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徐新芳 教授、博士生导师 收藏
苏州大学     材料与化学化工学部
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个人简介

2005年毕业于华东师范大学,获学士学位;同年直升本校研究生,硕博连读,2010年获博士学位(导师:胡文浩教授,杨琍苹教授);期间2007年9月-12月,中国科学技术大学交流学习(导师:龚流柱教授)。2010年8月至2014年9月美国马里兰大学博士后研究(导师:Michael P.Doyle教授)。2014年9月回国,任苏州大学材料与化学化工学部特聘教授、博士生导师。 研究工作和成果 近五年来,一直在金属卡宾化学的催化反应相关领域开展研究工作,从事新的合成方法学的发现,选择性催化研究,特别是不对称催化反应研究和杂环类化合物的高效合成,取得了一系列独创性的研究成果。迄今为止,已在国际核心期刊上发表SCI论文近30篇,第一或通讯作者20余篇。最近五年接连在Acc. Chem. Res. (1篇),Angew. Chem. Int. Ed. (5篇),J. Am. Chem. Soc. (3篇), Chem. Comm.(5篇),Org. Lett., Chem. Eur. J.,等权威期刊发表多篇一作研究论文,论文他引400余次。其中六篇研究论文被专业有机评论杂志Synfacts 评述,得到了国际同行的高度评价和广泛关注。

研究领域

不对称催化;金属卡宾反应;环丙烯化学;金属卡宾串联反应;多组分反应;多功能团杂环化合物和生物活性分子的高效合成;药物及其中间体的合成和工艺研究。

近期论文

The [3+3]-Cycloaddition Alternative for Heterocycle Syntheses: Catalytically Generated Metalloenolcarbenes as Dipolar Adducts, Xinfang Xu and Michael P. Doyle*, Acc. Chem. Res., 2014, 47, 1396-1405. Highly Diasteroselective Intermolecular 1,3-Dipolar Cycloaddition Reactions of Carbonyl Ylides with Aldimines to Afford Sterically Disfavored cis-Oxazolidines, Xinfang Xu, Xin Guo, Xingchun Han, Liping Yang and Wenhao Hu*, Org. Chem. Front., 2014, 1, 181-185. Recent Developments in the Synthetic Uses of Silyl-protected Enoldiazoacetates for Heterocyclic Syntheses, Xinfang Xu* and Michael P. Doyle*, Aust. J. Chem. 2014, 67, 365-373. Highly Enantioselective Dearomatizing Formal [3+3]-Cycloaddition Reactions of N-Acyliminopyridinium Ylides with Electrophilic Enolcarbene Intermediates, Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2013, 52, 12664-12668. A Donor-acceptor Cyclopropene as a Dipole Source for a Silver(I) Catalyzed Asymmetric Catalytic [3+3]-Cycloaddition with Nitrones, Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*, Chem. Commun., 2013, 49, 10287-10289. Simple and Sustainable Iron-Catalyzed Aerobic C-H Functionalization of N,N Dialkylanilines,Maxim O. Ratnikov, Xinfang Xu, and Michael P. Doyle*, J. Am. Chem. Soc., 2013, 135, 9475-9479 (Article). Dirhodium(II)-Catalyzed Formal [3+2+1]-Annulation of Azomethine Imines with Two Molecules of a Diazo Ketone, Xinfang Xu, Xichen Xu, Peter Y. Zavalij, and Michael P. Doyle*,Chem. Commun., 2013, 49, 2762-2764. Vinylogous Reactivity of Enol Diazoacetates with Donor–Acceptor Substituted Hydrazones. Synthesis of Substituted Pyrazole Derivatives, Xinfang Xu, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*, J. Org. Chem., 2013, 78, 1583-1588 (Article). Synthesis of Tetrahydropyridazines by a Metal–Carbene-Directed Enantioselective Vinylogous N-H Insertion/Lewis Acid-Catalyzed Diastereoselective Mannich Addition,Xinfang Xu,Peter Y. Zavalij, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2012, 51, 9829-9833.(Reviewed by Synfacts: 2012, 8,1181) Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Yu Qian, Xinfang Xu, Xiaochen Wang, Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2012, 51, 5900-5903. (Reviewed by Synfacts: 2012, 8,0861) Efficient Synthesis of Oxazoles by Dirhodium(II)-catalyzed Reactions of Styryl diazoacetate with Oximes, Xinfang Xu,Peter Y. Zavalij, Wenhao Hu, and Michael P. Doyle*,Chem. Commun., 2012, 48, 11522-11524. Unexpected Catalytic Reactions of Silyl-Protected Enol Diazoacetates with NitrileOxides That Form 5-Arylaminofuran-2(3H)-one-4-carboxylates, Xinfang Xu, Dmitry Shabashov, Peter Y. Zavalij, and Michael P. Doyle*, Org. Lett., 2012, 14, 800-803. Substrate-Dependent Divergent Outcomes from Catalytic Reactions of Silyl-Protected Enol Diazoacetates with Nitrile Oxides: Azabicyclo[3.1.0]hexanes or 5-Arylaminofuran-2(3H)-ones, Xinfang Xu, Dmitry Shabashov, Peter Y. Zavalij, and Michael P. Doyle*, J. Org. Chem., 2012, 77, 5313-5317 (Article). Divergent Outcomes of Carbene Transfer Reactions from Dirhodiumand Copper-Based Catalysts Separately or in Combination, Xinfang Xu, Wenhao Hu, Peter Y. Zavalij, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2011, 50, 11152-11155. (Reviewed by Synfacts: 2011, 9,0976) Highly Enantioselective Catalytic Synthesis of Functionalized Chiral Diazoacetoacetates, Xinfang Xu, Wenhao Hu, and Michael P. Doyle*, Angew. Chem. Int. Ed., 2011, 50, 6392-6395. Asymmetric Formal [3 + 3]-Cycloaddition Reactions of Nitrones with Electrophilic Vinylcarbene Intermediates, Xiaochen Wang, Xinfang Xu, Peter Y. Zavalij, and Michael P. Doyle*, J. Am. Chem. Soc., 2011, 133, 16402-16405. Cooperative Catalysis in Highly Enantioselective Mannich-type Three-component Reaction of a Diazoacetophenone with an Alcohol and an Imine, Xinfang Xu, Yu Qian, Liping Yang, and Wenhao Hu*, Chem. Commun., 2011, 47, 797-799. (Reviewed by Synfacts: 2011, 3,0304) Multifunctionalized 3-Hydroxypyrroles in a Three-Step, One-Pot Cascade Process from Methyl 3-TBSO-2-diazo-3-butenoate and Nitrones, Xinfang Xu, Maxim O. Ratnikov, Peter Y. Zavalij, and Michael P. Doyle*, Org. Lett., 2011, 13, 6122-6125. A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Brønsted Acid-Rh2(OAc)4 Co-catalyzed EnantioselectiveThree-Component Reactions, Yu Qian, Xinfang Xu, Liqin Jiang, Dipak Prajapati, and Wenhao Hu*, J. Org. Chem., 2010, 75, 7483-7486. Highly Diastereoselective Synthesis of Fully Substituted Tetrahydrofurans by a One-Pot Cascade Reaction of Aryldiazoacetates with Allyl Alcohols, Xinfang Xu, Xinchun Han, Liping Yang, and Wenhao Hu*, Chem. Eur. J., 2009, 15, 12604-12607.(Reviewed by Synfacts: 2010, 2, 0186) Cooperative Catalysis with Chiral Brønsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, Wenhao Hu*,Xinfang Xu, Jing Zhou, Weijun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liuzhu Gong*, J. Am. Chem. Soc., 2008, 130, 7782-7783. Selectivity Control in Enantioselective Four-component Reactions of Aryl Diazoacetates with Alcohols, Aldehydes and Amines: an Efficient Approach to Synthesizing Chiral -Amino--hydroxyesters, Xinfang Xu, Jing Zhou, Liping Yang, and Wenhao Hu*, Chem. Commun., 2008, 44, 6564-6566.(Reviewed by Synfacts: 2009, 2, 0173)

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