研究领域
Chemistry, biology, immunology, and evolution with viruses. The sizes and properties of virus particles put them at the interface between the worlds of chemistry and biology. We use techniques from both fields to tailor these particles for applications to cell targeting, diagnostics, vaccine development, catalysis, and materials self-assembly. This work involves combinations of small-molecule and polymer synthesis, bioconjugation, molecular biology, protein design, protein evolution, bioanalytical chemistry, enzymology, physiology, and immunology. It is an exciting training ground for modern molecular scientists and engineers.
Development of reactions for organic synthesis, chemical biology, and materials science. Molecular function is what matters most to our scientific lives, and good chemical reactions provide the means to achieve such function. We continue our efforts to develop and optimize reactions that meet the click chemistry standard for power and generality. Our current focus is on highly reliable reversible reactions, which open up new possibilities for polymer synthesis and modification, as well as for the controlled delivery of therapeutic and diagnostic agents to biological targets.
Traditional and combinatorial synthesis of biologically active compounds. We have a longstanding interest in the development of biologically active small molecules. We work closely with industrial and academic collaborators on such targets as antiviral agents, compounds to combat tobacco addiction, and treatments for inflammatory disease.
近期论文
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Improved Metal-Adhesive Polymers from Cu(I)-Catalyzed Azide–Alkyne Cycloaddition. Accurso, A.A.; Delaney, M.; O’Brien, J.; Kim, H.; Iovine, P.; Diaz Diaz, D.; Finn, M.G. Chem. Eur. J. . 2014, in press,
A Click Chemistry Organic Adhesives Experiment. Accurso, A.A.; Finn, M.G.; Fokin, V.V.; Díaz, D.D. Aust. J. Chem. . 2014, in press,
Learning from nature - novel synthetic biology approaches for biomaterial design. Bryksin, A.V.; Brown, A.C.; Baksh, M.M.; Finn, M.G.; Barker, T.H. Acta Biomaterialia. 2014, in press,
Undesired vs. Designed Enzymatic Cleavage of Linkers for Liver Targeting. Chirapu, S.R.; Bauman, J.N.; Eng, H.; Goosen, T.C.; Strelevitz, T.J.; Sinha, S.C.; Dow, R.L.; Finn, M.G. Bioorg. Med. Chem. Lett.. 2014, 24, 1144-1147.
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. Dong, J.; Krasnova, L.; Finn, M.G.; Sharpless, K.B. Angew. Chem. Int. Ed.. 2014, in press,
High Specificity in Response of the Sodium-Dependent Multivitamin Transporter to Derivatives of Pantothenic Acid. Chirapu, S.; Rotter, C.J.; Miller, E.L.; Varma, M.V.; Dow, R.L.; Finn, M.G. Curr. Top. Med. Chem. (special issue on “designing molecules to cross biological membranes”). 2013, 13, 837-842.
Relative Performance of Alkynes in Copper-Catalyzed Azide-Alkyne Cycloaddition. Kislukhin, A.; Hong, V.; Breitenkamp, K.; Finn, M.G. Bioconjugate Chem.. 2013, 24, 684-689.
Phase diagrams map the properties of anti-viral agents directed against Hepatitis B virus core assembly. Li, L.; Chirapu, S.; Finn, M.G.; Zlotnick, A. Antimicrob. Agents Chemother.. 2013, 57, 1505-1508.
Comparison of the effects of the GABAB receptor positive modulator BHF177 and GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. Li, X.; Risbrough, V.B.; Cates-Gatto, C.; Kaczanowska, K.; Finn, M.G.; Roberts, A.J.; Markou, A. Neuropharmacology . 2013, 70, 156-167.
Synthesis of biologically active N- and O-linked glycans with multi-sialylated poly-N-acetyllactosamine extensions using P. damsela α-2,6-sialyltransferase. Nycholat, C.M.; Peng, W.; McBride, R.; Antonopoulos, A.; De Vries, R.P.; Polonskaya, Z.; Finn, M.G.; Dell, A.; Haslam, S.M.; Paulson, J.C. J. Am. Chem. Soc.. 2013, 135, 18280-18283.
Small Molecule Regulation of Protein Conformation: Binding in the Flap of HIV Protease. Tiefenbrunn, T.; Forli, S.; Baksh, M.; Chang, M.; Happer, M.; Lin, Y.-C.; Perryman, A.; Rhee, J.-K.; Torbett, B.; Olson, A.; Elder, J.; Finn, M.G.; Stout, C. ACS Chem. Biol.. 2013, 8, 1223-1231.
Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids. Yin, Z.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J.; Finn, M.G.; Huang, X. ACS Chem. Biol.. 2013, 8, 1253-1262.
Direct Human Cartilage Repair Using 3D Bioprinting Technology. Cui, X.; Breitenkamp, K.; Finn, M.G.; Lotz, M.; D’Lima, D.D. Tissue Eng. Part A. 2012, 18, 1304-1312.
Novel Inhibitors for PRMT1 Discovered by High-Throughput Screening Using Activity-Based Fluorescence Polarization. Dillon, M.B.C.; Bachovchin, D.A.; Brown, S.J.; Finn, M.G.; Rosen, H.; Cravatt, B.F., Mowen, K.A. ACS Chem. Biol. . 2012, 7, 1198-1204.
Engineered Mutations Change the Structure and Stability of a Virus-Like Particle. Fiedler, J.D.; Higginson, C.; Hovlid, M.L.; Kislukhin, A.A.; Castillejos, A.; Manzenrieder, F.; Campbell, M.G.; Voss, N.R.; Potter, C.S.; Carragher, B.; Finn, M.G. Biomacromolecules . 2012, 13, 2339-2348.
Tyrosine Cross-Linking Reveals Interfacial Dynamics in Adeno-Associated Viral Capsids during Infection. Horowitz, E.D.; Finn, M.G.; Asokan, A. ACS Chem. Biol.. 2012, 7, 1059-1066.
Degradable Conjugates from Oxanobornadiene Reagents. Kislukhin, A.A.; Higginson, C.J.; Hong, V.P.; Finn, M.G. J. Am. Chem. Soc. . 2012, 134, 6491-6497.
Glycomimetic Ligands for the Human Asialoglycoprotein Receptor. Mamidyala, S.K.; Dutta, S.; Chrunyk, B.A.; Preville, C.; Wang, H.; Withka, J.M.; McColl, A.; Subashi, T.A.; Hawrylik, S.J.; Griffor, M.C.; Kim, S.; Pfefferkorn, J.A.; Price, D.A.; Menhaji-Klotz, E.; Mascitti, V.; Finn, M.G. J. Am. Chem. Soc. . 2012, 134, 1978-1981.
Resin-Supported Catalysts for CuAAC Click Reactions in Aqueous or Organic Solvents. Presolski, S.I.; Mamidyala, S.K.; Manzenrieder, F.; Finn, M.G. ACS Comb. Sci. . 2012, 14, 527-530.
Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy. Rhee, J.-K.; Baksh, M.; Nycholat, C.; Paulson, J.C.; Kitagishi, H.; Finn, M.G., Biomacromolecules. 2012, 13, 2333-2338.
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