Kartika, Rendy - Louisiana State University

个人简介

Rendy Kartika was born and raised in Malang, Indonesia. After graduating from Kolese Santo Yusup Catholic High School, Rendy moved to the USA. He attended Cal Poly Pomona University and graduated with a B.S. in chemistry in Spring 2003. Rendy was introduced to organic chemistry research in Prof. Douglas Klumpp’s laboratory, and his undergraduate thesis described the use of superacid to generate superelectrophilic dicationic species from simple organic compounds, such as cinnamic acid and its derivatives. He then continued his studies in chemistry at the University of Notre Dame, completing his doctoral work in organic synthesis under the direction of Prof. Richard Taylor in September 2008. Rendy’s graduate dissertation included synthetic methods development, such as the electrophile induced ether-transfer reaction, and its application in total synthesis directed towards polyketide natural products. He joined Prof. David Spiegel’s group at Yale University in October 2008, and worked on the chemical synthesis of advanced glycation endproducts and structurally diverse amidine oligomers. Rendy joined the faculty of the department of chemistry at LSU as an assistant professor in August 2011. He immensely enjoys college football and fishing in his spare time, thus making LSU and Baton Rouge a perfect place for him to work and live in for many years to come.

研究领域

Natural product chemistry, total synthesis, synthetic methodology, asymmetric synthesis, carbo- and heterocycles synthesis, diversity-oriented synthesis Natural products are chemical entities produced by organisms as secondary metabolites. Their structural complexity is considered privileged as they have been assembled and modified by evolution. Thus, natural products often exhibit very specific biological functions, making them highly relevant in modern drug discovery. In fact, over 70% of all newly approved small-molecule chemical entities ranging from antibacterial to anticancer drugs in the past 30 years have been derived from natural products. Research in natural product chemistry is an essential component of the Kartika group. We primarily focus on organic syntheses, particularly in the development of novel synthetic methodology and application in total synthesis of natural products. A few examples of biologically active natural products of interest in the Kartika group are depicted below.

近期论文

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Wang, T.; Kartika, R.; Spiegel, D. A. “Exploring Post-Translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones (MG-Hs).” J. Am. Chem. Soc. 2012, 134, 8958. Kartika, R.; Gruffi, T. R.; Taylor, R. E. “Concise Enantioselective Total Synthesis of Neopeltolide Macrolactone Highlighted by Ether Transfer.” Org. Lett. 2008, 10, 5047. Kartika, R.; Frein, J. D.; Taylor, R. E. “Electrophile-Induced Ether Transfer: Stereoselective Synthesis of 2,6-Disubstituted 3,4-Dihydropyrans.” J. Org. Chem. 2008, 73, 5592. Kartika, R.; Taylor, R. E. “Electrophile-Induced Ether Transfer: An Expedient Route to 2-Cyano-Tetrahydropyrans.” Heterocycles 2007, 74, 447. Kartika, R.; Taylor, R. E. “Electrophile-Induced Ether Transfer: Stereoselective Synthesis of 2,4,6-Trisubstituted Tetrahydropyrans.” Angew. Chem. Int. Ed. 2007, 46, 6874. Kartika, R.; Taylor, R. E. “An Exhaustive Hydrogenation Strategy to Bicyclic Alkaloids.” Chemtracts 2006, 19, 385. Liu, K.; Taylor, R. E.; Kartika, R. “Electrophile-Induced Ether Transfer: A New Approach to Polyketide Structural Units.” Org. Lett. 2006, 8, 5393. Klumpp, D. A.; Zhang, Y.; Do, D.; Kartika, R. “Reactions of Acenaphthenequinone and Aceanthrenequinone with Arenes in Superacid.” Applied Catalysis, A: General 2008, 336, 128. Zhang, Y.; Briski, J.; Zhang, Y.; Rendy, R.; Klumpp, D. A. “Superacid-Catalyzed Reactions of Olefinic Pyrazines: an Example of Anti-Markovnikov Addition Involving Superelectrophiles.” Org. Lett. 2005, 7, 2505. Klumpp, D. A.; Rendy, R.; Zhang, Y.; McElrea, A.; Gomez, A.; Dang, H. “Reactive Dications: The Superacid-Catalyzed Reactions of Alkynes Bearing Adjacent N-Heterocycles or Amine Groups.” J. Org. Chem. 2004, 69, 8108. Klumpp, D. A.; Rendy, R.; McElrea, A. “Superacid Catalyzed Ring-Opening Reactions Involving 2-Oxazolines and the Role of Superelectrophilic Intermediates.” Tetrahedron Lett. 2004, 45, 7959. Klumpp, D. A.; Rendy, R.; Zhang, Y.; Gomez, A.; McElrea, A. “Dicationic Intermediates Involving Protonated Amides: Dual Modes of Reactivity Including the Acylation of Arenes.” Org. Lett. 2004, 6, 1789. Rendy, R.; Zhang, Y.; McElrea, A.; Gomez, A.; Klumpp, D. A. “Superacid-Catalyzed Reactions of Cinnamic Acids and the Role of Superelectrophiles.” J. Org. Chem. 2004, 69, 2340. Zhang, Y.; McElrea, A.; Sanchez, G. V., Jr.; Do, D.; Gomez, A.: Aguirre, S. L.; Rendy, R.; Klumpp, D. A. “Dicationic Electrophiles from Olefinic Amines in Superacid.” J. Org. Chem. 2003, 68, 5119.