Burke, David - University of Cambridge

研究领域

My research interests lie in how computational approaches can be used to understand the relationship between protein sequence, protein structure and biological function and disease. My research has focused on many aspects of computational structural bioinformatics, including both the development of new algorithms and the application of these techniques to predict the effect genetic sequence variations have on the structure, dynamics, folding and function of proteins and their involvement in the onset and proliferation of disease. I am currently applying these approaches to strain variation in the Influenza virus and other infectious diseases.

近期论文

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Russell CA, Fonville JM, Brown AEX, Burke DF, Smith DL, James SL, Herfst S, van Boheemen S, Linster M, Schrauwen EJ, Katzelnick L, Mosterín A, Kuiken T, Maher E, Neumann G, Osterhaus ADME, Kawaoka Y, Fouchier RAM, Smith DJ (2012) The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host.Science 336 (6088) 1541-1547 Herfst S, Schrauwer EJA , Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus ADME, Fouchier RAM (2012) Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets. Science 336 (6088) 1534-1541 Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ. Antigenic and Genetic Characteristics of Swine-Origin (2009) A(H1N1) Influenza Viruses Circulating in Humans. Science 325(5937) :197-201