. In this perspective, we showcase key efforts toward the large-scale production of hiPSC-CMs, implementation of hiPSC-CMs in industry settings, and recent clinical applications of this technology. The key observations
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Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues Cell Stem Cell (IF 23.9) Pub Date : 2024-02-15 Chenxi Ye, Chuanlai Yang, Heqiang Zhang, Rui Gao, Yingnan Liao, Yali Zhang, Lingjun Jie, Yanhui Zhang, Tong Cheng, Yan Wang, Jie Ren
The creation of a functional 3D bioprinted human heart remains challenging, largely due to the lack of some crucial cardiac cell types, including the atrioventricular canal (AVC) cardiomyocytes, which are essential to slow down the electrical impulse between the atrium and ventricle. By utilizing single-cell RNA sequencing analysis and a 3D bioprinting technology, we discover that stage-specific activation
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Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate Cell Stem Cell (IF 23.9) Pub Date : 2024-02-08 Xiaomeng Hu, Kathy White, Chi Young, Ari G. Olroyd, Paul Kievit, Andrew J. Connolly, Tobias Deuse, Sonja Schrepfer
Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes mellitus is severely hampered by the requirement for continuous immunosuppression and its associated morbidity. We report that allogeneic transplantation of genetically engineered (B2M, CIITA, CD47), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent,
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Bioprinting functional neural networks Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 S, t, e, p, h, a, n, i, e, , M, ., , W, i, l, l, e, r, t, h
3D printing human tissue models derived from stem cells provides an increasingly popular tissue engineering strategy for probing biological questions. Here Yan et al.1 demonstrate how this technology can be used to model mature human neural tissues with functional neural networks in healthy and disease states.
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What is the scope of Cell Stem Cell now and in the future? Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Sheila Chari, Catherine Landis, Quan Wang, Christine Weber
Abstract not available
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Unraveling the brain’s response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Ilse Eidhof, Daniel Twohig, Anna Falk
COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.
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Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Arun Pandian Chandrasekaran, Mo Li
Despite advances in stem cell cultures, modeling early human development with stem cells in a dish remains challenging. Research by Hislop et al.,1 Okubo et al.,2 and Wei et al.3 paves the way for improved in vitro embryo models and culture conditions, offering valuable insights for regenerative medicine.
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Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Viviane Tabar, Roger A. Barker
Sham surgery is often required for cell therapies adopting a randomized placebo-controlled double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson’s disease, we argue that alternative trial designs should be considered instead, for several reasons relating to ethics, patient burden, ease of unblinding, and cost.
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Metabolic regulation of the hallmarks of stem cell biology Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Benjamin T. Jackson, Lydia W.S. Finley
Stem cells perform many different functions, each of which requires specific metabolic adaptations. Over the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic preferences and strategies that correlate with or exert control over specific cell states. This review aims to describe the common themes that emerge from the study of stem cell metabolism: (1) metabolic
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3D bioprinting of human neural tissues with functional connectivity Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Yuanwei Yan, Xueyan Li, Yu Gao, Sakthikumar Mathivanan, Linghai Kong, Yunlong Tao, Yi Dong, Xiang Li, Anita Bhattacharyya, Xinyu Zhao, Su-Chun Zhang
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SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G. Miller, Christopher J. Gibson, Alexander G. Bick, Jaime M. Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J. Venters, Pierre-Olivier Estève, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S. Sperling, Margaret A. Goodell
Abstract not available
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Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Sanghyun Park, Chan Wook Park, Jang Hyeon Eom, Mi-Young Jo, Hye-Jin Hur, Sung Kyoung Choi, Jae Souk Lee, Seung Taek Nam, Ki-Sang Jo, Young Woo Oh, Jungil Lee, Sieun Kim, Do-Hun Kim, Chul-Yong Park, Su Jin Kim, Ho-Young Lee, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Kim
Abstract not available
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SARS-CoV-2 infection causes dopaminergic neuron senescence Cell Stem Cell (IF 23.9) Pub Date : 2024-01-17 Liuliu Yang, Tae Wan Kim, Yuling Han, Manoj S. Nair, Oliver Harschnitz, Jiajun Zhu, Pengfei Wang, So Yeon Koo, Lauretta A. Lacko, Vasuretha Chandar, Yaron Bram, Tuo Zhang, Wei Zhang, Feng He, Chendong Pan, Junjie Wu, Yaoxing Huang, Todd Evans, Paul van der Valk, Maarten J. Titulaer, Jochem K.H. Spoor, Robert L. Furler O’Brien, Marianna Bugiani, Wilma D.J. Van de Berg, Robert E. Schwartz, David D. Ho
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Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy Cell Stem Cell (IF 23.9) Pub Date : 2024-01-17 Qian Li, Andrew Sharkey, Megan Sheridan, Elisa Magistrati, Anna Arutyunyan, Oisin Huhn, Carmen Sancho-Serra, Holly Anderson, Naomi McGovern, Laura Esposito, Ridma Fernando, Lucy Gardner, Roser Vento-Tormo, Margherita Yayoi Turco, Ashley Moffett
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Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-01-16 Xia Kang, Jin Qian, You-xing Shi, Xu-ting Bian, Li-dan Zhang, Gao-ming Li, Li-ting Wang, Jing Zhao, Zhen-yu Dong, Meng-meng Yang, Yu-Jia-Nan Chen, Kang-lai Tang, Hong-ming Miao
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Human conjunctiva organoids to study ocular surface homeostasis and disease Cell Stem Cell (IF 23.9) Pub Date : 2024-01-11 Marie Bannier-Hélaouët, Jeroen Korving, Ziliang Ma, Harry Begthel, Amir Giladi, Mart M. Lamers, Willine J. van de Wetering, Nobuyo Yawata, Makoto Yawata, Vanessa L.S. LaPointe, Mor M. Dickman, Rachel Kalmann, Saskia M. Imhoff, Johan H. van Es, Carmen López-Iglesias, Peter J. Peters, Bart L. Haagmans, Wei Wu, Hans Clevers
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A time- and single-cell-resolved model of murine bone marrow hematopoiesis Cell Stem Cell (IF 23.9) Pub Date : 2024-01-05 Iwo Kucinski, Joana Campos, Melania Barile, Francesco Severi, Natacha Bohin, Pedro N. Moreira, Lewis Allen, Hannah Lawson, Myriam L.R. Haltalli, Sarah J. Kinston, Dónal O'Carroll, Kamil R. Kranc, Berthold Göttgens
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The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Shree Bose, Xiling Shen
Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.
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Hallmarks of stemness in mammalian tissues Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Joep Beumer, Hans Clevers
All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key