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Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants Immunity (IF 32.4) Pub Date : 2024-03-14 Timothy S. Johnston, Shuk Hang Li, Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek, David B. Reeg, Daniel C. Douek, E. John Wherry, Scott E. Hensley
The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals. It remains unclear if exposures to antigenically distant SARS-CoV-2 variants can overcome memory B cell biases established by initial SARS-CoV-2 encounters. We determined the specificity and functionality of antibody
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans Immunity (IF 32.4) Pub Date : 2024-03-14 M. Alejandra Tortorici, Amin Addetia, Albert J. Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Immune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron breakthrough infections and bivalent COVID-19 vaccination primarily recall cross-reactive memory B cells induced by prior Wuhan-Hu-1 spike mRNA vaccination rather than priming Omicron-specific
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Dual checkpoint T(h1)eamwork makes the anti-cancer dream work Immunity (IF 32.4) Pub Date : 2024-03-12 Alisa Dietl, Anna Ralser, Karin Pelka
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging Immunity (IF 32.4) Pub Date : 2024-03-12 Conor M. Finlay, Judith E. Allen
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Predicting plasma cell retention and loss over a lifetime Immunity (IF 32.4) Pub Date : 2024-03-12 Marcus J. Robinson, David M. Tarlinton
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Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases Immunity (IF 32.4) Pub Date : 2024-03-12 Kate E. Lawlor, James M. Murphy, James E. Vince
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell death via necroptosis and pyroptosis—driven by membrane-damaging MLKL and gasdermins, respectively—can both initiate and propagate inflammatory responses. In this review, we provide
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Complement-ary protection for all ages Immunity (IF 32.4) Pub Date : 2024-03-12 Geongoo Han, Shipra Vaishnava
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The price of P2X7R freedom is neuroinflammation Immunity (IF 32.4) Pub Date : 2024-03-12 Mingqian Fang, Ren Lai
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Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells Immunity (IF 32.4) Pub Date : 2024-03-12 Wei Bu, Ashish Kumar, Nathan L. Board, JungHyun Kim, Kennichi Dowdell, Shu Zhang, Yona Lei, Anna Hostal, Tammy Krogmann, Yanmei Wang, Stefania Pittaluga, Joseph Marcotrigiano, Jeffrey I. Cohen
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion with B cells. We isolated gp42-specific monoclonal antibodies (mAbs), A10 and 4C12, which use distinct mechanisms to neutralize virus infection. mAb A10 was more potent than the only known neutralizing gp42 mAb, F-2-1, in neutralizing
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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer Immunity (IF 32.4) Pub Date : 2024-03-12 Acacia N. Shouse, Kathryn M. LaPorte, Thomas R. Malek
Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which
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Differentiation route determines the functional outputs of adult megakaryopoiesis Immunity (IF 32.4) Pub Date : 2024-03-05 Jing-Jing Li, Jingkun Liu, Yunqian Evelyn Li, Lin Veronica Chen, Hui Cheng, Yueying Li, Tao Cheng, Qian-Fei Wang, Bo O. Zhou
Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route). This raises the question of the importance of two alternative routes for megakaryopoiesis. Here, we developed fate-mapping systems to distinguish the
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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence Immunity (IF 32.4) Pub Date : 2024-03-05 Benjamin D. Simons, Omer Karin
Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV
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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy Immunity (IF 32.4) Pub Date : 2024-03-04 Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clement
Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single-cell profiling of on- versus pre-treatment biopsies identified T cell expansion as an early
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The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling Immunity (IF 32.4) Pub Date : 2024-03-01 An-Chieh Feng, Brandon J. Thomas, Prabhat K. Purbey, Filipe Menegatti de Melo, Xin Liu, Allison E. Daly, Fei Sun, Jerry Hung-Hao Lo, Lijing Cheng, Michael F. Carey, Philip O. Scumpia, Stephen T. Smale
Inducible nucleosome remodeling at hundreds of latent enhancers and several promoters shapes the transcriptional response to Toll-like receptor 4 (TLR4) signaling in macrophages. We aimed to define the identities of the transcription factors that promote TLR-induced remodeling. An analysis strategy based on ATAC-seq and single-cell ATAC-seq that enriched for genomic regions most likely to undergo remodeling
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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase Immunity (IF 32.4) Pub Date : 2024-03-01 Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E. Raab, Adrian Creanga, Tyler Stephens, Rebecca A. Gillespie, Hubza Z. Syeda, Brian E. Fisher, Michelle Skertic, Christina Yap, Andrew J. Schaub, Reda Rawi, Peter D. Kwong, Barney S. Graham, Adrian B. McDermott, Sarah F. Andrews, Neil P. King, Masaru Kanekiyo
Continuously evolving influenza viruses cause seasonal epidemics and pose global pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target, our understanding of the NA antigenic landscape still remains incomplete. Here, we describe NA-specific human antibodies that target the underside of the NA globular head domain, inhibit viral propagation of a wide range of human
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Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production Immunity (IF 32.4) Pub Date : 2024-02-28 Munesh K. Harioudh, Joseph Perez, Zhenlu Chong, Sharmila Nair, Lomon So, Kevin D. McCormick, Arundhati Ghosh, Lulu Shao, Rashmi Srivastava, Frank Soveg, Thomas S. Ebert, Maninjay K. Atianand, Veit Hornung, Ram Savan, Michael S. Diamond, Saumendra N. Sarkar
In response to viral infection, how cells balance translational shutdown to limit viral replication and the induction of antiviral components like interferons (IFNs) is not well understood. Moreover, how distinct isoforms of IFN-induced oligoadenylate synthetase 1 (OAS1) contribute to this antiviral response also requires further elucidation. Here, we show that human, but not mouse, OAS1 inhibits SARS-CoV-2
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Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells Immunity (IF 32.4) Pub Date : 2024-02-27 Rui Ding, Xiaoyan Yu, Zhilin Hu, Yu Dong, Haiyan Huang, Yuerong Zhang, Qiaoqiao Han, Zhi-Yu Ni, Ren Zhao, Youqiong Ye, Qiang Zou
RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated
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Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety Immunity (IF 32.4) Pub Date : 2024-02-22 Songqiang Huang, Wanting Dong, Xiaoqian Lin, Kangtai Xu, Kun Li, Siping Xiong, Zilong Wang, Xiaowei Nie, Jin-Song Bian
Na/K-ATPase (NKA) plays an important role in the central nervous system. However, little is known about its function in the microglia. Here, we found that NKAα1 forms a complex with the purinergic P2X7 receptor (P2X7R), an adenosine 5′-triphosphate (ATP)-gated ion channel, under physiological conditions. Chronic stress or treatment with lipopolysaccharide plus ATP decreased the membrane expression
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SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase Immunity (IF 32.4) Pub Date : 2024-02-22 Komal Srivastava, Juan Manuel Carreño, Charles Gleason, Brian Monahan, Gagandeep Singh, Anass Abbad, Johnstone Tcheou, Ariel Raskin, Giulio Kleiner, Harm van Bakel, Emilia Mia Sordillo, PARIS Study Group, Hala Alshammary, Angela A. Amoako, Dalles Andre, Mahmoud Awawda, Maria C. Bermúdez-González, Katherine F. Beach, Dominika Bielak, Gianna Y. Cai, Rachel L. Chernet, Christian Cognigni, Yuexing Chen
It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 infection and vaccination using >8,000 longitudinal samples collected over a 3-year period in New York City. Upon primary immunization, participants
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LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation Immunity (IF 32.4) Pub Date : 2024-02-13 Nicole Joller, Ana C. Anderson, Vijay K. Kuchroo
LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic. Although initially studied for their roles in restraining T cell responses, intense investigation over the last several years has started to pinpoint the unique functions of these molecules in other immune cell types. Understanding the distinct processes that these receptors regulate across
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Host-microbial crosstalk relies on “tuft” love Immunity (IF 32.4) Pub Date : 2024-02-13 Stefania De Santis, Theresa T. Pizarro
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Immunity as biophysics at the surface of a T cell Immunity (IF 32.4) Pub Date : 2024-02-13 Daniel S. Chen
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Neutrophils are itching to specialize Immunity (IF 32.4) Pub Date : 2024-02-13 Carlos H. Hiroki, Bryan G. Yipp
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A case of too much sugar: Lung DCs flummoxed by flu Immunity (IF 32.4) Pub Date : 2024-02-13 Ying Xi, Tiffany Horng
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases Immunity (IF 32.4) Pub Date : 2024-02-13 Anna H. Lippert, Christopher Paluch, Meike Gaglioni, Mai T. Vuong, James McColl, Edward Jenkins, Martin Fellermeyer, Joseph Clarke, Sumana Sharma, Sara Moreira da Silva, Billur Akkaya, Consuelo Anzilotti, Sara H. Morgan, Claire F. Jessup, Markus Körbel, Uzi Gileadi, Judith Leitner, Rachel Knox, Mami Chirifu, Jiandong Huo, Susan Yu, Nicole Ashman, Yuan Lui, Ian Wilkinson, Kathrine E. Attfield, Lars
Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RPTPs) such as CD45 from sites of receptor engagement. An agonist targeting the costimulatory receptor CD28 produced signals that depended on antibody immobilization
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The diversity, destiny, and memory of DAMs Immunity (IF 32.4) Pub Date : 2024-02-13 Hongbin Li, Ukpong B. Eyo
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks Immunity (IF 32.4) Pub Date : 2024-02-13 Carla A. Jaeger-Ruckstuhl, Yun Lo, Elena Fulton, Olivia G. Waltner, Tamer B. Shabaneh, Sylvain Simon, Pranav V. Muthuraman, Colin E. Correnti, Oliver J. Newsom, Ian A. Engstrom, Sami B. Kanaan, Shruti S. Bhise, Jobelle M.C. Peralta, Raymond Ruff, Jason P. Price, Sylvia M. Stull, Andrew R. Stevens, Grace Bugos, Mitchell G. Kluesner, Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M. Olson
The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8 T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary for T cell memory fate determination. Here, we examined CD27 signaling during Tn cell activation and differentiation. In conjunction with T cell receptor (TCR) stimulation, ligation of CD27 by a synthetic trimeric CD70 ligand
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The B7:CD28 family and friends: Unraveling coinhibitory interactions Immunity (IF 32.4) Pub Date : 2024-02-13 Kelly P. Burke, Apoorvi Chaudhri, Gordon J. Freeman, Arlene H. Sharpe
Immune responses must be tightly regulated to ensure both optimal protective immunity and tolerance. Costimulatory pathways within the B7:CD28 family provide essential signals for optimal T cell activation and clonal expansion. They provide crucial inhibitory signals that maintain immune homeostasis, control resolution of inflammation, regulate host defense, and promote tolerance to prevent autoimmunity
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Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision Immunity (IF 32.4) Pub Date : 2024-01-31 Kathleen Abadie, Elisa C. Clark, Rajesh M. Valanparambil, Obinna Ukogu, Wei Yang, Riza M. Daza, Kenneth K.H. Ng, Jumana Fathima, Allan L. Wang, Judong Lee, Tahseen H. Nasti, Avinash Bhandoola, Armita Nourmohammad, Rafi Ahmed, Jay Shendure, Junyue Cao, Hao Yuan Kueh
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Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis Immunity (IF 32.4) Pub Date : 2024-02-02 Thomas M. Savage, Katherine T. Fortson, Kenia de los Santos-Alexis, Angelica Oliveras-Alsina, Mathieu Rouanne, Sarah S. Rae, Jennifer R. Gamarra, Hani Shayya, Adam Kornberg, Renzo Cavero, Fangda Li, Arnold Han, Rebecca A. Haeusler, Julien Adam, Robert F. Schwabe, Nicholas Arpaia
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Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury Immunity (IF 32.4) Pub Date : 2024-02-02 Yangning Lan, Xiaoxuan Zhang, Shaorui Liu, Chen Guo, Yuxiao Jin, Hui Li, Linyixiao Wang, Jinghong Zhao, Yilin Hao, Zhicheng Li, Zhaoyuan Liu, Florent Ginhoux, Qi Xie, Heping Xu, Jie-Min Jia, Danyang He
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Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response Immunity (IF 32.4) Pub Date : 2024-01-31 Nikolai P. Jaschke, Dorit Breining, Maura Hofmann, Sophie Pählig, Ulrike Baschant, Reinhard Oertel, Sofia Traikov, Tatyana Grinenko, Francesco Saettini, Andrea Biondi, Myrto Stylianou, Henrik Bringmann, Cuiling Zhang, Tomomi M. Yoshida, Heike Weidner, Wolfram C. Poller, Filip K. Swirski, Andy Göbel, Lorenz C. Hofbauer, Martina Rauner, Tilman D. Rachner
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An atlas of cells in the human tonsil Immunity (IF 32.4) Pub Date : 2024-01-31 Ramon Massoni-Badosa, Sergio Aguilar-Fernández, Juan C. Nieto, Paula Soler-Vila, Marc Elosua-Bayes, Domenica Marchese, Marta Kulis, Amaia Vilas-Zornoza, Marco Matteo Bühler, Sonal Rashmi, Clara Alsinet, Ginevra Caratù, Catia Moutinho, Sara Ruiz, Patricia Lorden, Giulia Lunazzi, Dolors Colomer, Gerard Frigola, Will Blevins, Lucia Romero-Rivero, Holger Heyn
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A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection Immunity (IF 32.4) Pub Date : 2024-01-30 Naina Gour, Hwan Mee Yong, Aishwarya Magesh, Aishwarya Atakkatan, Felipe Andrade, Stephane Lajoie, Xinzhong Dong
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Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity Immunity (IF 32.4) Pub Date : 2024-01-30 Emily M. Eshleman, Taylor Rice, Crystal Potter, Amanda Waddell, Seika Hashimoto-Hill, Vivienne Woo, Sydney Field, Laura Engleman, Hee-Woong Lim, Michael A. Schumacher, Mark R. Frey, Lee A. Denson, Fred D. Finkelman, Theresa Alenghat
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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging Immunity (IF 32.4) Pub Date : 2024-01-22 Zhao Zhou, Jingfei Yao, Dongmei Wu, Xun Huang, Yushuang Wang, Xinmeng Li, Qiang Lu, Yifu Qiu
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Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation Immunity (IF 32.4) Pub Date : 2024-01-15 Henry J. Sutton, Xin Gao, Hannah G. Kelly, Brian J. Parker, Mariah Lofgren, Cherrelle Dacon, Deepyan Chatterjee, Robert A. Seder, Joshua Tan, Azza H. Idris, Teresa Neeman, Ian A. Cockburn
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TREMendous microglial effects on neurons Immunity (IF 32.4) Pub Date : 2024-01-09 Xiao-Fen Chen, Guojun Bu
TREM2 is exclusively expressed by microglia in the brain and is strongly associated with Alzheimer’s disease risk. In this issue of Immunity, Tagliatti et al. shed light on a novel role of TREM2 in shaping neuronal bioenergetics during development.
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You are the tumor queen, microbiome fiend, IL-17 Immunity (IF 32.4) Pub Date : 2024-01-09 Jessica A. Jana, Abigail E. Overacre-Delgoffe
The role of IL-17 signaling in cancer remains convoluted due to its role in regulating the gut microbiome. In a recent issue of Cancer Cell, Chandra et al. demonstrate that microbially driven IL-17 signaling promotes tumor growth.
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Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity Immunity (IF 32.4) Pub Date : 2024-01-09 Simone J.C.F.M. Moorlag, Lukas Folkman, Rob ter Horst, Thomas Krausgruber, Daniele Barreca, Linda C. Schuster, Victoria Fife, Vasiliki Matzaraki, Wenchao Li, Stephan Reichl, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Helga Dijkstra, Heidi Lemmers, Bram van Cranenbroek, Esther van Rijssen, Hans J.P.M. Koenen, Irma Joosten, Cheng-Jian Xu, Christoph Bock
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Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB–CD8+ memory T cells and accumulation of type 2 memory T cells Immunity (IF 32.4) Pub Date : 2024-01-09 Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A. Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N. Artyomov
Abstract not available
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Kidney macrophages tap the stream Immunity (IF 32.4) Pub Date : 2024-01-09 Pedro H.V. Saavedra, Justin S.A. Perry
Tissue-resident macrophages are essential for maintaining organismal homeostasis, but the precise mechanisms that macrophages use to perform this function are not fully understood. In this issue of Immunity, He et al. demonstrate that renal macrophages surveil and sample urine particles, ensuring optimal collecting duct flow and preventing kidney stone development.
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On blood and tissue-resident natural killer cells Immunity (IF 32.4) Pub Date : 2024-01-09 Emilie Narni-Mancinelli, Carole Berruyer, Eric Vivier
Conventional natural killer (cNK) cells patrol the organism via circulation and invade tissues in response to infection or inflammation. In this issue of Immunity, Torcellan et al. report that circulating cNK cells are recruited into infected skin and differentiate into long-lived tissue-resident NK cells capable of mediating an accelerated response upon reinfection.
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TIMely connections: APOE4, aging, and Alzheimer’s Immunity (IF 32.4) Pub Date : 2024-01-09 Qingyun Li
How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer’s disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.
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Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation Immunity (IF 32.4) Pub Date : 2024-01-09 Mohammad Arifuzzaman, Nicholas Collins, Chun-Jun Guo, David Artis
Nutrition profoundly shapes immunity and inflammation across the lifespan of mammals, from pre- and post-natal periods to later life. Emerging insights into diet-microbiota interactions indicate that nutrition has a dominant influence on the composition—and metabolic output—of the intestinal microbiota, which in turn has major consequences for host immunity and inflammation. Here, we discuss recent
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The MRGPR family of receptors in immunity Immunity (IF 32.4) Pub Date : 2024-01-09 Naina Gour, Xinzhong Dong
The discovery of Mas-related G protein-coupled receptors (Mrgprs) has opened a compelling chapter in our understanding of immunity and sensory biology. This family of receptors, with their unique expression and diverse ligands, has emerged as key players in inflammatory states and hold the potential to alleviate human diseases. This review will focus on the members of this receptor family expressed
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Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection Immunity (IF 32.4) Pub Date : 2024-01-02 Nicole Frumento, Ariadne Sinnis-Bourozikas, Harry T. Paul, Georgia Stavrakis, Muhammad N. Zahid, Shuyi Wang, Stuart C. Ray, Andrew I. Flyak, George M. Shaw, Andrea L. Cox, Justin R. Bailey
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Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development Immunity (IF 32.4) Pub Date : 2023-12-29 Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C. Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J. Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteoli
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Renal macrophages monitor and remove particles from urine to prevent tubule obstruction Immunity (IF 32.4) Pub Date : 2023-12-29 Jian He, Yangyang Cao, Qian Zhu, Xinge Wang, Guo Cheng, Qiang Wang, Rukun He, Haoran Lu, Yuancheng Weng, Genxiang Mao, Yizhong Bao, Jing Wang, Xiaoli Liu, Fei Han, Peng Shi, Xiao Z. Shen
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An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains Immunity (IF 32.4) Pub Date : 2023-12-29 Alon Millet, Jose Henrique Ledo, Sohail F. Tavazoie
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Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection Immunity (IF 32.4) Pub Date : 2023-12-28 Tommaso Torcellan, Christin Friedrich, Rémi Doucet-Ladevèze, Thomas Ossner, Virgínia Visaconill Solé, Sofie Riedmann, Milas Ugur, Fabian Imdahl, Stephan P. Rosshart, Sebastian J. Arnold, Mercedes Gomez de Agüero, Nicola Gagliani, Richard A. Flavell, Simone Backes, Wolfgang Kastenmüller, Georg Gasteiger
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Tissue factor binds to and inhibits interferon-α receptor 1 signaling Immunity (IF 32.4) Pub Date : 2023-12-22 Jayakumar Manoharan, Rajiv Rana, Georg Kuenze, Dheerendra Gupta, Ahmed Elwakiel, Saira Ambreen, Hongjie Wang, Kuheli Banerjee, Silke Zimmermann, Kunal Singh, Anubhuti Gupta, Sameen Fatima, Stefanie Kretschmer, Liliana Schaefer, Jinyang Zeng-Brouwers, Constantin Schwab, Moh’d Mohanad Al-Dabet, Ihsan Gadi, Heidi Altmann, Thea Koch, Berend Isermann
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Cytotoxic Th1 cells mushroom after fungal exposures in Crohn’s disease Immunity (IF 32.4) Pub Date : 2023-12-12 Martin Stražar, Ramnik J. Xavier
Fungi are consistently enriched in inflamed intestines, with elusive effects on host immunity. In a recent issue of Nature Medicine, Martini et al. identify a subset of Th1 cells able to lyse the epithelium, enriched in Crohn’s disease patient samples after fungal exposure.
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Chi3l1: New kid on the T cell blockade Immunity (IF 32.4) Pub Date : 2023-12-12 Mi He, Marleen Kok
T cell-excluded tumors are less responsive to immunotherapies. In this issue of Immunity, Taifour et al. show that secretion of the cytokine Chi3l1 by tumor cells induces T cell exclusion via neutrophil extracellular trap (NET) formation. Chi3l1 depletion stimulates T cell infiltration and synergizes with PD-1 blockade.
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A maelstrom of migrating monocytes drives neurodegeneration Immunity (IF 32.4) Pub Date : 2023-12-12 Nicole G. Coufal, Michelle L. Hermiston
Neurodegeneration is a devastating complication of Langerhans cell histiocytosis (LCH), but it is not clear how it develops. In this issue of Immunity, Wilk et al. demonstrate that circulating BRAFV600E+ myeloid cells damage the blood-brain barrier and infiltrate the brain. Dual inhibition of the MAPK and senescence pathways can block parenchymal injury, providing a potential therapeutic avenue for
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RNA vaccines: A transformational advance Immunity (IF 32.4) Pub Date : 2023-12-12 Brian D. Brown, Anthony S. Fauci, Yasmine Belkaid, Miriam Merad
Vaccines have stemmed many infectious diseases, but when SARS-CoV-2 emerged, traditional vaccine development would not have been fast enough. This year’s Nobel Prize in Physiology or Medicine recognizes work that enabled the rapid development of mRNA vaccines, which halted the COVID-19 pandemic. The feat was a product of basic biological insights coupled with technological innovations, which have transformed
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Stat5a sobers up inTOXicated T cells Immunity (IF 32.4) Pub Date : 2023-12-12 Lara V. Donhauser, Dietmar Zehn
Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable
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Sex-biased gut dopamine signaling in multiple sclerosis Immunity (IF 32.4) Pub Date : 2023-12-12 Shui Yu, Melody Y. Zeng
Multiple sclerosis shows a strong sex bias, with unclear mechanisms. In this issue of Immunity, Peng et al. elucidate a female-biased increase in intestinal dopamine signaling that diminishes protective Lactobacillus and exacerbates inflammation in a mouse model of multiple sclerosis.
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TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments Immunity (IF 32.4) Pub Date : 2023-12-12 Yuan-Li Tsai, Marcel Arias-Badia, Theresa A. Kadlecek, Yee May Lwin, Aahir Srinath, Neel H. Shah, Zhi-En Wang, Diane Barber, John Kuriyan, Lawrence Fong, Arthur Weiss
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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure Immunity (IF 32.4) Pub Date : 2023-12-12 Jean-Christophe Beltra, Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi, Leon Su, Lora Picton, Shin Foong Ngiow, Yuki Muroyama, Valentina Casella, Yinghui J. Huang, Josephine R. Giles, Divij Mathew, Jonathan Belman, Max Klapholz, Hélène Decaluwe, Alexander C. Huang, Shelley L. Berger, K. Christopher Garcia, E. John Wherry