Christian Staehelin - 中山大学

研究领域

Human existence and reproduction depends on a sustainable food supply. Research on the mechanisms underlying the interaction between nitrogen-fixing bacteria and host plants will promote agricultural improvements. The symbiosis between rhizobia and leguminous plants is the most important among various beneficial interactions. The formation of nitrogen-fixing nodules can be divided into several developmental stages and is regulated by elaborate signal communications between rhizobia and plants. Current research in our laboratory is focused on: 1. Biological functions of the bacterial type 3 effectors within host cells 2. Characterization of genes involved in the hydrolysis of Nodulation Factors 3. Symbiotic functions of Exo-oligosaccharides 4. The life cycle of Rhizobia 5. Relationship between soil bacteria and plant diversity

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1. Meixner, C., Ludwig-Mu¨ller, J., Miersch, O., Gressho, P., Staehelin, C., and Vierheilig, H. Lack of mycorrhizol autoregulation and phytohormonal changes in the supernodulating soybean mutant nts1007. Planta, 2005, 222, 709-715 2 Ovtsyna, A. O., Dolgikh, E. A., Kilanova, A. S., Tsyganov, V. E., Borisov, A. Y., Tikhonovich, I. A., and Staehelin, C. Nod factors induce nod factor cleaving enzymes in pea roots. Genetic and pharmacological approaches indicate different activation mechanisms. Plant Physiology, 2005, 139, 1051-1064 3 Heijden, M. G. A. v. d., Bakker, R., Verwaal, J., Scheublin, T. R., Rutten, M., Logtestijn, R. v., and Staehelin, C. Symbiotic bacteria as a determinant of plant community structure and plant productivity in dune grassland. FEMS Microbiology Ecology, 2006, 56, 178-781 4Staehelin, C., Forsberg, L. S., D'Haeze, W., Gao, M. Y., Carlson, R. W., Xie, Z. P., Pellock, B. J., Jones, K. M., Walker, G. C., Streit, W. R., and Broughton, W. J. Exo-oligosaccharides of Rhizobium sp. strain NGR234 are required for symbiosis with various legumes. Journal of Bacteriology, 2006, 188, 6168-6178 5 Catford, J. G., Staehelin, C., Larose, G. V., Piche´, Y., and Vierheilig, H. Systemically suppressed isoflavonoids and their stimulating effects on nodulation and mycorrhization in alfalfa split-root systems. Plant Soil, 2006, 285, 257-266 6 Xiong, J. S., Balland-Vanney, M., Xie, Z. P., Schultze, M., Kondorosi, A., Kondorosi, E., and Staehelin, C. Molecular cloning of a bifunctional beta-xylosidase/alpha-L-arabinosidase from alfalfa roots: heterologous expression in Medicago truncatula and substrate specificity of the purified enzyme. Journal of Experimental Botany, 2007, 58, 2799-2810 7 Meixner, C., Vegvari, G., ller, J. L.M., Gagnon, H., Steinkellner, S., Staehelin, C., Gresshoff, P., and Vierheili, H. Two defined alleles of the LRR receptor kinase GmNARK in supernodulating soybean govern differing autoregulation of mycorrhization. Physiologia Plantarum, 2007, 130, 261-270 8 Saad, M. M., Staehelin, C., Broughton, W. J., and Deakin, W. J. Protein-protein interactions within type III secretion system-dependent pili of Rhizobium sp. strain NGR234. Journal of Bacteriology, 2008, 190, 750-754 9 Xin, D. W., Qiu, H. M., Shan, D. P., Shan, C. Y., Liu, C. Y., Hu, G. H., Staehelin, C., and Chen, Q. S. Analysis of quantitative trait loci underlying the period of reproductive growth stages in soybean (Glycine max [L.] Merr.). Euphytica, 2008, 162, 155-165 10Dai, W. J., Zeng, Y., Xie, Z. P., and Staehelin, C. Symbiosis-promoting and deleterious effects of NopT, a novel type 3 effector of Rhizobium sp. strain NGR234. Journal of Bacteriology, 2008, 190, 5101-5110 11Khaosaad, T., Staehelin, C., Steinkellner, S., Hage-Ahmed, K., Ocampo, J. A., Garcia-Garrido, J. M., and Vierheilig, H. The Rhizobium sp. strain NGR234 systemically suppresses arbuscular mycorrhizal root colonization in a split-root system of barley (Hordeum vulgare). Physiologia plantarum, 2010, 140, 238-245 12 Staehelin, C., Xie, Z. P., Illana, A., and Vierheilig, H. Long-distance transport of signals during symbiosis: are nodule formation and mycorrhization autoregulated in a similar way? Plant signaling & behavior, 2011, 6, 372-377 13Zhang, L., Chen, X. J., Lu, H. B., Xie, Z. P., and Staehelin, C. Functional analysis of the type 3 effector nodulation outer protein L (NopL) from Rhizobium sp. NGR234 symbiotic effects, phosphorylation, and interference with mitogen-activated protein kinase signaling. Journal of Biological Chemistry, 2011, 286, 32178-32187 14Liu, Y., Yu, S. X., Xie, Z. P., and Staehelin, C. Analysis of a negative plant-soil feedback in a subtropical monsoon forest. Journal of Ecology, 2012, 100, 1019-1028 15 Liang, M. T., Yang, C. P., Xie, Z. P., and Staehelin, C. Use of the Cre-loxP recombination system as an estimate for Agrobacterium-mediated co-transformation of tobacco leaves. Biotechnology letters, 2012, 34, 747-754 16 Xin, D. W., Liao, S., Xie, Z. P., Hann, D. R., Steinle, L., Boller, T., and Staehelin, C. Functional analysis of NopM, a novel E3 ubiquitin ligase (NEL) domain effector of Rhizobium sp. strain NGR234. PLoS Pathogens, 2012, 8, e1002707 17Tian, Y., Liu, W., Cai, J., Zhang, L. Y., Wong, K. B., Feddermann, N., Boller, T., Xie, Z. P., and Staehelin, C. (2013) The Nodulation factor hydrolase of Medicago truncatula: Characterization of an enzyme specifically cleaving rhizobial nodulation signals. Plant Physiology. 163, 1179-1190 18 Wang, W., Xie, Z. P., and Staehelin, C. (2014) Functional analysis of chimeric lysin motif domain receptorsn mediating Nod factor-induced defense signaling in Arabidopsis thaliana and chitin-induced nodulation signaling in Lotus japonicus. The Plant Journal. 78, 56-69 19 Staehelin, C., and Krishnan, H. B. (2015) Nodulation outer proteins:double-edged swords of symbiotic rhizobia. Biochemical Journal, 470（3）, 263-274