陈香嵩 - 武汉大学 - 生命科学学院

个人简介

学习经历 2003.09-2007.06　华中农业大学，生命科学技术学院，国家生命科学与技术基地班，本科 2007.09-2012.12　华中农业大学，生命科学技术学院，作物遗传改良国家重点实验室，博士主要工作经历与任职情况： 2013.01-2013.12　华中农业大学，作物遗传改良国家重点实验室，科研助理 2014.01-2018.12　美国威斯康星大学-麦迪逊分校，博士后 2019.01至今，　　武汉大学生命科学学院，杂交水稻国家重点实验室，研究员

研究领域

真核生物的DNA缠绕在组蛋白八聚体上以染色质的形式存在于细胞核中，作为“骨架”的组蛋白上存在着动态的化学修饰，包括乙酰化、甲基化、磷酸化等。这些修饰对染色质的活动（DNA的复制及损伤修复、RNA转录等）有重要的调控作用。我们以模式植物拟南芥和水稻为材料，重点关注：1.组蛋白修饰（现阶段以乙酰化为主）调控染色质活动的具体机制，例如组蛋白修饰的相关酶或者识别蛋白是如何感知细胞内外的信号，并知道在何时作用于何处的；2.组蛋白修饰的相关调控蛋白在植物的生长发育和逆境响应等重要生物学进程中扮演的角色。

近期论文

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1. Kevin S. Mayer#, Xiangsong Chen#, Dean Sanders, Jiani Chen, Jianjun Jiang, Phu Nguyen, Mark Scalf, Lloyd M. Smith, and Xuehua Zhong. HOS15 acts with HISTONE DEACETYLASE 9 to modulate transcription and development. Plant Physiology. Accepted. # Co-first author 2. Xiangsong Chen, Li Lu, Shuiming Qian, Mark Scalf, Lloyd M. Smith, Xuehua Zhong. Canonical and non-canonical actions of Arabidopsis histone deacetylases in ribosomal RNA processing. Plant Cell (2018), 30:134–152. (Highlighted in Plant Cell (2018), 30:5–6.) 3. Li Lu#, Xiangsong Chen#, Shuiming Qian, Xuehua Zhong. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nature Communications (2018), 9:630. # co-first author. # Co-first author 4. Xiangsong Chen, Li Lu, Kevin Mayer, Mark Scalf, Shuiming Qian, Aaron Lomax, Lloyd Smith, Xuehua Zhong. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. eLife (2016), 5:e17214. 5. Yun Ju Kim, Ruozhong Wang, Lei Gao, Dongming Li, Chi Xu, Hyunggon Mang, Jien Jeon, Xiangsong Chen, Xuehua Zhong, June M. Kwak, Beixin Mo, Langtao Xiao, and Xuemei Chen. POWERDRESS and HDA9 interact and promote histone H3 deacetylation at specific genomic sites in Arabidopsis. PNAS (2016), 113: 14858-14863. 6. Li Lu, Xiangsong Chen, Dean Sanders, Shuiming Qian, Xuehua Zhong. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics (2015), 10:1044-1053. 7. Xiangsong Chen, Xiaoyun Liu, Yu Zhao, Dao-Xiu Zhou. Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice. Scientific Reports (2015), 5:13251. 8. Qingfeng Chen#, Xiangsong Chen#, Quan Wang, Faben Zhang, Zhiyong Lou, Qifa Zhang, Dao-Xiu Zhou. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genetics. (2013), 9:e1003239. # Co-first author 9. Xiangsong Chen, Dao-Xiu Zhou. Rice epigenomics and epigenetics: challenges and opportunities. Current Opinion in Plant Biology (2013), 16:164-169. 10. Tiantian Li, Xiangsong Chen, Xiaochao Zhong, Yu Zhao, Xiaoyun Liu, Shaoli Zhou, Saifeng Cheng, Dao-Xiu Zhou. Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice. Plant Cell (2013), 25:4725-4736. 11. Xiangsong Chen, Yongfeng Hu, Dao-Xiu Zhou. Epigenetic gene regulation by plant Jumonji group of histone demethylase. Biochimica et Biophysica Acta. (2011), 1809:421-426. 12. Fujun Qin, Qianwen Sun, Liming Huang, Xiangsong Chen, Dao-Xiu Zhou. Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression. Molecular Plant (2010), 3: 773-782.