-
Sexually dimorphic control of affective state processing and empathic behaviors Neuron (IF 16.2) Pub Date : 2024-03-01 Shunchang Fang, Zhengyi Luo, Zicheng Wei, Yuxin Qin, Jieyan Zheng, Hongyang Zhang, Jianhua Jin, Jiali Li, Chenjian Miao, Shana Yang, Yonglin Li, Zirui Liang, Xiao-Dan Yu, Xiao Min Zhang, Wei Xiong, Hongying Zhu, Wen-Biao Gan, Lianyan Huang, Boxing Li
Recognizing the affective states of social counterparts and responding appropriately fosters successful social interactions. However, little is known about how the affective states are expressed and perceived and how they influence social decisions. Here, we show that male and female mice emit distinct olfactory cues after experiencing distress. These cues activate distinct neural circuits in the piriform
-
Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD Neuron (IF 16.2) Pub Date : 2024-02-26 Chenyu Wang, Kimberly D. Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D. Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier, Kevin J. Bender
Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high levels of distress that contribute markedly to the negative aspects of the disorder. Here, we identify a mechanism that underlies hypersensitivity in a sensorimotor reflex found to be altered
-
Mechanisms of sex differences in Alzheimer’s disease Neuron (IF 16.2) Pub Date : 2024-02-22 Chloe Lopez-Lee, Eileen Ruth S. Torres, Gillian Carling, Li Gan
-
Primate neocortex performs balanced sensory amplification Neuron (IF 16.2) Pub Date : 2024-02-21 Jagruti J. Pattadkal, Boris V. Zemelman, Ila Fiete, Nicholas J. Priebe
-
Harnessing diversity to study Alzheimer’s disease: A new iPSC resource from the NIH CARD and ADNI Neuron (IF 16.2) Pub Date : 2024-02-21 Laurel A. Screven, Caroline B. Pantazis, Katherine M. Andersh, Samantha Hong, Dan Vitale, Erika Lara, Ray Yueh Ku, Peter Heutink, Jason Meyer, Kelley Faber, Kwangsik Nho, Andrew J. Saykin, Tatiana M. Foroud, Mike A. Nalls, Cornelis Blauwendraat, Andrew Singleton, Priyanka S. Narayan
-
Driving valence-specific behavior through single-cell resolution control in the amygdala Neuron (IF 16.2) Pub Date : 2024-02-21 Leonardo Jared Ramirez Sanchez, Bo Li
-
-
Tuned geometries of hippocampal representations meet the computational demands of social memory Neuron (IF 16.2) Pub Date : 2024-02-20 Lara M. Boyle, Lorenzo Posani, Sarah Irfan, Steven A. Siegelbaum, Stefano Fusi
-
Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis Neuron (IF 16.2) Pub Date : 2024-02-19 Mridu Kapur, Michael J. Molumby, Carlos Guzman, Sven Heinz, Susan L. Ackerman
-
Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons Neuron (IF 16.2) Pub Date : 2024-02-19 Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, Gen Ohtsuki, Toshiya Murai, Shusaku Uchida
Despite the rapid and sustained antidepressant effects of ketamine and its metabolites, their underlying cellular and molecular mechanisms are not fully understood. Here, we demonstrate that the sustained antidepressant-like behavioral effects of ()-hydroxynorketamine (HNK) in repeatedly stressed animal models involve neurobiological changes in the anterior paraventricular nucleus of the thalamus (aPVT)
-
Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice Neuron (IF 16.2) Pub Date : 2024-02-15 Yazi D. Ke, Annika van Hummel, Carol Au, Gabriella Chan, Wei Siang Lee, Julia van der Hoven, Magdalena Przybyla, Yuanyuan Deng, Miheer Sabale, Nicolle Morey, Josefine Bertz, Astrid Feiten, Stefania Ippati, Claire H. Stevens, Shu Yang, Amadeus Gladbach, Nikolas K. Haass, Jillian J. Kril, Ian P. Blair, Fabien Delerue, Lars M. Ittner
-
Episodic memory development: Bridging animal and human research Neuron (IF 16.2) Pub Date : 2024-02-14 Juraj Bevandić, Loïc J. Chareyron, Jocelyne Bachevalier, Francesca Cacucci, Lisa Genzel, Nora S. Newcombe, Faraneh Vargha-Khadem, H. Freyja Ólafsdóttir
-
ASICs mediate fast excitatory synaptic transmission for tactile discrimination Neuron (IF 16.2) Pub Date : 2024-02-14 Akihiro Yamada, Jennifer Ling, Ayaka I. Yamada, Hidemasa Furue, Jianguo G. Gu
-
Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference Neuron (IF 16.2) Pub Date : 2024-02-14 Yijuan Zou, Chuanjun Tong, Wanling Peng, Yue Qiu, Jiangxue Li, Ying Xia, Mengchao Pei, Kaiwei Zhang, Weishuai Li, Min Xu, Zhifeng Liang
-
Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain Neuron (IF 16.2) Pub Date : 2024-02-13 Ya-Dong Li, Yan-Jia Luo, Wei-Kun Su, Jing Ge, Andrew Crowther, Ze-Ka Chen, Lu Wang, Michael Lazarus, Zi-Long Liu, Wei-Min Qu, Zhi-Li Huang
-
Epigenetic dysregulation in Alzheimer’s disease peripheral immunity Neuron (IF 16.2) Pub Date : 2024-02-09 Abhirami Ramakrishnan, Natalie Piehl, Brooke Simonton, Milan Parikh, Ziyang Zhang, Victoria Teregulova, Lynn van Olst, David Gate
-
Data science opportunities of large language models for neuroscience and biomedicine Neuron (IF 16.2) Pub Date : 2024-02-09 Danilo Bzdok, Andrew Thieme, Oleksiy Levkovskyy, Paul Wren, Thomas Ray, Siva Reddy
Large language models (LLMs) are a new asset class in the machine-learning landscape. Here we offer a primer on defining properties of these modeling techniques. We then reflect on new modes of investigation in which LLMs can be used to reframe classic neuroscience questions to deliver fresh answers. We reason that LLMs have the potential to (1) enrich neuroscience datasets by adding valuable meta-information
-
Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses Neuron (IF 16.2) Pub Date : 2024-02-07 Jinye Dai, Jason Aoto, Thomas C. Südhof
-
The brain’s go-getter circuit: Anterior cingulate cortex to nucleus accumbens and its disruption by stress Neuron (IF 16.2) Pub Date : 2024-02-07 Simone Astori, Carmen Sandi
-
-
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons Neuron (IF 16.2) Pub Date : 2024-02-07 Juliet Goldsmith, Alban Ordureau, J. Wade Harper, Erika L.F. Holzbaur
-
Does high-frequency stimulation of sensory axons break the causal link between pain relief and paresthesia? Neuron (IF 16.2) Pub Date : 2024-02-07 Evan R. Rogers, Scott F. Lempka, Marco Capogrosso
-
A role for the cerebellum in motor-triggered alleviation of anxiety Neuron (IF 16.2) Pub Date : 2024-01-31 Xiao-Yang Zhang, Wen-Xia Wu, Li-Ping Shen, Miao-Jin Ji, Peng-Fei Zhao, Lei Yu, Jun Yin, Shu-Tao Xie, Yun-Yong Xie, Yang-Xun Zhang, Hong-Zhao Li, Qi-Peng Zhang, Chao Yan, Fei Wang, Chris I. De Zeeuw, Jian-Jun Wang, Jing-Ning Zhu
-
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology Neuron (IF 16.2) Pub Date : 2024-01-31 Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E. Gorzynski, Tanner D. Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michael E. Belloy, Nandita Kasireddy, Andrés Peña-Tauber, Kennedy Williams, Ilaria Stewart, Lia Talozzi, Thomas S. Wingo, James J. Lah, Suman Jayadev, Chadwick M. Hales, Michael D. Greicius
The ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). Knockdown of ε4 may provide a therapeutic strategy for AD, but the effect of APOE loss of function (LoF) on AD pathogenesis is unknown. We searched for APOE LoF variants in a large cohort of controls and patients with AD and identified seven heterozygote carriers of APOE LoF variants
-
Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective Neuron (IF 16.2) Pub Date : 2024-01-30 Zezhong Lv, Lixi Chen, Ping Chen, Huipai Peng, Yi Rong, Wei Hong, Qiang Zhou, Nan Li, Boxing Li, Rosa C. Paolicelli, Yang Zhan
-
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish Neuron (IF 16.2) Pub Date : 2024-01-30 Margherita Zaupa, Nagarjuna Nagaraj, Anna Sylenko, Herwig Baier, Suphansa Sawamiphak, Alessandro Filosa
-
The mediodorsal thalamus in executive control Neuron (IF 16.2) Pub Date : 2024-01-30 Mathieu Wolff, Michael M. Halassa
Executive control, the ability to organize thoughts and action plans in real time, is a defining feature of higher cognition. Classical theories have emphasized cortical contributions to this process, but recent studies have reinvigorated interest in the role of the thalamus. Although it is well established that local thalamic damage diminishes cognitive capacity, such observations have been difficult
-
Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites Neuron (IF 16.2) Pub Date : 2024-01-29 Andrew D. Nelson, Amanda M. Catalfio, Julie P. Gupta, Lia Min, René N. Caballero-Florán, Kendall P. Dean, Carina C. Elvira, Kimberly D. Derderian, Henry Kyoung, Atehsa Sahagun, Stephan J. Sanders, Kevin J. Bender, Paul M. Jenkins
Dysfunction in sodium channels and their ankyrin scaffolding partners have both been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In particular, the genes SCN2A, which encodes the sodium channel NaV1.2, and ANK2, which encodes ankyrin-B, have strong ASD association. Recent studies indicate that ASD-associated haploinsufficiency in Scn2a impairs dendritic excitability
-
Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders Neuron (IF 16.2) Pub Date : 2024-01-29 Dongmei Cao, Pei Zhang, Sheng Wang
Over the years, the field of GPCR drug design has undergone a remarkable evolution, fueled by advancements in science and technology. This evolution has given rise to a diverse range of ideas and approaches in structure-based drug design, bolstering the versatility and strength of the GPCR drug design toolbox. This review encapsulates the iterative development process, navigating challenges and opportunities
-
Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns Neuron (IF 16.2) Pub Date : 2024-01-29 Humingzhu Li, Tao Jiang, Sile An, Mingrui Xu, Lingfeng Gou, Biyu Ren, Xiaoxue Shi, Xiaofei Wang, Jun Yan, Jing Yuan, Xiaohong Xu, Qing-Feng Wu, Qingming Luo, Hui Gong, Wen-Jie Bian, Anan Li, Xiang Yu
-
Beyond hippocampus: Thalamic and prefrontal contributions to an evolving memory Neuron (IF 16.2) Pub Date : 2024-01-24 Nakul Yadav, Andrew Toader, Priya Rajasethupathy
The hippocampus has long been at the center of memory research, and rightfully so. However, with emerging technological capabilities, we can increasingly appreciate memory as a more dynamic and brain-wide process. In this perspective, our goal is to begin developing models to understand the gradual evolution, reorganization, and stabilization of memories across the brain after their initial formation
-
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle Neuron (IF 16.2) Pub Date : 2024-01-23 Giovanna Sonsalla, Ana Belen Malpartida, Therese Riedemann, Mirjana Gusic, Ejona Rusha, Giorgia Bulli, Sonia Najas, Aleks Janjic, Bob A. Hersbach, Pawel Smialowski, Micha Drukker, Wolfgang Enard, Jochen H.M. Prehn, Holger Prokisch, Magdalena Götz, Giacomo Masserdotti
-
Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons Neuron (IF 16.2) Pub Date : 2024-01-25 Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchida
-
Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins Neuron (IF 16.2) Pub Date : 2024-01-23 Michael R. Strickland, Michael J. Rau, Brock Summers, Katherine Basore, John Wulf, Hong Jiang, Yun Chen, Jason D. Ulrich, Gwendalyn J. Randolph, Rui Zhang, James A.J. Fitzpatrick, Anil G. Cashikar, David M. Holtzman
The Apolipoprotein E gene (APOE) is of great interest due to its role as a risk factor for late-onset Alzheimer’s disease. ApoE is secreted by astrocytes in the central nervous system in high-density lipoprotein (HDL)-like lipoproteins. Structural models of lipidated ApoE of high resolution could aid in a mechanistic understanding of how ApoE functions in health and disease. Using monoclonal Fab and
-
Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state Neuron (IF 16.2) Pub Date : 2024-01-23 Adam D. Jackson, Joshua L. Cohen, Aarron J. Phensy, Edward F. Chang, Heather E. Dawes, Vikaas S. Sohal
-
Tranceformation: Digital dissemination of hypnosis Neuron (IF 16.2) Pub Date : 2024-01-22 David Spiegel
Hypnosis is an underutilized tool despite evidence of efficacy from randomized clinical trials. In this NeuroView, I discuss potential mechanisms in the context of brain networks and propose the use of app-based instruction in self-hypnosis.
-
Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity Neuron (IF 16.2) Pub Date : 2024-01-23 Dong Yang, Yu Wang, Tianbo Qi, Xi Zhang, Leyao Shen, Jingrui Ma, Zhengyuan Pang, Neeraj K. Lal, Daniel B. McClatchy, Saba Heydari Seradj, Verina H. Leung, Kristina Wang, Yi Xie, Filip S. Polli, Anton Maximov, Oscar Christian Gonzalez, Luis de Lecea, Hollis T. Cline, Vineet Augustine, John R. Yates III, Li Ye
-
A septal-ventral tegmental area circuit drives exploratory behavior Neuron (IF 16.2) Pub Date : 2024-01-23 Petra Mocellin, Oliver Barnstedt, Kevin Luxem, Hiroshi Kaneko, Silvia Vieweg, Julia U. Henschke, Dennis Dalügge, Falko Fuhrmann, Anna Karpova, Janelle M.P. Pakan, Michael R. Kreutz, Sanja Mikulovic, Stefan Remy
-
Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome Neuron (IF 16.2) Pub Date : 2024-01-22 Piero Sanfilippo, Alexander J. Kim, Anuradha Bhukel, Juyoun Yoo, Pegah S. Mirshahidi, Vijaya Pandey, Harry Bevir, Ashley Yuen, Parmis S. Mirshahidi, Peiyi Guo, Hong-Sheng Li, James A. Wohlschlegel, Yoshinori Aso, S. Lawrence Zipursky
Neurons express various combinations of neurotransmitter receptor (NR) subunits and receive inputs from multiple neuron types expressing different neurotransmitters. Localizing NR subunits to specific synaptic inputs has been challenging. Here, we use epitope-tagged endogenous NR subunits, expansion light-sheet microscopy, and electron microscopy (EM) connectomics to molecularly characterize synapses
-
Neuronal ensembles: Building blocks of neural circuits Neuron (IF 16.2) Pub Date : 2024-01-22 Rafael Yuste, Rosa Cossart, Emre Yaksi
Neuronal ensembles, defined as groups of neurons displaying recurring patterns of coordinated activity, represent an intermediate functional level between individual neurons and brain areas. Novel methods to measure and optically manipulate the activity of neuronal populations have provided evidence of ensembles in the neocortex and hippocampus. Ensembles can be activated intrinsically or in response
-
Can mirror self-recognition in mice unpack the neural underpinnings of self-awareness? Neuron (IF 16.2) Pub Date : 2024-01-17 Christian Keysers, Frédéric Michon
In this issue of Neuron, Yokose et al. show that mice groom a mark on their forehead when exposed to a mirror. Comparing this behavior with hominids’ helps carve self-awareness into its component parts and explore the neural mechanisms of its shared components.
-
Functional specificity of recurrent inhibition in visual cortex Neuron (IF 16.2) Pub Date : 2024-01-19 Petr Znamenskiy, Mean-Hwan Kim, Dylan R. Muir, M. Florencia Iacaruso, Sonja B. Hofer, Thomas D. Mrsic-Flogel
In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring visual responses and synaptic connectivity of parvalbumin-expressing
-
Guiding axon regeneration: Instructions from blood vessels Neuron (IF 16.2) Pub Date : 2024-01-17 Amparo Acker-Palmer
In this issue of Neuron, Bhat et al.1 unveil the temporary reawakening of an embryonic guidance program, which facilitates the alignment of blood neovessels, creating a supportive “bridge” microenvironment for axon regrowth and tissue regeneration after peripheral nervous system (PNS) injury.
-
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior Neuron (IF 16.2) Pub Date : 2024-01-18 Mai-Anh T. Vu, Eleanor H. Brown, Michelle J. Wen, Christian A. Noggle, Zicheng Zhang, Kevin J. Monk, Safa Bouabid, Lydia Mroz, Benjamin M. Graham, Yizhou Zhuo, Yulong Li, Timothy M. Otchy, Lin Tian, Ian G. Davison, David A. Boas, Mark W. Howe
Neural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally occurring patterns of large-scale, distributed dynamics within and across deep brain regions such as the striatum. We designed a new micro-fiber array approach
-
Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function Neuron (IF 16.2) Pub Date : 2024-01-18 Wenran Ren, Jianhui Chen, Wenjing Wang, Qingqing Li, Xia Yin, Guanglei Zhuang, Hong Zhou, Wenwen Zeng
-
Selective vulnerability of layer 5a corticostriatal neurons in Huntington’s disease Neuron (IF 16.2) Pub Date : 2024-01-17 Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R. Paul, Alison R. Weiss, William Liguore, Thomas S. Carroll, David A. Davis, Jodi McBride, Nathaniel Heintz
-
Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice Neuron (IF 16.2) Pub Date : 2024-01-15 Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida
Chronic stress is a major risk factor for psychiatric disorders, including depression. Although depression is a highly heterogeneous syndrome, it remains unclear how chronic stress drives individual differences in behavioral responses. In this study, we developed a subtyping-based approach wherein stressed male mice were divided into four subtypes based on their behavioral patterns of social interaction
-
Dissociable neuronal substrates of visual feature attention and working memory Neuron (IF 16.2) Pub Date : 2024-01-15 Diego Mendoza-Halliday, Haoran Xu, Frederico A.C. Azevedo, Robert Desimone
Attention and working memory (WM) are distinct cognitive functions, yet given their close interactions, it is often assumed that they share the same neuronal mechanisms. We show that in macaques performing a WM-guided feature attention task, the activity of most neurons in areas middle temporal (MT), medial superior temporal (MST), lateral intraparietal (LIP), and posterior lateral prefrontal cortex
-
Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse Neuron (IF 16.2) Pub Date : 2024-01-11 Jing-Jing Chen, Walter A. Kaufmann, Chong Chen, Itaru Arai, Olena Kim, Ryuichi Shigemoto, Peter Jonas
The coupling between Ca2+ channels and release sensors is a key factor defining the signaling properties of a synapse. However, the coupling nanotopography at many synapses remains unknown, and it is unclear how it changes during development. To address these questions, we examined coupling at the cerebellar inhibitory basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission
-
Dopamine’s reach: Unlocked by sleep loss Neuron (IF 16.2) Pub Date : 2024-01-03 Bibi Alika Sulaman, Tyler Kudlak, Ada Eban-Rothschild
In this issue of Neuron, Wu et al.1 employ cutting-edge techniques to provide a mechanistic understanding of how sleep deprivation induces an altered affective state. They reveal a key function for dopaminergic signaling, and the formation of cortical spines, in this process.
-
Alcohol withdrawal and pain: Peripheral mechanisms join central circuits Neuron (IF 16.2) Pub Date : 2024-01-03 Volker Neugebauer, Igor Ponomarev
Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al.1 identify a peripheral mechanism of an alcohol-withdrawal-induced headache-like condition, which is centered on mast-cell-specific receptor MrgprB2 activated by corticotropin-releasing factor (CRF) in dura mater to drive nociception.
-
Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation Neuron (IF 16.2) Pub Date : 2023-12-21 Maria C. Dadarlat, Yujiao Jennifer Sun, Michael P. Stryker
Electrical stimulation is an effective tool for mapping and altering brain connectivity, with applications ranging from treating pharmacology-resistant neurological disorders to providing sensory feedback for neural prostheses. Paramount to the success of these applications is the ability to manipulate electrical currents to precisely control evoked neural activity patterns. However, little is known
-
Restoration of a paraventricular thalamo-accumbal behavioral suppression circuit prevents reinstatement of heroin seeking Neuron (IF 16.2) Pub Date : 2023-12-22 Jacqueline E. Paniccia, Kelsey M. Vollmer, Lisa M. Green, Roger I. Grant, Kion T. Winston, Sophie Buchmaier, Annaka M. Westphal, Rachel E. Clarke, Elizabeth M. Doncheck, Bogdan Bordieanu, Logan M. Manusky, Michael R. Martino, Amy L. Ward, Jennifer A. Rinker, Jacqueline F. McGinty, Michael D. Scofield, James M. Otis
-
D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning Neuron (IF 16.2) Pub Date : 2023-12-21 Jennifer E. Zachry, Munir Gunes Kutlu, Hye Jean Yoon, Michael Z. Leonard, Maxime Chevée, Dev D. Patel, Anthony Gaidici, Veronika Kondev, Kimberly C. Thibeault, Rishik Bethi, Jennifer Tat, Patrick R. Melugin, Atagun U. Isiktas, Max E. Joffe, Denise J. Cai, P. Jeffrey Conn, Brad A. Grueter, Erin S. Calipari
-
Human-specific translational control of neuronal mitochondria and excitability Neuron (IF 16.2) Pub Date : 2023-12-20 Alicia R. Lane, Meghan E. Wynne, Victor Faundez
How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al.1 reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs. These findings suggest that FMRP-mediated translation adapts mitochondria to excitability energy
-
Seeing stars: Astroglia modulate visual circuits during behavioral-state transitions Neuron (IF 16.2) Pub Date : 2023-12-20 Alex B. Chen, Marc Duque, Florian Engert
In this issue of Neuron, Uribe-Arias et al.1 show that, in larval zebrafish, astrocyte-like cells exhibit calcium responses to norepinephrine during behavioral-state transitions and alter neuronal response properties. Thus, astroglia can sculpt neuronal dynamics in behaviorally meaningful ways.
-
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function Neuron (IF 16.2) Pub Date : 2023-12-20 Leonardo A. Parra-Rivas, Kayalvizhi Madhivanan, Brent D. Aulston, Lina Wang, Dube Dheeraj Prakashchand, Nicholas P. Boyer, Veronica M. Saia-Cereda, Kristen Branes-Guerrero, Donald P. Pizzo, Pritha Bagchi, V.S. Sundar, Yong Tang, Utpal Das, David A. Scott, Padmini Rangamani, Yuki Ogawa
Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a fraction of α-syn is phosphorylated at this site, and most studies have focused on the pathologic roles of this post-translational modification. We found that unlike wild-type (WT) α-syn, which is widely expressed throughout
-
Lights, fiber, action! A primer on in vivo fiber photometry Neuron (IF 16.2) Pub Date : 2023-12-15 Eleanor H. Simpson, Thomas Akam, Tommaso Patriarchi, Marta Blanco-Pozo, Lauren M. Burgeno, Ali Mohebi, Stephanie J. Cragg, Mark E. Walton
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery
-
Layer 6b controls brain state via apical dendrites and the higher-order thalamocortical system Neuron (IF 16.2) Pub Date : 2023-12-14 Timothy Adam Zolnik, Anna Bronec, Annemarie Ross, Marcel Staab, Robert N.S. Sachdev, Zoltán Molnár, Britta Johanna Eickholt, Matthew Evan Larkum
-
Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex Neuron (IF 16.2) Pub Date : 2023-12-14 Ning Cheng, Qiqi Dong, Zhen Zhang, Li Wang, Xiaojing Chen, Cheng Wang