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个人简介

Ph.D. The Ohio State University (Craig J. Forsyth, advisor) Postdoc. Memorial Sloan Kettering Cancer Center (Sameul J. Danishefsky, advisor)

研究领域

Research in the Wang group is focused on the development of new synthetic methods for natural product synthesis. Of particular interest are the discovery of new synthetic strategies via visible light photocatalysis and cooperative catalysis, and their applications in the synthesis of small molecules, peptides, and proteins.

近期论文

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Wu, K.#; Wang, L.#; Colon-Rodriguez, S.; Flechsig, G.*; Wang, T.* "Amidyl Radical Directed Remote Allylation of Unactivated sp3 C-H Bonds via Organic Photoredox Catalysis" Angew. Chem. Int. Ed. 2019, 58, 1774-1778. Kaur, S.; Zhao, G.; Busch, E.#; Wang, T.* "Metal-free Photocatalytic Thiol-Ene/Thiol-Yne Reactions" Org. Biomol. Chem. 2018, Advance Article.(Invited submission for "New Talent Themed Collection") Wu, K.; Du, Y.; Wei, Z.; Wang, T.* "Synthesis of Functionalized Pyrroloindolines via a Visible-Light-Induced Radical Cascade Reaction: Rapid Synthesis of (±) Flustraminol B" Chem. Commun. 2018, 54, 7443-7446. Wu, K.; Fang, C.; Kaur, S.; Liu, P.*; Wang, T.* "Methylene Blue Catalyzed Oxidative Cleavage of N-Carbonylated Indoles"Synthesis, 2018, 50, 2897-2907. (Invited submission for special issue "Modern Radical Methods and their Strategic Application in Synthesis") Zhao, G.; Wang, T.* "Stereoselective Synthesis of 2-Deoxyglycosides from Glycals by Visible-Light-Induced Photoacid Catalysis" Angew. Chem. Int. Ed. 2018, 57, 6120-6124. Du, Y.; Wei, Z.; Wang, T.* "Visible-Light-Mediated Synthesis of Oxidized Amides via Organic Photoredox Catalysis" Synthesis, 2018, 50, 3379-3386. (Invited submission for special issue "Photoredox Methods and their Strategic Applications in Synthesis") Wu, K.; Du, Y.; Wang, T.* “Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±) Flustramide B” Org. Lett. 2017, 19, 5669-5672. Zhao, G.; Kaur, S.; Wang, T.* "Visible-Light-Mediated Thiol-Ene Reactions through Organic Photoredox Catalysis" Org. Lett. 2017, 19, 3291-3294. Levinson, A. M.; McGee, J. H.; Roberts, A. G.; Creech, G. S.; Wang, T.; Peterson, M. T.; Hendrickson, R. C.; Verdine, G. L.; Danishefsky, S. J. "Total Chemical Synthesis and Folding of All-L and All-D Variants of Oncogenic Kras(G12V)" J. Am. Chem. Soc. 2017, 139, 7632-7639. Wang, T.; Danishefsky, S. J. “Solid-phase Peptide Synthesis and Solid-phase Fragment Coupling Mediated by Isonitriles” Proc. Natl. Acad. Sci. USA 2013, 110, 11708-11713. Wang, T.; Danishefsky, S. J. “Revisiting Oxytocin through the Medium of Isonitriles” J. Am. Chem. Soc. 2012, 134, 13244-13247. Wang, B.; Hansen, T.; Weyer, L.; Wu, D.; Wang, T.; Christmann, M.; Lu, Y.; Ying, L.; Engler, M.; Cink, R.; Lee, C. S.; Ahmed, F.; Forsyth, C. J. “Total Synthesis of Phorboxazole A via de Novo Oxazole Formation: Convergent Total Synthesis” J. Am. Chem. Soc. 2011, 133, 1506-1516. Wang, B.; Hansen, T.; Wang, T.; Wu, D.; Weyer, L.; Ying, L.; Engler, M.; Sanville, M.; Leitheiser, C.; Christmann, M.; Lu, Y.; Chen, J.; Zunker, N.; Cink, R.; Ahmend, F.; Lee, C. S.; Forsyth, C. J. “Total Synthesis of Phorboxazole A via de Novo Oxazole Formation: Strategy and Component Assembly” J. Am. Chem. Soc. 2011, 133, 1484-1505.

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