个人简介

Young Chemist Award, Department of Chemistry, NUS, 2018 Asian Core Program Lectureship Award from China, 2017 4th Green&Sustainable Manufacturing Award, The GSK-Singapore Partnership, 2017 SkolTech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014

研究领域

The research program in WU group have broadly and deeply involved in two research fields of organic synthesis, including photocatalysis and continuous-flow synthesis. My research interests focus on developing green and sustainable chemical synthesis by integrating several novel technologies: i) photocatalysis (clean energy), ii) CH and SiH activation (atom-, step-economic synthesis), iii) natural gas-involved transformation (inexpensive feedstocks), iv) flow technology (sustainable process). Our long-term goal is to advance otherwise difficult or ineffective chemical reactions using advanced flow techniques, as well as to develop new chemical strategies to aid the multistep flow process. Our group’s research is truly multidisciplinary including both organic chemistry and engineering aspects, which provides opportunities to learn areas of research outside of traditional organic synthesis. Students in my group will get trained on photocatalysis, continuous-flow synthesis, multistep synthesis, and green chemistry. They will build indepth chemistry background and strong problem-solving techniques. The advantages of continuous flow processing are increasingly being appreciated both by industry and academia, and students expertized in this field will find enormous job opportunities.

近期论文

Ng, C. K., Toh, R. W., Lin, T. T., Luo, H.-K., Hor, T. S. A.,* Wu, J.* "Metal-salen molecular cages as efficient and recyclable heterogeneous catalysts for cycloaddition of CO2 with epoxides at ambient conditions" Chem. Sci. 2019, 10, 1549-1554. DOI: 10.1039/C8SC05019H. Li, J., Luo Y., Cheo, H. W., Lan, Y.,* Wu, J.* "Photoredox Catalysis Modulated Nickel-Catalyzed Divergent Difunctionalization of Ethylene" Chem 2019, 5, 192-203. DOI: 10.1016/j.chempr.2018.10.006. Xue, C.-W., Li, J., Lee, J. P., Zhang, P.,* Wu, J.* "Continuous Amination of Aryl/Heteroaryl Halides Using Aqueous Ammonia in a Teflon AF-2400 Tube-in-Tube Micro-Flow Reactor" Reaction Chemistry & Engineering 2018, 4, 346-350 (Invited article for special issue "RCE Emerging Investigators 2019"). DOI: 10.1039/C8RE00216A. Cao, H., Jiang, H., Feng, H., Kwan, J. M. C., Liu, X., Wu, J.* "Photo-Induced Decarboxylative Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the Absence of Sacrificial Hydrogen Acceptors" J. Am. Chem. Soc. 2018, 47, 16360-16367. DOI: 10.1021/jacs.8b11218. This paper was highlighted by Synfacts 2019, 15, 0159 (By Prof. Paul Knochel). Hou, J., Ee, A., Cao, H., Ong, H.-W., Xu, J.-H. Wu, J.* "Visible‐Light‐Mediated Metal‐Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)-H Alkanes" Angew. Chem. Int. Ed. 2018, 57, 17220-17224. DOI: 10.1002/anie.201811266. Deng, H.-P., Zhou, Q., Wu, J.* "Micro-Tubing Reactor-Assisted Aliphatic C-H Functionalization Utilizing HCl as the Hydrogen Atom Transfer Catalyst Precursor in Conjunction with an Organo Photoredox Catalyst" Angew. Chem. Int. Ed. 2018, Accepted Article. DOI: 10.1002/anie.201804844. Wu, W.-B., Wong, Y.-C., Tan, Z.-K.,* Wu, J.* "Photo-induced thiol coupling and C–H activation using nanocrystalline lead-halide perovskite catalysts" Catal. Sci. Technol. 2018, 8, 4257-4263. DOI: 10.1039/c8cy01240g. Li, J.-S., Wu, J.* "Recent Development of Photo-Mediated Generation of Silyl Radicals and Their Application in Organic Synthesis" ChemPhotoChem 2018, Accepted Article. DOI: 10.1002/cptc.201800110 (Invited Review). Liu, H., Ma, L., Zhou, R., Chen, X.,* Fang, W., Wu, J.* "One-Pot Photo-Mediated Giese Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization to Access Naphthalene Derivatives from Toluenes and Enones" ACS Catal. 2018, 8, 6224−6229. DOI: 10.1021/acscatal.8b00481. Hou, J., Li, J.-S., Wu, J.* "Recent Development of Light-Mediated Carboxylation Using CO2 as the Feedstock" Asian J. Org. Chem. 2018, 7, 1439-1447. DOI: 10.1002/ajoc.201800226 (Invited Review). Fan, X.-Z., Rong, J.-W., Wu, H.-L., Zhou, Q., Deng, H.-P., Tan, J. D., Xue, C.-W., Wu, L.-Z., Tao, H.-R., Wu, J.* "Eosin Y as a Direct Hydrogen Atom Transfer Photocatalyst for the Functionalization of C-H Bonds" Angew. Chem. Int. Ed. 2018, 57, 8514-8518. Manuscript. DOI: 10.1002/anie.201803220. This paper has been selected as Hot Topic in Organocatalysis and Photocatalysis. Hou, J., Ee, A., Feng, W., Xu, J.-H., Zhao, Y.,* Wu, J.* "Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle Synthesis" J. Am. Chem. Soc. 2018, 140, 5257-5263. DOI: 10.1021/jacs.8b01561 Toh, R. W., Li, J. S., Wu, J. Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations. J. Vis. Exp. 2018, (131), e56897, doi:10.3791/56897. Zhou, R.; Goh, Y. Y.; Liu, H.; Tao, H.; Li, L.; Wu, J.* “Visible-Light-Mediated Metal-Free Hydrosilylation of Alkenes through Selective Hydrogen Atom Transfer for Si-H Activation” Angew. Chem. Int. Ed. 2017, 56(52), 16621-16625. DOI: 10.1002/anie.201711250. Deng, H.; Fan, X.; Chen, Z.; Xu, Q.; & Wu, J.* "Photo-induced nickel-catalyzed chemo- and regioselective hydroalkylation of internal alkynes with ether and amide a-hetero C(sp3)-H bonds" J. Am. Chem. Soc. 2017, 139, 13579-13584. DOI: 10.1021/jacs.7b08158 Zhou, R.; Liu, H.; Tao, H.; Yu, X.; & Wu, J.* "Metal-free direct alkylation of unfunctionalized allylic/benzylic sp 3 C–H bonds via photoredox induced radical cation deprotonation." Chem. Sci. 2017, 8(6), 4654-4659., DOI: 10.1039/C7SC00953D. Xue, F.†; Deng, H.†; Xue, C.; Mohamed, D. K. B.; Tang, K. Y.; Wu, J.* “Reaction Discovery Using Acetylene Gas as the Chemical Feedstock Accelerated by the ‘Stop-Flow’ Micro-Tubing Reactor System” Chem. Sci. 2017, 8(5), 3623-3627. DOI: 10.1039/C7SC00408G. (†Co-first authors)