Wu, Jie - National University of Singapore

个人简介

Young Chemist Award, Department of Chemistry, NUS, 2018 Asian Core Program Lectureship Award from China, 2017 4th Green&Sustainable Manufacturing Award, The GSK-Singapore Partnership, 2017 SkolTech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014 Since July 2015, Jie has been appointed as an assistant professor at National University of Singapore in the Chemistry Department. Before that, he worked as a senior scientist in Snapdragon Chemistry Inc. at Boston which is established by his postdoc advisor Prof. Timothy Jamison for half a year. From July. 2012 - March. 2015, he was a postdoctoral researcher in the Department of Chemistry and Chemical Engineering at MIT, working with Prof. Timothy Jamison and Prof. Alan Hatton. His postdoc research was aimed at utilizing CO2 as a green C1 source to synthesize useful chemicals in continuous flow reactors. From Sep 2006 - May 2012 he earned his Ph.D degree under the supervision of Prof. James Panek in the Department of Chemistry at Boston University. His PhD thesis was Total Synthesis of (-)-Virginiamycin M2 and Chiral Organosilane Based Sequential Transformations to Access Polycyclic Scaffolds. From Sep 2002 - July 2006 he was an undergraduate student at Beijing Normal University worked with Prof. Zhang Zhanbin.

个人简介

Young Chemist Award, Department of Chemistry, NUS, 2018
Asian Core Program Lectureship Award from China, 2017
4th Green&Sustainable Manufacturing Award, The GSK-Singapore Partnership, 2017
SkolTech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014

Since July 2015, Jie has been appointed as an assistant professor at National University of Singapore in the Chemistry Department. Before that, he worked as a senior scientist in Snapdragon Chemistry Inc. at Boston which is established by his postdoc advisor Prof. Timothy Jamison for half a year.

From July. 2012 - March. 2015, he was a postdoctoral researcher in the Department of Chemistry and Chemical Engineering at MIT, working with Prof. Timothy Jamison and Prof. Alan Hatton. His postdoc research was aimed at utilizing CO2 as a green C1 source to synthesize useful chemicals in continuous flow reactors.

From Sep 2006 - May 2012 he earned his Ph.D degree under the supervision of Prof. James Panek in the Department of Chemistry at Boston University. His PhD thesis was Total Synthesis of (-)-Virginiamycin M2 and Chiral Organosilane Based Sequential Transformations to Access Polycyclic Scaffolds.

From Sep 2002 - July 2006 he was an undergraduate student at Beijing Normal University worked with Prof. Zhang Zhanbin.

研究领域

The research program in WU group have broadly and deeply involved in two research fields of organic synthesis, including photocatalysis and continuous-flow synthesis. My research interests focus on developing green and sustainable chemical synthesis by integrating several novel technologies: i) photocatalysis (clean energy), ii) CH and SiH activation (atom-, step-economic synthesis), iii) natural gas-involved transformation (inexpensive feedstocks), iv) flow technology (sustainable process). Our long-term goal is to advance otherwise difficult or ineffective chemical reactions using advanced flow techniques, as well as to develop new chemical strategies to aid the multistep flow process. Our group’s research is truly multidisciplinary including both organic chemistry and engineering aspects, which provides opportunities to learn areas of research outside of traditional organic synthesis. Students in my group will get trained on photocatalysis, continuous-flow synthesis, multistep synthesis, and green chemistry. They will build indepth chemistry background and strong problem-solving techniques. The advantages of continuous flow processing are increasingly being appreciated both by industry and academia, and students expertized in this field will find enormous job opportunities.

研究领域

专业：

研究方向：

研究领域和兴趣：

The research program in WU group have broadly and deeply involved in two research fields of organic synthesis, including photocatalysis and continuous-flow synthesis. My research interests focus on developing green and sustainable chemical synthesis by integrating several novel technologies: i) photocatalysis (clean energy), ii) CH and SiH activation (atom-, step-economic synthesis), iii) natural gas-involved transformation (inexpensive feedstocks), iv) flow technology (sustainable process). Our long-term goal is to advance otherwise difficult or ineffective chemical reactions using advanced flow techniques, as well as to develop new chemical strategies to aid the multistep flow process. Our group’s research is truly multidisciplinary including both organic chemistry and engineering aspects, which provides opportunities to learn areas of research outside of traditional organic synthesis. Students in my group will get trained on photocatalysis, continuous-flow synthesis, multistep synthesis, and green chemistry. They will build indepth chemistry background and strong problem-solving techniques. The advantages of continuous flow processing are increasingly being appreciated both by industry and academia, and students expertized in this field will find enormous job opportunities.

近期论文

Zhang, Y., Yang, X., Tang, H., Liang, D., Wu, J.*, and Huang, D.* (2019), Pyrenediones as Versatile Photocatalysts for Oxygenation Reactions with in situ Generation of Hydrogen Peroxide under Visible Light.2019, Green Chem., 2019, Accepted Manuscript. DOI: 10.1039/C9GC03152A Kuang, Y. , Wang, K. , Shi, X. , Huang, X. , Meggers, E. and Wu, J.* (2019), Asymmetric Synthesis of 1,4‐Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom Transfer Photocatalysis with Chiral Lewis Acid Catalysis. Angew. Chem. Int. Ed.. 2019, 58, 16859-16863. DOI:10.1002/anie.201910414 Liu, R., Chia, S. P. M., Goh, Y. Y., Cheo, H. W., Fan, B., Li, R., Zhou, R., Wu, J.* "Visible‐Light‐Mediated Regioselective Allylation, Benzylation, and Silylation of Methylene‐Malononitriles via Photoredox‐Induced Radical Cation Fragmentation" Eur. J. Org. Chem. 2019, Accepted Article. DOI: 10.1002/ejoc.201900902. Fan, X., Xiao, P., Jiao, Z., Yang, T., Dai, X., Xu, W., Tan, J. D., Cui, G.,* Su, H., Fang, W., Wu, J.* "Neutral-Eosin-Y-Photocatalyzed Silane Chlorination Using Dichloromethane" Angew. Chem. Int. Ed. 2019, 58, 12580-12584. DOI: 10.1002/anie.201908556. Zhou, R., Li, J., Cheo, H. W., Chua, R., Zhan, G., Hou, Z., Wu, J.* "Visible-light-mediated Deuteration of Silanes with Deuterium Oxide" Chem. Sci. 2019, 10, 7340–7344. DOI: 10.1039/C9SC02818H. Xu, J.-H., Wu, W.-B., Wu, J.* "Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic Conditions" Org. Lett. 2019, 21, 5321–5325. DOI: 10.1021/acs.orglett.9b01940. Ou, W., Zhang, G., Wu, J., Su, C.* "Photocatalytic Cascade Radical Cyclization Approach to Bioactive Indoline-Alkaloids over Donor–Acceptor Type Conjugated Microporous Polymer" ACS Catal. 2019, 9, 5178–5183. DOI: 10.1021/acscatal.9b00693. Wong, Y. -C., Wu, W.-B., Wang, T., Ng, J. D. A., Khoo, K. H.,* Wu, J.*, Tan, Z.-K. "Color Patterning of Luminescent Perovskites via Light‐Mediated Halide Exchange with Haloalkanes" Adv. Mater. 2019, 1901247. DOI: 10.1002/adma.201901247. "Young Career Focus: Dr. Jie Wu" Synform 2019, 05, A68–A70. DOI: 10.1055/s-0037-1612161. Ng, C. K., Toh, R. W., Lin, T. T., Luo, H.-K., Hor, T. S. A.,* Wu, J.* "Metal-salen molecular cages as efficient and recyclable heterogeneous catalysts for cycloaddition of CO2 with epoxides at ambient conditions" Chem. Sci. 2019, 10, 1549-1554. DOI: 10.1039/C8SC05019H. Li, J., Luo Y., Cheo, H. W., Lan, Y.,* Wu, J.* "Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of Ethylene" Chem 2019, 5, 192-203. DOI: 10.1016/j.chempr.2018.10.006. Xue, C.-W., Li, J., Lee, J. P., Zhang, P.,* Wu, J.* "Continuous Amination of Aryl/Heteroaryl Halides Using Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor" Reaction Chemistry & Engineering 2018, 4, 346-350 (Invited article for special issue "RCE Emerging Investigators 2019"). DOI: 10.1039/C8RE00216A. Cao, H., Jiang, H., Feng, H., Kwan, J. M. C., Liu, X., Wu, J.* "Photo-Induced Decarboxylative Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the Absence of Sacrificial Hydrogen Acceptors" J. Am. Chem. Soc. 2018, 47, 16360-16367. DOI: 10.1021/jacs.8b11218. This paper was highlighted by Synfacts 2019, 15, 0159 (By Prof. Paul Knochel). Hou, J., Ee, A., Cao, H., Ong, H.-W., Xu, J.-H. Wu, J.* "Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)-H Alkanes" Angew. Chem. Int. Ed. 2018, 57, 17220-17224. DOI: 10.1002/anie.201811266. Deng, H.-P., Zhou, Q., Wu, J.* "Micro-Tubing Reactor-Assisted Aliphatic C-H Functionalization Utilizing HCl as the Hydrogen Atom Transfer Catalyst Precursor in Conjunction with an Organo Photoredox Catalyst" Angew. Chem. Int. Ed. 2018, Accepted Article. DOI: 10.1002/anie.201804844. Wu, W.-B., Wong, Y.-C., Tan, Z.-K.,* Wu, J.* "Photo-induced thiol coupling and C–H activation using nanocrystalline lead-halide perovskite catalysts" Catal. Sci. Technol. 2018, 8, 4257-4263. DOI: 10.1039/c8cy01240g. Li, J.-S., Wu, J.* "Recent Development of Photo-Mediated Generation of Silyl Radicals and Their Application in Organic Synthesis" ChemPhotoChem 2018, Accepted Article. DOI: 10.1002/cptc.201800110 (Invited Review). Liu, H., Ma, L., Zhou, R., Chen, X.,* Fang, W., Wu, J.* "One-Pot Photo-Mediated Giese Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization to Access Naphthalene Derivatives from Toluenes and Enones" ACS Catal. 2018, 8, 6224−6229. DOI: 10.1021/acscatal.8b00481.

近期论文

Zhang, Y., Yang, X., Tang, H., Liang, D., Wu, J.*, and Huang, D.* (2019), Pyrenediones as Versatile Photocatalysts for Oxygenation Reactions with in situ Generation of Hydrogen Peroxide under Visible Light.2019, Green Chem., 2019, Accepted Manuscript. DOI: 10.1039/C9GC03152A

Kuang, Y. , Wang, K. , Shi, X. , Huang, X. , Meggers, E. and Wu, J.* (2019), Asymmetric Synthesis of 1,4‐Dicarbonyl Compounds from Aldehydes via the Marriage of Hydrogen Atom Transfer Photocatalysis with Chiral Lewis Acid Catalysis. Angew. Chem. Int. Ed.. 2019, 58, 16859-16863. DOI:10.1002/anie.201910414

Liu, R., Chia, S. P. M., Goh, Y. Y., Cheo, H. W., Fan, B., Li, R., Zhou, R., Wu, J.* "Visible‐Light‐Mediated Regioselective Allylation, Benzylation, and Silylation of Methylene‐Malononitriles via Photoredox‐Induced Radical Cation Fragmentation" Eur. J. Org. Chem. 2019, Accepted Article. DOI: 10.1002/ejoc.201900902.

Fan, X., Xiao, P., Jiao, Z., Yang, T., Dai, X., Xu, W., Tan, J. D., Cui, G.,* Su, H., Fang, W., Wu, J.* "Neutral-Eosin-Y-Photocatalyzed Silane Chlorination Using Dichloromethane" Angew. Chem. Int. Ed. 2019, 58, 12580-12584. DOI: 10.1002/anie.201908556.

Zhou, R., Li, J., Cheo, H. W., Chua, R., Zhan, G., Hou, Z., Wu, J.* "Visible-light-mediated Deuteration of Silanes with Deuterium Oxide" Chem. Sci. 2019, 10, 7340–7344. DOI: 10.1039/C9SC02818H.

Xu, J.-H., Wu, W.-B., Wu, J.* "Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic Conditions" Org. Lett. 2019, 21, 5321–5325. DOI: 10.1021/acs.orglett.9b01940.

Ou, W., Zhang, G., Wu, J., Su, C.* "Photocatalytic Cascade Radical Cyclization Approach to Bioactive Indoline-Alkaloids over Donor–Acceptor Type Conjugated Microporous Polymer" ACS Catal. 2019, 9, 5178–5183. DOI: 10.1021/acscatal.9b00693.

Wong, Y. -C., Wu, W.-B., Wang, T., Ng, J. D. A., Khoo, K. H.,* Wu, J.*, Tan, Z.-K. "Color Patterning of Luminescent Perovskites via Light‐Mediated Halide Exchange with Haloalkanes" Adv. Mater. 2019, 1901247. DOI: 10.1002/adma.201901247.

"Young Career Focus: Dr. Jie Wu" Synform 2019, 05, A68–A70. DOI: 10.1055/s-0037-1612161.

Ng, C. K., Toh, R. W., Lin, T. T., Luo, H.-K., Hor, T. S. A.,* Wu, J.* "Metal-salen molecular cages as efficient and recyclable heterogeneous catalysts for cycloaddition of CO2 with epoxides at ambient conditions" Chem. Sci. 2019, 10, 1549-1554. DOI: 10.1039/C8SC05019H.

Li, J., Luo Y., Cheo, H. W., Lan, Y.,* Wu, J.* "Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of Ethylene" Chem 2019, 5, 192-203. DOI: 10.1016/j.chempr.2018.10.006.

Xue, C.-W., Li, J., Lee, J. P., Zhang, P.,* Wu, J.* "Continuous Amination of Aryl/Heteroaryl Halides Using Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor" Reaction Chemistry & Engineering 2018, 4, 346-350  (Invited article for special issue "RCE Emerging Investigators 2019"). DOI: 10.1039/C8RE00216A.

Cao, H., Jiang, H., Feng, H., Kwan, J. M. C., Liu, X., Wu, J.* "Photo-Induced Decarboxylative Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the Absence of Sacrificial Hydrogen Acceptors" J. Am. Chem. Soc. 2018, 47, 16360-16367. DOI: 10.1021/jacs.8b11218. This paper was highlighted by Synfacts 2019, 15, 0159 (By Prof. Paul Knochel).

Hou, J., Ee, A., Cao, H., Ong, H.-W., Xu, J.-H. Wu, J.* "Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)-H Alkanes" Angew. Chem. Int. Ed. 2018, 57, 17220-17224. DOI: 10.1002/anie.201811266.

Deng, H.-P., Zhou, Q., Wu, J.* "Micro-Tubing Reactor-Assisted Aliphatic C-H Functionalization Utilizing HCl as the Hydrogen Atom Transfer Catalyst Precursor in Conjunction with an Organo Photoredox Catalyst" Angew. Chem. Int. Ed. 2018, Accepted Article. DOI: 10.1002/anie.201804844.

Wu, W.-B., Wong, Y.-C., Tan, Z.-K.,* Wu, J.* "Photo-induced thiol coupling and C–H activation using nanocrystalline lead-halide perovskite catalysts" Catal. Sci. Technol. 2018, 8, 4257-4263. DOI: 10.1039/c8cy01240g.

Li, J.-S., Wu, J.* "Recent Development of Photo-Mediated Generation of Silyl Radicals and Their Application in Organic Synthesis" ChemPhotoChem 2018, Accepted Article. DOI: 10.1002/cptc.201800110 (Invited Review).

Liu, H., Ma, L., Zhou, R., Chen, X.,* Fang, W., Wu, J.* "One-Pot Photo-Mediated Giese Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization to Access Naphthalene Derivatives from Toluenes and Enones" ACS Catal. 2018, 8, 6224−6229. DOI: 10.1021/acscatal.8b00481.