Lei, Ming - University of Oxford - Department of Pharmacology

个人简介

Dr. Ming Lei joined the department in 2013. He received MB, BS and M Med at Tongji Medical University (Wuhan) in China and D.Phil in Physiology at University of Oxford in 1997. After 4 years experience of postdoctoral fellowship at Universities of Leeds and Oxford, he was awarded the Wellcome Trust Research Career Development Fellowship and started his research group in 2001 at University of Oxford. In 2005, he moved to University of Manchester as a senior lecturer and became Reader in Cardiac Physiology in 2012. He has published ~80 original articles and reviews in peer-review journals including those in top journals in the fields of cardiovascular research and physiology. His research has received substantial support from UK government and charity funding bodies including Medical Research Council, The Wellcome Trust and British Heart Foundation. He has been the guest editor of Progress in Molecular Biology and Biophysics, Guest Associate Editor of Frontier in Physiology and has been invited to give plenary/keynote lectures in various international scientific conferences and institutes. He is member of The Physiological Society, American Biophysical Society, British Society For Cardiovascular Research and European Working Group on Cardiac Cellular Electrophysiology, European Society of Cardiology.

研究领域

Dr. Lei’s research seeks to understand cardiac ion channel function and its regulation under both physiological and pathophysiological conditions in a direction that will lead to a better understanding of hypertrophic and arrhythmic disorders, and the development of effective new therapeutic modalities. Dr Lei’s group combines advanced genetic manipulation technology with the state-of-the-art multi-scale electrophysiological and molecular approaches that extend through in vivo, ex vivo heart, isolated cardiac tissue and single cell electrophysiological and Ca2+ signal recording techniques, and integration of the results of these with a clarification of their molecular correlates and a reconstruction of their whole organ implications through mathematical modeling.

近期论文

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Egom, EE, Kruzliak, P, Rotrekl, V, and Lei, M (2015) The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. Ju, Y, Lee, BH, Trajanovska, S, Hao, G, Allen, DG, Lei, M, and Cannell, MB (2015) The involvement of TRPC3 channels in sinoatrial arrhythmias. Wang, Y, Tsui, H, Bolton, EL, Wang, X, Huang, CL, Solaro, RJ, Ke, Y, and Lei, M (2015) Novel insights into mechanisms for Pak1-mediated regulation of cardiac Ca(2+) homeostasis. Lei, M, Wang, X, Ke, Y, and Solaro, RJ (2015) Regulation of Ca(2+) transient by PP2A in normal and failing heart. Butters, TD, Castro, SJ, Lowe, T, Zhang, Y, Lei, M, Withers, PJ, and Zhang, H (2014) Optimal iodine staining of cardiac tissue for X-ray computed tomography. Wang, R, Wang, Y, Lin, WK, Zhang, Y, Liu, W, Huang, K, Terrar, DA, Solaro, RJ, Wang, X, Ke, Y, and Lei, M (2014) Inhibition of Angiotensin II-Induced Cardiac Hypertrophy and Associated Ventricular Arrhythmias by a p21 Activated Kinase 1 Bioactive Peptide.