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Dual‐Emissive Iridium(III) Complexes and Their Applications in Biological Sensing and Imaging ChemBioChem (IF 3.2) Pub Date : 2024-03-16 Zhipeng Ruan, Jun Yang, Yonghua Li, Kenneth Yin Zhang
Phosphorescent iridium(III) complexes are widely recognized for their unique properties in the excited triplet state, making them crucial for various applications including biological sensing and imaging. Most of these complexes display single phosphorescence emission from the lowest‐lying triplet state after undergoing highly efficient intersystem crossing (ISC) and ultrafast internal conversion (IC)
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Natural Products That Contain Higher Homologated Amino Acids ChemBioChem (IF 3.2) Pub Date : 2024-03-15 Skyler L. Owens, Shopno R. Ahmed, Rebecca M. Lang, Laura E. Stewart, Shogo Mori
This review focuses on discussing natural products (NPs) that contain higher homologs of amino acids (homoAAs) in the structure as well as the proposed and characterized biosynthesis of these non‐proteinogenic amino acids. Homologation of amino acids includes the insertion of a methylene group into its side chain. It is not a very common modification found in NP biosynthesis as approximately 450 homoAA‐containing
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Molecular Driving Forces in the Self‐Association of Silaffin Peptide R5 from MD Simulations ChemBioChem (IF 3.2) Pub Date : 2024-03-15 Coco Moke Mao, Janani Sampath, Jim Pfaendtner
The 19‐residue silaffin‐R5 peptide has been widely studied for its ability to precipitate uniform SiO2 particles through mild temperature and pH pathways, in the absence of any organic solvents. There is consensus that post‐translational modification (PTM) of side chains has a large impact on the biomineralization process. Thus, it is imperative to understand the precise mechanisms that dictate the
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Research Progress on the Assembly of Large DNA Fragments ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Wei Tan, Qing Miao, Xuemei Jia, Ying Liu, Shuai Li, Dayong Yang
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Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Kai H. Schülke, Jana S. Fröse, Alina Klein, Marc Garcia-Borràs, Stephan C. Hammer
S‐Adenosyl‐l‐methionine (SAM) is an important cosubstrate in various biochemical processes, including selective methyl transfer reactions. Simple methods for the (re)generation of SAM analogs could expand the chemistry accessible with SAM‐dependent transferases and go beyond methylation chemistry. Here we present an efficient enzyme engineering strategy to synthesize different SAM analogs from “off‐the‐shelf”
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Porphyrin‐BODIPY Dyad: Enhancing Photodynamic Inactivation via Antenna Effect ChemBioChem (IF 3.2) Pub Date : 2024-03-13 María Eugenia Pérez, Javier Esteban Durantini, Sol Romina Martinez, Andrés Matías Durantini, María Elisa Milanesio, Edgardo N. Durantini
A porphyrin‐BODIPY dyad (P‐BDP) was obtained through covalent bonding, featuring a two‐segment design comprising a light‐harvesting antenna system connected to an energy acceptor unit. The absorption spectrum of P‐BDP resulted from an overlap of the individual spectra of its constituent parts, with the fluorescence emission of the BODIPY unit experiencing significant quenching (96%) due to the presence
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Novel Triazole‐Containing “Dipeptides”: Synthesis, Molecular Docking And Analgesic Activity Studies ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Tariel V. Ghochikyan, Arusyak G. Zhamharyan, Shushanik G. Afrikyan, Vardges R. Frangyan, Armen Galstyan
Dipeptides of a new structure based on β‐triazolalanines and (L)‐α‐amino acids were synthesized and optimal conditions were developed that ensure both chemical and optical purity of the final products. Molecular docking was carried out and possible intermolecular interactions of dipeptides with potential targets were established. Based on these studies, the analgesic property of chosen dipeptides was
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Monitoring Anthracycline Cancer Drug–Nucleosome Interaction by NMR using a Specific Isotope Labeling Approach for Nucleosomal DNA ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Clara L. van Emmerik, Vincenzo Lobbia, Jacques Neefjes, Frank H.T. Nelissen, Hugo van Ingen
Chromatinized DNA is targeted by proteins and small molecules to regulate chromatin function. For example, anthracycline cancer drugs evict nucleosomes in a mechanism that is still poorly understood. We here developed a flexible method for specific isotope labeling of nucleosomal DNA enabling NMR studies of such nucleosome interactions. We describe the synthesis of segmental one‐strand 13C‐thymidine
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BioluminescenceThe Vibrant Glow of Nature and its Chemical Mechanisms ChemBioChem (IF 3.2) Pub Date : 2024-03-12 Stefan Schramm, Dieter Weiß
Bioluminescence, the mesmerizing natural phenomenon where living organisms produce light through chemical reactions, has long captivated scientists and laypersons alike, offering a rich tapestry of insights into biological function, ecology, evolution as well as the underlying chemistry. This comprehensive review systematically explores the phenomenon of bioluminescence, addressing its historical context
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Binding dynamics of a stapled peptide targeting the transcription factor NF‐Y ChemBioChem (IF 3.2) Pub Date : 2024-03-12 Canan Durukan, Federica Arbore, Rasmus Klintrot, Carlo Bigiotti, Ioana M. Ilie, Jocelyne Vreede, Tom N. Grossmann, Sven Hennig
Transcription factors (TFs) play a central role in gene regulation, and their malfunction can result in a plethora of severe diseases. TFs are therefore interesting therapeutic targets, but their involvement in protein‐protein interaction networks and the frequent lack of well‐defined binding pockets render them challenging targets for classical small molecules. As an alternative, peptide‐based scaffolds
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Strategies for the Construction of Multicyclic Phage Display Libraries ChemBioChem (IF 3.2) Pub Date : 2024-03-11 Fa-Jie Chen, Nicole Pinnette, Jianmin Gao
Peptide therapeutics have gained great interest due to their multiple advantages over small molecule and antibody‐based drugs. Peptide drugs are easier to synthesize, have the potential for oral bioavailability, and are large enough to target protein‐protein interactions that are undruggable by small molecules. However, two major limitations have made it difficult to develop novel peptide therapeutics
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Bacterial hydrazine biosynthetic pathways featuring cupin/methionyl tRNA synthetase‐like enzymes ChemBioChem (IF 3.2) Pub Date : 2024-03-09 Kenichi Matsuda, Toshiyuki Wakimoto
Nitrogen‐Nitrogen (N–N) bond‐containing functional groups in natural products and synthetic drugs play significant roles in exerting biological activities. The mechanisms of N–N bond formation in natural organic molecules have garnered increasing attention over the decades. Recent advances have illuminated various enzymatic and nonenzymatic strategies, and our understanding of natural N–N bond construction
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U1 SNRNP BIOGENESIS DEFFECTS IN NEURODEGENERATIVE DISEASES ChemBioChem (IF 3.2) Pub Date : 2024-03-09 Sebastien Campagne
The U1 small ribonucleoprotein (U1 snRNP) plays a pivotal role in the intricate process of gene expression, specifically within nuclear RNA processing. By initiating the splicing reaction and modulating 3’‐end processing, U1 snRNP exerts precise control over RNA metabolism and gene expression. This ribonucleoparticle is abundantly present, and its complex biogenesis necessitates shuttling between the
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Measuring Ligand‐bound Protein Complexes with Proximity Labeling: A Practical Guide. ChemBioChem (IF 3.2) Pub Date : 2024-03-08 Pavitra Goyal, Andrew J. Tao, Elizabeth J. Mumby, Justin G. English, Fleur M. Ferguson
Identifying the drug‐target interactome of small molecule therapeutics is essential for understanding the full pharmacological effects of a compound. These therapies often induce changes within the cellular proteome, leading to unexpected consequences such as changes in the targets complexation state or off‐target interactions between the compound and additional proteins. Currently, unbiased target‐ID
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High cell density cultivation combined with high specific enzyme activity: Cultivation protocol for the production of an amine transaminase from Bacillus megaterium in E. coli. ChemBioChem (IF 3.2) Pub Date : 2024-03-08 Berit Rothkranz, Matthias Rieb, Evelin Lisa Unrau, Ilona Frindi-Wosch, Johannes Hemmerich, Torsten Sehl, Dörte Rother
High cell density cultivation is an established method for the production of various industrially important products such as recombinant proteins. However, these protocols are often not suitable for biocatalytic processes as often the focus lies on biomass production rather than high specific activities of the enzyme. In contrast, a range of shake flask protocols are well known with high specific activities
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Biophysical Investigation of RNA•DNA:DNA triple helix and RNA:DNA heteroduplex formation by the lncRNAs MEG3 and Fendrr ChemBioChem (IF 3.2) Pub Date : 2024-03-08 Nina M Krause, Jasleen Kaur Bains, Julius Blechar, Christian Richter, Irene Bessi, Phillip Grote, Matthias Leisegang, Ralf P Brandes, Harald Schwalbe
Long non‐coding RNAs (lncRNAs) are important regulators of gene expression and can associate with DNA as RNA:DNA heteroduplexes or RNA•DNA:DNA triple helix structures. Here, we review in vitro biochemical and biophysical experiments including electromobility shift assays (EMSA), circular dichroism (CD) spectroscopy, thermal melting analysis, microscale thermophoresis (MST), single‐molecule Förster
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OptoProfilin: A Single Component Biosensor of Applied Cellular Stress ChemBioChem (IF 3.2) Pub Date : 2024-03-08 Noah Mann, Jahiem T Hill, Kenneth Wang, Robert Hughes
The actin cytoskeleton is a biosensor of cellular stress and a potential prognosticator of human disease. In particular, aberrant cytoskeletal structures such as stress granules formed in response to energetic and oxidative stress are closely linked to ageing, cancer, cardiovascular disease, and viral infection. Whether these cytoskeletal phenomena can be harnessed for the development of biosensors
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Identification of a 2‐aminobenzimidazole scaffold that potentiates gram‐positive selective antibiotics against gram‐negative bacteria ChemBioChem (IF 3.2) Pub Date : 2024-03-07 Ansley M. Nemeth, Roberta J. Melander, Richard D. Smith, Robert K. Ernst, Christian Corey Melander
The development of novel therapeutic approaches is crucial in the fight against multi‐drug resistant (MDR) bacteria, particularly gram‐negative species. Small molecule adjuvants that enhance the activity of otherwise gram‐positive selective antibiotics against gram‐negative bacteria have the potential to expand current treatment options. We have previously reported adjuvants based upon a 2‐aminoimidazole
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Synthesis and Macrodomain Binding of Gln‐carba‐ADPr‐peptide ChemBioChem (IF 3.2) Pub Date : 2024-03-05 Sande B Engelsma, Aurelio Pio Nardozza, Pieter de Saint Aulaire, Herman S Overkleeft, Gijsbert A van der Marel, Andreas G Ladurner, Dmitri Filippov
Mono‐ADP‐ribosylation is a dynamic post‐translational modification (PTM) with important roles in cell signalling. This modification occurs on a wide variety of amino acids, and one of the canonical modification sites within proteins is the side chain of glutamic acid. Given the transient nature of this modification (acylal linkage) and the high sensitivity of ADP‐ribosylated glutamic acid, stabilized
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Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases ChemBioChem (IF 3.2) Pub Date : 2024-03-05 Yingfang He, Aro Delparente, Caitlin V. M. L Jie, Claudia Keller, Roland Humm, Dominik Heer, Ludovic Collin, Roger Schibli, Luca Gobbi, Uwe Grether, Linjing Mu
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Conversion of β‐1,6‐glucans to gentiobiose using an endo‐β‐1,6‐glucanase PsGly30A from Paenibacillus sp. GKG ChemBioChem (IF 3.2) Pub Date : 2024-03-05 Gediminas Plakys, Nina Urbelienė, Gintaras Urbelis, Justas Vaitekūnas, Linas Labanauskas, Edita Mažonienė, Rolandas Meškys
A plethora of di‐ and oligosaccharides isolated from the natural sources are used in food and pharmaceutical industry. An enzymatic hydrolysis of fungal cell wall β‐glucans is a good alternative to produce the desired oligosaccharides with different functionalities, such as the flavour enhancer gentiobiose. We have previously identified PsGly30A as a potential yeast cell wall degrading β‐1,6‐glycosidase
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Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo ChemBioChem (IF 3.2) Pub Date : 2024-03-05 Angelika Seliwjorstow, Masanari Takamiya, Sepand Rastegar, Zbigniew Pianowski
This study explores the potential of controlling organismal development with light by using reversible photomodulation of activity in bioactive compounds. Specifically, our research focuses on plinabulin 1, an inhibitor of tubulin dynamics that contains a photochromic motif called hemipiperazine. The two isomeric forms, Z‐1 and E‐1, can partially interconvert with light, yet show remarkable thermal
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A Dual‐gene Reporter‐amplifier Architecture for Enhancing the Sensitivity of Molecular MRI by Water Exchange ChemBioChem (IF 3.2) Pub Date : 2024-03-05 Yimeng Huang, Xinyue Chen, Ziyue Zhu, Arnab Mukherjee
The development of genetic reporters for magnetic resonance imaging (MRI) is essential for investigating biological functions in vivo. However, current MRI reporters have low sensitivity, making it challenging to create significant contrast against the tissue background, especially when only a small fraction of cells express the reporter. To overcome this limitation, we developed an approach for amplifying
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Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors ̶ Towards Wound Healing ChemBioChem (IF 3.2) Pub Date : 2024-03-02 Josep Mas-Roselló, Hermann Tenor, Timea Szabo, Reto Naef, Simon Sieber, Karl Gademann
Inefficient wound healing poses a global health challenge with a lack of efficient treatments. Wound healing issues often correlate with low endogenous nitric oxide (NO) levels. While exogenous delivery with NO‐releasing compounds represents a promising therapeutic strategy, controlling the release of the highly reactive NO remains challenging. Phosphodiesterase 5 (PDE5) inhibitors, like sildenafil
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O‐nitrobenzyl Caged Molecule Enables Photo‐controlled Release of Thiabendazole ChemBioChem (IF 3.2) Pub Date : 2024-03-01 Wen Fu, Zhongli Shao, Zhiping Xu, Zhong Li, Xusheng Shao
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Amine-Carbamate Self-Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads ChemBioChem (IF 3.2) Pub Date : 2024-02-28 Mattia Mason, Lydia Bisbal Lopez, Fazel Bashiri, Aurélie Herrero, Aurélien Baron, Raffaella Bucci, Luca Pignataro, Cesare Gennari, Alberto Dal Corso
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Ether Bond Cleavage of a Phenylcoumaran β-5 Lignin Model Compound and Polymeric Lignin Catalysed by a LigE-type Etherase from Agrobacterium sp. ChemBioChem (IF 3.2) Pub Date : 2024-02-28 Goran M. M. Rashid, Guillaume N. Rivière, Betty Cottyn-Boitte, Amel Majira, Laurent Cézard, Victoria Sodré, Richard Lam, Julia A. Fairbairn, Stéphanie Baumberger, Timothy D. H. Bugg
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The Biocatalytic Potential of Aromatic Ammonia‐Lyase from Loktanella atrilutea ChemBioChem (IF 3.2) Pub Date : 2024-02-28 Raluca Bianca Tomoaiaga, Gyoparka Agoston, Krisztina Boros, Levente Csaba Nagy, Monica Ioana Tosa, Csaba Paizs, Laszlo Csaba Bencze
Characterization of the aromatic ammonia‐lyase from Loktanella atrilutea (LaAAL) revealed reduced activity towards canonical AAL substrates: L‐Phe, L‐Tyr, and L‐His, contrasted by its pronounced efficiency towards 3,4‐dimethoxy‐L‐phenylalanine. Assessing optimal conditions, LaAAL exhibited maximal activity at pH 9.5 in the ammonia elimination reaction route, distinct from the typical pH ranges of most
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Photoisomerization and Light-Controlled Antibacterial Activity of Fluoroquinolone-Azoisoxazole Hybrids ChemBioChem (IF 3.2) Pub Date : 2024-02-26 Anirban Dolai, Supriya Bhunia, Santosh Kumar Jana, Satyajit Bera, Sukhendu Mandal, Subhas Samanta
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Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine ChemBioChem (IF 3.2) Pub Date : 2024-02-26 HaRam Kim, Boghos Taslakjian, Sarah Kim, Matthew V. Tirrell, Mustafa O. Guler
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Phylogeny-guided Characterization of Bacterial Hydrazine Biosynthesis Mediated by Cupin/methionyl tRNA Synthetase-like Enzymes ChemBioChem (IF 3.2) Pub Date : 2024-02-25 Kenichi Matsuda, Yuto Nakahara, Atina Rizkiya Choirunnisa, Kuga Arima, Toshiyuki Wakimoto
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Bacterial Glycolipid Acting on Protein Transport across Membranes ChemBioChem (IF 3.2) Pub Date : 2024-02-24 Shoko Mori, Masafumi Shionyu, Keiko Shimamoto, Kaoru Nomura
The process of protein transport across membranes involves a variety of factors and has been extensively investigated. Traditionally, proteinaceous translocons and chaperones have been recognized as crucial factors in this process. However, recent studies have highlighted the significant roles played by lipids and a glycolipid present in biological membranes in membrane protein transport. Membrane
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Structural‐Functional Correlations between Unique N‐terminal Region and C‐terminal Conserved Motif in Short‐chain cis‐Prenyltransferase from Tomato ChemBioChem (IF 3.2) Pub Date : 2024-02-23 Riki Imaizumi, Hiroaki Matsuura, Taro Yanai, Kohei Takeshita, Shuto Misawa, Haruhiko Yamaguchi, Naoki Sakai, Yukino Miyagi‐Inoue, Miki Suenaga‐Hiromori, Toshiyuki Waki, Kunishige Kataoka, Toru Nakayama, Masaki Yamamoto, Seiji Takahashi, Satoshi Yamashita
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Nonlinear impact of electrolyte solutions on protein dynamics ChemBioChem (IF 3.2) Pub Date : 2024-02-23 Hosein Geraili Daronkola, Benedikt Soeldner, Himanshu Singh, Rasmus Linser, Ana Vila Verde
Halophilic organisms have adapted to multi‐molar salt concentrations, their cytoplasmic proteins functioning despite stronger attraction between hydrophobic groups. These proteins, of interest in biotechnology because of decreasing fresh‐water resources, have excess acidic amino acids. It has been suggested that conformational fluctuations ‐‐ critical for protein function ‐‐ decrease in the presence
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Exploring a Solvent Dependent Strategy to Control Self‐Assembling Behavior and Cellular Interaction in Laminin‐Mimetic Short Peptide based Supramolecular Hydrogels ChemBioChem (IF 3.2) Pub Date : 2024-02-23 Shambhavi Kashyap, Vijay Kumar Pal, Sweta Mohanty, Sangita Roy
Self‐assembled hydrogels, fabricated through diverse non‐covalent interactions, have been extensively studied in regenerative medicines. Inspired from bioactive functional motifs of ECM protein, short peptide sequences have shown remarkable abilities to replicate the intrinsic features of the natural extracellular milieu. In this direction, we have fabricated two short hydrophobic bioactive sequences
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Development of an Enzyme Cascade System for the Synthesis of Enantiomerically Pure D-Amino Acids Utilizing Ancestral L-Amino Acid Oxidase ChemBioChem (IF 3.2) Pub Date : 2024-02-22 Hayato Araseki, Narumi Sugishima, Taichi Chisuga, Shogo Nakano
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Modifications of Protein-Bound Substrates by Trans-Acting Enzymes in Natural Products Biosynthesis ChemBioChem (IF 3.2) Pub Date : 2024-02-22 Leigh E. Skala, Benjamin Philmus, Taifo Mahmud
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Mushroom Tyrosinase: Six Isoenzymes Catalyzing Distinct Reactions ChemBioChem (IF 3.2) Pub Date : 2024-02-22 Matthias Pretzler, Annette Rompel
“Mushroom tyrosinase” from the common button mushroom is the most frequently used source of tyrosinase activity, both for basic and applied research. Here, the complete tyrosinase family from Agaricus bisporus var. bisporus (abPPO1‐6) was cloned from mRNA and expressed heterologously using a single protocol. All six isoenzymes accept a wide range of phenolic and catecholic substrates, but display pronounced
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DNA Logic Gates Integrated on DNA Substrates in Molecular Computing ChemBioChem (IF 3.2) Pub Date : 2024-02-22 Andrea C. Bardales, Viktor Smirnov, Katherine Taylor, Dmitry M. Kolpashchikov
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Engineering A‐type Dye‐decolorizing Peroxidases by Modification of a Conserved Glutamate Residue ChemBioChem (IF 3.2) Pub Date : 2024-02-20 Enikő Hermann, Carolina F. Rodrigues, Lígia O. Martins, Clemens Peterbauer, Chris Oostenbrink
Dye‐decolorizing peroxidases (DyPs) are recently identified microbial enzymes that have been used in several Biotechnology applications from wastewater treatment to lignin valorization. However, their properties and mechanism of action still have many open questions. Their heme‐containing active site is buried by three conserved flexible loops with a putative role in modulating substrate access and
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Functional and Mechanistic Characterization of the 4,5-diepi-Isoishwarane Synthase from the Liverwort Radula lindenbergiana ChemBioChem (IF 3.2) Pub Date : 2024-02-19 Houchao Xu, Tobias G. Köllner, Feng Chen, Jeroen S. Dickschat
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Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor ChemBioChem (IF 3.2) Pub Date : 2024-02-19 Laura V. De Paus, Yu An, Antonius P. A. Janssen, Richard J. B. H. N. van den Berg, Laura H. Heitman, Mario van der Stelt
We present a series of bifunctional photoaffinity CB2R selective probes based on the 5-fluoropyridin-2-yl-benzyl-imidazoleidine-2,4-dione derivative LEI-102, with both inverse agonist and partial agonist behaviour in vitro. These photoaffinity probes have improved affinity and potency compared to previously published LEI-121.
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A Facile Access to Green Fluorescent Albumin Derivatives ChemBioChem (IF 3.2) Pub Date : 2024-02-18 Mario Saletti, Marco Paolino, Jacopo Venditti, Claudia Bonechi, Germano Giuliani, Stefania Lamponi, Giusy Tassone, Antonella Boccia, Chiara Botta, Lluís Blancafort, Federica Poggialini, Chiara Vagaggini, Andrea Cappelli
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Light-Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer ChemBioChem (IF 3.2) Pub Date : 2024-02-16 Chloé Breton-Patient, Sébastien Billotte, Patricia Duchambon, Gaëlle Fontaine, Sophie Bombard, Sandrine Piguel
Photopharmacology is an emerging field that utilizes photo-responsive molecules to enable control over the activity of a drug using light. The aim is to limit the therapeutic action of a drug at the level of diseased tissues and organs. Considering the well-known implications of protein kinases in cancer and the therapeutic issues associated with protein kinase inhibitors, the photopharmacology is
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Rational design of a circularly permuted flavin-based fluorescent protein ChemBioChem (IF 3.2) Pub Date : 2024-02-14 Nolan T. Anderson, Jason Xie, Asish N. Chacko, Vannie Liu, Kang-Ching Fan, Arnab Mukherjee
Flavin-based fluorescent proteins are oxygen-independent reporters that hold great promise for imaging anaerobic and hypoxic biological systems. In this study, we explored the feasibility of applying circular permutation, a valuable method for the creation of fluorescent sensors, to flavin-based fluorescent proteins. We used rational design and structural data to identify a suitable location for circular
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Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog ChemBioChem (IF 3.2) Pub Date : 2024-02-16 Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta
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Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications ChemBioChem (IF 3.2) Pub Date : 2024-02-14 Bénédicte Fromager, Julien Cambedouzou, Emilie Marhuenda, Thomas Iskratsch, Mathieu Pinault, Norbert Bakalara, David Cornu
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Methylation of Phenyl Rings in Ester-Stabilized Phosphorus Ylides Vastly Enhances Their Protonophoric Activity ChemBioChem (IF 3.2) Pub Date : 2024-02-14 Tatyana I. Rokitskaya, Roman S. Kirsanov, Ljudmila S. Khailova, Alisa A. Panteleeva, Konstantin G. Lyamzaev, Galina A. Korshunova, Elena A. Kotova, Yuri N. Antonenko
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Identification, characterization and application of M16AT, a new organic solvent–tolerant (R)–enantio–selective type IV amine transaminase from Mycobacterium sp. ACS1612 ChemBioChem (IF 3.2) Pub Date : 2024-02-13 Tingting Li, Hai Zhu, Weiwei Jia, Xia Tian, Ziwen Xu, Jiang Zhu, Wencheng Liu, Yang Cao
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Biophysical and Biochemical Characterization of Structurally Diverse Small Molecule Hits for KRAS Inhibition ChemBioChem (IF 3.2) Pub Date : 2024-02-13 Cynthia V. Pagba, Amit K. Gupta, Kasuni Dilsha, Parisa Sadrpour, Jacob Jakubec, Priyanka Prakash, Dharini van der Hoeven, Kwang-Jin Cho, Scott Gilbertson, Alemayehu A. Gorfe
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Aldehyde Reductase Activity of Carboxylic Acid Reductases ChemBioChem (IF 3.2) Pub Date : 2024-02-13 Margit Winkler, Hannah G. Breuer, Lukas Schober
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Human 2′-Deoxynucleoside 5′-Phosphate N-Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80 ChemBioChem (IF 3.2) Pub Date : 2024-02-13 Anna E. Carberry, Suneeta Devi, David J. Harrison, Rafael G. da Silva
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Front Cover: Assessing Lanthanide-Dependent Methanol Dehydrogenase Activity: The Assay Matters (ChemBioChem 5/2024) ChemBioChem (IF 3.2) Pub Date : 2024-02-12 Manh Tri Phi, Helena Singer, Felix Zäh, Christoph Haisch, Sabine Schneider, Huub J. M. Op den Camp, Lena J. Daumann
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Front Cover: A Facile and General Tandem Oligonucleotide Synthesis Methodology for DNA and RNA (ChemBioChem 6/2024) ChemBioChem (IF 3.2) Pub Date : 2024-02-12 Jagandeep S. Saraya, Derek K. O'Flaherty
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Organocatalytic Synthesis and DNA Interactive Studies of New 1,2,3-triazolyl-thiazolidines Hybrids ChemBioChem (IF 3.2) Pub Date : 2024-02-09 Allya Larroza, Liane K. Soares, Roberto B. Morais, Mariana F. Bach, Caroline G. Jacoby, Bernardo A. Iglesias, Paulo Henrique Schneider, Diego Alves
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Selective Aza-Michael Addition to Dehydrated Amino Acids in Natural Antimicrobial Peptides ChemBioChem (IF 3.2) Pub Date : 2024-02-09 Michela Vargiu, Yanli Xu, Oscar P. Kuipers, Gerard Roelfes
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The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry ChemBioChem (IF 3.2) Pub Date : 2024-02-08 Søren Lau Borcher Møller, Michelle H. Rasmussen, Jun Li, Esben B. Svenningsen, Gustav J. Wørmer, Thomas Tørring, Thomas B. Poulsen
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Systematic Analysis of the MIO-forming Residues of Aromatic Ammonia Lyases ChemBioChem (IF 3.2) Pub Date : 2024-02-07 Yannik Brack, Chenghai Sun, Dong Yi, Uwe T. Bornscheuer
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Endogenous Production and Vibrational Analysis of Heavy-Isotope-Labeled Peptides from Cyanobacteria ChemBioChem (IF 3.2) Pub Date : 2024-02-04 John G. Ricca, Xavier Mayali, Jing Qu, Peter K. Weber, Gerald Poirier, Craig P. Dufresne, J. William Louda, Andrew C. Terentis
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