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个人简介

教育经历 2006-2010 美国阿克伦大学高分子科学系,博士(导师: Alexei P. Sokolov) 2004-2006 香港中文大学物理系, 硕士 (导师:郝少康) 2000-2004 中国科学技术大学物理系,本科 科研经历 2015-至今 上海交通大学物理与天文学院&自然科学研究院,教授,博士生导师 2010-2014 美国橡树岭国家实验室,博士后(Jeremy C. Smith) 学术任职 上海人工智能实验室 顾问科学家 上海交通大学张江高等研究院人工智能生物医药中心 主任(筹) 招聘 沪渝人工智能研究院 副院长(主页更新中) 上海交通大学-金赛药业数字医疗创新实验室 主任

研究领域

生物大分子动力学 低温保存技术机理 AI药物蛋白质设计

近期论文

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L. Zheng, Z. Liu, Q. Zhang*, S. Li, J. Huang, L. Zhang, B. Zan, M. Tyagi, H. Cheng*, T. Zuo, V. G. Sakai, T. Yamada,C. Yang, P. Tan, F. Jiang, H. Chen, W. Zhuang*, L. Hong* Universal Dynamical Onset in Water at Distinct Material Interfaces Chemical Science, 2022. (on line) S. Li, P. Tan, J. Li, M. Tang, and L. Hong* Many-body effect renders universal subdiffusion to water on different proteins Physical Review Research, 4, L22003 (2022). X. Qian*, D. Han, L. Zheng, J. Chen, M. Tyag, Q. Li, F. Du, S. Zheng, X. Huang*, S. Zhang, J. Shi, H. Huang*, X. Shi, J. Chen, H Qin, J. Bernholc, X. Chen, L. Q Chen, L. Hong*, Q. M. Zhang High-entropy polymer produces a giant electrocaloric effect at low fields Nature, 600.7890 (2021): 664-669. Z. Lin, M. Mao, C. Yang, Y. Tong, Q. Li, J. Yue, G. Yang, L. Hong, X. Yu, L. Gu, X. Huang, L. Suo and L. Chen Amorphous anion-rich titanium polysulfides for aluminum-ion batteries Science Advances, 7, no. 35 (2021): eabg6314 J. Huang, Q. Xu, Z. Liu, N. Jain, M. Tyagi, D. Wei, and L. Hong* Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density Molecules, 26, no. 18 (2021): 5693. J. Li, X. Hu, T. Neusius, X. Cheng, M.D. Smith, A. Godec, L. Hong, R. Metzler, J.C. Smith Reply to: Insufficient evidence for ageing in protein dynamics Nature Physics, 17, 775–776 (2021) P. Tan, J. Yue, Y. Yu, B. B. Liu, T. Liu; L. Zheng, L. He, X. Zhang, L. Suo, L. Hong* Solid-like Nano-Anion-Cluster Constructs Free Lithium-ion Conducting Super-Fluid Framework in Water-in-salt Electrolyte. The Journal of Physical Chemistry C, (2021), 125, 22, 11838–11847 R. Li, Z. Liu, L. Li, J. Huang, T. Yamada, V. G. Sakai, P. Tan* and L. Hong* Anomalous sub-diffusion of water in biosystems: From hydrated protein powders to concentrated protein solution to living cells Structural Dynamics,7, no. 5 (2020): 054703. Z. Dominik, P. Tan, L. Hong, D. D. Bari, V. G. Sakai, and J. Peters. Differences between calcium rich and depleted α-lactalbumin investigated by molecular dynamics simulations and incoherent neutron scattering Physical Review E, 101, no. 3 (2020): 032415 M. Yu, P. Tan, Y. Ye, D. J. Voneshen, X. Xing* and L. Hong* One Dimensional Nature of Protein Low Energy Vibrations Physical Review Research, 2, no. 3 (2020): 032050. P. Tan, J. Huang, E. Mamontov, V.G. Sakai, F. Merzel, Z. Liu, Y. Ye, L. Hong* Decoupling between translation and rotation of water in the proximity of a protein molecule Physical Chemistry Chemical Physics, 22, no. 32 (2020): 18132-18140. L. Liu, S. Jiang, M. Xing, C. Chen, C. Lai, N. Li, G. Liu, D. Wu, H. Gao, L. Hong, P. Tan, S. Chen, Z. Deng, G. Wu, L. Wang Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System. mBio, 11, no. 2 (2020). Z. Liu, C. Yang, L. Zhang, Y. Yu, M. Yu, V.G Sakai, M. S. Tyagi, T. Yamada, L. He, X. Zhang, L. Hong* Heterogeneity of Water Molecules on the Free Surface of Thin Reduced Graphene Oxide Sheets The Journal of Physical Chemistry C, 2020 124 (20), 11064-11074 L. Zheng, L. Hong* Combining Neutron Scattering, Deuteration Technique, and Molecular Dynamics Simulations to Study Dynamics of Protein and Its Surface Water Molecules Chinese Journal of Polymer Science, 37:1083–1091 K. L. Ngai, L. Hong, S. Capaccioli, A. Paciaroni Uncovering a novel transition in the dynamics of proteins in the dry state Journal of Molecular Liquids, 286:110810 T. Zuo, C. Ma, G. Jiao, Z. Han, S. Xiao, H. Liang, L. Hong, D. Bowron, A. Soper, C. C. Han, H. Cheng Water/Cosolvent Attraction Induced Phase Separation: A Molecular Picture of Cononsolvency Macromolecules, 52:457-464 P. Tan, J. Li, L. Hong* Statistical properties for diffusive motion of hydration water on protein surface Physica B: Condensed Matter, 562:1-5 X. Ma, Q. Wang, Y. Li, P. Tan, H. Wu, P. Wang, X. Dong, L. Hong, and G. Meng How BamA recruits OMP substrates via poly-POTRAs domain The FASEB Journal, 33:13063-14842 Z. Liu, C. Yang, J. Huang, G. Ciampalini, J. Li, V. G. Sakai, M. Tyagi, H. ONeill, Q. Zhang, S. Capacciol, K. L. Ngai, and L. Hong* Direct Experimental Characterization of Contributions from Self-motion of Hydrogen and from Interatomic Motion of Heavy Atoms to Protein Anharmonicity Journal of Physical Chemistry B, 122.43 (2018): 9956-9961. P. Tan, Z. Fu, L. Petridis, S. Qian, J. Li and L. Hong* A two-fold structural classification method for determining the accurate ensemble of protein structures Communications in Computational Physics, 25:1010-1023

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