Nguyen, Hung - University of California, Irvine - Department of Chemical Engineering and Materials Science

个人简介

The overall theme of Prof. Nguyen’s research is to elucidate the fundamental principles that govern the self-assembly of nanoscale structures in biological or biomimetic systems and ion complexes in phase-separating fluids using computational and theoretical methods. The Nguyen group aims to understand how environmental conditions impact the formation, functionality and performance of these nanostructures and ion complexes for useful applications in bioengineering, nanotechnology and energy. Dr. Nguyen received his B.S. degree in chemical engineering from the University of Florida. Then he went to the North Carolina State University to work on his Ph.D. dissertation, "Computer simulations of protein folding and aggregation," under the guidance of Professor Carol K. Hall in chemical and biomolecular engineering. Subsequently, Dr. Nguyen became a postdoctoral researcher working with Professor Charles L. Brooks III in molecular biology, computational chemistry and biophysics at the Scripps Research Institute (La Jolla, CA) and then at the University of Michigan. He examined the self-assembly and maturation process of viral capsids, which is a fundamental concept in virology and is of significant biomedical interest in nanotechnology and vaccine development.

研究领域

Our research group focuses on four key areas: Morphological control of nanostructures self-assembled by peptide amphiphiles for use in tissue engineering and drug/gene delivery Deciphering kinetics of DNA hybridization and self-assembly in structural DNA nanotechnology Computational design of organic nanowires using perylenediimide DNA base surrogates Elucidation of phase separation in complex fluids for extracting metal ions from spent nuclear fuels

近期论文

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A. Mazaheripour, G. Kladnik, J.-M. Jocson, A.G. Wardrip, C.B. Markegard, N. Frey, A. Cossaro, L. Floreano, A. Verdini, A. Bartlett, A.M. Burke, N. Hüsken, K. Miller, K. Van Wonterghem, R. Lopez, M. Lu, A. Masurkar, M.N. Dickson, S. Sharifzadeh, H.D. Nguyen, I. Kymissis, D. Cvetko, A. Morgante and A.A. Gorodetsky, "Unexpected Length Dependence of Excited-State Charge Transfer Dynamics for Surface-Confined Perylenediimide Ensembles," Materials Horizons (2017) L.X. Dang., Q.N. Vo, M. Nilsson and H.D. Nguyen, "Rate theory on water exchange in aqueous uranyl ion," Chem. Phys. Let., 671: 58-62 (2017), Frontiers Article A.G. Wardrip, A. Mazaheripour, N. Hüsken, J.-M. Jocson, A. Bartlett, R.C. Lopez, N. Frey, C.B. Markegard, G. Kladnik, A. Cossaro, L. Floreano, A. Verdini, A.M. Burke, M.N. Dickson, I. Kymissis, D. Cvetko, A. Morgante, S. Sharifzadeh, H.D. Nguyen and A.A. Gorodetsky, "Length-Independent Charge Transport in Chimeric Molecular Wires," Angew. Chem. Int. Ed., 55: 1-6 (2016) C.B. Markegard, C.P. Gallivan, D.D. Cheng and H.D. Nguyen, "Effects of Concentration and Temperature on DNA Hybridization by Two Closely Related Sequences via Large-Scale Coarse-Grained Simulations," J. Phys. Chem. B, 120 (32): 7795–7806 (2016) Q.N. Vo, J.L. Unangst, H.D. Nguyen* and M. Nilsson*, "Quantifying Dimer and Trimer Formation of Tri-n-Butyl Phosphates in Different Alkane Diluents: FTIR Study,"J. Phys. Chem. B, 120(28): 6976-6984 (2016), *corresponding authors Q.N. Vo, L.X. Dang, M. Nilsson* and H.D. Nguyen*, "Quantifying Dimer and Trimer Formation by Tri-N-Butyl Phosphates in N-Dodecane: Molecular Dynamics Simulations,"J. Phys. Chem. B, 120(28): 6985-6994 (2016), *corresponding authors C.B. Markegard, A. Mazaheripour, J.M. Jocson, A.M. Burke, M.N. Dickson, A.A. Gorodetsky* and H.D. Nguyen*, “Molecular Dynamics Simulations of Perylenediimide DNA Base Surrogates,” J. Phys. Chem. B, 119(35): 11459–11465 (2015), *corresponding authors I.W. Fu and H.D. Nguyen, “Sequence-Dependent Structural Stability of Self-Assembled Cylindrical Nanofibers by Peptide Amphiphiles,” Biomacromolecules, 16(7): 2209-2219 (2015)