柳晓泉 - 中国药科大学

个人简介

1984年于南京药学院药学系获学士学位 1989年于中国药科大学获硕士学位 2001年于中国药科大学获博士学位工作经历 1984～1992年中国药科大学药理教研室任助教 1992～1996年中国药科大学药代中心任讲师 1996～2002年中国药科大学药代中心任副教授 2003～至今中国药科大学药代中心任教授

研究领域

致力于药物代谢动力学基础理论和应用的研究，以药物代谢动力学新理论、新模型、新技术和新方法的研究及其在新药开发研究中的应用为主要的研究方向。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Hua He,, Xi Li, Haidong Wang, Wenting Zhang, Huiyong Jiang,Shijun Wang,Linhua Yuan, Yao Liu, and Xiaoquan LiuEffects of Salvianolic Acid A on Plasma and Tissue Dimethylarginine Levels in a Rat Model of Myocardial Infarction J Cardiovasc Pharmacol 2013：61：482-488 2. Hua He, Shijun Wang, Xi Li, Haidong Wang, Wenting Zhang, Linhua Yuan,Xiaoquan Liu A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction Metabolism 2013;62：1357-1366 3. Chen Y, Cao Y, Zhou J, Liu X Mechanism-based pharmacokinetic- pharmacodynamic modeling of bidirectional effect of danshensu on plasma homocysteine in rats. Pharm Res 2009 ;26(8):1863-73. 4. Cao Y, Chai JG, Chen YC, Zhao J, Zhou J, Shao JP, Ma C,Liu XD,Liu XQ Beneficial effects of danshensu, an active component of silvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rat. Br J Pharmacol 2009;157(3):482-90 5. Wang H, Ma C, Zhou J, Liu XQ.Stereoselective analysis of tiopronin enantiomers in rat plasma using high-performance liquid chromatography-electrospray ionization mass spectrometry after chiral derivatization. Chirality 2009;21(5):531-8. 6.Cao YG, Zhang L，Ma C, Chang BB, Chen YC, Tang YQ, Liu XD, Liu XQ Metabolism of protocatechuic acid influence fatty acid oxidation in rat heart: new anti-angina mechanism implication Biochem Pharmacol 2009;77(6):1096-1104 7. Cao YG, Chen YC，Hao K , Zhang M, Liu XQ An in vivo approach for globally estimation the drug flow between blood and tissue foe nafamostat mesilate: the main hydrolysis site determination in human. Biol Pharm Bull 2008;35(11): 1985-1989. 8.Wang H, Chen Y, Zhou J, Ma C, Chen YC, Liu XQ. Stereoselective determination of ornidazole enantiomers in human plasma and urine samples by chiral LC: application to pharmacokinetic study Chromatographia 2008;67(11/12):875-881 9. Cao YG, Zhang M, Yu D, Shao JP, Chen YC, Liu XQ A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study. Anal Bioanal Chem. 2008;391 (3):1063-71. 10.Hao K, Liu XQ, Wang GJ， Zhao XP Pharmacokinetics, tissue distribution and excretion of gambogic acid in rat. Eur J Drug Metab Pharmacokinet 2007;32(2):63-68 11.Ge lin, Jun Tang, Xiaoquan Liu, Yang Jian and Jiang Zheng Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes. Drug Metab Dispos,2007;35(4):607-613 12.Hao K, Zhao XP, Liu XQ, Wang GJ Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study. Biomed Chromatogr. 2007;21(3):279-283 13.Hao K, Chen YC, Cao YG, Liu XQ, Wang GJ Pharmacokinetic-pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats. Acta Pharmacol Sin. 2007;28(5):738-43 14.Cao YG, Liu XQ, Chen YC, Hao K, Wang GJ Warfarin maintenance dose adjustment with indirect pharmacodynamic model in rats.Eur J Pharm Sci.2007;30(2)：175-180 15.Zhao XP, Zhong J, Liu XQ, Wang GJ CYP3A4 mediated in vitro metabolism of vinflunine in human liver Microsomes. Acta Pharmacol Sin. 2007;28(1):118-24 16.J Zhong, X.Q. Liu, Y. Chen, X.P. Zhao, Y.S. Wang, G.J. Wang Determination of renolazine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry Chromatographia 2006;63(3/4):123-127 17.Zhao X，Liu X, Wang Y， Chen Y， Wang G Determination of vinflunine in rat plasma by liquid chromatography- electrospray ionization mass spectrometry for a pharmacokinetic study J Pharm Biomed Anal 2006;41(3):906-911 18.Liu YT, Hao K, Liu XQ, Wang GJ. Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes. Acta Pharmacol Sin 2006;27(9):1253-1258 19.Zhao XP, Liu XQ, Wang YS, Wang H, Wang GJ. Pharmacokinetics, tissue distribution and excretion of vinflunine. Eur J Drug Metab Pharmacokinet 2006;31(2):59-64 20. Chen Y, Liu XQ, Zhong J, Zhao X, Wang Y, Wang G. Stereoselective pharmacokinetics of ornidazole after intravenous administration of individual enantiomers and the racemate. Chirality 2006;18(10)：799-802 21. K Hao, XP Zhao, XQ Liu, GJ Wang LC determination of curcumin in dog plasma for a pharmacokinetic study. Chromatographia 2006;64(9/10):531-535 22. Yongsheng Wang, Xiaoping Zhao, Jiao Zhong, Xiaoquan Liu, Guangji Wang Simple determination of pirfenidone in rat plasma via high-performance liquid chromatography. Biomed Chromatogr 2006;20:1375-1379