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个人简介

南京大学教授,博士生导师,国家杰出青年基金获得者,英国皇家化学会会士。1998年于中国科学院大连化学物理研究所获博士学位。2000-2002年,日本兵库大学日本学术振兴会(JSPS)特别研究员;2002-2005年,加拿大滑铁卢大学博士后。2005年获聘南京大学教授,2006年起任博士生导师,2008年入选教育部“新世纪优秀人才”, 2011年-2014年任加拿大滑铁卢大学工程学院兼职教授,2014年获国家杰出青年科学基金,2016年入选江苏省“333高层次人才”(第二层次)。英国皇家化学会会士、中国化学会高级会员、美国化学会会员,兼任国际分子印迹学会理事会理事、中国质谱学会常务理事、中国化学会色谱专业委员会委员、中国化学会质谱专业委员会委员、中国生物化学与分子生物学会蛋白质组学专业委员会委员、《Analytica Methods》副主编、《Electrophoresis》、《Separation Science Plus》、《Journal of Chromatography Open》、《科学通报》、《分析化学》、《质谱学报》和《色谱》等杂志编委。主要从事分子识别、亲和分离、疾病诊断、单细胞分析和癌症纳米治疗等研究,主持国家重大科研仪器项目和基金委重点项目等国家级科研项目10余项,已在Chemical Society Review,Accounts of Chemical Research,Angewandte Chemie International Edition,Nature Protocols,Adcanced Science, ACS Nano和Chemical Science等期刊上发表论文160余篇,目前h因子51(谷歌学术),主编及合著著作2部,出版专章7章,获授权专利15项。2011年和2017年先后获中国分析测试协会科学技术奖一等奖共2次,2016年获Phenomenex & Analytical Scientist联合颁发的科学人文奖银奖。2020年荣获美国化学会测量科学进展讲座奖。

研究领域

以仿生分子识别为核心,结合纳米技术、先进材料、分离科学、生物质谱和拉曼光谱等手段,发展生物分离、组学分析、疾病诊断分析、单细胞分析、癌症靶向及免疫治疗新方法和新材料。 1、仿生分子识别(硼亲和识别、分子印迹、适配体筛选) 2、生物分离及组学分析 3、疾病诊断分析 4、单细胞分析 5、癌症靶向及免疫治疗

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly imprinted polymer-based smart prodrug delivery system for specific targeting, prolonged retention and tumor microenvironment-triggered release. Angewandte Chemie International Edition, 2021, 60, 2663–2667. Wei Li, Yanyan Ma, Zhanchen Guo, Rongrong Xing, Zhen Liu*. Efficient Screening of Glycan-Specific Aptamers using Glycosylated Peptide as a Scaffold. Analytical Chemistry, 2021, 93, 2, 956–963. Shuxin Xu, Lisheng Wang, Zhen Liu*. Molecularly Imprinted Polymer Nanoparticles: An Emerging Versatile Platform for Cancer Therapy. Angewandte Chemie International Edition, 2021, 60, 3858-3869. Hui He, Lingli Zhou, Zhen Liu*. Advances in Protein biomarker assay via the combination of molecular imprinting and surface-enhanced Raman scattering. Acta Chimica Sinica, 2021, 79, 45-57 Jia Liu, Dan Xie, Zhen Liu*. Probing nucleus-enriched proteins in single living cells via subcellular-resolved plasmonic immunosandwich assay. Analyst, 2021, 146, 2878–2885. Jia Liu, Hui He, Dan Xie, Yanrong Wen, Zhen Liu*. Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays. Nature Protocols, 2021, 16, 3522–3546. Hengye Li*, Hui He, Zhen Liu*. Recent progress and application of boronate affinity materials in bioanalysis. Trends in Analytical Chemistry, 2021, 140, 116271. Zhanchen Guo, Yang Chen, Shuangshou Wang, Jilei Pang, Zhen Liu*. Dendritic mesoporous silica nanospheres: towards the ultimate minimum particle size for ultra-efficient liquid chromatographic separation. ACS Applied Materials & Interfaces, 2021, 13, 22970-22977. Yanrong Wen, Jialing Zhao, Hui He, Quan Zhao, Zhen Liu*. Multiplexed Single-cell Plasmonic Immunoassay of Intracellular Signaling Proteins Enables Non-Destructive Monitoring of Cell Fate. Analytical Chemistry, 2021, 93, 14204–14213. Peng Dou, Yumiao Xiang, Liang liang, Zhen Liu*. Preparation of multi-functional magnetic nanoparticles for harvesting Low-molecular-weight glycoproteins. Chinese Journal of Chromatography, 2021, 39, 1102-1110 Rongrong Xing, Zhanchen Guo, Haifeng Lu, Qi Zhang, Zhen Liu*. Molecular Imprinting and Cladding Produces Antibody Mimics with Significantly Improved Affinity and Specificity. Science Bulletin, 2021, DOI: 10.1016/j.scib.2021.10.006. Haifeng Lu, Shuxin Xu, Zhanchen Guo, Menghuan Zhao, Zhen Liu*. Redox-Responsive Molecularly Imprinted Nanoparticles for Targeted Intracellular Delivery of Protein toward Cancer Therapy. ACS Nano, 2021, DOI: 10.1021/acsnano.1c07166. Zhanchen Guo, Rongrong Xing, Menghuan Zhao, Ying Li, Haifeng Lu, Zhen Liu*. Controllable Engineering and Functionalizing of Nanoparticles for Targeting Specific Proteins towards Biomedical Applications. Advanced Science, 2021, DOI: 10.1002/advs.202101713. Xin Wang, Jiangang He, Qi Luo, Zhen Liu*. Automated hyphenation of in-tube boronate affinity solid-phase microextraction with high performance liquid chromatography for the determination of cis-diol compounds in tea beverages. Chinese Journal of Chromatography, 2020, 38, 137-142 Yanyan Ma, Xinglin Li, Jia Liu, Wei Li, Zhen Liu*. Convenient Construction of Orthogonal Dual Aptamer-Based Plasmonic Immunosandwich Assay for Probing Protein Disease Markers in Complex Samples and Living Animals. ACS Sensors, 2020, 5, 1436–1444. Yanyan Ma, Wei Li, Rongrong Xing, Pengfei Li, Zhen Liu*. Epitope-Imprinted Magnetic Nanoparticles as a General Platform for Efficient in Vitro Evolution of Protein-Binding Aptamers. ACS Sensors, 2020, 5, 2537−2544. Andrew Sulaiman, Sarah McGarry, Sara El-Sahli, Li Li, Jason Chambers, Alexandra Phan, Emil Al-Kadi, Zaina Kahiel, Eliya Farah, Guang Ji, Seung-Hwan Lee, Krishna K. Inampudi, Tommy Alain, Xuguang Li, Sheng Liu, Xianghui Han, Peiyong Zheng, Zhen Liu, Suresh Gadde,* Lisheng Wang*. Nanoparticles Loaded with Wnt and YAP/Mevalonate Inhibitors in Combination with Paclitaxel Stop the Growth of TNBC Patient-Derived Xenografts and Diminish Tumorigenesis. Advanced Therapy, 2020, 2000123. Yanrong Wen, Jia Liu, Hui He, Shawn S.C. Li, Zhen Liu*. Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs. Analytical Chemistry, 2020, 92, 12498−12508. Rongrong Xing, Yanyan Ma, Yijia Wang, Yanrong Wen, Zhen Liu*. Specific recognition towards proteins and peptides via controllable oriented surface imprinting of boronate affinity-anchored epitope. Chemical Science, 2019, 10, 1831-1835 (ESI higly cited paper). Rongrong Xing, Yanrong Wen, Hui He, Zhanchen Guo, Zhen Liu*. Recent progress in the combination of molecularly imprinted polymer-based affinity extraction and mass spectrometry for targeted proteomic analysis. Trends in Analytical Chemistry, 2019, 110, 417-428.

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