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个人简介

南京大学物理学院教授、博士生导师。2004年毕业于中国科学院近代物理研究所,获“粒子物理与原子核物理”专业博士学位。2004-2006年在南京大学物理学院做博士后,开展理论与计算生物物理研究。2006年起在南京大学物理学院任讲师、副教授、教授。曾在日本京都大学生物物理系学术访问和开展合作研究。

研究领域

主要从事生物大分子体系组装与功能动力学的理论与计算机模拟研究 包括 1)辅助因子耦合的蛋白质折叠、别构运动、聚集物理机制的理论与计算研究 2)生物大分子机器功能动力学 3)多尺度理论和计算方法

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Wenfei Li*, Jun Wang, Jian Zhang, Shoji Takada*, and Wei Wang* Overcoming the Bottleneck of the Enzymatic Cycle by Steric Frustration, Phys. Rev. Lett. 2019, 122, 238102. H Zorgati, M Larsson, W Ren, AYL Sim, J Gettemans, JM Grimes, Wenfei Li*, R. C. Robinson*, The role of gelsolin domain 3 in familial amyloidosis (Finnish type) Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 13958-13963. Jianyang Kong, Jiachen Li, Jiajun Lu, Weifei Li*, Wei Wang Role of substrate-product frustration on enzyme functional dynamics Phys. Rev. E 2019, 100, 052409 W. Di, X. Gao, W. Huang, Y. Sun, H. Lei, Y. Liu, W. Li, Y. Li, X. Wang, M. Qin, Z. Zhu*, Y. Cao*, W. Wang* Direct Measurement of Length Scale Dependence of the Hydrophobic Free Energy of a Single Collapsed Polymer Nanosphere, Phys. Rev. Lett., 2019, 122: 047801. R. Song, X. Wu, B. Xue, Y. Yang, W. Huang, G. Zeng, J. Wang, W. Li, Y. Cao, W. Wang*, J. Lu*, H. Dong* J. Am. Chem. Soc. 2018, 141 (1), 223-231 Chao Liu, Yangyang Zhang, Jian Zhang, Jun Wang, Wenfei Li*; Wei Wang*, Interplay between translational diffusion and large-amplitude angular jumps of water molecules, J. Chem. Phys. 2018, 148: 184502. Shintaroh Kubo, Wenfei Li, Shoji Takada*, Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations, Plos Comput. Biol., 2017, 13(9): e1005748. Weitong Ren, Wenfei Li*; Jun Wang, Jian Zhang, Wei Wang* Consequences of Energetic Frustration on the Ligand-Coupled Folding/Dimerization Dynamics of Allosteric Protein S100A12 , J. Phys. Chem. B, 2017 , 121(42): 9799-9806. Wenfei Li, Jun Wang*, Jian Zhang and Wei Wang* Molecular simulations of metal-coupled protein folding, Curr. Opin. Struct. Biol. 2015, 30, 25-31. Wenfei Li*, Jian Zhang, Jun Wang, and Wei Wang* Multiscale theory and computational method for biomolecule simulations Acta Physica Sinica, 64, 098701 (2015) (in chinese) Shoji Takada, Ryo Kanada, Cheng Tan, Tsuyoshi Terakawa, Wenfei Li, and Hiroo Kenzaki,Modeling Structural Dynamics of Biomolecular Complexes by Coarse-Grained Molecular Simulations, Accounts of Chemical Research, 2015, 48, 3026-3035 Wenfei Li, Wei Wang* and Shoji Takada* Energy landscape views for interplays among folding, binding, and allostery of calmodulin domains, Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 10550-10555. Chunmei Lv#, Xiang Gao#, Wenfei Li#, Bo Xue, Meng Qin, Leslie D. Burtnick, Hao Zhou, Yi Cao*, Robert C. Robinson*, Wei Wang* Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin Nature Communications 2014, 5, 4623. (# contributed equally) Chao Liu, Wenfei Li*, and Wei Wang* Correlation of Reorientational Jumps of Water Molecules in Bulk Water Phys. Rev. E 2013, 87, 052309. Cheng Tan, Wenfei Li*, and Wei Wang* Localized Frustration and Binding-Induced Conformational Change in Recognition of 5sRNA by TFIIIA Zinc Finger J. Phys. Chem. B 2013, 117, 15917-15925 Wenfei Li, Tsuyoshi Terakawa, Wei Wang* and Shoji Takada* Energy landscape and multiroute folding of topologically complex proteins adenylate kinase and 2ouf-knot, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 17789-17794. Wenhui Xi, Wenfei Li*, and Wei Wang* Template Induced Conformational Change of Amyloid-β Monomer J. Phys. Chem. B, 2012, 116, 7398–7405 Wenfei Li, Peter G. Wolynes*, and Shoji Takada* Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 3504–3509. Wenfei Li, Meng Qin, Zuoxiu Tie, and Wei Wang* Effects of solvents on the intrinsic propensity of peptide backbone conformations Phys. Rev. E 2011, 84, 041933. Hiroo Kenzaki, Nobuyasu Koga, Naoto Hori, Ryo Kanada, Wenfei Li, Kei-ichi Okazaki, Xin-Qiu Yao, and Shoji Takada CafeMol: A coarse-grained biomolecular simulator for simulating proteins at work, J. Chem. Theory & Comput., 2011, 7, 1979-1989.

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