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Pickering emulsion biocatalysis: Bridging interfacial design with enzymatic reactions Biotechnol. Adv. (IF 16.0) Pub Date : 2024-03-07 Chengmei Yin, Xiangyao Chen, Haiyang Zhang, Yong Xue, Hao Dong, Xiangzhao Mao
Non-homogeneous enzyme-catalyzed systems are more widely used than homogeneous systems. Distinguished from the conventional biphasic approach, Pickering emulsion stabilized by ultrafine solid particles opens up an innovative platform for biocatalysis. Their vast specific surface area significantly enhances enzyme-substrate interactions, dramatically increasing catalytic efficiency. This review comprehensively
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Next generation probiotics: Engineering live biotherapeutics Biotechnol. Adv. (IF 16.0) Pub Date : 2024-03-02 Sanjeeva Kumar Murali, Thomas J. Mansell
The population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, also called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance
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The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-27 Jianlong Wang, Xuan Guo
The Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent
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New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-21 Mrudulakumari Vasudevan Ushasree, Qi Jia, Seon Gil Do, Eun Yeol Lee
Historically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites
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Progress in cyclodextrins as important molecules regulating catalytic processes of glycoside hydrolases Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-19 Xiaoxiao Li, Zhengyu Jin, Yuxiang Bai, Birte Svensson
Cyclodextrins (CDs) are important starch derivatives and commonly comprise α-, β-, and γ-CDs. Their hydrophilic surface and hydrophobic inner cavity enable regulation of enzyme catalysis through direct or indirect interactions. Clarifying interactions between CDs and enzyme is of great value for enzyme screening, mechanism exploration, regulation of catalysis, and applications. We summarize the interactions
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Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-13 Brahma N. Singh, Meisam Tabatabaei, Abhay Pandit, Lothar Elling, Vijai K. Gupta
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CRISPR-Cas systems of lactic acid bacteria and applications in food science Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-11 Yanhua Cui, Xiaojun Qu
CRISPR-Cas (Clustered regularly interspaced short palindromic repeats-CRISPR associated proteins) systems are widely distributed in lactic acid bacteria (LAB), contributing to their RNA-mediated adaptive defense immunity. The CRISPR-Cas-based genetic tools have exhibited powerful capability. It has been highly utilized in different organisms, accelerating the development of life science. The review
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The thin line between monooxygenases and peroxygenases. P450s, UPOs, MMOs, and LPMOs: A brick to bridge fields of expertise Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-08 Davide Decembrino, David Cannella
Many scientific fields, although driven by similar purposes and dealing with similar technologies, often appear so isolated and far from each other that even the vocabularies to describe the very same phenomenon might differ. Concerning the vast field of biocatalysis, a special role is played by those redox enzymes that employ oxygen-based chemistry to unlock transformations otherwise possible only
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Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-07 Yongdan Wang, Qiang Fu, So Young Park, Yong Suk Lee, Seo-Young Park, Dong-Yup Lee, Seongkyu Yoon
Recombinant adeno-associated virus (rAAV) is one of the prominent gene delivery vehicles that has opened promising opportunities for novel gene therapeutic approaches. However, the current major viral vector production platform, triple transfection in mammalian cells, may not meet the increasing demand. Thus, it is highly required to understand production bottlenecks from the host cell perspective
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Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-26 Zhijin Gong, Jiayao Chen, Xinyu Jiao, Hao Gong, Danzi Pan, Lingli Liu, Yang Zhang, Kai Wang, Meng Wang, Hui Cao, Tianwei Tan
The construction of high-performance microbial cell factories (MCFs) is the centerpiece of biomanufacturing. However, the complex metabolic regulatory network of microorganisms poses great challenges for the efficient design and construction of MCFs. The genome-scale metabolic network models (GSMs) can systematically simulate the metabolic regulation process of microorganisms in silico, providing effective
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Molecular imprinting technology for biomedical applications Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-22 Julija Sarvutienė, Urte Samukaite-Bubniene, Simonas Ramanavicius, Arunas Ramanavicius
Molecularly imprinted polymers (MIPs), a type of biomimetic material, have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favourable specificity and selectivity for target analytes, and widely used for various biological applications. It was demonstrated that MIPs with significant selectivity towards protein-based targets could be applied in medicine
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PHA is not just a bioplastic! Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-23 Helen Park, Hongtao He, Xu Yan, Xu Liu, Nigel S. Scrutton, Guo-Qiang Chen
Polyhydroxyalkanoates (PHA) have evolved into versatile biopolymers, transcending their origins as mere bioplastics. This extensive review delves into the multifaceted landscape of PHA applications, shedding light on the diverse industries that have harnessed their potential. PHA has proven to be an invaluable eco-conscious option for packaging materials, finding use in films foams, paper coatings
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Rumen microbes, enzymes, metabolisms, and application in lignocellulosic waste conversion - A comprehensive review Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-09 Jinsong Liang, Ru Zhang, Jianning Chang, Le Chen, Mohammad Nabi, Haibo Zhang, Guangming Zhang, Panyue Zhang
The rumen of ruminants is a natural anaerobic fermentation system that efficiently degrades lignocellulosic biomass and mainly depends on synergistic interactions between multiple microbes and their secreted enzymes. Ruminal microbes have been employed as biomass waste converters and are receiving increasing attention because of their degradation performance. To explore the application of ruminal microbes
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Passive microfluidic devices for cell separation Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-12 Tianlong Zhang, Dino Di Carlo, Chwee Teck Lim, Tianyuan Zhou, Guizhong Tian, Tao Tang, Amy Q. Shen, Weihua Li, Ming Li, Yang Yang, Keisuke Goda, Ruopeng Yan, Cheng Lei, Yoichiroh Hosokawa, Yaxiaer Yalikun
The separation of specific cell populations is instrumental in gaining insights into cellular processes, elucidating disease mechanisms, and advancing applications in tissue engineering, regenerative medicine, diagnostics, and cell therapies. Microfluidic methods for cell separation have propelled the field forward, benefitting from miniaturization, advanced fabrication technologies, a profound understanding
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Resource allocation in mammalian systems Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-11 Hratch M. Baghdassarian, Nathan E. Lewis
Cells execute biological functions to support phenotypes such as growth, migration, and secretion. Complementarily, each function of a cell has resource costs that constrain phenotype. Resource allocation by a cell allows it to manage these costs and optimize their phenotypes. In fact, the management of resource constraints (e.g., nutrient availability, bioenergetic capacity, and macromolecular machinery
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Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: A review Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-08 Nathalia Vieira Porphirio Veríssimo, Cassamo Usemane Mussagy, Heitor Buzetti Simões Bento, Jorge Fernando Brandão Pereira, Valéria de Carvalho Santos-Ebinuma
Biopharmaceuticals have allowed the control of previously untreatable diseases. However, their low solubility and stability still hinder their application, transport, and storage. Hence, researchers have applied different compounds to preserve and enhance the delivery of biopharmaceuticals, such as ionic liquids (ILs) and deep eutectic solvents (DESs). Although the biopharmaceutical industry can employ
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A guide to the use of bioassays in exploration of natural resources Biotechnol. Adv. (IF 16.0) Pub Date : 2024-01-05 Jerica Sabotič, Engin Bayram, David Ezra, Susana P. Gaudêncio, Berat Z. Haznedaroğlu, Nika Janež, Leila Ktari, Anna Luganini, Manolis Mandalakis, Ivo Safarik, Dina Simes, Evita Strode, Anna Toruńska-Sitarz, Despoina Varamogianni-Mamatsi, Giovanna Cristina Varese, Marlen I. Vasquez
Bioassays are the main tool to decipher bioactivities from natural resources thus their selection and quality are critical for optimal bioprospecting. They are used both in the early stages of compounds isolation/purification/identification, and in later stages to evaluate their safety and efficacy. In this review, we provide a comprehensive overview of the most common bioassays used in the discovery
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Strategies for the biological production of ectoine by using different chassis strains Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-28 Yifan Feng, Min Qiu, Lei Shao, Yujia Jiang, Wenming Zhang, Wankui Jiang, Fengxue Xin, Min Jiang
As an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production
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Survival strategies of Bacillus spp. in saline soils: Key factors to promote plant growth and health Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-19 María F. Valencia-Marin, Salvador Chávez-Avila, Paulina Guzmán-Guzmán, Ma del Carmen Orozco-Mosqueda, Sergio de los Santos-Villalobos, Bernard R. Glick, Gustavo Santoyo
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Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-21 Muhammad Bilal, Sarmad Ahmad Qamar, Diego Carballares, Ángel Berenguer-Murcia, Roberto Fernandez-Lafuente
Proteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability
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Bacillus genus industrial applications and innovation: First steps towards a circular bioeconomy Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-14 Leonardo Wedderhoff Herrmann, Luiz Alberto Junior Letti, Rafaela de Oliveira Penha, Vanete Thomaz Soccol, Cristine Rodrigues, Carlos Ricardo Soccol
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Utilization of gene manipulation system for advancing the biotechnological potential of halophiles: A review Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-13 Tong Xu, Ruchira Mitra, Dan Tan, Zhengjun Li, Cheng Zhou, Tao Chen, Zhengwei Xie, Jing Han
Halophiles are salt-loving microorganisms known to have their natural resistance against media contamination even when cultivated in nonsterile and continuous bioprocess system, thus acting as promising cell factories for Next Generation of Industrial Biotechnology (NGIB). NGIB — a successor to the traditional industrial biotechnology, is a more sustainable and efficient bioprocess technology while
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Pioneering DNA assembling techniques and their applications in eukaryotic microalgae Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-13 Li Guo, Guanpin Yang
Assembling DNA fragments is a fundamental manipulation of cloning microalgal genes and carrying out microalgal synthetic biological studies. From the earliest DNA recombination to current trait and metabolic pathway engineering, we are always accompanied by homology-based DNA assembling. The improvement and modification of pioneering DNA assembling techniques and the combinational applications of the
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Bioinspired nanoplatforms for human-machine interfaces: Recent progress in materials and device applications Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-06 Pasha W. Sayyad, Sang-Joon Park, Tae-Jun Ha
The panoramic characteristics of human–machine interfaces (HMIs) have prompted the needs to update the biotechnology community with the recent trends, developments, and future research direction toward next-generation bioelectronics. Bioinspired materials are promising for integrating various bioelectronic devices to realize HMIs. With the advancement of scientific biotechnology, state-of-the-art bioelectronic
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Metal-organic frameworks for enzyme immobilization and nanozymes: A laccase-focused review Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-10 Lynette Alvarado-Ramírez, Gerson Machorro-García, Andrea López-Legarrea, Dulce Trejo-Ayala, Magdalena de Jesús Rostro-Alanis, Manuel Sánchez-Sánchez, Rosa M. Blanco, José Rodríguez-Rodríguez, Roberto Parra-Saldívar
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Discovering the secondary metabolic potential of Saccharothrix Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-03 Bin Wei, Xian Luo, Zhen-Yi Zhou, Gang-Ao Hu, Lei Li, Hou-Wen Lin, Hong Wang
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Universal and unique strategies for the production of polyunsaturated fatty acids in industrial oleaginous microorganisms Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-02 Chun-Xiao Yan, Ying Zhang, Wen-Qian Yang, Wang Ma, Xiao-Man Sun, He Huang
Polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (ARA), are beneficial for reducing blood cholesterol and enhancing memory. Traditional PUFA production relies on extraction from plants and animals, which is unsustainable. Thus, using microorganisms as lipid-producing factories holds promise as an alternative way for PUFA production
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Recombinant production of antimicrobial peptides in plants Biotechnol. Adv. (IF 16.0) Pub Date : 2023-12-01 Farhad Nazarian-Firouzabadi, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez
Classical plant breeding methods are limited in their ability to confer disease resistance on plants. However, in recent years, advancements in molecular breeding and biotechnological have provided new approaches to overcome these limitations and protect plants from disease. Antimicrobial peptides (AMPs) constitute promising agents that may be able to protect against infectious agents. Recently, peptides
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Artificial carbon assimilation: From unnatural reactions and pathways to synthetic autotrophic systems Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-25 Xue Yang, Yanfei Zhang, Guoping Zhao
Synthetic biology is being increasingly used to establish novel carbon assimilation pathways and artificial autotrophic strains that can be used in low-carbon biomanufacturing. Currently, artificial pathway design has made significant progress from advocacy to practice within a relatively short span of just over ten years. However, there is still huge scope for exploration of pathway diversity, operational
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Challenges in developing cell culture media using machine learning Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-19 Takamasa Hashizume, Bei-Wen Ying
Microbial and mammalian cells are widely used in the food, pharmaceutical, and medical industries. Developing or optimizing culture media is essential to improve cell culture performance as a critical technology in cell culture engineering. Methodologies for media optimization have been developed to a great extent, such as the approaches of one-factor-at-a-time (OFAT) and response surface methodology
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Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-14 Maddy L. Newby, Joel D. Allen, Max Crispin
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins that embellish viral particles. This observation has catalyzed the development of numerous viral glycoprotein mimetics as vaccines. Glycans can dominate the surface of viral glycoproteins and as such, the viral glycome can influence the antigenicity and immunogenicity
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Engineering status of protein for improving microbial cell factories Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-07 Pei Zhou, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu, Xiulai Chen
With the development of metabolic engineering and synthetic biology, microbial cell factories (MCFs) have provided an efficient and sustainable method to synthesize a series of chemicals from renewable feedstocks. However, the efficiency of MCFs is usually limited by the inappropriate status of protein. Thus, engineering status of protein is essential to achieve efficient bioproduction with high titer
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Production and characterization of starch-lignin based materials: A review Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-11 Jonathan A. Diaz-Baca, Pedram Fatehi
In their pristine state, starch and lignin are abundant and inexpensive natural polymers frequently considered green alternatives to oil-based and synthetic polymers. Despite their availability and owing to their physicochemical properties; starch and lignin are not often utilized in their pristine forms for high-performance applications. Generally, chemical and physical modifications transform them
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Abiotic stress as a dynamic strategy for enhancing high value phytochemicals in microalgae: Critical insights, challenges and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-07 Uganeeswary Suparmaniam, Man Kee Lam, Jun Wei Lim, Inn Shi Tan, Bridgid Lai Fui Chin, Siew Hoong Shuit, Steven Lim, Yean Ling Pang, Peck Loo Kiew
Microalgae showcase an extraordinary capacity for synthesizing high-value phytochemicals (HVPCs), offering substantial potential for diverse applications across various industries. Emerging research suggests that subjecting microalgae to abiotic stress during cultivation and the harvesting stages can further enhance the accumulation of valuable metabolites within their cells, including carotenoids
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Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms Biotechnol. Adv. (IF 16.0) Pub Date : 2023-11-03 Ruiyang Ding, Yang Li, Yang Yu, Zhiwei Sun, Junchao Duan
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Has the time finally come for green oleochemicals and biodiesel production using large-scale enzyme technologies? Current status and new developments Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-30 Ahmad Mustafa, Shah Faisal, Inas A. Ahmed, Mamoona Munir, Eliane Pereira Cipolatti, Evelin Andrade Manoel, Carlo Pastore, Luigi di Bitonto, Dieter Hanelt, Febri Odel Nitbani, Zeinhom M. El-Bahy, Abrar Inayat, Tamer M.M. Abdellatief, Konstantza Tonova, Awais Bokhari, Abdelfatah Abomohra
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Unleashing the capacity of Rhodococcus for converting lignin into lipids Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-31 Zhi-Min Zhao, Zhi-Hua Liu, Tongtong Zhang, Rongqian Meng, Zhiqun Gong, Yibing Li, Jing Hu, Arthur J. Ragauskas, Bing-Zhi Li, Ying-Jin Yuan
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Cell wall polysaccharides of streptococci: A genetic and structural perspective Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-31 Zoe Kampff, Douwe van Sinderen, Jennifer Mahony
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Next-generation feedstocks methanol and ethylene glycol and their potential in industrial biotechnology Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-31 Nils Wagner, Linxuan Wen, Cláudio J.R. Frazão, Thomas Walther
Microbial fermentation processes are expected to play an important role in reducing dependence on fossil-based raw materials for the production of everyday chemicals. In order to meet the growing demand for biotechnological products in the future, alternative carbon sources that do not compete with human nutrition must be exploited. The chemical conversion of the industrially emitted greenhouse gas
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Bacillus sp. as a microbial cell factory: Advancements and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-28 Jinyi Qian, Yuzhou Wang, Zijian Hu, Tianqiong Shi, Yuetong Wang, Chao Ye, He Huang
Bacillus sp. is one of the most distinctive gram-positive bacteria, able to grow efficiently using cheap carbon sources and secrete a variety of useful substances, which are widely used in food, pharmaceutical, agricultural and environmental industries. At the same time, Bacillus sp. is also recognized as a safe genus with a relatively clear genetic background, which is conducive to the industrial
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3D biofabrication and space: A ‘far-fetched dream’ or a ‘forthcoming reality’? Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-18 Nilotpal Majumder, Sourabh Ghosh
The long duration space missions across the Low Earth Orbit (LEO) often expose the voyagers to an abrupt zero gravity influence. The severe extraterrestrial cosmic radiation directly causes a plethora of moderate to chronic healthcare crises. The only feasible solution to manage critical injuries on board is surgical interventions or immediate return to Earth. This led the group of space medicine practitioners
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Scaling up stem cell production: harnessing the potential of microfluidic devices Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-14 Lin Ding, Steve Oh, Jesus Shrestha, Alan Lam, Yaqing Wang, Payar Radfar, Majid Ebrahimi Warkiani
Stem cells are specialised cells characterised by their unique ability to both self-renew and transform into a wide array of specialised cell types. The widespread interest in stem cells for regenerative medicine and cultivated meat has led to a significant demand for these cells in both research and practical applications. Despite the growing need for stem cell manufacturing, the industry faces significant
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Challenges and opportunities for engineered Escherichia coli as a pivotal chassis toward versatile tyrosine-derived chemicals production Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-16 Sefli Sri Wahyu Effendi, I-Son Ng
Growing concerns over limited fossil resources and associated environmental problems are motivating the development of sustainable processes for the production of high-volume fuels and high-value-added compounds. The shikimate pathway, an imperative pathway in most microorganisms, is branched with tyrosine as the rate-limiting step precursor of valuable aromatic substances. Such occurrence suggests
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Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp. Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-14 Yang Tan, Jing Liang, Mingchi Lai, Sai Wan, Xiaozhou Luo, Fuli Li
The gut microbiota plays a significant role in influencing human immunity, metabolism, development, and behavior by producing a wide range of metabolites. While there is accumulating data on several microbiota-derived small molecules that contribute to host health and disease, our knowledge regarding the molecular mechanisms underlying metabolite-mediated microbe-host interactions remains limited.
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Biomanufacturing of glycosylated antibodies: Challenges, solutions, and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-07 Kashyap Kumar Dubey, Akshay Kumar, Anshu Baldia, Deepanshi Rajput, Suneel Kateriya, Rajani Singh, , Ravi Tandon, Yogendra Kumar Mishra
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Biotechnology to reduce logistics burden and promote environmental stewardship for Air Force civil engineering requirements Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-04 Rachel Krebs, Karen E. Farrington, Glenn R. Johnson, Heather R. Luckarift, Robert A. Diltz, Jeffery R. Owens
This review provides discussion of advances in biotechnology with specific application to civil engineering requirements for airfield and airbase operations. The broad objectives are soil stabilization, waste management, and environmental protection. The biotechnology focal areas address (1) treatment of soil and sand by biomineralization and biopolymer addition, (2) reduction of solid organic waste
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Methane mitigation in ruminants with structural analogues and other chemical compounds targeting archaeal methanogenesis pathways Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-02 Amlan Kumar Patra, Ryszard Puchala
Ruminants are responsible for enteric methane production contributing significantly to the anthropogenic greenhouse gases in the atmosphere. Moreover, dietary energy is lost as methane gas without being available for animal use. Therefore, many mitigation strategies aiming at interventions at animals, diet, and microbiota have been explored by researchers. Specific chemical analogues targeting the
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Exploitation of lignocellulosic-based biomass biorefinery: A critical review of renewable bioresource, sustainability and economic views Biotechnol. Adv. (IF 16.0) Pub Date : 2023-10-01 Zhonghao Chen, Lin Chen, Kuan Shiong Khoo, Vijai Kumar Gupta, Minaxi Sharma, Pau Loke Show, Pow-Seng Yap
Urbanization has driven the demand for fossil fuels, however, the overly exploited resource has caused severe damage on environmental pollution. Biorefining using abundant lignocellulosic biomass is an emerging strategy to replace traditional fossil fuels. Value-added lignin biomass reduces the waste pollution in the environment and provides a green path of conversion to obtain renewable resources
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Progress and prospect: Biosynthesis of plant natural products based on plant chassis Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-30 Junjie Lin, Xue Yin, Youran Zeng, Xinyu Hong, Shuncang Zhang, Beimi Cui, Qinlong Zhu, Zongsuo Liang, Zheyong Xue, Dongfeng Yang
Plant-derived natural products are a specific class of active substances with numerous applications in the medical, energy, and industrial fields. Many of these substances are in high demand and have become the fundamental materials for various purposes. Recently, the use of synthetic biology to produce plant-derived natural products has become a significant trend. Plant chassis, in particular, offer
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Cytoskeleton as a roadmap navigating rhizobia to establish symbiotic root nodulation in legumes Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-27 Kateřina Hlaváčková, Jozef Šamaj, Miroslav Ovečka
Legumes enter into symbiotic associations with soil nitrogen-fixing rhizobia, culminating in the creation of new organs, root nodules. This complex process relies on chemical and physical interaction between legumes and rhizobia, including early signalling events informing the host legume plant of a potentially beneficial microbe and triggering the nodulation program. The great significance of this
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Cupriavidus necator as a platform for polyhydroxyalkanoate production: An overview of strains, metabolism, and modeling approaches Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-27 Maria Silvia Morlino, Rebecca Serna García, Filippo Savio, Guido Zampieri, Tomas Morosinotto, Laura Treu, Stefano Campanaro
Cupriavidus necator is a bacterium with a high phenotypic diversity and versatile metabolic capabilities. It has been extensively studied as a model hydrogen oxidizer, as well as a producer of polyhydroxyalkanoates (PHA), plastic-like biopolymers with a high potential to substitute petroleum-based materials. Thanks to its adaptability to diverse metabolic lifestyles and to the ability to accumulate
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CRISPR genetic toolkits of classical food microorganisms: Current state and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-21 Xueqin Lv, Yang Li, Xiang Xiu, Chao Liao, Yameng Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu
Production of food-related products using microorganisms in an environmentally friendly manner is a crucial solution to global food safety and environmental pollution issues. Traditional microbial modification methods rely on artificial selection or natural mutations, which require time for repeated screening and reproduction, leading to unstable results. Therefore, it is imperative to develop rapid
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Microbial production of L-methionine and its precursors using systems metabolic engineering Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-20 Mengmeng Cai, Zhifei Liu, Zhenqiang Zhao, Hongxuan Wu, Meijuan Xu, Zhiming Rao
L-methionine is an essential amino acid with versatile applications in food, feed, cosmetics and pharmaceuticals. At present, the production of L-methionine mainly relies on chemical synthesis, which conflicts with the concern over serious environmental problems and sustainable development goals. In recent years, microbial production of natural products has been amply rewarded with the emergence and
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Biomass directional pyrolysis based on element economy to produce high-quality fuels, chemicals, carbon materials – A review Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-25 Huiyan Zhang, Ke Yang, Yujie Tao, Qing Yang, Lujiang Xu, Chao Liu, Longlong Ma, Rui Xiao
Biomass is regarded as the only carbon-containing renewable energy source and has performed an increasingly important role in the gradual substitution of conventional fossil energy, which also contributes to the goals of carbon neutrality. In the past decade, the academic field has paid much greater attention to the development of biomass pyrolysis technologies. However, most biomass conversion technologies
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Subcellular compartmentalization in the biosynthesis and engineering of plant natural products Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-16 Lu Yao, Xiuming Wu, Xun Jiang, Muhammad Shan, Zhuoxiang Zhang, Yiting Li, Aiguo Yang, Yu Li, Changqing Yang
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are synthesized in plant cells by enzymes that are distributed in different subcellular compartments with unique microenvironments, such as ions, co-factors and substrates. Plant metabolic engineering is an emerging and promising
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Progress advances in the production of bio-sourced methionine and its hydroxyl analogues Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-19 Jean Marie François
The essential sulphur-containing amino acid, methionine, is becoming a mass-commodity product with an annual production that exceeded 1,500,000 tons in 2018. This amino acid is today almost exclusively produced by chemical process from fossil resources. The environmental problems caused by this industrial process, and the expected scarcity of oil resources in the coming years, have recently accelerated
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Biosensor-guided discovery and engineering of metabolic enzymes Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-09 Hyun Gyu Hwang, Dae-Yeol Ye, Gyoo Yeol Jung
A variety of chemicals have been produced through metabolic engineering approaches, and enhancing biosynthesis performance can be achieved by using enzymes with high catalytic efficiency. Accordingly, a number of efforts have been made to discover enzymes in nature for various applications. In addition, enzyme engineering approaches have been attempted to suit specific industrial purposes. However
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Design strategies for positively charged endolysins: Insights into Artilysin development Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-06 Jose Vicente Carratalá, Anna Arís, Elena Garcia-Fruitós, Neus Ferrer-Miralles
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development of novel antibacterial agents. The use of genetic engineering techniques for the production and modification of endolysins offers the opportunity to customize their properties and activity against specific bacterial targets, paving
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CRISPR/Cas9-mediated genome editing techniques and new breeding strategies in cereals – current status, improvements, and perspectives Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-02 Sunny Ahmar, Goetz Hensel, Damian Gruszka
Cereal crops, including triticeae species (barley, wheat, rye), as well as edible cereals (wheat, corn, rice, oat, rye, sorghum), are significant suppliers for human consumption, livestock feed, and breweries. Over the past half-century, modern varieties of cereal crops with increased yields have contributed to global food security. However, presently cultivated elite crop varieties were developed