汤华 - 天津医科大学

个人简介

教育背景 1994.1-1997.5：美国哈佛大学，肿瘤学，博士后，修斯医学研究所 Research Associate 1992.1-1993.12：复旦大学上海医学院，病毒学，博士后 1987.8-1990.7：天津医科大学, 微生物学(研究生), 获医学博士学位 1984.9-1987.7：天津医科大学，微生物学(博士研究生), 获医学硕士学位 1979.9-1984.8：南华大学(原衡阳医学院)，临床医学系, 获医学学士学位工作经历 2001.8-至今：天津医科大学教授，博士生导师，天津市生命科学中心实验室主(2001在)，病原生物学系主任(2016-现在) ，研究生院副院长（2003-2009），基础医学院副院长（2009-现在），医学微生物学教研室主（2007-2015），国家基础医学实验教学示范中心主任（2011-2015） 1997.6-2002.5：　美国哈佛大学医学院，医学讲师 1992.10-1993.12：复旦大学上海医学院，副教授 1990.8-1991.12:　天津医科大学，微生物学教研室，讲师荣誉奖励 1. 天津市自然科学二等奖(2015年) 2. 中华医学科技奖三等奖(2015年) 3. 天津市有突出贡献专家(2015年) 4.《医学微生物学课程和教学模式创新发展的实践》，天津医科大学教学成果一等奖 (2008) （1） 5. 全国归侨侨眷先进个人荣誉称号（2004） 6. 天津市抗击非典先进个人(2003) 7. 天津市优秀留学人员（2009）

研究领域

致力于非编码RNA对肿瘤发生发展及病毒增殖的调控作用与机制研究，揭示miRNA上调靶基因表达新机制、发现HBV编码miRNA并调控病毒增殖等。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Guo J, Yang Z, Yang X, Li T, Min Li, Tang H*. miR-346 functions as a pro-survival factor under ER stress by activating mitophagy. Cancer Lett. Cancer Lett. 2017 Oct 26;413:69-81. 2.Fan HX, Zhang QG, Zhao XP, Lv P, Liu M, Tang H*Transcriptomic profiling of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma. Oncotarget,2017 Jun 30;8(39):65421-65434 3.Liu Y, Zhang Y, Wu H, Li Y, Zhang Y, Liu M, Li X, Tang H*. miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis. Cell Death Dis. 2017 April 6; 8(4): e2739. 4.Yang X, Li FF, Sun HH, Fang HX, Liu M, Li X, Tang H*. Hepatitis B virus-encoded miRNA controls viral replication. Journal of Virology. 2017 Apr 28;91(10). pii: e01919-16. 5.Liu Q, Guo X, Que S, Yang X, Fan H, Liu M, Li X, Tang H*. LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. Oncotarget.2017 Jul 4;8(27):43768-43781. 6.Ying Zhu, Yan Zhang, Zhenghua Sui, Yi Zhang, Min Liu, Hua Tang*. USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells. Oncotarget. 2017 Jul 25;8(30):48725-48736. 7.Chen Z, , Wang X, Liu R, Chen L, Yi J, Qi B, Shuang Z, Liu M, Li X, Li S, Tang H*. KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells. Oncotarget. 2017 Mar 14;8(11):17712-17725 8.Lv J, Fan H, Zhao X, Lv P, Fan J, Zhang Y, Min Liu M, Tang H*. Long non-coding RNA Unigene56159 Promotes Epithelial-mesenchymal Transition by Acting as a ceRNA of miR-140-5p in Hepatocellular Carcinoma Cells. Cancer Lett. 2016: 382: 166-175 9.Yang Z, Wang XL, Bai R, Liu WY, Li X, Liu M, Tang H*. miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells. Br J Cancer. 2016: 115:731-740 10.Sun Y, Yang X, Liu M, Tang H*. B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells. Cancer Lett. 2016: ;375(2):284-92 11.Wang X, Diao C, Yang X, Yang Z, Liu M, Li X, Tang H*. ICP4-induced miR-101 attenuates HSV-1 replication. Sci Rep. 2016: 17;6:23205. doi: 10.1038/srep23205. 12.Guo J, Lv J, Liu M, Tang H*. miR-346 Up-regulates Argonaute 2 (AGO2) Protein Expression to Augment the Activity of Other MiRNAs and Contributes to Cervical Cancer Cell Malignancy. J Biol Chem. 2015; 290 (51):30342-50. 13.Song G, Wang R, Guo J, Liu X, Wang F, Qi Y, Wan H, Liu M, Li X, Tang H*. .miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively. Sci Rep. 2015 Oct 28;5:15793. doi: 10.1038/srep15793. 14.Li Q, Zhang L, Wan H, Liu M, Li X, Tang H*. CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget. 2015 Oct 27;6(33):34924-40 15.Gao R, Cai C, Gan J, Yang X, Shuang Z, Liu M, Li S, Tang H*.miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells. Oncotarget. 2015 : 6(8):6014-28 16.Zhang Y, Dai JC, Deng H,Wan HY, Liu M, Wang J, Li SP, Li X and Tang H*. miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop. Br J Cancer. 2015, 112(2):365-74: 365-74 17.Wan HY,Li QQ, Zhang Y, Tian W, Li YN, Liu M, Li X, Tang H*. MiR-124 Represses Vasculogenic Mimicry and Cell Motility by Targeting AmotL1 in Cervical Cancer Cells. Cancer Lett. 2014 Dec 1;355(1):148-58. 18.Ren ZJ, Nong XY, Lv YR, An PP, Li X, Liu M, Tang H*. miR-509-5p joins Mdm2/p53 feedback loop and regulates cancer cells growth. Cell Death Dis. 2014 Aug 21;5: e1387. 19.Zhang PP, Wang XL, Zhao W, Qi B, Yang Q, Wan HY, Shuang ZY, Liu M, Li X, Li SP, Tang H*. DNA methylation-mediated repression of miR-941 enhances Lysine (K)-specific demethylase 6B expression in hepatoma cells. J Biol Chem. 2014 Aug 29; 289 (35):24724-35.20.Liu RY, Diao CF, Zhang Y, Wu N, Wan HY, Nong XY, Liu M, Tang H*. miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells. Cancer Lett. 2013, 335(2):351-60.