夏江 - 香港中文大学

个人简介

2021-now Professor, Department of Chemistry, and School of Life Sciences (by courtesy), the Chinese University of Hong Kong, China 2015-2021 Associate Professor, the Chinese University of Hong Kong 2009-2014 Assistant Professor, the Chinese University of Hong Kong 2007-2008 Postdoc (Advisor: Linda Hsieh-Wilson) California Institute of Technology/Howard Hughes Medical Institute, USA 2002-2006 PhD. (Advisor: Prof. Chaitan Khosla) Stanford University, USA 1999-2002 M.Sc. (Advisor: Prof. Wenxia Tang) Nanjing University, China 1995-1999 B.Sc. Department for Intensive Instruction, Nanjing University, China

研究领域

Chemical biology Protein reactions Site-selective protein reactions (cysteine, tyrosine to lysine reactions); Chemical labeling or modification of proteins, enzymes, antibodies, and organelles ex vivo and in vivo Peptides and enzymes against bacterial infection Mechanism-based design of peptide inhibitors of signaling pathways in host cells to intervene host-pathogen interaction Synthetic biology Synthetic organelles for biosynthesis Multienzyme complexes, synthetic metabolon, and phase-separated protein coacervates in vitro and in vivo; Regulation of metabolic flux in prokaryotic and eukaryotic cells for better biosynthesis of carotenoids, artemisinin, cannabinoids, or amorphadiene, etc Engineering exosomes for biomedical research Engineering exosomes for targeted therapy of cartilage and skin regeneration and anti-infection

近期论文

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Liang, Y.†; Iqbal, Z.†; Lu, J.; Wang, J.; Zhang, H.; Chen, X.; Duan, L.*; Xia, J.* Cell-Derived Nanovesicle-Mediated Drug Delivery to the Brain: Principles and Strategies for Vesicle Engineering. Molecular Therapy 2022 Accepted. (Review) Yuan, D.†; Zhang, Y.†; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.*; Xia, J.* Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J. Am. Chem. Soc. Accepted. Wang, C.; Li, Y.; Liu, L.; Liu, M.; Chen, X.; Zhou, S.; Cui, P.; Du, X.; Qiu, L.; Wang, J.*; Jiang, P.*; Xia, J.* Antimicrobial Nanozyme-Enzyme Complex Catalyzing Cascade Reaction of Glucose to Hydroxyl Radical to Combat Bacterial Infection Journal of Drug Delivery Science and Technology, 2022, accepted. Liang, Y.; Igbal, Z.; Wang, J.; Xu, L.; Xu, X.; Ouyang, K.; Zhang, H.; Lu, J.; Duan, L.; Xia, J.* Cell-Derived Extracellular Vesicles for CRISPR/Cas9 Delivery: Engineering Strategies for Cargo Packaging and Loading Biomaterials Science, 2022, 10, 4095 – 4106. Shinge, S. A. U.; Xiao, Y.; Xia, J.; Liang, Y.; Duan, L. New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery Extracellular Vesicles and Circulating Nucleic Acids 2022, 3, 150-162. Wei, Q.; Wang, Y.; Liu, Z.; Liu, M.; Cao, S.; Jiang, H.; Xia, J.* Multienzyme Assembly on Caveolar Membranes In Cellulo ACS Catalysis 2022, 12, 8372-8379. Lei, X.; Li, M.; Wang, C.; Cui, P.; Qiu, L.; Zhou, S.; Jiang, P.; Li, H.; Zhao, D.; Ni, X.; Wang, J.; Xia, J.* Degradable Microneedle Patches Loaded with Antibacterial Gelatin Nanoparticles to Treat Staphylococcal Infection-Induced Chronic Wounds International Journal of Biological Macromolecules, 2022, 217, 55-65. Liang, Y.; Xu, X.; Xu, L.; Ouyang, K.; Zhang, H.; Duan, L.; Xia, J.* Chondrocyte-Specific Genome Editing Enabled by Hybrid Exosomes for Osteoarthritis Treatment Theranostics, 2022, 12, 4866-4878. Wang, Y.†; Liu, M.†; Wei, Q.; Wu, W.; He, Y.; Gao, J.; Zhou, R.; Jiang, L.; Qu, J.; Xia, J.* Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote Angew. Chem. Int. Ed. 2022, e202203909. Huang, J.; Liu, F.; Su, H.; Xiong, J.; Yang, L.; Xia, J.; Liang, Y.* Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering Gels 2022, 8, 138. Huang, J.; Lei, L.; Huang, Z.; Rong, Z.; Li, H.; Xie, Y.; Duan, L.; Xiong, J.; Wang, D.; Zhu, S.; Liang, Y.*; Wang, J.*; Xia, J.* Gelatin – Recombinant Type III Collagen Hydrogel to Promote Wound Healing Int. J. Bioprinting 2022, 8, 517. Wang, X.; Qiu, L.; Wang, C.; Gao, Z.; Zhou, S.; Cui, P.; Jiang, P.; Hu, H.; Ni, X.*; Du, X.; Wang, J.*; Xia, J.* “Nanodot–doped peptide hydrogel for antibacterial phototherapy and wound healing” Biomater. Sci accepted Xu, L.; Liang, Y.; Xu, X.; Xia, J.; Wen, C.; Zhang, P.; Duan, L.* “Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems” Bioengineered 2021, doi.org/10.1080/21655979.2021.1982320. Huang, J.; Zhang, J.; Xiong, J.; Sun, S.; Xia, J.*; Yang, L.*; Liang, Y.* “Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing” Stem Cells International 2021, doi.org/10.1155/2021/1285087. So, W. H#.; Bao, Y.#; Chen, X.; Xia, J.* “On-Resin Ugi Reaction for C-Terminally Modified and Head-to-Tail Cyclized Antibacterial Peptides” Org. Lett. 2021, 23, 8277–8281. （# equal contribution) Bao, Y.; Qiu, J.; Xia, J.* “Covalent Reactive Peptides to Block Protein – Protein Interactions and Inhibit Microbe-Host Interaction” Methods in Molecular Biology 2021 in press. Duan, L.; Ouyang, K.; Wang, J.; Xu, L.; Xu, X.; Wen, C.; Xie, Y.; Liang, Y.*; Xia, J.* “Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing” ChemBioChem 2021, doi.org/10.1002/cbic.202100359. Chen, X.; Liu, M.; Zhang, P.; Xu, M.; Yuan, W.; Bian, L.; Liu, Y. Xia, J.*; Leung, S. S. Y.* “Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii” ACS Infectious Diseases, revised. Wang, R.; Liu, M.; Wang, H.; Xia, J.; Li, H.* “GB Tags: Small Covalent Peptide Tags Based on Protein Fragment Reconstitution” Bioconjugate Chem. 2021, 32, 1926-1934. Ho, M. K. Y.; Zhang, P.; Chen, X.; Xia, J.*; Leung, S. S. Y.* “Bacteriophage endolysins against gram-positive bacteria, an overview on the clinical development and recent advances on the delivery and formulation strategies” Critical Reviews in Microbiology, 2021, 1-24. Liu, L.; Wang, C.; Li, Y.; Qiu, L.; Zhou, S.; Cui, P.; Jiang, P.; Ni, X.; Liu, R.; Du, X.; Wang, J.*; Xia, J.* “Manganese Dioxide Nanozyme for Reactive Oxygen Therapy of Bacterial Infection and Wound Healing” Biomater. Sci. 2021, 9, 5965 – 5976. Feng, L.; Wang, P.; Feng, Y.; Zhang, J.; Chen, Q.; Xie, Y.; Luo, J.; Xia, J.; Yao, S.; Sun, H. “A reversible microarray immobilization strategy based on thiol-quinone reaction” Chin. Chem. Lett. 2021 doi.org/10.1016/j.cclet.2021.06.056 Zhang, W.; Wu, Y.; Liu, L.; Xiao, X.; Cong, Z.; Shao, N.; Qiao, Z.; Chen, K.; Liu, S.; Zhang, H.; Ji, Z.; Shao, X.; Dai, Y.; He, H.; Xia, J.; Fei, J.; Liu, R. “Membrane-Targeting Mechanism of Host Defense Peptides Inspiring the Design of Polypeptide-Conjugated Gold Nanoparticles Exhibiting Effective Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus” J. Mater. Chem. B 2021, 5092-5101. Wei, Q.; Xia, J.* “Self-assembled Multienzyme Nanostructures for Biocatalysis in Cellulo” Methods in Molecular Biology 2021, in press. (Book chapter) Liu, M.; Chen, X.; Xia, J.* “Multienzyme Catalysis in Phase-Separated Protein Condensates” Methods in Molecular Biology 2021, in press. (Book chapter) Chen, X.; Liu, M.; Zhang, P.; Leung, S. S. Y.*; Xia, J.* “Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumannii” ACS Infect. Dis. 2021, 7, 2192–2204. Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* “Antimicrobial peptides towards clinical application: delivery and formulation” Adv. Drug Deliv. Rev. 2021, 175, 113818. Li, Q.; Zeng, C.; Liu, H.; Yung, K. W. Y.; Chen, C.; Xie, Q.; Zhang, Y.; Wah, S. W. C.; Mak, B. S. W.; Xia, J.; Xiong, S.; Ngo, J. C. K. “Novel protein–protein interaction inhibitor of SRPKs alters the splicing isoforms of VEGF and inhibits angiogenesis” iScience 2021, 24, 102423. Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic gold nanoparticles for skin infection” ACS Appl. Bio Mater. 2021, 4, 3124–3132. Qiu, L.; Wang, C.; Lei, X.; Du, X.; Guo, Q.; Zhou, S.; Cui, P.; Hong, T.; Jiang, P.; Wang, J.*; Li, Y.*; Xia, J.* “Gelatinase-responsive release of antibacterial photodynamic peptide against Staphylococcus aureus” Biomater. Sci. 2021, 9, 3433-3444. Huang, J.; Huang, Z.; Liang, Y.; Yuan, W.; Bian, L.; Duan, L.; Rong, Z.; Xiong, J.*; Wang, D.*; Xia, J.* “3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair” Biomater. Sci. 2021, 9, 2620. Liang Yujie, Xia, J.* “Non-surgical osteoarthritis therapy, intra-articular drug delivery toward clinical applications” J. Drug Targeting 2021, 1-16. Liang, Y.; Duan, L.; Lu, J.; Xia, J.* “Engineering exosomes for targeted drug delivery” Theranostics 2021, 11, 3183-3195. Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated delivery of gene vectors for gene therapy” Nanoscale 2021, 13, 1387 – 1397. (Featured on back cover). Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis” Curr. Med. Chem. 2021, 28, 6458-6483. Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Biomaterials 2021, 269, 120539. Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* “Antibacterial photodynamic peptides for staphylococcal skin infection” Biomater. Sci. 2020, 8, 6695-6702. Wei, Q.; He, S.; Qu, J.; Xia, J.* “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo” Bioconjug. Chem. 2020, 31, 2413–2420. Xiao, X.; Zhang, S.; Chen, S.; Qian, Y.; Xie, J.; Cong, Z.; Zhang, D.; Zou, J.; Zhang, W.; Ji, Z.; Cui, R.; Qiao, Z.; Jiang, W.; Dai, Y.; Wang, Y.; Shao, X.; Sun, Y.; Xia, J.; Fei, J.; Liu, R. “An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance” Biomater. Sci. 2020, 8, 6883-6889. Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria” Int. J. Pharmaceutics 2020, 589, 119833 Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* “Mesenchymal Stem Cell − Derived Exosomes for Treatment of Autism Spectrum Disorder” ACS Appl. Bio Mater. 2020,3, 6384−6393. Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy” ACS Appl. Mater. Interfaces 2020, 12, 36938–36947. Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”Anal. Chem. 2020, 92, 9322–9329. Zhao, P.; Yin, C.; Zhang, Y.; Chen, X.; Yang, B.; Xia, J.; Bian, L. “Mussel Cuticle-Mimetic Ultra-Tough, Self-Healing Elastomers with Double-Locked Nanodomains Exhibit Fast Stimuli-Responsive Shape Transformation” J. Mater. Chem. A 2020, 8, 12463-12471. Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* “Phase-separated multienzyme biosynthesis” Biomacromolecules 2020, 21, 2391-2399. Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism” Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. Lai, S. N.; Zhou, X.; Ouyang, X.; Zhou, H.; Liang, Y.; Xia, J.; Zheng, B. “Artificial Cells Capable of Long-Lived Protein Synthesis by Using Aptamer Grafted Polymer Hydrogel” ACS Synth. Biol. 2020, 9, 76–83. So, W. H.; Xia, J.* “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides” Org. Lett. 2020, 22, 214-218.