Minichiello, Liliana - University of Oxford - Department of Pharmacology

个人简介

Dr. Liliana Minichiello, is a Reader in Cellular and Molecular Neuroscience, and has joined the Department of Pharmacology in October 2012. She received a Laurea in Biological Sciences from the University of Naples, Federico II, Italy and then went on for her graduate studies in Molecular Biology first at the University of Naples, Federico II, Italy (group of Prof Arturo Leone), and then at The National Cancer Institute, NIH, Bethesda, (MD) USA (group of Dr Pier Paolo Di Fiore). This was followed by a few years spent at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, for her postdoctoral training (group of Dr Rüdiger Klein), where she worked on the biological functions of neurotrophin receptor tyrosine kinases (Trks) in the mouse nervous system by generation and analysis of genetic mouse models. She then became the leader of a group at the EMBL Mouse Biology Unit in Monterotondo, Rome, Italy (2000-09). She was then appointed as Reader and Deputy Director of the Centre for Neuroregeneration at the University of Edinburgh, Scotland, moving to Oxford in 2012. Dr Minichiello is presently a visiting scientist at the Mouse Biology Unit, EMBL-Monterotondo, Rome, Italy. She has held a visiting professorship at the Lund Stem Cell Center, Lund University, Lund, Sweden (2005-2010). She has been awarded prestigious fellowship for her postdoctoral studies such as EMBO long-term fellowship, and has organized and taught on many EMBO courses in the past few years.

研究领域

our main research interest has long been to define molecular and cellular mechanisms underlying synaptic plasticity, learning and memory. Key achievements include the genetic demonstration that the neurotrophin receptor TrkB is a potent regulator of hippocampal synaptic plasticity via activation of pathway/s through its PLCγ-site; that the molecular pathways required for learning are also those generating long-term potentiation (LTP, which is considered to be the mechanism for acquisition and storage of information by synapses in the brain) when measured directly on the relevant circuit of a learning animal; that TrkB modulates specific phases of fear learning and amygdalar synaptic plasticity by specific docking sites.

近期论文

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Dai, N, Zhao, L, Wrighting, D, Kramer, D, Majithia, A, Wang, Y, Cracan, V, Borges-Rivera, D, Mootha, VK, Nahrendorf, M, Thorburn, DR, Minichiello, L, Altshuler, D, and Avruch, J (2015) Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Hepburn, L, Prajsnar, TK, Klapholz, C, Moreno, P, Loynes, CA, Ogryzko, NV, Brown, K, Schiebler, M, Hegyi, K, Antrobus, R, Hammond, KL, Connolly, J, Ochoa, B, Bryant, C, Otto, M, Surewaard, B, Seneviratne, SL, Grogono, DM, Cachat, J, Ny, T, Kaser, A, Torok, ME, Peacock, SJ, Holden, M, Blundell, T, Wang, L, Ligoxygakis, P, Minichiello, L, Woods, CG, Foster, SJ, Renshaw, SA, and Floto, RA (2014) Innate immunity. A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus. Koudelka, J, Horn, JM, Vatanashevanopakorn, C, and Minichiello, L (2014) Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system.