洪亮 - 上海交通大学 - 物理与天文学院

个人简介

教育经历 2006-2010 美国阿克伦大学高分子科学系，博士(导师: Alexei P. Sokolov) 2004-2006 香港中文大学物理系，硕士 (导师：郝少康) 2000-2004 中国科学技术大学物理系，本科科研经历 2015-至今上海交通大学物理与天文学院&自然科学研究院，教授，博士生导师 2010-2014 美国橡树岭国家实验室，博士后（Jeremy C. Smith）学术任职上海人工智能实验室顾问科学家上海交通大学张江高等研究院人工智能生物医药中心主任（筹）招聘沪渝人工智能研究院副院长（主页更新中）上海交通大学-金赛药业数字医疗创新实验室主任

个人简介

研究领域

生物大分子动力学低温保存技术机理 AI药物蛋白质设计

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近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

L. Zheng, Z. Liu, Q. Zhang*, S. Li, J. Huang, L. Zhang, B. Zan, M. Tyagi, H. Cheng*, T. Zuo, V. G. Sakai, T. Yamada,C. Yang, P. Tan, F. Jiang, H. Chen, W. Zhuang*, L. Hong* Universal Dynamical Onset in Water at Distinct Material Interfaces Chemical Science, 2022. (on line) S. Li, P. Tan, J. Li, M. Tang, and L. Hong* Many-body effect renders universal subdiffusion to water on different proteins Physical Review Research, 4, L22003 (2022). X. Qian*, D. Han, L. Zheng, J. Chen, M. Tyag, Q. Li, F. Du, S. Zheng, X. Huang*, S. Zhang, J. Shi, H. Huang*, X. Shi, J. Chen, H Qin, J. Bernholc, X. Chen, L. Q Chen, L. Hong*, Q. M. Zhang High-entropy polymer produces a giant electrocaloric effect at low fields Nature, 600.7890 (2021): 664-669. Z. Lin, M. Mao, C. Yang, Y. Tong, Q. Li, J. Yue, G. Yang, L. Hong, X. Yu, L. Gu, X. Huang, L. Suo and L. Chen Amorphous anion-rich titanium polysulfides for aluminum-ion batteries Science Advances, 7, no. 35 (2021): eabg6314 J. Huang, Q. Xu, Z. Liu, N. Jain, M. Tyagi, D. Wei, and L. Hong* Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density Molecules, 26, no. 18 (2021): 5693. J. Li, X. Hu, T. Neusius, X. Cheng, M.D. Smith, A. Godec, L. Hong, R. Metzler, J.C. Smith Reply to: Insufficient evidence for ageing in protein dynamics Nature Physics, 17, 775–776 (2021) P. Tan, J. Yue, Y. Yu, B. B. Liu, T. Liu; L. Zheng, L. He, X. Zhang, L. Suo, L. Hong* Solid-like Nano-Anion-Cluster Constructs Free Lithium-ion Conducting Super-Fluid Framework in Water-in-salt Electrolyte. The Journal of Physical Chemistry C, (2021), 125, 22, 11838–11847 R. Li, Z. Liu, L. Li, J. Huang, T. Yamada, V. G. Sakai, P. Tan* and L. Hong* Anomalous sub-diffusion of water in biosystems: From hydrated protein powders to concentrated protein solution to living cells Structural Dynamics,7, no. 5 (2020): 054703. Z. Dominik, P. Tan, L. Hong, D. D. Bari, V. G. Sakai, and J. Peters. Differences between calcium rich and depleted α-lactalbumin investigated by molecular dynamics simulations and incoherent neutron scattering Physical Review E, 101, no. 3 (2020): 032415 M. Yu, P. Tan, Y. Ye, D. J. Voneshen, X. Xing* and L. Hong* One Dimensional Nature of Protein Low Energy Vibrations Physical Review Research, 2, no. 3 (2020): 032050. P. Tan, J. Huang, E. Mamontov, V.G. Sakai, F. Merzel, Z. Liu, Y. Ye, L. Hong* Decoupling between translation and rotation of water in the proximity of a protein molecule Physical Chemistry Chemical Physics, 22, no. 32 (2020): 18132-18140. L. Liu, S. Jiang, M. Xing, C. Chen, C. Lai, N. Li, G. Liu, D. Wu, H. Gao, L. Hong, P. Tan, S. Chen, Z. Deng, G. Wu, L. Wang Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System. mBio, 11, no. 2 (2020). Z. Liu, C. Yang, L. Zhang, Y. Yu, M. Yu, V.G Sakai, M. S. Tyagi, T. Yamada, L. He, X. Zhang, L. Hong* Heterogeneity of Water Molecules on the Free Surface of Thin Reduced Graphene Oxide Sheets The Journal of Physical Chemistry C, 2020 124 (20), 11064-11074 L. Zheng, L. Hong* Combining Neutron Scattering, Deuteration Technique, and Molecular Dynamics Simulations to Study Dynamics of Protein and Its Surface Water Molecules Chinese Journal of Polymer Science, 37:1083–1091 K. L. Ngai, L. Hong, S. Capaccioli, A. Paciaroni Uncovering a novel transition in the dynamics of proteins in the dry state Journal of Molecular Liquids, 286:110810 T. Zuo, C. Ma, G. Jiao, Z. Han, S. Xiao, H. Liang, L. Hong, D. Bowron, A. Soper, C. C. Han, H. Cheng Water/Cosolvent Attraction Induced Phase Separation: A Molecular Picture of Cononsolvency Macromolecules, 52:457-464 P. Tan, J. Li, L. Hong* Statistical properties for diffusive motion of hydration water on protein surface Physica B: Condensed Matter, 562:1-5 X. Ma, Q. Wang, Y. Li, P. Tan, H. Wu, P. Wang, X. Dong, L. Hong, and G. Meng How BamA recruits OMP substrates via poly-POTRAs domain The FASEB Journal, 33:13063-14842 Z. Liu, C. Yang, J. Huang, G. Ciampalini, J. Li, V. G. Sakai, M. Tyagi, H. ONeill, Q. Zhang, S. Capacciol, K. L. Ngai, and L. Hong* Direct Experimental Characterization of Contributions from Self-motion of Hydrogen and from Interatomic Motion of Heavy Atoms to Protein Anharmonicity Journal of Physical Chemistry B, 122.43 (2018): 9956-9961. P. Tan, Z. Fu, L. Petridis, S. Qian, J. Li and L. Hong* A two-fold structural classification method for determining the accurate ensemble of protein structures Communications in Computational Physics, 25:1010-1023

近期论文

L. Zheng, Z. Liu, Q. Zhang*, S. Li, J. Huang, L. Zhang, B. Zan, M. Tyagi, H. Cheng*, T. Zuo, V. G. Sakai, T. Yamada,C. Yang, P. Tan, F. Jiang, H. Chen, W. Zhuang*, L. Hong* Universal Dynamical Onset in Water at Distinct Material Interfaces Chemical Science, 2022. (on line)

S. Li, P. Tan, J. Li, M. Tang, and L. Hong* Many-body effect renders universal subdiffusion to water on different proteins Physical Review Research, 4, L22003 (2022).

X. Qian*, D. Han, L. Zheng, J. Chen, M. Tyag, Q. Li, F. Du, S. Zheng, X. Huang*, S. Zhang, J. Shi, H. Huang*, X. Shi, J. Chen, H Qin, J. Bernholc, X. Chen, L. Q Chen, L. Hong*, Q. M. Zhang High-entropy polymer produces a giant electrocaloric effect at low fields Nature, 600.7890 (2021): 664-669.

Z. Lin, M. Mao, C. Yang, Y. Tong, Q. Li, J. Yue, G. Yang, L. Hong, X. Yu, L. Gu, X. Huang, L. Suo and L. Chen Amorphous anion-rich titanium polysulfides for aluminum-ion batteries Science Advances, 7, no. 35 (2021): eabg6314

J. Huang, Q. Xu, Z. Liu, N. Jain, M. Tyagi, D. Wei, and L. Hong* Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density Molecules, 26, no. 18 (2021): 5693.

J. Li, X. Hu, T. Neusius, X. Cheng, M.D. Smith, A. Godec, L. Hong, R. Metzler, J.C. Smith Reply to: Insufficient evidence for ageing in protein dynamics Nature Physics, 17, 775–776 (2021)

P. Tan, J. Yue, Y. Yu, B. B. Liu, T. Liu; L. Zheng, L. He, X. Zhang, L. Suo, L. Hong* Solid-like Nano-Anion-Cluster Constructs Free Lithium-ion Conducting Super-Fluid Framework in Water-in-salt Electrolyte. The Journal of Physical Chemistry C, (2021), 125, 22, 11838–11847

R. Li, Z. Liu, L. Li, J. Huang, T. Yamada, V. G. Sakai, P. Tan* and L. Hong* Anomalous sub-diffusion of water in biosystems: From hydrated protein powders to concentrated protein solution to living cells Structural Dynamics,7, no. 5 (2020): 054703.

Z. Dominik, P. Tan, L. Hong, D. D. Bari, V. G. Sakai, and J. Peters. Differences between calcium rich and depleted α-lactalbumin investigated by molecular dynamics simulations and incoherent neutron scattering Physical Review E, 101, no. 3 (2020): 032415

M. Yu, P. Tan, Y. Ye, D. J. Voneshen, X. Xing* and L. Hong* One Dimensional Nature of Protein Low Energy Vibrations Physical Review Research, 2, no. 3 (2020): 032050.

P. Tan, J. Huang, E. Mamontov, V.G. Sakai, F. Merzel, Z. Liu, Y. Ye, L. Hong* Decoupling between translation and rotation of water in the proximity of a protein molecule Physical Chemistry Chemical Physics, 22, no. 32 (2020): 18132-18140.

L. Liu, S. Jiang, M. Xing, C. Chen, C. Lai, N. Li, G. Liu, D. Wu, H. Gao, L. Hong, P. Tan, S. Chen, Z. Deng, G. Wu, L. Wang Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System. mBio, 11, no. 2 (2020).

Z. Liu, C. Yang, L. Zhang, Y. Yu, M. Yu, V.G Sakai, M. S. Tyagi, T. Yamada, L. He, X. Zhang, L. Hong* Heterogeneity of Water Molecules on the Free Surface of Thin Reduced Graphene Oxide Sheets The Journal of Physical Chemistry C, 2020 124 (20), 11064-11074

L. Zheng, L. Hong* Combining Neutron Scattering, Deuteration Technique, and Molecular Dynamics Simulations to Study Dynamics of Protein and Its Surface Water Molecules Chinese Journal of Polymer Science, 37:1083–1091

K. L. Ngai, L. Hong, S. Capaccioli, A. Paciaroni Uncovering a novel transition in the dynamics of proteins in the dry state Journal of Molecular Liquids, 286:110810

T. Zuo, C. Ma, G. Jiao, Z. Han, S. Xiao, H. Liang, L. Hong, D. Bowron, A. Soper, C. C. Han, H. Cheng Water/Cosolvent Attraction Induced Phase Separation: A Molecular Picture of Cononsolvency Macromolecules, 52:457-464

P. Tan, J. Li, L. Hong* Statistical properties for diffusive motion of hydration water on protein surface Physica B: Condensed Matter, 562:1-5

X. Ma, Q. Wang, Y. Li, P. Tan, H. Wu, P. Wang, X. Dong, L. Hong, and G. Meng How BamA recruits OMP substrates via poly-POTRAs domain The FASEB Journal, 33:13063-14842

Z. Liu, C. Yang, J. Huang, G. Ciampalini, J. Li, V. G. Sakai, M. Tyagi, H. ONeill, Q. Zhang, S. Capacciol, K. L. Ngai, and L. Hong* Direct Experimental Characterization of Contributions from Self-motion of Hydrogen and from Interatomic Motion of Heavy Atoms to Protein Anharmonicity Journal of Physical Chemistry B, 122.43 (2018): 9956-9961.

P. Tan, Z. Fu, L. Petridis, S. Qian, J. Li and L. Hong* A two-fold structural classification method for determining the accurate ensemble of protein structures Communications in Computational Physics, 25:1010-1023