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Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion Biomaterials (IF 14.0) Pub Date : 2024-03-16 Yu Huang, Weichao Hu, Kaige Xu, Ruijue Dan, Shali Tan, Zhenzhen Shu, Xin Li, Hangzong Liu, Chaoqiang Fan, Malcolm Xing, Shiming Yang
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing
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ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction Biomaterials (IF 14.0) Pub Date : 2024-03-16 Shuqin Wang, Yuejun Yao, Liang Song, Zihe Zhai, Shifen Li, Zhaolong Wang, Liyin Shen, Yang Zhu, Wenxing Liu, Changyou Gao
Despite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical
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“On/off”-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX Biomaterials (IF 14.0) Pub Date : 2024-03-14 Shuaijun Li, Caiting Meng, Qian Hao, Ruina Zhou, Luyao Dai, Yucheng Guo, Sitong Zhao, Xin Zhou, Chunju Lou, Ji Xu, Peng Xu, Jinfan Yang, Yifan Ding, Yanni Lv, Shengli Han, Shuai Li, Jing Li, Huafeng Kang, Zhengtao Xiao, Mingqian Tan, Xiaobin Ma, Hao Wu
Non-small cell lung cancer (NSCLC) brain metastases present a significant treatment challenge due to limited drug delivery efficiency and severe adverse reactions. In this study, we address these challenges by designing a “on/off” switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct “on/off” switchable release
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Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection Biomaterials (IF 14.0) Pub Date : 2024-03-14 Menglin Sun, Jiameng Wang, Xiaobo Huang, Ruiqiang Hang, Peide Han, Jiqiang Guo, Xiaohong Yao, Paul K. Chu, Xiangyu Zhang
The poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO nanorod arrays and -arginine (BaTiO/LA)
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MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes Biomaterials (IF 14.0) Pub Date : 2024-03-13 Yangyang Zhu, Pin Chen, Bochuan Hu, Suqin Zhong, Kai Yan, Yu Wu, Shanshan Li, Yinyin Yang, Zexin Xu, Yutong Lu, Ying Ouyang, Hui Bao, Weiguang Gu, Longping Wen, Yunjiao Zhang
Myeloid-derived suppressor cells (MDSCs) play a crucial role in the immune escape mechanisms that limit the efficacy of immunotherapeutic strategies. In the tumor microenvironment, NLRP3 inflammasome-driven Interleukin-1β (IL-1β) production serves to dampen antitumor immune responses, promoting tumor growth, progression, and immunosuppression. In this study, we revealed that gold nanoparticles (Au
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Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation Biomaterials (IF 14.0) Pub Date : 2024-03-11 Baoyi Li, Menghang Zu, Aodi Jiang, Yingui Cao, Jiaxue Wu, Mohammad-Ali Shahbazi, Xiaoxiao Shi, Rui L. Reis, Subhas C. Kundu, Bo Xiao
The therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs)
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Perfusable adipose decellularized extracellular matrix biological scaffold co-recellularized with adipose-derived stem cells and L6 promotes functional skeletal muscle regeneration following volumetric muscle loss Biomaterials (IF 14.0) Pub Date : 2024-03-11 Wei Liang, Meng Han, Guan Li, Wanwen Dang, Huiting Wu, Xiaoyu Meng, Yonghuan Zhen, Weibo Lin, Rigele Ao, Xiaoqing Hu, Yang An
Muscle tissue engineering is a promising therapeutic strategy for volumetric muscle loss (VML). Among them, decellularized extracellular matrix (dECM) biological scaffolds have shown certain effects in restoring muscle function. However, researchers have inconsistent or even contradictory results on whether dECM biological scaffolds can efficiently regenerate muscle fibers and restore muscle function
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Progress in the development of piezoelectric biomaterials for tissue remodeling Biomaterials (IF 14.0) Pub Date : 2024-03-11 Amit Nain, Srishti Chakraborty, Snigdha Roy Barman, Pratik Gavit, Sushma Indrakumar, Akhilesh Agarwal, Zong-Hong Lin, Kaushik Chatterjee
Piezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering
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Degradation-controlled tissue extracellular sponge for rapid hemostasis and wound repair after kidney injury Biomaterials (IF 14.0) Pub Date : 2024-03-11 Jae Yun Kim, Tugce Sen, Jae Yeon Lee, Dong-Woo Cho
Patients diagnosed with T1a cancer undergo partial nephrectomy to remove the tumors. In the process of removing the tumors, loss of kidney volume is inevitable, and current surgical methods focus solely on hemostasis and wound closure. Here, we developed an implantable form of decellularized extracellular matrix sponge to target both hemostasis and wound healing at the lesion site. A porous form of
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Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity Biomaterials (IF 14.0) Pub Date : 2024-03-09 Tim Kaden, Raquel Alonso-Roman, Parastoo Akbarimoghaddam, Alexander S. Mosig, Katja Graf, Martin Raasch, Bianca Hoffmann, Marc T. Figge, Bernhard Hube, Mark S. Gresnigt
is a commensal yeast of the human intestinal microbiota that, under predisposing conditions, can become pathogenic and cause life-threatening systemic infections (candidiasis). Fungal-host interactions during candidiasis are commonly studied using conventional 2D models, which have provided critical insights into the pathogenicity. However, microphysiological models with a higher biological complexity
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Local delivery of stem cell spheroids with protein/polyphenol self-assembling armor to improve myocardial infarction treatment via immunoprotection and immunoregulation Biomaterials (IF 14.0) Pub Date : 2024-03-08 Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which
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An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-27 Huan Wang, Xinchen Liu, Xiangyu Yan, Yong Du, Fang Pu, Jinsong Ren, Xiaogang Qu
Anticancer nanomedicines used for ferroptosis therapy generally rely on the direct delivery of Fenton catalysts to drive lipid peroxidation in cancer cells. However, the therapeutic efficacy is limited by the ferroptosis resistance caused by the intracellular anti-ferroptotic signals. Herein, we report the intrinsic ATPase-mimicking activity of a vanadium carbide MXene nanozyme (PVCMs) to pharmacologically
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Ultrasound-augmented enzyodynamic-Ca2+ overload synergetic tumor nanotherapy Biomaterials (IF 14.0) Pub Date : 2024-02-26 Meiqi Chang, Lu Zhang, Tingting Zhang, Yanqiu Duan, Wei Feng, Shaoling Yang, Yu Chen, Zeyu Wang
The excessive intracellular Ca can induce oxidative stress, mitochondrial damage and cell apoptosis, which has been extensively explored for tumor therapy. However, the low Ca accumulation originated from Ca-based nanosystems substantially weakens the therapeutic effect. Herein, a functional plant polyphenol-appended enzyodynamic nanozyme system CaFeO@BSA-curcumin (abbreviation as CFO-CUR) has been
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Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA–cGAS–STING signaling Biomaterials (IF 14.0) Pub Date : 2024-02-26 Xinying Yu, Bei Li, Jie Yan, Wenxi Li, Hao Tian, Guohao Wang, Songtao Zhou, Yunlu Dai
Proteotoxic stress, caused by the accumulation of abnormal unfolded or misfolded cellular proteins, can efficiently activate inflammatory innate immune response. Initiating the mitochondrial proteotoxic stress might go forward to enable the cytosolic release of intramitochondrial DNA (mtDNA) for the immune-related mtDNA–cGAS–STING activation, which however is easily eliminated by a cell self-protection
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Multichannel-optical imaging for in vivo evaluating the safety and therapeutic efficacy of stem cells in tumor model in terms of cell tropism, proliferation and NF-κB activity Biomaterials (IF 14.0) Pub Date : 2024-02-23 Dehua Huang, Xue Yang, Zhao Peng, Hongqiang Yin, Yongyang Liu, Yejun Zhang, Chunyan Li, Guangcun Chen, Qiangbin Wang
Stem cell-based cancer treatment has garnered significant attention, yet its safety and efficacy remain incompletely understood. The nuclear factor-kappa B (NF-κB) pathway, a critical signaling mechanism involved in tumor growth, angiogenesis, and invasion, serves as an essential metric for evaluating the behavior of stem cells in tumor models. Herein, we report the development of a triple-channel
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Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration Biomaterials (IF 14.0) Pub Date : 2024-02-23 Sojung Kwak, Cho Lok Song, Jinhyuk Lee, Sungyeon Kim, Seungyoon Nam, Young-Jun Park, Jungwoon Lee
Cellular skin substitutes such as epidermal constructs have been developed for various applications, including wound healing and skin regeneration. These cellular models are mostly derived from primary cells such as keratinocytes and fibroblasts in a two-dimensional (2D) state, and further development of three-dimensional (3D) cultured organoids is needed to provide insight into the epidermal phenotype
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Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation Biomaterials (IF 14.0) Pub Date : 2024-02-21 Jiale Dong, Wei Zhou, Xianli Hu, Jiaxiang Bai, Siming Zhang, Xianzuo Zhang, Lei Yu, Peng Yang, Lingtong Kong, Mingkai Liu, Xifu Shang, Zheng Su, Dechun Geng, Chen Zhu
Implant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria colonizing the surface of implants disrupt bone formation-related cells and interfere with the osteoimmune system, resulting in an impaired immune microenvironment and osteogenesis disorders. Inspired by nature, a zeolitic imidazolate framework (ZIF)-sealed smart drug delivery system on Ti substrates (ZSTG)
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Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-21 Fenggang Qi, Qunqun Bao, Ping Hu, Yuedong Guo, Yang Yan, Xudong Yao, Jianlin Shi
Surgical intervention followed by chemotherapy is the principal treatment strategy for bladder cancer, which is hindered by significant surgical risks, toxicity from chemotherapy, and high rates of recurrence after surgery. In this context, a novel approach using mild magnetic hyperthermia therapy (MHT) for bladder cancer treatment through the intra-bladder delivery of magnetic nanoparticles is presented
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Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-02-20 Rui Sun, Huajian Chen, Man Wang, Toru Yoshitomi, Masaki Takeguchi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Combination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic FeO nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes
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Multi-functional dual-layer nanofibrous membrane for prevention of postoperative pancreatic leakage Biomaterials (IF 14.0) Pub Date : 2024-02-19 Prayas Chakma Shanto, Md Abdullah Al Fahad, Hae Il Jung, Myeongki Park, Hyeyoung Kim, Sang Ho Bae, Byong-Taek Lee
Postoperative pancreatic leakage due to pancreatitis in patients is a life-threatening surgical complication. The majority of commercial barriers are unable to meet the demands for pancreatic leakage due to poor adhesiveness, toxicity, and inability to degrade. In this study, we fabricated mitomycin-c and thrombin-loaded multifunctional dual-layer nanofibrous membrane with a combination of alginate
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Small-diameter vascular graft composing of core-shell structured micro-nanofibers loaded with heparin and VEGF for endothelialization and prevention of neointimal hyperplasia Biomaterials (IF 14.0) Pub Date : 2024-02-14 Md Abdullah Al Fahad, Hyun-Yong Lee, Seongsu Park, Minji Choi, Prayas Chakma Shanto, Myeongki Park, Sang Ho Bae, Byong-Taek Lee
Despite the significant progress made in recent years, clinical issues with small-diameter vascular grafts related to low mechanical strength, thrombosis, intimal hyperplasia, and insufficient endothelialization remain unresolved. This study aims to design and fabricate a core-shell fibrous small-diameter vascular graft by co-axial electrospinning process, which will mechanically and biologically meet
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Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration Biomaterials (IF 14.0) Pub Date : 2024-02-13 Lei Liu, Wantao Wang, Lin Huang, Yiwen Xian, Wenzheng Ma, Jinghao Fan, Yixi Li, Hongmei Liu, Zhaomin Zheng, Decheng Wu
Chronic local inflammation and resulting cellular dysfunction of nucleus pulposus (NP) cells are important pathogenic factors of intervertebral disc degeneration (IDD). Injectable pathological microenvironment-responsive hydrogels hold significant potential for treating IDD by adapting to dynamic microenvironment of IDD. Herein, we proposed an injectable gelatin-based hydrogel drug delivery system
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Patient-derived tumor spheroid-induced angiogenesis preclinical platform for exploring therapeutic vulnerabilities in cancer Biomaterials (IF 14.0) Pub Date : 2024-02-12 Jihoon Ko, Sujin Hyung, You Jeong Heo, Sangmin Jung, Seung Tae Kim, Se Hoon Park, Jung Yong Hong, Sung Hee Lim, Kyoung-Mee Kim, Sanghee Yoo, Noo Li Jeon, Jeeyun Lee
This study addresses the demand for research models that can support patient-treatment decisions and clarify the complexities of a tumor microenvironment by developing an advanced non-animal preclinical cancer model. Based on patient-derived tumor spheroids (PDTS), the proposed model reconstructs the tumor microenvironment with emphasis on tumor spheroid-driven angiogenesis. The resulting microfluidic
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Corrigendum to “On-site fabrication of bi-layered adhesive mesenchymal stromal cell dressings for the treatment of heart failure” [Biomaterials 209 (2019) 41–53] Biomaterials (IF 14.0) Pub Date : 2024-02-09 Kazuya Kobayashi, Yuki Ichihara, Nobuhiko Sato, Nobuyoshi Umeda, Laura Fields, Masafumi Fukumitsu, Yoshiyuki Tago, Tomoya Ito, Satoshi Kainuma, Mihai Podaru, Fiona Lewis-McDougall, Kenichi Yamahara, Rakesh Uppal, Ken Suzuki
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Corrigendum to “Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure” [Biomaterials 154 (2018) 12–23] Biomaterials (IF 14.0) Pub Date : 2024-02-09 Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki
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Targeted platelet with hydrogen peroxide responsive behavior for non-alcoholic steatohepatitis detection Biomaterials (IF 14.0) Pub Date : 2024-02-08 Jingjing Liu, Xingang Liu, Yi Shan, Hui Jun Ting, Xiaodong Yu, Jiong-Wei Wang, Bin Liu
The most common chronic liver illness, non-alcoholic fatty liver disease (NAFLD), refers to a range of abnormalities of the liver with varying degrees of steatosis. When the clinical symptoms including liver damage, inflammation, and fibrosis, are added to the initial steatosis, NAFLD becomes non-alcoholic steatohepatitis (NASH), the problematic and severe stage. The diagnosis of NASH at the right
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Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers Biomaterials (IF 14.0) Pub Date : 2024-02-07 Wei Zhang, Shuo Xiang, Yuxin Han, Haiyan Wang, Yuxian Deng, Panpan Bian, Yoshio Bando, Dmitri Golberg, Qunhong Weng
The porous nature and structural variability of covalent organic frameworks (COFs) make them preferred for drug loading and delivery applications. However, most COF materials suffer from poor luminescent properties and inefficiency for cell uptake. Herein, we experimentally demonstrate the crucial role of long alkoxy chains in the synthesis of crystalline COF nanostructures with high cellular uptake
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Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis Biomaterials (IF 14.0) Pub Date : 2024-02-07 Hui-Chun Huang, Ting-Yun Wang, Joshua Rousseau, Mark Orlando, Michelle Mungaray, Chamonix Michaud, Christopher Plaisier, Zhen Bouman Chen, Kuei-Chun Wang
Atherosclerosis, a chronic inflammatory disease, is the primary cause of myocardial infarction and ischemic stroke. Recent studies have demonstrated that dysregulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) contributes to plaque development, making YAP/TAZ potential therapeutic targets. However, systemic modulation of YAP/TAZ expression or activities
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Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury Biomaterials (IF 14.0) Pub Date : 2024-02-06 Dora Livkisa, Tzu-Hsin Chang, Thierry Burnouf, Andreas Czosseck, Nhi Thao Ngoc Le, Gleb Shamrin, Wei-Ting Yeh, Masao Kamimura, David J. Lundy
Extracellular vesicles (EVs) from cultured cells or bodily fluids have been demonstrated to show therapeutic value following myocardial infarction. However, challenges in donor variation, EV generation and isolation methods, and material availability have hindered their therapeutic use. Here, we show that human clinical-grade platelet concentrates from a blood establishment can be used to rapidly generate
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Aged breast matrix bound vesicles promote breast cancer invasiveness Biomaterials (IF 14.0) Pub Date : 2024-02-04 Jun Yang, Gokhan Bahcecioglu, George Ronan, Pinar Zorlutuna
Aging is one of the inherent risk factors for breast cancer. Although the influence of age-related cellular alterations on breast cancer development has been extensively explored, little is known about the alterations in the aging breast tissue microenvironment, specifically the extracellular matrix (ECM). Here, for the first time in literature, we have identified tissue resident matrix bound vesicles
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Intraoperative application of intelligent, responsive, self-assembling hydrogel rectifies oxygen and energy metabolism in traumatically injured brain Biomaterials (IF 14.0) Pub Date : 2024-01-31 Yuhan Han, Weiji Weng, Yongkang Zhang, Qiyuan Feng, Yuxiao Ma, Ankang Quan, Xianhua Fu, Xinxin Zhao, Loren Skudder-Hill, Jiyao Jiang, Yan Zhou, Honglin Chen, Junfeng Feng
In managing severe traumatic brain injury (TBI), emergency surgery involving the removal of damaged brain tissue and intracerebral hemorrhage is a priority. Secondary brain injury caused by oxidative stress and energy metabolic disorders, triggered by both primary mechanical brain damage and surgical insult, is also a determining factor in the prognosis of TBI. Unfortunately, the effectiveness of traditional
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Glutaminolysis inhibition boosts photodynamic therapy to eliminate cancer stem cells Biomaterials (IF 14.0) Pub Date : 2024-02-02 Qiang Wang, Shiyou Li, Chen Xu, Xing Wang, Tian Yang, Chong Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li
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Bone formation by human paediatric marrow stromal cells in a functional allogeneic immune system Biomaterials (IF 14.0) Pub Date : 2024-01-31 Virginia Palomares Cabeza, Niamh Fahy, Caoimhe H. Kiernan, Andrea Lolli, Janneke Witte-Bouma, Shorouk Fahmy Garcia, Ana Merino, Nicole Kops, Yanto Ridwan, Eppo B. Wolvius, Pieter A.J. Brama, Martin Hoogduijn, Eric Farrell
Allogeneic stem-cell based regenerative medicine is a promising approach for bone defect repair. The use of chondrogenically differentiated human marrow stromal cells (MSCs) has been shown to lead to bone formation by endochondral ossification in immunodeficient pre-clinical models. However, an insight into the interactions between the allogeneic immune system and the human MSC-derived bone grafts
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A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia Biomaterials (IF 14.0) Pub Date : 2024-02-01 Wonmin Choi, Gil Aizik, Claire A. Ostertag-Hill, Daniel S. Kohane
Local anesthetics are effective in relieving pain, but their duration of action is short. Therefore, the development of injectable sustained release systems to prolong the effect of local anesthetics has been of interest. In such systems delivering conventional local anesthetics, it has been challenging to achieve long durations of effect, particularly without incurring tissue toxicity. To overcome
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Nonmetallic graphite for tumor magnetic hyperthermia therapy Biomaterials (IF 14.0) Pub Date : 2024-02-01 Guangchao Xie, Shuyue Guo, Bingjie Li, Wenjing Hou, Yanqi Zhang, Jinbin Pan, Xi Wei, Shao-Kai Sun
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Bioactive nanomaterials kickstart early repair processes and Potentiate temporally modulated healing of healthy and diabetic wounds Biomaterials (IF 14.0) Pub Date : 2024-01-30 Deepanjan Ghosh, Jordan R. Yaron, Muhammad Raisul Abedin, Sudhakar Godeshala, Suneel Kumar, Jacquelyn Kilbourne, Francois Berthiaume, Kaushal Rege
Slow-healing and chronic wounds represent a major global economic and medical burden, and there is significant unmet need for novel therapies which act to both accelerate wound closure and enhance biomechanical recovery of the skin. Here, we report a new approach in which bioactives that augment early stages of wound healing can kickstart and engender effective wound closure in healthy and diabetic
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Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization Biomaterials (IF 14.0) Pub Date : 2024-01-27 Yi-Di Xu, Xiang-Chao Liang, Zhi-Peng Li, Zhao-Sheng Wu, Jie Yang, Shi-Zhen Jia, Rui Peng, Zhen-Yan Li, Xiao-He Wang, Fang-Ji Luo, Jia-Jing Chen, Wen-Xiang Cheng, Peng Zhang, Zhen-Gang Zha, Rong Zeng, Huan-Tian Zhang
Bromodomain-containing protein 4 (BRD4) is the most well-studied BET protein that is important for the innate immune response. We recently revealed that targeting BRD4 triggers apoptosis in tumor-associated macrophages, but its role in synovial macrophages and joint inflammation is largely unknown. Herein, we demonstrated that BRD4 was highly expressed in the iNOS-positive M1 macrophages in the human
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Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis Biomaterials (IF 14.0) Pub Date : 2024-01-23 Bingjie Wang, Teng Wang, Tianze Jiang, Shuang Li, Lianxiao Zhang, Xia Zhao, Xiaojia Yang, Xueyang Wang
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An injectable hydrogel microsphere-integrated training court to inspire tumor-infiltrating T lymphocyte potential Biomaterials (IF 14.0) Pub Date : 2024-01-25 Jiachen He, Junjie Niu, Lin Wang, Wen Zhang, Xu He, Xiongjinfu Zhang, Wei Hu, Yunkai Tang, Huilin Yang, Jie Sun, Wenguo Cui, Qin Shi
Although tumor-infiltrating T lymphocytes (TIL-Ts) play a crucial role in solid tumor immunotherapy, their clinical application has been limited because of the immunosuppressive microenvironment. Herein, we developed an injectable hydrogel microsphere-integrated training court (MS-ITC) to inspire the function of TIL-Ts and amplify TIL-Ts, through grafting with anti-CD3 and anti-CD28 antibodies and
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Immunosuppressive enzyme-responsive nanoparticles for enhanced accumulation in liver allograft to overcome acute rejection Biomaterials (IF 14.0) Pub Date : 2024-01-19 Feixiang Luo, Mingqian Li, Yuguo Chen, Shifei Song, Haiyang Yu, Peng Zhang, Chunsheng Xiao, Guoyue Lv, Xuesi Chen
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Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma Biomaterials (IF 14.0) Pub Date : 2024-01-21 Qin Shi, Wen Zhang, Yongjie Zhou, Songjiang Huang, Jiaze Yu, Minjie Yang, Zihan Zhang, Jingqin Ma, Jianjun Luo, Shengxiang Rao, Daru Lu, Shaojun Peng, Yongbin Cao, Lingxiao Liu, Zhiping Yan
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Platelet-derived drug delivery systems: Pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond Biomaterials (IF 14.0) Pub Date : 2024-01-20 Yalan Zhu, Lingling Xu, Yong Kang, Qinzhen Cheng, Yiling He, Xiaoyuan Ji
Platelets play a critical role as circulating cells in the human body and contribute to essential physiological processes such as blood clotting, hemostasis, vascular repair, and thrombus formation. Currently, platelets are extensively employed in the development of innovative biomimetic drug delivery systems, offering significant enhancements in circulation time, biocompatibility, and targeted delivery
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Nanomedicines for reversing immunosuppressive microenvironment of hepatocellular carcinoma Biomaterials (IF 14.0) Pub Date : 2024-01-22 Xier Pan, Shuting Ni, Kaili Hu
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On-chip recapitulation of the tumor microenvironment: A decade of progress Biomaterials (IF 14.0) Pub Date : 2024-01-22 S.M. Giannitelli, V. Peluzzi, S. Raniolo, G. Roscilli, M. Trombetta, P. Mozetic, A. Rainer
One of the hurdles to the development of new anticancer therapies is the lack of in vitro models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding the dynamic relationships between the components of the TME in a controllable, scalable, and reliable setting would indeed support the discovery of biological targets impacting cancer diagnosis and therapy. Cancer research
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Nanotherapeutics for prostate cancer treatment: A comprehensive review Biomaterials (IF 14.0) Pub Date : 2024-01-16 Ruimin Hu, Jin Lan, Dinglin Zhang, Wenhao Shen
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Gint4.T-siHDGF chimera-capped mesoporous silica nanoparticles encapsulating temozolomide for synergistic glioblastoma therapy Biomaterials (IF 14.0) Pub Date : 2024-01-20 Huaijun Fei, Yang Jin, Nan Jiang, Yuhan Zhou, Ningcheng Wei, Yifan Liu, Jiayi Miao, Liying Zhang, Rui Li, Aixia Zhang, Shuhu Du
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Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory Programs to induce stem cell differentiation Biomaterials (IF 14.0) Pub Date : 2024-01-18 Anna L. Kersey, Daniel Y. Cheng, Kaivalya A. Deo, Christina R. Dubell, Ting-Ching Wang, Manish K. Jaiswal, Min Hee Kim, Aparna Murali, Sarah Hargett, Sumana Mallick, Tanmay P. Lele, Irtisha Singh, Akhilesh K. Gaharwar
Engineered matrices provide a valuable platform to understand the impact of biophysical factors on cellular behavior such as migration, proliferation, differentiation, and tissue remodeling, through mechanotransduction. While recent studies have identified some mechanisms of 3D mechanotransduction, there is still a critical knowledge gap in comprehending the interplay between 3D confinement, ECM properties
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Camptothesome-based combination nanotherapeutic regimen for improved colorectal cancer immunochemotherapy Biomaterials (IF 14.0) Pub Date : 2024-01-18 Zhiren Wang, Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Jinha Chung, Minhyeok Kim, Aaron James Scott, Jianqin Lu
Camptothesome is a sphingomyelin-conjugated camptothecin (SM-CSS-CPT) nanovesicle that fortified the therapeutic delivery of CPT in diverse cancer types. To mitigate the Camptothesome-induced IDO1 negative feedback mechanism, we had co-encapsulated, indoximod (IND, IDO1 inhibitor) into Camptothesome using doxorubicin-derived IND (DOX-IND). To maximize the therapeutic potential of DOX-IND/Camptothesome
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Arginine-assembly as NO nano-donor prevents the negative feedback of macrophage repolarization by mitochondrial dysfunction for cancer immunotherapy Biomaterials (IF 14.0) Pub Date : 2024-01-17 Xiao Zheng, Ying Liu, Yiqiong Liu, Jie Zang, Kun Wang, Zichen Yang, Nana Chen, Jiuyuan Sun, Li Huang, Yan Li, Liangyi Xue, Hui Zhi, Xiaoyou Zhang, Min Yu, Shiyu Chen, Haiqing Dong, Yongyong Li
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Gel-mediated recruitment of conventional type 1 dendritic cells potentiates the therapeutic effects of radiotherapy Biomaterials (IF 14.0) Pub Date : 2024-01-11 Yumin Wu, Quguang Li, Yifan Yan, Yu Hao, Chunjie Wang, Bo Liu, Yujie Zhu, Zhuang Liu, Liangzhu Feng
The efficacy of radiotherapy has not yet achieved optimal results, partially due to insufficient priming and infiltration of effector immune cells within the tumor microenvironment (TME), which often exhibits suppressive phenotypes. In particular, the infiltration of X–C motif chemokine receptor 1 (XCR1)-expressing conventional type-1 dendritic cells (cDC1s), which are critical in priming CD8+ cytotoxic
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Brazilin-Ce nanoparticles attenuate inflammation by de/anti-phosphorylation of IKKβ Biomaterials (IF 14.0) Pub Date : 2024-01-05 Shengxuan Li, Kun Wang, Kai Jiang, Dongmei Xing, Ruhua Deng, Yue Xu, Yue Ding, Huida Guan, Lin-Lin Chen, Dandan Wang, Yang Chen, Wenbo Bu, Yaozu Xiang
Inflammation is associated with a series of diseases like cancer, cardiovascular disease and infection, and phosphorylation/dephosphorylation modification of proteins are important in inflammation regulation. Here we designed and synthesized a novel Brazilin-Ce nanoparticle (BX-Ce NPs) using Brazilin, which has been used for anti-inflammation in cardiovascular diseases but with narrow therapeutic window
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Near-infrared light-activatable, analgesic nanocomposite delivery system for comprehensive therapy of diabetic wounds in rats Biomaterials (IF 14.0) Pub Date : 2024-01-07 Sufang Chen, Haixia Wang, Jingyi Du, Zhendong Ding, Tienan Wang, Linan Zhang, Jing Yang, Yu Guan, Chaojin Chen, Mingqiang Li, Ziqing Hei, Yu Tao, Weifeng Yao
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Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis Biomaterials (IF 14.0) Pub Date : 2024-01-05 Sijie Chen, Tianliang Ma, Jiahao Wang, Shuailong Liang, Haiqin Liao, Wanlin Tan, Mingyu Chen, Xiaohui Zhou, Yan Xu, Long Wang, Chengcheng Niu
Combination therapy based on sonodynamic therapy (SDT) combined with immune checkpoint blockers anti-PD-L1 provides effective anti-tumor effects. We designed a combination therapy based on M1/PLGA@IR780/CAT NPs of SDT-enhanced immunity combined with immune checkpoint blockers against PD-L1, which was based on M1 macrophage membrane-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded
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Protein-based nanoparticles for therapeutic nucleic acid delivery Biomaterials (IF 14.0) Pub Date : 2024-01-02 Feyisayo Eweje, Michelle L. Walsh, Kiran Ahmad, Vanessa Ibrahim, Assma Alrefai, Jiaxuan Chen, Elliot L. Chaikof
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Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment Biomaterials (IF 14.0) Pub Date : 2024-01-06 Yuzhi Jin, Yangyue Huang, Hui Ren, Huanhuan Huang, Chunyu Lai, Wenjun Wang, Zhou Tong, Hangyu Zhang, Wei Wu, Chuan Liu, Xuanwen Bao, Weijia Fang, Hongjun Li, Peng Zhao, Xiaomeng Dai
The tumor microenvironment (TME), which is mostly composed of tumor cells, immune cells, signaling molecules, stromal tissue, and the vascular system, is an integrated system that is conducive to the formation of tumors. TME heterogeneity makes the response to immunotherapy different in different tumors, such as "immune-cold" and "immune-hot" tumors. Tumor-associated macrophages, myeloid-derived suppressor
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Bionanoengineered 2D monoelemental selenene for piezothrombolysis Biomaterials (IF 14.0) Pub Date : 2024-01-06 Hui Hu, Lili Xia, Junfeng Wang, Xuefei Huang, Qianqian Zhao, Xinyu Song, Lei Hu, Shuai Ren, Chao Lu, Yongzhen Ren, Xiaoqin Qian, Wei Feng, Zhongqiu Wang, Yu Chen
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Retraction notice to “Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds” [Biomaterials 33/12 (2012) 8094–8103] Biomaterials (IF 14.0) Pub Date : 2024-01-04 Ylva Gustafsson, Johannes Haag, Philipp Jungebluth, Vanessa Lundin, Mei Ling Lim, Silvia Baiguera, Fatemeh Ajalloueian, Costantino Del Gaudio, Alessandra Bianco, Guido Moll, Sebastian Sjöqvist, Greg Lemon, Ana Isabel Teixeira, Paolo Macchiarini
Abstract not available
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Macrophage-mediated fracture healing: Unraveling molecular mechanisms and therapeutic implications using hydrogel-based interventions Biomaterials (IF 14.0) Pub Date : 2024-01-01 Bobin Mi, Yuan Xiong, Li Lu, Jiewen Liao, Guohui Liu, Yanli Zhao
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Injectable microcapillary network hydrogels engineered by liquid-liquid phase separation for stem cell transplantation Biomaterials (IF 14.0) Pub Date : 2023-12-28 Akihiro Nishiguchi, Shima Ito, Kazuhiro Nagasaka, Hiyori Komatsu, Koichiro Uto, Tetsushi Taguchi
Injectable hydrogels are promising carriers for cell delivery in regenerative medicine. However, injectable hydrogels composed of crosslinked polymer networks are often non-microporous and prevent biological communication with host tissues through signals, nutrients, oxygen, and cells, thereby limiting graft survival and tissue integration. Here we report injectable hydrogels with liquid-liquid phase