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个人简介

李娟教授,国家优秀青年基金获得者,2013年毕业于福州大学获分析化学博士学位,2013-2014年在美国佛罗里达大学从事博士后研究。2014年底回福州大学工作。主要从事生化分析和生物成像的研究工作,通过构建生物相容性好的功能生物探针,发展活细胞高灵敏、高特异性成像方法和膜蛋白功能调控策略,期望为化学、生命、医学等学科提供先进的研究工具。近年来,以第一/通讯作者在国际高水平刊物上发表SCI论文38篇,包括J. Am. Chem. Soc. 5篇、Angew. Chem. Int. Ed. 1篇,Chem .Soc. Rev. 1篇、Adv. Funct. Mater. 1篇、Anal. Chem. 8篇等。先后主持2项国家自然科学基金(其中一项为国家优秀青年基金),福建省杰出青年科学基金等项目,2016年入选福建省引进高层次人才(境外B类),2017年入选福建省青年拔尖创新人才。《高等学校化学学报》、《Chemical Research in Chinese Universities》青年执行编委

研究领域

主要从事生化分析和生物成像的研究工作,通过构建生物相容性好的功能生物探针,发展活细胞高灵敏、高特异性成像方法和膜蛋白功能调控策略,期望为化学、生命、医学等学科提供先进的研究工具

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang* and Weihong Tan, Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors, Angewandte Chemie International Edition 2020, doi: 10.1002/anie.202002145. Jingying Li, Liping Wang, Jinmiao Tian, Zhilan Zhou, Juan Li* and Huanghao Yang*, Nongenetic engineering strategies for regulating receptor oligomerization in living cells, Chemical Society Reviews 2020, 49, 1545-1568. Jie Zhou, Zhentao Shao, Jia Liu, Qiao Duan, Xiang Wang, Juan Li* and HuangHao Yang*, From Endocytosis to Non-endocytosis: The Emerging Era of Gene Delivery, ACS Applied Bio Materials 2020, Doi: 10.1021/acsabm.9b01131. Shan Chen, Zhifei Xu, Wen Yang, Xiahui Lin, Jingying Li, Juan Li* and Huanghao Yang, Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction, Angewandte Chemie International Edition 2019, 58, 18186-18190. Liping Wang, Hong Liang, Jin Sun, Yichang Liu, Jinyu Li, Jingying Li, Juan Li* and Huanghao Yang*, Bispecific aptamer induced artificial protein-Pairing: a strategy for selective inhibition of receptor function, Journal of the American Chemical Society 2019, 141, 12673-12681. Xiangyu Ou, Yanyan Chen, Lili Xie, Jie Chen, Jie Zan, Xiao-Feng Chen, Zhongzhu Hong, Yu He, Juan Li* and Huanghao Yang*, X-ray Nanocrystal scintillator-based aptasensor for autofluorescence-free detection, Analytical Chemistry 2019, 91, 10149-10155. Da Zhang#, Cuilin Zhang#, Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu* and Huanghao Yang*, Near-Infrared light activated thermosensitive ion channel to remotely control transgene system for thrombolysis therapy, Small 2019, 1901176. Jie Zhou, Liqin Sun, Liping Wang, Yichang Liu, Jinyu Li, Jingying Li, Juan Li* and Huanghao Yang*, Self-assembled and size-controllable oligonucleotide nanospheres for effective antisense gene delivery through an endocytosis-independent pathway, Angewandte Chemie International Edition 2019, 58, 5236-5240. Kai-Long Zhang, Ying-Jie Wang, Jin Sun, Jie Zhou, Chao Xing, Guoming Huang, Juan Li* and Huanghao Yang*, Artificial chimeric exosomes for anti-phagocytosis and targeted cancer therapy, Chemical Science 2019, 10, 1555-1561. Jingying Li, Shuya Liu, Liqin Sun, Wei Li, Suyun Zhang, Sheng Yang, Juan Li* and Huanghao Yang*, Amplified visualization of protein-specific glycosylation in zebrafish via proximity-induced hybridization chain reaction, Journal of the American Chemical Society 2018, 140, 16589-16595. Chao Xing, Yuqing Huang, Junduan Dai, Lin Zhong, Huimeng Wang, Yuhong Lin, Juan Li, Chunhua Lu* and Huanghao Yang*, Spatial Regulation of Biomolecular Interactions with a Switchable Trident-Shaped DNA Nanoactuator, ACS applied materials & interfaces 2018, 10, 32579-32587. Shan Chen, Jingying Li, Hong Liang, Xiahui Lin, Juan Li* and Huanghao Yang*, Light-induced activation of c-Met signalling by photocontrolled DNA assembly, Chemistry - A European Journal 2018, 24, 15988-15992. Yan Lin, Ying Wu, Rong Wang, Guo Tao, Peifu Luo, Xiang Lin, Guoming Huang*, Juan Li and Huanghao Yang*, Two-dimensional tellurium nanosheets for photoacoustic imaging-guided photodynamic therapy, Chemical Communications 2018, 54, 8579-8582. Qiushui Chen, Jing Wu, Xiangyu Ou, Bolong Huang, Jawaher Almutlaq, Ayan A. Zhumekenov, Xinwei Guan, Sanyang Han, Liangliang Liang, Zhigao Yi, Juan Li, Xiaoji Xie, Yu Wang, Ying Li, Dianyuan Fan, Daniel B. L. Teh, Angelo H. All, Omar F. Mohammed, Osman M. Bakr, Tom Wu, Marco Bettinelli, Huanghao Yang*, Wei Huang* and Xiaogang Liu*, All-Inorganic perovskite nanocrystal scintillators, Nature 2018, 561, 88-93. Xiang-Yu Ou, Tao Guo, Liang Song, Han-Yu Liang, Qi-Zhao Zhang, Jia-Qi Liao, Jing-Ying Li, Juan Li* and Huang-Hao Yang*, Autofluorescence-free immunoassay using X-ray scintillating nanotags, Analytical Chemistry 2018, 90, 6992-6997. Liping Wang, Peipei Li, Xue Xiao, Jingying Li, Juan Li*, Huanghao Yang* and Weihong Tan, Generating lung-metastatic osteosarcoma targeting aptamers for in vivo and clinical tissue imaging, Talanta 2018, 188, 66-73. Hong Liang, Shan Chen, Peipei Li, Liping Wang, Jingying Li, Juan Li*, Huanghao Yang* and Weihong Tan, Nongenetic approach for Imaging protein dimerization by aptamer recognition and proximity-induced DNA assembly, Journal of the American Chemical Society 2018, 140, 4186-4190. Li-Sen Lin, Jibin Song, Liang Song, Kai-Mei Ke, Yi-Jing Liu, Zi-Jian Zhou, Zhe-Yu Shen, Juan Li, Zhen Yang, Wei Tang, Gang Niu, Huang-Hao Yang* and Xiaoyuan Chen*, Simultaneous fenton-like ion delivery and glutathione depletion by MnO2-based nanoagent to enhance chemodynamic therapy, Angewandte Chemie International Edition 2018, 57, 4902-4906. Liang Song, Pei-Pei Li, Wen Yang, Xia-Hui Lin, Hong Liang, Xiao-Feng Chen, Gang Liu, Juan Li* and Huang-Hao Yang*, Low-dose X-ray activation of W(VI)-doped persistent luminescence nanoparticles for deep-tissue photodynamic therapy, Advanced Functional Materials 2018, 28, 1707496. Tao Guo, Yan Lin, Wei-Jian Zhang, Jin-Sheng Hong, Ru-Hui Lin, Xiao-Ping Wu, Juan Li, Chun-Hua Lu* and Huang-Hao Yang*, High-efficiency X-ray luminescence in Eu3+-activated tungstate nanoprobes for optical imaging through energy transfer sensitization, Nanoscale 2018, 10, 1607-1612. Jingying Li, Jie Zhou, Tong Liu, Shan Chen, Juan Li* and Huanghao Yang*, Circular DNA: a stable probe for highly efficient mRNA imaging and gene therapy in living cells, Chemical Communications 2018, 54, 896-899.

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