Wang, Binghe - Georgia State University

个人简介

B. Wang was born in 1962 in Beijing, China. In 1966, at the beginning of the so-called Culture Revolution, his whole family was sent to the countryside in Hebei Province. Therefore, he spent his formative years interacting with people who were not the most fortunate but maintained some of the most optimistic views on life. The hard life in the countryside taught him many lessons that prove very useful later on in life. In 1978 when China re-opened its universities, he was admitted into Beijing Medical College (now Beijing University Health Sciences Center) where he met his wife, Siming. After receiving his B.S. degree in Medicinal Chemistry, he started his graduate career first at the University of British Columbia, Department of Chemistry. Still longing for a career in medicinal chemistry, he later transferred to the University of Kansas, which has one of the best medicinal chemistry programs in the world. While at the University of Kansas working under the guidance of the late Professor Matt Mertes and Professor Kristin Bowman-James, he studied thymidylate synthase, a target enzyme for cancer chemotherapy, and the design and synthesis of molecular catalysts. After receiving his Ph.D. degree, he worked with Professors Victor Hruby at the University of Arizona and Ronald T. Borchardt at the University of Kansas before embarking on his own independent academic career in 1994 at the University of Oklahoma College of Pharmacy as an assistant professor of medicinal chemistry. He moved to North Carolina State University as an assistant professor of chemistry in 1996 and was tenured in 2000. In 2003, he was recruited to the position of Professor and Georgia Research Alliance Eminent Scholar in Drug Discovery at Georgia State University. In 2009, he founded the Center for Diagnostics and Therapeutics, and has been serving as its founding director. He served as the Chemistry Department Chair between 2011-2014, Associate Dean for Natural and Computational Sciences in the College of Arts and Sciences 2014-2017, interim dean in 2016, and Associate Dean for Research and Graduate Studies 2017-2018. He was named Regents’ Professor in 2013.

研究领域

Research Interests Medicinal Chemistry (Drug Design); Pharmaceutical Chemistry (Drug Delivery); Bio-organic Chemistry (Molecular recognition and diagnostics); Organic Chemistry Drug Design Carbon monoxide prodrugs, Anti-cancer, Anti-inflammation, and Anti-viral drugs Drug Delivery Prodrugs and Targeted drug delivery: Prodrugs of gasotransmitters such as CO and H2S, Peptide, and Receptor-mediated prodrugs. Targeted Drug Delivery: Receptor mediated drug delivery, Biomarker mediated drug delivery, Mitochondria targeting, New chemical strategies in drug delivery, Click chemistry in drug delivery.

近期论文

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Bauer, N.; Yang, X.; Yuan, Z.; Wang, B. “Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor” Chem. Sci. 2023, in press: https://doi.org/10.1039/D1SC03832J Yang, X.; Tripathi, R.; Wang, M.; Lu, W.; Anifowose, A.; Tan, C.; Wang, B. “Toward “CO in a pill:” Silica-immobilized Organic CO Prodrugs for Studying the Feasibility of Systemic Delivery of CO via in situ Gastrointestinal CO release” Mol. Pharmaceutics 2023, in press: https://doi.org/10.1021/acs.molpharmaceut.2c01104. Wang, B.; Du, Y-C. N. “The anti-metastasis effect of low-dose CO” Ann. Pancr. Cancer 2023, manuscript accepted: doi: 10.21037/apc-2022-4. Kondengadan, M.S.; Bansal, S; Yang, C.; Liu, D.; Fultz, Z.; and Wang, B. “Click Chemistry and Drug Delivery: A Bird’s-eye View” 2023, published on-line: https://doi.org/10.1016/j.apsb.2022.10.015 Dong, R.; Yang, X.; Wang, B., and Ji, X. “Mutual Leveraging of Proximity Effects and Click Chemistry in Chemical Biology” Med. Res. Rev. 2023, published on-line, doi: 10.1002/med.21927. Yang, X.; Yuan, Z.; Lu, W.; Yang, C.; Wang, M.; Tripathi, R.; Fultz, Z.; Tan, C.; and Wang, B. “De Novo Construction of Fluorophores via CO Insertion-initiated Lactamization: A Chemical Strategy Towards Highly Sensitive and Highly Selective Turn-on Fluorescent Probes for Carbon Monoxide” J. Am. Chem. Soc. 2023, 145, 78-88. PMID: 36548940 Manuscripts in Preparation De La Cruz, K.; Lu, W.; Ghorpade, R.; Yang, X.; and Wang, B. “CO Production from a-Ketoacids using Immobilized Catalysts” 2023, manuscript in preparation Yang, X.; Lu, W.; Luo, M.; Kumar, M.; and Wang, B. “Inhibitors of Membrane Fusion: New Antiviral Agents” 2023 manuscript in preparation Yu, B.; Yuan, Z.; Yang, X.; Wang, B. “The Elephant in Sulfur Signaling: Its Redox Chemistry” Med. Res. Rev. 2023, manuscript in preparation Yang, X.; Lu, W.; and Wang, B. “CO Prodrug Activation by pH-sensitive Enolization” 2023 manuscript in preparation Yang, X.; Liu, D.; Lu, W.; and Wang, B. “Carbon Monoxide Does Not Activate HO-1 in Cell Culture” 2023 manuscript in preparation Liu, D.; Yang, X.; and Wang, B. “Sensing a CO-releasing Molecule (CORM) Does Not Equate to Sensing CO: The Case of DPHP” 2023, manuscript in preparation Kondengadan, M.S.; Bansal, S.; Chaudhury, M.; and Wang, B. “Redox-sensitive Linkers for Drug Delivery Applications” 2023, manuscript in preparation Tripathi, R.; Guglani, A.; Ghorpade, R.; and Wang, B. “Biotin-mediated Drug Delivery and Labeling: Is It Simply through Transporter Mediated? 2023, manuscript in preparation Yang, C.; Tripathi, R. and Wang, B. “The Application of Click Chemistry to Enable Development of PROTACs” 2023, manuscript in preparation. Yang, X.; Liu, D.; and Wang, B. “Let CO Shine: Fluorescent Probes for Sensing, Detection, and Quantification of CO” 2023, manuscript in preparation Bauer, N.; Yuan, Z.; Yang, X.; Wang, B. “The Chemical Reactivity, CO-independent Biological Activity, and Unreliable CO-donating Characteristics of Four Most Commonly Used CO-releasing Molecules for Studying CO Biology: CORM-2, CORM-3, CORM-401, and CORM-A1” 2023, manuscript in preparation Wang, B. “Nucleic Acid-based Therapeutics: A Tour de Force,” a Preface for “Medicinal Chemistry of Nucleic Acid” 2022, Zhang, L.; Tang, X.; Xi, Z.; and Chattopadhyya, J. Editors, John Wiley and Sons, New Jersey, in “Wiley Series in Drug Discovery and Development” Wang, B, Serial Editor. ISBN: 978-1-119-69274-4 Tripathi, R.; Anifowose, A.; Lu, W.; Yang, X.; and Wang, B. “Upregulation of p53 through Induction of MDM2 Degradation: Improved Potency through the Introduction of an Alkylketone Sidechain on the Anthraquinone Core” J. Enzy. Inhib. Drug Design 2022, 37, 2370-2381. De La Cruz, L.K.; Bauer, N.; Cachuela, A.; Tam, S. Tripathi, R. Yang, X.; Wang, B. “Light-activated CO donor as a Universal CO Surrogate for Pd-catalyzed and Light-mediated Carbonylation ” Org. Lett. 2022, 24, 4902-4907.