Kwon, Ohyun - University of California, Los Angeles - Department of Chemistry & Biochemistry

个人简介

Ohyun Kwon received her B.S. (1991) and M.S. (1993) from Seoul National University in South Korea. In 1993, she came to the U.S. to pursue her Ph.D. (1998) from Columbia University under the guidance of S. J. Danishefsky. Her thesis work involved the synthesis of biologically significant glycolipid, asialo GM1 and Globo-H human breast tumor antigen molecule, as well as complex phomoidride terpenoids, CP-225,917 and CP-263,114. She then went to Harvard University as a Howard Hughes Postdoctoral Fellow to study chemical genetics in S. L. Schreiber's lab. There, she completed a diversity-oriented combinatorial synthesis (DOS) of a library of muticyclic compounds, as well as a library of macrocycles. Kwon joined the faculty as an assistant professor at UCLA in 2001. She has been a member of the Molecular Biology Institute (MBI) and UCLA Jonsson Comprehensive Cancer Center (JCCC) since 2005.

研究领域

At the core of the Kwon group’s research lies the design and development of new reactions and reagents that empower the chemical synthesis of natural products and unnatural small molecules of medicinal significance. One of the central themes of the group’s research is the redox-based deconstructive radical chemistry of terpenes, terpenoids, and commodity chemicals, whereas another involves enantioselective phosphorus organocatalysis and the development of novel chiral phosphines such as the HypPhos catalysts now sold by Sigma–Aldrich.

近期论文

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Swain, M.; Bunnell, T. B.; Kim, J. Kwon, O. “Dealkenylative Alkynylation Using Catalytic Fe(II) and Vitamin C.” J. Am. Chem. Soc. 2022, Hagiwara, H; Watanabe, M.; Fujioka, Y.; Kadosaka, T.; Koizumi, T.; Koya, T.; Nakao, M.; Kamada, R.; Temma, T.; Okada, K.; Moreno, J. M.; Kwon, O.; Sabe, H.; Ohba, Y.; Anzai, T. “Stimulation of the mitochondrial calcium uniporter mitigates chronic heart failure-associated ventricular arrhythmia in mice.” Heart Rhythm 2022, Khong, S.; Venkatesh, T.; Kwon, O. “Nucleophilic Phosphine Catalysis: The Untold Story” 2021; Asian J. Org. Chem. 2021, Shankar, T. S.; Ramadurai, D. K. A.; Steinhorst, K.; Sommakia, S.; Badolia, R.; Krokidi, A. T.; Calder, D.; Navankasattusas, S.; Sander, P.; Kwon, O. S.; Aravamundhan, A.; Ling, J.; Dendorfer, A.; Xie, C.; Kwon, O.; Cheng, E. H. Y.; Whitehead, K. J.; Richardson, R. S.; Spitzer, K. W.; Schdelseker, J.; Chaudhuri, D.; Drakos, S. G. “Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis” Nat. Commun. 2021, 12, 4583. Xie, C.; Smaligo, A. J.; Song, X.-R.; Kwon, O. “Phosphorus-Based Catalysis” ACS Cent. Sci. 2021, 7, 536–558. Chen, V. Y.; Kwon, O. “Unified Approach to Furan Natural Products via Phosphine–Palladium Catalysis” Angew. Chem. Int. Ed. 2021, 60, 8874–8881 Swain, M.; Sadykhov, G.; Wang, R.; Kwon, O. “Dealkenylative Alkenylation: Formal σ‐Bond Metathesis of Olefins” Angew. Chem. Int. Ed. 2020, 59, 17565–17571.[abstract] [pdf] Synfacts highlight [Link] Blank, B.; Andrews, I.; Kwon, O. “Phosphine-Catalyzed (4 + 1) Annulation: Rearrangement of Allenylic Carbamates to 3-Pyrrolines Through Phosphonium Diene Intermediates” ChemCatChem. 2020, 12, 4352–4372. Wilting, F.; Kopp, R.; Gurnev, P. A.; Schedel, A.; Dupper, N. J.; Kwon, O.; Nicke, A.; Gudermann, T.; Schredelseker, J. “The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake” Br J Pharmacol. 2020, Smaligo, A. J.; Wu, J.; Burton, N. R.; Hacker, A. S.; Shaikh, A. C.; Quintana, J. C.; Wang, R.; Xie, C.; Kwon, O. “Oxodealkenylative cleavage of alkene C(sp3)–C(sp2) bonds: A practical method for introducing carbonyls into chiral pool materials” Angew. Chem. Int. Ed. 2020, 59, 1211–1215. Smaligo, A. J.; Kwon, O. “Dealkenylative thiylation of C(sp3)–C(sp2) bonds” Org. Lett. 2019, 21, 8592–8597. Shaikh, A. C.; Kwon, O. “Discussion Addendum for: Phosphine-Catalyzed [3 + 2] Annulation: Synthesis of Ethyl 5-(tert-Butyl)-2-phenyl-1-tosyl-3-pyrroline-3-carboxylate” Org. Synth. 2019, 96, 214–231. Zhang, K.; Cai, L.; Hong, S.; Kwon, O. “Phosphine-Catalyzed α-Umpolung–Aldol Reaction for the Synthesis of Benzo[b]azapin-3-ones” Org. Lett. 2019, 21, 5143–5146. Cai, L.; Zhang, K.; Chen, S.; Lepage, R. J.; Houk, K. N.; Krenske, E. H.; Kwon, O. “Catalytic asymmetric Staudinger–aza-Wittig reaction for the synthesis of heterocyclic amines” J. Am. Chem. Soc. 2019, 141, 9537–9542. Smaligo, A. J.; Swain, M.; Quintana, J. C.; Tan, M. F.; Kim, D. A.; Kwon, O. “Hydrodealkenylative C(sp3)–C(sp2) bond fragmentation” Science 2019, 364, 681–685. Shaikh, A. C.; Kwon, O. “Discussion Addendum for: Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Ethyl 6-Phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate” Org. Synth. 2019, 96, 110–123. Khong, S.; Xie, C.; Wang, X.; Tan, H.; Kwon, O. “Chiral Aminophosphines Derived from Hydroxyproline and Their Application in Allene–Imine [4 + 2] Annulation” J. Antibiot. 2019, 72, DOI:10.1038/s41429-019-0181-0. [pdf] Liu, H.; Lin, Y.; Zhao, Y.; Xiao, M.; Zhou, L.; Wang, Q.; Zhang, C.; Wang, D.; Kwon, O.; Guo, H. “Phosphine-Promoted [4+3] Annulation of Allenoate with Aziridines for Synthesis of Tetrahydroazepines: Phosphine-Dependent [3+3] and [4+3] Pathways” RSC Adv. 2019, 9, 1214–1221. Kearney, S. E., et al. “Canvas: a crowd-sourced, natural product screening library for exploring biological space” ACS Central Sci. 2018, 4 (12), 1727–1741. Guo, H.; Fan, Y. C.; Sun, Z.; Wu, Y.; Kwon, O. “Phosphine Organocatalysis” Chem. Rev. 2018, 118 (20), 10049–10293. Xu, Q.; Dupper, N. J.; Smaligo, A. J.; Fan, Y. C.; Cai, L.; Wang, Z.; Langenbacher, A. D.; Chen, J.; Kwon, O. “Catalytic Enantioselective Synthesis of Guvacine Derivatives through [4 + 2] Annulations of Imines with α-Methylallenoates” Org. Lett. 2018, 20 (19), 6089–6093. Lee, C. J.; Swain, M.; Kwon, O. “Synthesis of Cyclic β-Silylalkenyl Triflates via an Alkenyl Cation Intermediate” Org. Lett. 2018, 20 (17), 5474–5477. Smaligo, A. J.; Vardhineedi, S.; Kwon, O. “Carvone-Derived P-Stereogenic Phosphines: Design, Synthesis, and Use in Allene–Imine [3 + 2] Annulation” ACS Catal. 2018, 8 (6), 5188–5192. Zhang, K.; Cai, L.; Yang, Z.; Houk, K. N.; Kwon, O. “Bridged [2.2.1] Bicyclic Phosphine Oxide Facilitates Catalytic γ-umpolung–Wittig Olefination” Chem. Sci. 2018, 9, 1867–1872.