个人简介

B.S. 1974, Hebrew University Ph.D. 1983, Weizmann Institute Awards & Honors Fellow of National Academy of Inventors, 2013

研究领域

Materials Chemistry/Organic Chemistry

Biotechnology, synthesis of biopolymers, peptide chemistry As biomaterials scientists, our goal is to improve health care and quality of life by developing advanced biomedical products for tissue repair, replacement, and the delivery of pharmaceutical agents. The Kohn Lab has furthered the field of tissue engineering by creating the first combinatorial library of polymers in which the chemical, mechanical and physical properties can be varied incrementally and predictably. In addition to basic studies, our lab has helped to translate our technologies into clinical or pre-clinical products, including surgical meshes, cardiovascular stents, bone regeneration scaffolds, and ocular drug delivery systems. Our ultimate goal is to increase the number of viable biomaterials candidates and to accelerate their development into medical devices that alleviate the pain and suffering of patients throughout the world.

近期论文

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Joy A, Anim-Danso E, Kohn J. Simple, rapid, and highly sensitive detection of diphosgene and triphosgene by spectrophotometric methods. Talanta 2009;80(1):231-5. Holmes PF, Bohrer M, Kohn J. Exploration of polymethacrylate structure-property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery. Prog Polym Sci 2008;33(8):787-796. Sheihet L, Chandra P, Batheja P, Devore D, Kohn J, Michniak B. Tyrosine-derived nanospheres for enhanced topical skin penetration. Int J Pharm 2008;350(1-2):312-9. Sheihet L, Piotrowska K, Dubin RA, Kohn J, Devore D. Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery. Biomacromolecules 2007;8(3):998-1003. Kohn J, Welsh WJ, Knight D. A new approach to the rationale discovery of polymeric biomaterials. Biomaterials 2007;28:4171-4177. Pesnell A, Bolikal D, Weber N, Zeltinger J, Brandom D, Kohn J. A Focused Library of Tyrosine-Derived Polycarbonates for the Discovery of Optimal Polymers for Use in Degradable Stents. 2005 November 28, 2005; Boston, MA (USA). Materials Research Society. Smith JR, Seyda A, Weber N, Knight D, Abramson S, Kohn J. Integration of combinatorial synthesis, rapid screening, and computational modeling in biomaterials development. Macromol. Rapid Commun. 2004;25:127–140. Nardin C, Bolikal D, Kohn J. Nontoxic block copolymer nanospheres: Design and characterization. Langmuir 2004;20((26)):11721-5. Kohn J. New approaches to biomaterials design. Nature Materials 2004;3:745-747. Fang JB, Sanghi R, Kohn J, Goldman AS. Tantalum pentachloride as a coupling agent for stereohindered amide bond formation. Inorg. Chim. Acta 2004;357:2415-2426. Bourke SL, Kohn J. Polymers derived from the amino acid L-tyrosine: Polycarbonates, polyarylates and copolymers with poly(ethylene glycol). Adv. Drug Del. Rev. 2003;55(4):447-466. Bourke SL, Al-Khalili M, Briggs T, Michniak BB, Kohn J, Poole-Warren LA. A photo-crosslinked poly(vinyl alcohol) hydrogel growth factor release vehicle for wound healing applications. AAPS PharmSci. 2003;5 article 33(4):article 33. Auguste DT, Prud’homme RK, Ahl PL, Meers P, Kohn J. Novel polymer constructs for liposome protection. 2003 November 20, 2003; San Fransisco, CA. American Institute of Chemical Engineers. Auguste DT, Prud’homme RK, Ahl PL, Meers P, Kohn J. Association of hydrophobically modified poly(ethylene glycol) with fusogenic liposomes. Biochim. Biophys. Acta 2003;1616:184-195. Yang B-S, Lal J, Mihailescu M, Monkenbusch M, Richter D, Huang JS, Kohn J, Russel WB, Prud’homme RK. Neutron spin-echo study of dynamics of hydrophobically modified polymer-doped surfactant bilayers. Langmuir 2002;18:6-13. Schachter DM, Kohn J. A synthetic polymer matrix for the delayed or pulsatile release of water-soluble peptides. J. Control. Rel. 2002;78:143-153. Perez-Luna VH, Kohn J, Graham DJ, Ratner BD. Poly(desaminotyrosyl-tyrosine carbonate ethyl ester) studied by XPS. Surf. Sci. Spectra 2002;9:6-11. d'Acunzo F, Le TQ, Kohn J. Alternating multiblock amphiphilic copolymers of PEG and tyrosine-derived diphenols. II. Self-assembly in aqueous solution and at hydrophobic surfaces. Macromolecules 2002;35:9366-9371. d'Acunzo F, Kohn J. Alternating multiblock amphiphilic copolymers of PEG and tyrosine-derived diphenols. I. Synthesis and characterization. Macromolecules 2002;35:9360-9365. Yang B-S, Lal J, Kohn J, Huang JS, Russel WB, Prud'homme RK. Interaction of surfactant lamellar phase and a strictly alternating comb-graft amphiphilic polymer based on PEG. Langmuir 2001;17(21):6692-6698.