研究领域
主要从事人类肝炎病毒，流感病毒感染引起宿主炎症应答的机理。结合临床标本的分析与检测，从转录水平和翻译水平研究病毒感染诱导白介素，干扰素等细胞因子表达调控规律。研究宿主炎症因子网络的形成以及抗病毒免疫应答影响病毒感染的进程。病毒感染诱导环加氧酶（COX-2）及下游炎症反应通路，白介素（IL-27,IL-32），III型干扰素（IFN-lambda）以及氧化氮合成酶（iNOS）的相关信号通路研究。
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Liu S, Peng NF, Xie JJ, Hao Q, Zhang M, Zhang Y, Xia ZC, Xu G, Zhao FP, Wang Q, Han T, Zhu Y*, Human hepatitis B virus S and E antigens inhibit major vault protein signaling in interferon induction pathways. Journal of Hepatology 2015, 62. 1015–1023. Han T, Wan Y, Wang J, Zhao P, Yuan Y, Wang L, She Y, Broering R, Lu M, Ye L, Zhu Y*. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway. J Immunol. 2015, 194(6):2757-68. Zhao F, Xu G, Zhou Y, Wang L, Xie J, Ren S, Liu S, Zhu Y*. MicroRNA-26b Inhibits Hepatitis B Virus Transcription and Replication by Targeting the Host Factor CHORDC1 Protein. J Biol Chem. 2014, 289(50):35029-41. Wang J, Wang Q, Han T, Li YK, Zhu SL, Ao F, Feng J, Jing MZ, Wang L, Ye LB and Zhu Y*. Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst Cellular & Molecular Immunology. 2014, 1–12 (In Press) Li Y, Xie J, Xu X, Wang J, Ao F, Wan Y, Zhu Y*. MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1. Protein Cell. 2013.4(2):130-41. Li Y, Xie J, Xu X, Liu L, Wan Y, Liu Y, Zhu C, Zhu Y*. Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1). J Biol Chem. 2013. 288(29):20927-41. Wang Q, Chen X, Feng J, Cao Y, Song Y, Wang H, Zhu C, Liu S, Zhu Y*. Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses. J Virol. 2013. 87(20):11244-54. Yue X, Wang H, Zhao F, Liu S, Wu J, Ren W, Zhu Y*. Hepatitis B virus-induced calreticulin protein is involved in IFN resistance. J Immunol. 2012;189(1):279-86. Liu S, Hao Q, Wang Y, Yue X, Peng N, Chen YN, Wu J, Zhu Y*. Major Vault Protein: A Virus-Induced Host Factor against Viral Replication through the Induction of Type-I Interferon. Hepatology. 2012. 56: 57-66. Liu L, Cao Z, Chen J, Li R, Cao Y, Zhu C, Wu K, Wu J, Liu F, Zhu Y*. Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A Signaling. J Biol Chem. 2012 Apr 6;287(15):11899-910. Fang J, Hao Q, Liu L, Li Y, Wu J, Huo X, Zhu Y*. Epigenetic Changes Mediated by miR29 Activate Cyclooxygenase-2 and Interferon-λ1 Production during Viral Infection. J Virol. 2012. 86(2) 2010-2020. Li W, Sun W, Liu L, Yang F, Li YK, Chen YN, Fang JL, Zhang WJ, Wu JG, Zhu Y*. Interleukin 32: A Host Proinflammatory Factor against Influenza Viral Replication is Upregulated by Aberrant Epigenetic Modifications during Influenza A Virus Infection. J Immunol. 2010. 185, 5056 -5065. Li W, Yang F, Liu Y, Gong R, Liu L, Feng Y, Hu P, Sun W, Hao Q, Kang L, Wu J, and Zhu Y*. Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur. J. Immunol. 2009. 39: 1019-1024. Rasool ST, Tang H, Wu J, Li W, Mukhtar MM, Zhang J, Mu Y, Xing HX, Wu J, Zhu Y*. Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication. Immunol Lett. 2008. 117(2):161-167. Li W, Liu Y, Mukhtar MM, Gong R, Pan Y, Rasool ST, Gao Y, Kang L, Hao Q, Peng G, Chen Y, Chen X, Wu J, Zhu Y*. Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. PLoS ONE. 2008 Apr 16;3(4):e1985. Liu M, Yang Y, Gu C, Yue Y, Wu KK, Wu J, Zhu Y*. Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. FASEB J. 2007. 21(7):1586-96.
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