Vinnikov, Ilya - 上海交通大学 - 生命科学技术学院

个人简介

教育经历： 2008-03-31: 医学博士（荣誉-优等）海德堡大学医学院论文题目:活化蛋白C在糖尿病中对细胞进行保护的分子机制 2003-06-30：理科硕士（优等）莫斯科州立大学基础医学论文题目：活化蛋白C在糖尿病中对细胞进行保护的分子机制研究经历： 2016至今：特别研究员——上海交通大学生命科学技术学院 2014-2016：联合研究员——分子细胞生物学和分子代谢控制德国海德堡癌症研究中心(DKFZ) 海德堡大学。 2009-2014：高级研究员——分子细胞生物学，德国海德堡癌症研究中心(DKFZ)。 2008-2009：博士后——内科医学海德堡大学医学院。 2004-2008：研究员(博士)——内科医学海德堡大学医学医院。 2002-2003：研究员——生物催化、生物有机化学研究所、俄罗斯科学院（莫斯科）。 2001-2002：本科研究员——生物催化、生物有机化学研究所、俄罗斯科学院（莫斯科）。

研究领域

Keywords: neuroscience, microRNA, metabolism, neurodegeneration, obesity, circadian, transcription regulation and epigenetic control in eukaryotes, mouse. Chronic metabolic and neurodegenerative syndromes, such as diabetes mellitus, obesity or Parkinson’s disease, represent a growing epidemic, especially in the constantly aging western populations. These currently incurable complex traits result from a failure in the interplay of environmental factors, humoral signals, extra- and intracellular enzymatic cascades, genetic and epigenetic signals in the central nervous system and in the periphery. Physiological and pathophysiological mechanisms involved in these processes require intensive research to provide the patients with novel therapeutic strategies. The lab has a strong interest in studying the role of distinct neuronal population-specific non-coding RNAs in chronic complex traits disorders. In perspective, the integration of expression and functional data from mouse and patient brain samples will provide novel insights for future genome wide association studies aiming to identify genetic variants within non-coding RNA genes and/or within the genes influenced by these RNA species aiming to decipher the mechanisms involved in metabolic and neurodegenerative disorders.

近期论文

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Domanskyi A., Alter H., Vogt M.A., Gass P., and Vinnikov I.A. (2014) Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance, Front Cell Neurosci 8. Vinnikov I.A.§, Hajdukiewicz K., Reymann J., Beneke J., Czajkowski R., Roth L.C., Novak M., Roller A., Dörner N., Starkuviene V., Theis F.J., Erfle H., Schütz G., Grinevich V., and Konopka W. (2014) Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice, The Journal of Neuroscience 34, 10659-10674. §, co-corresponding author. Wang H., Vinnikov I., Shahzad K., Bock F., Ranjan S., Wolter J., Kashif M., Oh J., Bierhaus A., Nawroth P., Kirschfink M., Conway E.M., Madhusudhan T., and Isermann B. (2012) The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition, Thromb Haemost 108, 1141-1153. Wang H., Madhusudhan T., He T., Hummel B., Schmidt S., Vinnikov I.A., Shahzad K., Kashif M., Muller-Krebs S., Schwenger V., Bierhaus A., Rudofsky G., Nawroth P.P., and Isermann B. (2011) Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy, Blood 117, 5231-5242. Kashif M., Hellwig A., Kolleker A., Shahzad K., Wang H., Lang S., Wolter J., Thati M., Vinnikov I., Bierhaus A., Nawroth P.P., and Isermann B. (2011) p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth, Development 138, 2235-2247. Domanskyi A., Geissler C., Vinnikov I.A., Alter H., Schober A., Vogt M.A., Gass P., Parlato R., and Schuetz G. (2011) Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models, Faseb Journal 25, 2898-2910. Seehaus S., Shahzad K., Kashif M., Vinnikov I.A., Schiller M., Wang H., Madhusudhan T., Eckstein V., Bierhaus A., Bea F., Blessing E., Weiler H., Frommhold D., Nawroth P.P., and Isermann B. (2009) Hypercoagulability Inhibits Monocyte Transendothelial Migration Through Protease-Activated Receptor-1-, Phospholipase-C beta-, Phosphoinositide 3-Kinase-, and Nitric Oxide-Dependent Signaling in Monocytes and Promotes Plaque Stability, Circulation 120, 774-U141. Isermann B., Vinnikov I.A.*, Madhusudhan T., Herzog S., Kashif M., Blautzik J., Corat M.A.F., Zeier M., Blessing E., Oh J., Gerlitz B., Berg D.T., Grinnell B.W., Chavakis T., Esmon C.T., Weiler H., Bierhaus A., and Nawroth P.P. (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis, Nature Medicine 13, 1349-1358. *, equally contributed first author. previewed in: Brownlee M. (2007) Preventing kidney cell suicide, Nature Medicine 13, 1284-1285. highlighted in: Gilbert R.E., and Marsden P.A. (2008) Activated Protein C and Diabetic Nephropathy, New England Journal of Medicine 358, 1628-1630. Zakharova M.Y., Kozyr A.V., Ignatova A.N., Vinnikov I.A., Shemiyakin I.G., and Kolesnikov A.V. (2005) Purification of filamentous bacteriophage for phage display using size-exclusion chromatography, Biotechniques 38, 194-198.