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Puddu F*, Oelschlaegel T*, Guerini I, Geisler NJ, Niu H, Herzog M, Salguero I, Ochoa-Monta?o B, Viré E, Sung P, Adams DJ, Keane TM and Jackson SP. (2015) Synthetic viability genomic screening defines Sae2 function in DNA repair. EMBO Journal 34, 1509-22. *These authors contributed equally to this work. Blackford AN, Nieminuszczy J, Schwab RA, Galanty Y, Jackson SP^, Niedzwiedz W^. (2015) TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Molecular Cell 57, 1133-41. ^Co-corresponding authors. Ochi T*, Blackford AN*, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL^, Jackson SP^ (2015) PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science 347, 185-188. *These authors contributed equally to this work. ^Co-corresponding authors. Davies OR*, Forment JV*, Sun M, Belotserkovskaya R, Coates J, Galanty Y, Demir M, Morton CR, Rzechorzek NJ, Jackson SP^, Pellegrini L^. (2015) CtIP tetramer assembly is required for DNA-end resection and repair. Nature Structural and Molecular Biology 22, 150-157. *These authors contributed equally to this work. ^Co-corresponding authors. Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP. (2014) Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nature Cell Biology 16, 1016-1026. Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP. (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344, 527-532. Britton S, Coates J, Jackson SP. (2013) A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J. Cell Biol. 202, 579-595. Kaidi A, Jackson SP. (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-74. Jackson SP, Durocher D. (2013) Regulation of DNA Damage Responses by Ubiquitin and SUMO. Mol. Cell 49, 795-807. Galanty Y, Belotserkovskaya R, Coates J, Jackson SP. (2012) RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev. 26, 1179-95. Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AMR, Turnell AS, Stewart GS, Grand RJ, Jackson SP (2012) Regulation of DNA-End Resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell 45(4), 505-516. Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S^, Jackson SP^ (2012) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 8, 301-310 ^Co-corresponding authors Polo SE and Jackson SP. (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 25, 409-433. Kaidi A, Weinert BT, Choudhary C, Jackson SP. (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329, 1348-1353. Jackson SP and Bartek J. (2009) The DNA damage response in human biology and disease. Nature 461, 1071-1078. Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP. (2009) Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 462, 935-9. Lloyd J*, Chapman JR*, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP^, Smerdon SJ^. (2009) A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 139, 100-11. *These authors contributed equally to this work. ^Co-corresponding authors. Huertas P, Cortés-Ledesma F, Sartori AA, Aguilera A, Jackson SP. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455: 689-692.