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Tantalum Particles Promote M2 Macrophage Polarization and Regulate Local Bone Metabolism via Macrophage-Derived Exosomes Influencing the Fates of BMSCs Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-18 Junjun Yang, Xiaoyuan Gong, Tao Li, Zengzilu Xia, Rui He, Xiongbo Song, Xin Wang, Jiangyi Wu, Jiajia Chen, Fangzheng Wang, Ran Xiong, Yangjing Lin, Guangxing Chen, Liu Yang, Kaiyong Cai
In this study, we explored the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta-induced
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The Combination of Membrane Disruption and FtsZ Targeting by a Chemotherapeutic Hydrogel Synergistically Combats Pathogens Infections Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-16 Xianyuan Wei, Jintong Guo, Xiaorui Geng, Bin Xue, Shaohui Huang, Zhen Yuan
The emergence of multidrug-resistant (MDR) bacteria poses a significant challenge to global health. Due to a shortage of antibiotics, alternative therapeutic strategies are urgently needed. Unfortunately, colistin, the last-resort antibiotic, has unavoidable nephrotoxicity and hepatotoxicity, and its single killing mechanism is prone to drug resistance. To address this challenge, we propose a promising
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The H2O2 Self-sufficient 3D Printed β-TCP Scaffolds with Synergistic Anti-tumor Effect and Reinforced Osseointegration Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-15 Qing Wang, Jingyan Qiu, Hang Zhang, Xuan Wang, Yanzheng Chen, Xiang Li, Jinsong Pan
Tumor recurrence and massive bone defects are two critical challenges for postoperative treatment of oral and maxillofacial tumor, posing serious threats to the health of patients. Herein, in order to eliminate residual tumor cells and promote osteogenesis simultaneously, the hydrogen peroxide (H2O2) self-sufficient TCP-PDA-CaO2-CeO2 (TPCC) scaffolds are designed by preparing CaO2 or/and CeO2 nanoparticles
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Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-15 Xin Wei, Jiaxin Chen, Hui-Yuan Shen, Kai Jiang, Haohao Ren, Yao Liu, En Luo, Jin Zhang, Jia-Zhuang Xu, Zhong-Ming Li
Structural engineering is an appealing means to modulate osteogenesis without the intervention of exogenous cells or therapeutic agents. In this work, we developed a novel three-dimensional (3D) scaffold with anisotropic micropores and nanotopographical patterns. Scaffolds with oriented pores were fabricated via the selective extraction of water-soluble polyethylene oxide (PEO) from its poly(ε-caprolactone)
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Unveiling the Impact of Hemodynamics on Endothelial Inflammation-mediated Hepatocellular Carcinoma Metastasis Using a Biomimetic Vascular Flow Model Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Jia He, Peiyan Duan, Yi Liu, Tang Feng, Shuo Wang, Xinyi Lin, Jing Xie, Xiaoheng Liu
Distant metastasis of hepatocellular carcinoma (HCC) mediated by hematogenous dissemination is a leading cause of HCC-related deaths. The inflammatory response of vascular endothelial cells facilitates this process by promoting the adhesion and invasion of tumor cells in the circulatory system. While the regulation of this inflammation-mediated metastasis through upregulation of adhesion molecules
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Scalable and Versatile Metal Ion Solidificated Alginate Hydrogel for Skin Wound Infection Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 By Haomiao Zhang, Ye Lu, Lei Huang, Ping Liu, Jun Ni, Tianqi Yang, Yihong Li, Yu Zhong, Xinping He, Xinhui Xia, Jiancang Zhou
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. In this work, we have proposed novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+, Co2+, Ni2+, Cu2+, and Zn2+) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure
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Robust Gradient Hydrogel‐Loaded Nanofiber Fleshy Artificial Skin via A Coupled Microfluidic Electrospinning‐Reactive Coating Strategy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-16 Qing Li, Rong Chen, Tingting Cui, Yuting Bai, Jie Hu, Jiafei Yu, Gefei Wang, Su Chen
Skin regeneration has attracted tremendous interest due to the important role of skin for human protection and beauty. Thus, methods allowing artificial skin to be carried out in a controllable fashion are potentially important for wound healing, which involves an intersection of materials, medicine, biology and other disciplines. Herein, aiming at a new general methodology for fleshy materials, we
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Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-16 Qiyao Sun, Siyuan Tao, Giovanni Bovone, Garam Han, Dhananjay Deshmukh, Mark W. Tibbitt, Qun Ren, Pascal Bertsch, Gilberto Siqueira, Peter Fischer
Hydrogels provide a versatile platform for biomedical material fabrication that can be structurally and mechanically fine‐tuned to various tissues and applications. Applications of hydrogels in biomedicine range from highly dynamic injectable hydrogels that can flow through syringe needles and maintain or recover their structure after extrusion to solid‐like wound‐healing patches that need to be stretchable
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Towards the Improvement of the Mechanical and Tribological Properties of Braided Ligament for ACL Reconstruction: A “Carrot and Stick” Strategy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Shenglin Li, Shuhan Wang, Jiasheng Shao, Jiali Wang, Wenliang Liu, Linxin Chen, Zeng Li, Chao Zhang, Jian Song
Bone tunnel enlargement has been troubling the clinical adoption of braided artificial ligaments for decades, to which mechanical and tribological performance promotion shall be an effective and promising approach. Herein, a “carrot and stick” strategy has been introduced with two types of polyethylene terephthalate (PET) fibers to fabricate hybrid textures, which is expected to advance fatigue and
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Zein‐Based Triple‐Drug Nanoparticles to Promote Anti‐inflammatory Responses for Nerve Regeneration after Spinal Cord Injury Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Jingxuan Wang, Yan Lin, Chunhan Li, Fei Lei, Hongli Luo, Pei Jing, Yao Fu, Zhirong Zhang, Changguang Wang, Zerong Liu, Jun Jiang, Meiling Zhou, Xingjie Du, Zhongbing Liu, Xiangyu Zhou, Xiaoduan Sun, Zhirong Zhong
Defects in autophagy contribute to neurological deficits and motor dysfunction after spinal cord injury. Here a nanosystem was developed to deliver autophagy‐promoting, anti‐inflammatory drugs to nerve cells in the injured spinal cord. Celastrol, metformin, and everolimus as the mTOR inhibitor were combined into the zein‐based nanoparticles, aiming to solubilize the drugs and prolong their circulation
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Nanomaterials Boost CAR‐T Therapy for Solid Tumors Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Jun Long, Yian Wang, Xianjie Jiang, Junshang Ge, Mingfen Chen, Boshu Zheng, Rong Wang, Meifeng Wang, Meifang Xu, Qi Ke, Jie Wang
T cell engineering, particularly via chimeric antigen receptor (CAR) modifications for enhancing tumor specificity, has shown efficacy in treating hematologic malignancies. The extension of CAR‐T cell therapy to solid tumors, however, is impeded by several challenges: the absence of tumor‐specific antigens, antigen heterogeneity, a complex immunosuppressive tumor microenvironment, and physical barriers
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Ferried Albumin‐Inspired Bioadhesive with Dynamic Interfacial Bonds for Emergency Rescue Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Yiming Chen, Huiying Li, Renfeng Xu, Yan Fang, Qinhui Chen, Zhengchao Wang, Haiqing Liu, Yunxiang Weng
Emergency prehospital wound closure and hemorrhage control are the first priorities for life‐saving. A majority bioadhesives form bonds with tissues through irreversible cross‐linking, and the remobilization of misalignment may cause severe secondary damage to tissues. Therefore, developing an adhesive that can quickly and tolerably adhere to traumatized dynamic tissue or organ surfaces in emergency
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A Golgi Apparatus‐Targeted Photothermal Agent with Protein Anchoring for Enhanced Cancer Photothermal Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-14 Mingwan Shi, Zhongliang Fu, Wei Pan, Kaiye Wang, Xiaohan Liu, Na Li, Bo Tang
The Golgi apparatus (GA) is central in shuttling proteins from the endoplasmic reticulum to different cellular areas. Therefore, targeting the GA to precisely destroy its proteins through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy. Herein, we introduce a GA‐targeted photothermal agent based on protein anchoring for enhanced photothermal therapy of tumor
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Design of a novel delivery efficiency feedback system for biphasic dissolving microarray patches based on poly(lactic acid) and moisture-indicating silica Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Huanhuan Li, Qonita Kurnia Anjani, Aaron R.J. Hutton, Juan Luis Paris, Natalia Moreno-Castellanos, Achmad Himawan, Eneko Larrañeta, Ryan F. Donnelly
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end-user surveys have hindered their commercialization efforts. One prevalent issue highlighted in these surveys is the lack of clear indicators for successful patch insertion
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3D Bioprinted Human Skin Model Recapitulating Native‐like Tissue Maturation and Immunocompetence as an Advanced Platform for Skin Sensitization Assessment Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Bibrita Bhar, Eshani Das, Kodieswaran Manikumar, Biman B. Mandal
Physiologically‐relevant in vitro skin models hold utmost importance for efficacy assessments of pharmaceutical and cosmeceutical formulations, offering valuable alternatives to animal testing. Here, we present an advanced immunocompetent three‐dimensional (3D) bioprinted human skin model to assess skin sensitization. Initially, a photopolymerizable bioink is formulated using silk fibroin methacrylate
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Bioactive Conjugated Polymer‐Based Biodegradable 3D Bionic Scaffolds for Facilitating Bone Defect Repair (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Qiong Yuan, Benkai Bao, Meiqi Li, Ling Li, Xinyi Zhang, Yanli Tang
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Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Dong Ha Lee, Sunyoung Lim, Sung Soo Kwak, Joohee Kim
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Polyelectrolyte‐Cation Complexes Using PAsp‐Sr Complexes Induce Biomimetic Mineralization with Antibacterial Ability (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Yuedan Xu, Dongni Shen, Zihuai Zhou, Yi Sun, Xinni Pan, Wei Liu, Chun Hung Chu, Ling Zhang, Matthias Hannig, Baiping Fu
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Zirconium‐Based Metal‐Organic Framework Capable of Binding Proinflammatory Mediators in Hydrogel Form Promotes Wound Healing Process through a Multiscale Adsorption Mechanism (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 UnJin Ryu, Pham Ngoc Chien, Suin Jang, Xuan‐Tung Trinh, Hyeon Shin Lee, Le Thi Van Anh, Xin Rui Zhang, Nguyen Ngan Giang, Nguyen Van Long, Sun‐Young Nam, Chan Yeong Heo, Kyung Min Choi
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Patient‐Derived Microphysiological Systems for Precision Medicine (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Jihoon Ko, Jiyoung Song, Nakwon Choi, Hong Nam Kim
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Dual‐Targeting Nanovesicles Carrying CSF1/CD47 Identified from Single‐Cell Transcriptomics of Innate Immune Cells in Heart Transplant for Alleviating Acute Rejection (Adv. Healthcare Mater. 7/2024) Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-13 Zhanxue Xu, Xiaofan Mao, Xingyu Lu, Peilin Shi, Jingping Ye, Xinrui Yang, Qingling Fu, Chao He, Dandan Su, Yichu Nie, Longshan Liu, Changxi Wang, Benjie Zhou, Wei Luo, Fang Cheng, Hongbo Chen
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Micro‐Engineered Heart Tissues on‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Carla Cofiño‐Fabres, Tom Boonen, José M. Rivera‐Arbeláez, Minke Rijpkema, Lisanne Blauw, Patrick C. N. Rensen, Verena Schwach, Marcelo C. Ribeiro, Robert Passier
Advanced in vitro models that recapitulate the structural organization and function of the human heart are highly needed for accurate disease modeling, more predictable drug screening and safety pharmacology. Conventional 3D Engineered Heart Tissues (EHTs) lack heterotypic cell complexity and culture under flow, whereas microfluidic Heart‐on‐Chip (HoC) models in general lack the 3D configuration and
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A self‐assembled 3D model demonstrates how stiffness educates tumor cell phenotypes and therapy resistance in pancreatic cancer Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Ying Liu, Babatunde O. Okesola, David Osuna de la Peña, Weiqi Li, Meng‐Lay Lin, Sara Maria David Trabulo, Marianthi Tatari, Rita T. Lawlor, Aldo Scarpa, Wen Wang, Martin Knight, Daniela Loessner, Christopher Heeschen, Alvaro Mata, Oliver M. T. Pearce
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression and therapy resistance. To further our understanding of how stiffening of the tumor microenvironment (TME) contributes to aggressiveness, we develop a three‐dimensional (3D) self‐assembling hydrogel disease model based on peptide amphiphiles (PAs, PA‐E3Y) designed
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Promoting Diabetic Wound Healing through a Hydrogel-Based Cascade Regulation Strategy of Fibroblast-Macrophage Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Nuo Jin, Zilin Wang, Xi Tang, Nianqiang Jin, Xiaohong Wang
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Inverse‐vaccines for Rheumatoid Arthritis Re‐establish Metabolic and Immunological Homeostasis in Joint Tissues Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Abhirami Thumsi, Diego Martínez, Srivatsan J. Swaminathan, Arezoo Esrafili, Abhirami P. Suresh, Madan Mohan Chandrasekhar Jaggarappu, Kelly Lintecum, Michelle Halim, Shivani V. Mantri, Yasmine Sleiman, Nicole Appel, Haiwei Gu, Marion Curtis, Cristal Zuniga, Abhinav P. Acharya
Rheumatoid arthritis (RA) causes inflammatory and metabolic imbalances in tissue, which then exacerbates inflammation in affected joints. Therefore, restoring tissue homeostasis is necessary for the remission of RA symptoms. In fact, the changes in immunological and metabolic tissue homeostasis at different stages of the disease is not well understood. Herein, the changes in the immunological metabolic
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Clickable Granular Hydrogel Scaffolds for Delivery of Neural Progenitor Cells to Sites of Spinal Cord Injury Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-12 Thomas J. Tigner, Gabrielle Dampf, Ashley Tucker, Yu‐Chi Huang, Vipin Jagrit, Abigail J. Clevenger, Arpita Mohapatra, Shreya A. Raghavan, Jennifer N. Dulin, Daniel L. Alge
Spinal cord injury (SCI) is a serious condition with limited treatment options. Neural progenitor cell (NPC) transplantation is a promising treatment option, and the identification of novel biomaterial scaffolds that support NPC engraftment and therapeutic activity is a top research priority. The objective of this study was to evaluate in situ assembled poly (ethylene glycol) (PEG)‐based granular hydrogels
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Targeting ABCA1 via Extracellular Vesicle-Encapsulated Staurosporine as a Therapeutic Strategy to Enhance Radiosensitivity Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-11 Qi Yang, Wenyan Gao, Xinyue Li, Xin Li, Xuantong Zhou, Wenxin Li, Changchun Zhou, Aiping Luo, Zhihua Liu
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2D is Better: Engineering Polydopamine into Cationic Nanosheets to Enhance Anti‐inflammatory Capability Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-11 Lulu Liu, Chenxin Lu, Zhenchao Tao, Zhengbao Zha, Hua Wang, Zhaohua Miao
Polydopamine nanomaterials have emerged as one of the most popular organic materials for management of oxidative stress‐mediated inflammatory diseases. However, their current anti‐inflammatory ability is still unsatisfied because of limited phenolic hydroxyl groups and oxidation reaction‐medicated reactive oxygen and nitrogen species (RONS) scavenging. Herein, via fusing dimension engineering and surface
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Precision Culture Scaling to Establish High‐Throughput Vasculogenesis Models Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-11 Nicholas R. Dennison, Maximilian Fusenig, Lisa Grönnert, Manfred F. Maitz, Maria Alejandra Ramirez Martinez, Manja Wobus, Uwe Freudenberg, Martin Bornhäuser, Jens Friedrichs, Peter D. Westenskow, Carsten Werner
Hydrogel‐based 3D cell cultures can recapitulate (patho)physiological phenomena ex vivo. However, due to their complex multifactorial regulation, adapting these tissue and disease models for high‐throughput screening workflows remains challenging. In this study, a new Precision Culture Scaling (PCS‐X) methodology combines statistical techniques (Design of Experiment and Multiple Linear Regression)
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Label-Free Single Microparticles and Cell Aggregates Sorting in Continuous Cell-Based Manufacturing Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-11 Lingyan Gong, Linwei He, Nan Lu, Chayakorn Petchakup, King Ho Holden Li, Chor Yong Tay, Han Wei Hou
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Challenges and Strategies for Endothelializing Decellularized Small-Diameter Tissue-Engineered Vessel Grafts Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-10 Heng Ding, Xiaojie Hou, Zhen Gao, Yingqiang Guo, Bin Liao, Juyi Wan
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Enhancing Osteosacoma Killing and CT Imaging Using Ultra High Drug Loading and NIR‐Responsive Bismuth Sulfide @Mesoporous Silica Nanoparticles Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-09 Yao Lu, Lihua Li, Zefeng Lin, Mei Li, Xiaoming Hu, Yu Zhang, Mingying Peng, Hong Xia, Gang Han
In the original version of this article, there was a mistake in Figure 7c due to errors during the compilation of the images. The correct figure is shown below. This mistake does not affect the results, discussions and conclusions published in this work. We really apologize for this mistake.
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Uplifting Anti‐tumor Immunotherapy with Lymph Node‐targeted and Ratio‐controlled Co‐delivery of Tumor Cell Lysate and Adjuvant Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-08 Guanhong Cui, Yinping Sun, Liping Qu, Cui Shen, Yu Sun, Fenghua Meng, Yiran Zheng, Zhiyuan Zhong
Cancer vaccines provide a potential strategy to cure patients. Their clinical utilization and efficacy is, however, limited by incomplete coverage of tumor neoantigens and unspecific and restricted activation of dendritic cells (DCs). Tumor cell lysates (TCL) containing a broad spectrum of neoantigens, while are considered ideal in formulating personalized vaccines, induce generally poor antigen presentation
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Identification of Pancreatic Metastasis Cells and Cell Spheroids by the Organelle-Targeting Sensor Array Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-08 Guoyang Zhang, Zirui Wang, Lijun Ma, Jiguang Li, Jiahao Han, Mingguang Zhu, Zixuan Zhang, Shilong Zhang, Xin Zhang, Zhuo Wang
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Triboelectric-Responsive Drug Delivery Hydrogel for Accelerating Infected Wound Healing Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-08 Xuan Qin, Haoliang Shi, Zhen Wen, Binbin Chu, Hongyang Li, Houyu Wang, Yao He, Xuhui Sun
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Rationally Designed Benzobisthiadiazole‐Based Covalent Organic Framework for High‐performance NIR‐II Fluorescence Imaging‐guided Photodynamic Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-08 Xian Zhang, You Dou, Shuang Liu, Peiyao Chen, Yating Wen, Junrong Li, Yao Sun, Ruiping Zhang
Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy in deep‐tissue, due to short excitation/emission wavelengths. Herein, we propose the first example of NIR‐II emissive and benzobisthiadiazole‐based COF‐980. Comparing to its ligands, the structure of COF‐980 could more efficiently reducing
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Biomimetic MicroRNAs-Selenium-Nanocomposites for Targeted and Combined Hyperlipidemia Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-08 Tong Li, Libing Liu, Kongdi Zhu, Yun Luo, Xin Huang, Yulan Dong, Jiaqiang Huang
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Microfluidic Chip-Assisted Upconversion Luminescence Biosensing Platform for Point-of-Care Virus Diagnostics Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-07 Yuan Liu, Xinyue Lao, Man-Chung Wong, Menglin Song, Huang Lai, Pui Wang, Yingjin Ma, Lihua Li, Mo Yang, Honglin Chen, Jianhua Hao
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An Organ-on-Chip Platform for Simulating Drug Metabolism Along the Gut–Liver Axis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-07 Mara Lucchetti, Kehinde Oluwasegun Aina, Léa Grandmougin, Christian Jäger, Pau Pérez Escriva, Elisabeth Letellier, Alexander S. Mosig, Paul Wilmes
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Emerging Strategies for Beta Cell Encapsulation for Type 1 Diabetes Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-07 Mette Steen Toftdal, Lars Groth Grunnet, Menglin Chen
Diabetes is a prevalent chronic disease affecting millions of people globally. To address this health challenge, advanced beta cell therapy using biomaterials‐based macroscale, microscale, and nanoscale encapsulation devices must tackle various obstacles. First, overcoming foreign body responses have been a major focus of research. Strategies such as immunomodulatory materials and physical immunoshielding
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Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle-Shaped Microfluidic Device Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-07 Cristina Quílez, Eun Y. Jeon, Alberto Pappalardo, Pooja Pathak, Hasan E. Abaci
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Off‐the‐Shelf Synthetic Biodegradable Grafts Transform In Situ into a Living Arteriovenous Fistula in a Large Animal Model Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-07 Paul J. Besseling, Wojciech Szymczyk, Martin Teraa, Raechel J. Toorop, Dan Jing Wu, Rob C. H. Driessen, Arturo M. Lichauco, Henk M. Janssen, Melanie van de Kaa, Krista den Ouden, Petra M. de Bree, Joost O. Fledderus, Carlijn V. C. Bouten, Gert J. de Borst, Patricia Y. W. Dankers, Marianne C. Verhaar
Current vascular access options require frequent interventions. In situ tissue engineering may overcome these limitations by combining the initial success of synthetic grafts with the long‐term advantages of autologous vessels by using biodegradable grafts that transform into autologous vascular tissue at the site of implantation. Scaffolds(6mm‐Ø) made of supramolecular polycarbonate‐bisurea(PC‐BU)
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Scale-Up Preparation of Manganese-Iron Prussian Blue Nanozymes as Potent Oral Nanomedicines for Acute Ulcerative Colitis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-06 Chengyun Hu, Xue Yuan, Ronghua Zhao, Biao Hong, Chuang Chen, Qingjun Zhu, Yanmin Zheng, Jinming Hu, Yue Yuan, Zhengyan Wu, Jia Zhang, Chaoliang Tang
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Platinum Nanoparticles‐Enhanced Ferritin‐Mn2+ Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-06 Shuangqing Liu, Liya Tian, Mengyao Mu, Ziyan Liu, Mengzhen Dong, Yufang Gong, Hui Liu, Ximing Wang, Qingwei Meng, Haidong Zhang, Xiao Sun
Nanoplatforms with high Mn2+ coordination can display efficient T1 magnetic resonance imaging (MRI) contrast enhancement. Herein, we firstly proposed an earth gravity‐like method for enhanced interaction between Ferritin (Fn) and Mn2+ by the growth of platinum nanoparticles (PNs) in Fn's cage structure via a biomineralization method. Fn has good biocompatibility and can provide a suitable growth site
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Peptide-Based Hydrogel for Nanosystems Encapsulation: the Next Generation of Localized Delivery Systems for the Treatment of Intestinal Inflammations Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-06 Valentina Andretto, Annalisa Rosso, Serena Zilio, Jacqueline Sidi-Boumedine, Gilles Boschetti, Sharanya Sankar, Marie Buffier, Adriana Erica Miele, Morgane Denis, Pierre-Antoine Choffour, Stéphanie Briançon, Stéphane Nancey, David Kryza, Giovanna Lollo
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An AIE controlled “off‐on” Cu2+‐sensitive probe for early detection of renal fibrosis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-06 Jie Zhou, Fusui Luo, Xiaomeng Dong, Huili Ma, Min Guan, Jin Zhang, Yiwen Sun, Junfen Feng
Early detection of renal fibrosis (RF) is very important given that it is irreversible when it progresses to the terminal stage. A key marker of RF pathogenesis is activation of myomyofibroblasts, and its targeted imaging may be a promising approach for early detection of RF, but there is no study has directly imaged activation of renal myomyofibroblasts. Cu2+ plays a major role in the fibrotic activity
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Supramolecular Heterodimer Peptides Assembly for Nanoparticles Functionalization Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-05 Clélia Mathieu, Shayamita Ghosh, Julien Draussin, Adeline Gasser, Guillaume Jacquot, Mainak Banerjee, Tanushree Gupta, Marc Schmutz, Céline Mirjolet, Olivier Tillement, François Lux, Andrey S. Klymchenko, Mariel Donzeau, Xavier Pivot, Sébastien Harlepp, Alexandre Detappe
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Highly Sensitive and Fast Responding Flexible Force Sensors Using ZnO/ZnMgO Coaxial Nanotubes on Graphene Layers for Breath Sensing Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-05 Asad Ali, Jamin Lee, Kyoungho Kim, Hongseok Oh, Gyu-Chul Yi
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Development of 3D Printed Biodegradable, Entirely X-ray Visible Stents for Rabbit Carotid Artery Implantation Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-05 Yihong Shen, Chaojie Tang, Binbin Sun, Yufan Wu, Xiao Yu, Jie Cui, Mianmian Zhang, Mohamed EL-Newehy, Hany EL-Hamshary, Peter Barlis, Wu Wang, Xiumei Mo
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Development of Polymethine Dyes for NIR-II Fluorescence Imaging and Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-05 Xin Chen, Jieyan Li, Shubham Roy, Zia Ullah, Jingsi Gu, Haiyan Huang, Chen Yu, Xuejin Wang, Han Wang, Yinghe Zhang, Bing Guo
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Engineered Microenvironmental Cues from Fiber‐Reinforced Hydrogel Composites Drive Tenogenesis and Aligned Collagen Deposition Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-05 Robert N. Kent, Maggie E. Jewett, Trevor P. Buck, Mohamed Said, LeeAnn A. Hold, Eileen A. Crawford, Megan L. Killian, Adam C. Abraham, Alice H. Huang, Brendon M. Baker
Effective tendon regeneration following injury is contingent on appropriate differentiation of recruited cells and deposition of mature, aligned, collagenous extracellular matrix that can withstand the extreme mechanical demands placed on the tissue. As such, myriad biomaterial approaches have been explored to provide biochemical and physical cues that encourage tenogenesis and template aligned matrix
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A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-04 Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weilu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li, Bin Li
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Injectable Double Crosslinked Hydrogel-Polypropylene Composite Mesh for Repairing Full-Thickness Abdominal Wall Defects Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-03 Yixin Zhao, Xiaopei Li, Ni Sun, Yan Mao, Teng Ma, Xiangping Liu, Tao Cheng, Xiangyu Shao, Haifeng Zhang, Xianggang Huang, Junsheng Li, Ningping Huang, Haibo Wang
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Dual‐ROS Sensitive Moieties Conjugate Inhibits Curcumin Oxidative Degradation for Colitis Precise Therapy Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-03 Dunsheng Liang, Xiaofan Shen, Lu Han, Hao Ren, Tao Zang, Lulu Tan, Zhaoxiang Lu, Xiaoping Liao, Berwin Singh Swami Vetha, Yahong Liu, Chaoqun Zhang, Jian Sun
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Tougher Bioadhesives through Dual Stimulation Strategies Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-02 Elwin W. J. Ang, Ivan Djordjevic, Ivan Solic, Chen Yee Goh, Terry W. J. Steele
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Antimicrobial Peptide- and Dentin Matrix-Functionalized Hydrogel for Vital Pulp Therapy via Synergistic Bacteriostasis, Immunomodulation, and Dentinogenesis Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-02 Zhuo Xie, Wentao Jiang, Hui Liu, Lingling Chen, Chengkai Xuan, Zhenxing Wang, Xuetao Shi, Zhengmei Lin, Xianling Gao
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Microphysiological Blood-Brain Barrier Systems for Disease Modeling and Drug Development Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-02 Atharva R. Mulay, Jihyun Hwang, Deok-Ho Kim
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Remodeling Microenvironment for Implant-Associated Osteomyelitis by Dual Metal Peroxide Adv. Healthcare Mater. (IF 10.0) Pub Date : 2024-03-02 Xin Guan, Siyuan Wu, Sixue Ouyang, Shuchen Ren, Naiqian Cui, Xiaohu Wu, Dayong Xiang, Wenting Chen, Bin Yu, Peng Zhao, Bowei Wang
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